OBGYN
OBGYN
Gynaecology
● Urinary frequency and urgency and painful voiding + dyschezia + dysmenorrhoea + sacral backache with
menses + deep dyspareunia ⇒ endometriosis
○ Ectopic endometrium in the pouch of douglas / rectovaginal septum ⇒ dyschezia
● Progesterone is the hormone to confirm ovulation
○ Infertile woman → test to assess ovulation? Mid-luteal progesterone (7 days before the expected next
period) → if low → repeat
● Urinary incontinence
○ Stress incontinence = on sneezing / coughing
■ Treatment in order: (1) Conservative: Pelvic floor exercises 8 reps 3 sets a day for 3 months
(2) Surgical: Retropubic mid-urethral tape (tension-free vaginal tape)
(3) Duloxetine
○ Urge incontinence
■ Treatment in order = (1) Behavioural modification: Bladder retraining for 6 weeks
Minimum; modifying fluid intake, avoiding caffeine and alcohol
(2) Antimuscarinics: oxybutynin, tolterodine, darifenacin
(don’t give immediate-release oxybutynin to frail old women)
○ Ring pessary is for cystocele
● PCOS
○ PCOS clinical picture → do ultrasound pelvis → 12+ follicles on the ovaries can help make the diagnosis
○ LH is very high ⇒ LH:FSH ratio is > 2
○ Management: depends on what you’re trying to fix (and on the complaint in the vignette).
■ Menstrual irregularities? Weight loss + contraceptives (COCP/cyclical progestogen/IUS)
■ Infertility? Weight loss + clomifene citrate
If clomifene fails → +metformin or +gonadotropins or +laparoscopic ovarian drilling
● Gynae ethics
● Suspected femal genital mutilation (FGM) + >18 years old → initiate safeguarding procedures
● Suspected femal genital mutilation (FGM) + <18 years old → report to the police
● African patient + bloating + heavy regular periods + big uterus size ⇒ fibroids
● A woman with ovarian torsion is with the gensurg team ⇒ call the gynaecology on call, do NOT take her to
theatre :)))) even if she’s dying
● Young woman with acute pelvic pain in A&E → transvaginal ultrasound (diagnose PID and r/o ovarian cyst or
adnexal torsion)
● Vulvar pathologies
○ Lichen sclerosus ⇒ vulvar itching that is worst at night + white atrophic plaques + dyspareunia ⇒ treat
with topical steroids ⇒ follow-up at 3 and 6 months to ensure response to treatment
■ No follow-up ⇒ 4% incidence of malignant change to squamous cell carcinoma of the vulva
Qs one-liners
Oncology
● Ovarian cancer
○ 50+ years old woman + vague abdominal symptoms
■ + no abnormal masses palpable ⇒ request CA-125
■ + ascites on examination ⇒ urgent referral to gynae
■ pelvic/abdominal mass on exam ⇒ urgent referral to gynae
○ 50+ years old woman + vague abdominal symptoms + raised CA-125 ⇒ refer for an urgent ultrasound
○ 50+ years old woman + vague abdominal symptoms + raised CA-125 + ultrasound positive for Ovarian
cancer ⇒ urgent referral to gynae
● Endometrial hyperplasia
○ EH is premalignant and can lead to endometrial carcinoma. It is caused by excess unopposed oestrogen.
○ Investigations: TVUS (to check for endometrial thickness) → if ≥4mm → confirm with endometrial
sampling / formal endometrial curettage by doing hysteroscopy and biopsy
○ Management
■ EH without atypia → IUS (first-line) or continuous oral progestogen
● Cervical cancer
○ Guideline picture on the right shows the new way (that is doing HR-HPV
before cytology)
○ The old way is liquid cytology and we start with it, and move on depending
on the result (pap smear = cervical cytology)
■ Negative/normal cytology ⇒ routine recall (same as new)
■ Inflammatory only ⇒ repeat swab in 6 months
■ Severe inflammation only ⇒ take swabs for infection
■ Inadequate cytology ⇒ repeat sample
■ Inadequate after repeating ⇒ colposcopy
■ Borderline cytology ⇒ HPV test
■ Mild dyskaryosis ⇒ HPV test
■ Borderline and HPV+ ⇒ colposcopy
■ Mild dyskaryosis and HPV+ ⇒ colposcopy
■ Mild dyskaryosis and HPV testing not available or inadequate ⇒ colposcopy
■ Mod/severe dyskaryosis ⇒ urgent colposcopy (2-week wait)
■ Suspected invasion ⇒ urgent colposcopy (2-week wait)
■ Abnormal glandular cells ⇒ urgent colposcopy (2-week wait)
○ Abnormal bleeding (even if brown discharge) that persists for more than 6-8 weeks + normal cervical
smear + normal cervix on speculum exam + swabs are negative ⇒ refer to colposcopy (i don’t understand
why, check question GY2042)
○ Management of PID:
■ Outpatient management: ceftriaxone 500 > doxymetro 500
● Ceftriaxone single-dose IM 500mg
↓ followed by ↓
● Doxycycline BID oral 100mg for 14 days
+ Metronidazole BID oral 400mg for 14 days
■ Inpatient management: ceftriaxone 2g > doxymetro 500
● Ceftriaxone IV daily 2 grams for 14 days
+ doxycycline BID oral 100mg for 14 days
+ metronidazole BID oral 400mg for 14 days
■ Do not wait for swab results before commencing antibiotics
■ If you had to change after results, probabs the switch will be to ofloxacin, as gonorrhoea is getting
resistant to fluoroquinolones
Qs one-liners
● Tubo-ovarian abscess is a complication of PID
○ On ultrasound ⇒ multilocular complex adnexal mass with debris, septations, and irregular thick walls
● C-section + Postpartum fever + foul-smelling discharge + empty endometrial cavity on ultrasound + placenta
and membranes were examined to be complete intraoperatively = endometritis
○ Management: any of the following combinations
■ Co-amoxiclav (augmentin)
■ Gentamicin + clindamycin (gentaclinda)
■ Gentamicin + cefotaxime + metronidazole (genta + cefometro)
● Vaginal infections
○ Swabs
○ Fish / foul smell + grey discharge = bacterial vaginosis = gardnerella vaginalis = >4.5 = metro
○ Foul smell + Green-yellow discharge = trichomonas vaginalis = >4.5 = metro
○ Candida <4.5 (acidic)
Qs one-liners
Contraception
● Choosing contraceptives
dysmenorrhea menorrhagia irregularity contraception VTE risk other
IUS (Mirena) ✔ ✔ ✔
Copper IUD ✘ ✔ None
COCP ✔ ✔ ✔ ✔ ↑ ✘ migraine with aura
POPs ✔ ✔ Breastfeeding
Depo-provera injectable ✔ IM in sickle cell disease
Etonogestrel implants ✔
Tranexamic acid ✔ ✔ ✘ ✘
Mefenamic acid ✔ ✔ ✘ ✘
Desired duration
IUS (Mirena) 5 years
Copper IUD years
Depo-provera injectable 3 months
Etonogestrel implants 3 years
COCP 6+ weeks
○ Most effective contraceptives in order: Nexplanon > IUS > tubal ligation
■ Basics
● You want highly effective contraception for a patient who needs to be on a teratogenic drug.
Common teratogenic drugs: MTX, sodium valproate, retinoids, warfarin
Highly-effective contraception: Copper IUD, IUS, depo-provera+condom combo
● Enzyme inducers can decrease the efficacy of contraceptives.
Enzyme-inducers: CRAP GPs:
Carbamazepine, Rifampicin (& Ritonavir), chronic Alcohol use, Phenytoin, Griseofulvin,
Phenobarbital, Sulfonylureas, & St john’s wort
Affected contraceptives: COCPs, POPs, implants, emergency contraceptives
■ Scenarios
● Taking enzyme inducers + non-teratogens → use IUD / IUS / depo provera
● Taking enzyme inducers + teratogens → use IUD / IUS / depo provera + condom combo
● Taking non-enzyme-inducers + teratogens → use IUD / IUS / SDI
● Taking enzyme inducers or teratogen and needs emergency contraception → copper IUD
Qs one-liners
■ Any missed COCP (whether 1 or 2 or more) ⇒ take the last pill ASAP even if it means taking 2 per day
■ The question is: what else to do other than taking the last pill ASAP? It depends:
● If 1 pill of COCP is missed
○ Continue with the rest of the pack as usual + No need for additional contraception
● If 2 or more pills of COCP are missed
○ Abstain from unprotected intercourse for 7 days of taking the pill regularly
○ What if she already had unprotected intercourse?
■ If the pills were missed in WK1 + had unprotected intercourse ⇒ emergency contraception
■ If the pills were missed in WK2 ⇒ no need for emergency contraception
■ If the pills were missed in WK3 ⇒ no need for emergency contraception + skip the HFI
■ If it’s traditional POP ⇒ if it’s more than 3 hours late ⇒ take the missed pill ASAP (but don’t take 2x a
day) + continue remaining pack as usual + abstain from unprotected sex for the next 48 hours
■ If it’s Cerazette (desogestrel) ⇒ if it’s more than 12 hours late ⇒ same as above
■ If unprotected intercourse happened after the missed pill and within 48h of restarting ⇒ take
emergency contraception
● Emergency contraception
○ Within 72 hours (3 days)? Progestogen-only Levonelle pill (levonorgestrel)
○ Within 120 hours (5 days)? Copper IUCD or ellaOne pill (ulipristal acetate)
● Mirena coil inserted ⇒ first 3-6 months: irregular and heavy periods + spotting ⇒ reassure
By 1 year: infrequent bleeding or amenorrhoea
● Depo-provera ⇒ first 3-6 months: intermenstrual unscheduled bleeding
● Continuous combined HRT ⇒ first 4-6 months: irregular breakthrough bleeding or spotting ⇒ reassure
○ When to investigate and not reassure?
■ If bleeding persists beyond 6 months
Qs one-liners
■ If it’s abnormally heavy (unlike mirena coil)
■ If it happens after a period of HRT-induced amenorrhoea
● PV bleeding in pregnancy
○ Painless PV bleeding + vitals indicative of blood loss (↑HR ↑RR ↓BP) ⇒ placenta previa
■ Women with placenta previa shouldn’t have intercourse
■ Management of placenta previa
● First: Speculum examination
● Second: Arrange a routine ultrasound (if not already arranged) to be done at 32 weeks
● Third: Advice the patient to avoid sexual intercourse
■ 30 weeks old woman + postcoital bleeding. Management? Speculum examination (NOT advice!)
○ Painless PV bleeding + vitals normal ⇒ vasa previa (it’s foetal blood not maternal blood)
○ Painful PV bleeding + CTG abnormalities (e.g. foetal tachycardia >160 BPM) ⇒ placental abruption
○ Painful PV bleeding → most initial test → ultrasound abdomen
○ Painful PV bleeding → single best action → CTG (placental abruption would show foetal distress and
immediate delivery is needed)
○ Avoid digital vaginal examination in women with vaginal bleeding until the position of the placenta is
known with certainty. Speculum exam is alright to perform.
● Hyperemesis gravidarum
○ Can present with ketonuria 3adi
○ Management of nausea and vomiting
■ First ⇒ IV fluids
■ Second ⇒ antiemetics
● First-line ⇒ antiemetics that end with -ine ⇒ cyclizine, prochlorperazine, promethazine,
chlorpromazine, doxylamine with pyridoxine
● Second-line ⇒ metoclopramide, ondansetron, domperidone
■ Third ⇒ IV steroids
■ If all fails ⇒ consider parenteral nutrition
■ Absolute last resort ⇒ termination of a wanted pregnancy
○ Adjunct management (not acutely needed)
■ First: correct electrolyte abnormalities ⇒ If she’s hypokalaemic ⇒ Give NaCl 0.9% with KCl
■ Next: IV / oral thiamine to ↓risk of Wernicke’s d/t prolonged vomiting and dec absorption of thiamine
■ Next: Glucose if needed
■ Dalteparin (LMWH) to ↓risk of thrombosis caused by dehydration
● Ectopic pregnancy
○ Hemodynamically stable? Laparoscopic removal
○ Hemodynamically unstable? Immediate laparotomy (laparotomy is quicker than laparoscopy)
● Anaemia in pregnancy
○ First trimester ⇒ <110 is anaemia. If >110, reassure (physiological haemodynamic anaemia)
○ Second and third trimesters ⇒ <105 is anaemia. If >105, reassure (physiological haemodynamic anaemia)
○ Postpartum ⇒ <100 is anaemia. If >100, reassure (physiological haemodynamic anaemia)
● Pregnant + severe abdominal pain + tenderness over previous c-section (can also be post myomectomy) +
absent uterine contractility → uterine rupture
● Never choose uterine rupture in a primigravid woman with 0 history of c-sections or myomectomies
● Cocaine increases risk of placental abruption.
○ Cocaine user + pregnant + loss of blood and abdominal pain → choose “placental abruption” but not
“placental abruption secondary to preeclampsia” because there are no features of preeclampsia in the
stem, even tho she is a cocaine user, do not assume.
● Miscarriages
○ Miscarriage = loss of pregnancy < 24 weeks gestation (time of viability)
○ “Spontaneous miscarriage” is a miscarriage that is not induced, and includes all of the options above.
○ PV bleeding at 6 weeks + no foetal cardiac activity detected on TVUS → rescan in 7 days
■ Baby’s heart starts beating at 5 weeks, but can start later. Rescan to ensure this is not a miscarriage
Gynaecology
● Columnar epithelium is normally in the endocervix ⇒ if it migrates beyond
the cervical os ⇒ cervical ectropion
○ Post-coital and intermenstrual bleeding
○ Excessive discharge but it’s non-purulent
○ Can be caused by pregnancy or OCP use or in ovulatory phase in young
women
○ Investigation → colposcopy → red ring around the cervical os
○ Mgmt:
■ Is it caused by OCP use? Discontinue OCPs.
■ Is there no bleeding? No need to treat.
■ Otherwise burn it ⇒ cryotherapy or ablation (using silver nitrate or diathermy)