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Health Sciences and Medicine

School of Medical Laboratory Sciences

Hematology-II Model Exam for Graduating Class Medical Laboratory Sciences Students

1. A Laboratory technologist who is working in Wolaita Sodo University

Comprehensive Specialized Hospital found many hyper segmented neutrophils,
ovalocytes and macrocytic RBCs while examining the peripheral morphology of
the patient’ blood specimen. As laboratory personnel, what do you suspect for the
patient?
A. Association with coxackie virus
B. Intestinal parasitic infections
C. Megaloblastic erythropoiesis
D. Recovery from acute infections
2. Hemolytic Disease of the Fetus and New born (HDFN) can result in all of the
following except:

A. Erythroblastosisfetalis

B. Kernicterus

C. Compensated anemia

D. Hepatospleenomegaly

3. A 26 years old immune suppressed patient was admitted to Emergency ward of

WSUCSH. He had a high bleeding due to a car accident wrong traffic light use.
The physician transfused of 3 unit red cell after securing the recommended
procedures. How would this affect the hematocrit and the hemoglobin of the

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patient?

A. Increases the hematocrit by 3% and the hemoglobin by 1 gm.

B. Increases the hematocrit by 6% and the hemoglobin by 2gm.

C. Increases the hematocrit by 2% and the hemoglobin by 6 gm.

D. Does not affect both hematocrit and hemoglobin.

4. During the occurrence of Hemolytic Disease of the Fetus and New born (HDFN)
following delivery, red blood cell destruction continues with the release of indirect
bilirubin which results in jaundice and kernicterus in fetus is due to:

A. Uncompensated anemia

B. Deficiency of glucuronyl transferase

C. Increased erythropoiesis

D. Hepatospleenomegaly

5. A 46- year old woman with organomegally, fatigue, weakness, fever and
unexplained weight loss. A physician suspected a blood cancer and requested
complete blood count and peripheral morphology. A laboratory technologist
performed CBC and peripheral smear, the following results were obtained:-
● Increased band cells, metamyelocytes, myelocytes

● Normal platelet and red cell count

● low Neutrophil alkaline phosphatase score

● Increased circulating basophils

If you are clinical haematologist, what type of leukemia you suspected based
on above information.

A. Acute myeloid leukemia.

B. Chronic myeloid leukemia

C. Acute lymphoblastic leukemia

D. Chronic lymphocytic leukemia

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6. A 60 years old man has hemoglobin of 9g/dL. He also has the following
laboratory results: MCV normal; MCHC normal; Retic count is typically high.
Which one of the following is the most likely laboratory diagnosis?

A. Iron deficiency anemia

B. Megaloblasticanemia

C. Hemolyticanemia

D. Thalassemia

7. What is the purpose of washing red cells for three times in IAT after reading the
0
saline at 37 C?

A. To remove all unbound proteins (IgG)

B. To remove all bound proteins (IgG)

C. To remove plasma proteins and glycerol

D. To reduce plasma proteins

8. The mating of parents of which two ABO phenotypes can potentially produce
offspring with all of the common four blood types?

A. Blood group AB and O

B. Blood group AB and A

C. Blood group AB and B

D. Blood group A and B

9. In order to ensure best practice, quality control, quality assurance, and

continuous quality improvement in the Laboratory Medicine, we should include
the review and approval of all except:

A. Analysis of trends and problem solving

B. Calibration of equipment and record keeping

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C. Errors in pre-analytical phase of total testing process only

D. Clinical audits, external quality assessment results, and accreditation

10. Spheroidal cells with 3-12 spicules of uneven length irregularly distributed over
the cell surface which are seen in disorders of lipid metabolism and alcoholic
liver cirrhosis are:

A. Acanthocytes

B. Dacrocytes

C. Drepanocytes

D. Stomatocytes

11. All of the following are the Signs of Accelerated Bone Marrow Erythropoiesis
except?

A. Hypo cellular bone marrow

B. Increase in RBC precursors

C. M:E ratio falls

D. Reticulocytosis

12. Osmotic fragility test (OFT) is primarily useful in the diagnosis and confirmation
of:

A.

B. Hereditary spherocytosis

C. Hereditary stomatocytrsis
D. Hereditary acantocytosis
E. Leptocytosis (target cells)

13. One is characterized by the accumulation of iron in the mitochondria of

immature nucleated RBCs (ringed sideroblasts) in the bone marrow:

A. Iron deficiency anemia

B. Sideroblastic anemia

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C. Thalassemias

D. Megaloblastic anemia

14. Terminal Deoxynucleotidyl Transferase Test (TdT) is a useful study to

differentiate between

A. ALL and AML

B. ALL and CML

C. CML and AML

D. ALL and CLL

15. What test is performed to exclude hemolysis in the evaluation of Normochromic
Normocytic anemia?

A. Reticulocyte count

B. Serum ferritin

C. Serum transferrin

D. Complete blood count (CBC)

16. Bleeding time (BT) is increased in:

A.
B. Failure to cleanse the area
C. Puncturing a cold blood less area
D. Making superficial puncture
E. Applying pressure to the punctured area
0 0
17. In leucocyte cytochemistry, which one is located in the 1 and 2 granules of
granulocytes and their precursors, in eosinophil granules and in the azurophil
granules of monocytes?
A.

B. Myeloperoxidase

C. Sudan black B
D. Neutrophil alkaline phosphatase
E. Periodic acid-Schiff reaction

18. The accumulation of abnormal white cells in the bone marrow may cause all of
the following except?

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A.

B. Bone marrow failure

C. Infiltration of organs

D. Abnormal white cells

E. A raised total red cell count

19. The amount of myeloblasts or lymphoblasts in the bone marrow at clinical

presentation of acute leukemia, which fails to differentiate normally but are
capable of further divisions are over:

A.

B. 25%

C. 30%

D. 50%

E. 75%

20.

21.
22. After complete blood count was done, the laboratory technologist found the
following results: MCV=75fl, MCH=24pg, and MCHC=26%.What would be the
most likely description of the red cell appearance in the stained blood film?
A.
B. Microcytic normocromic C. Macrocytic
normocromic
C. Microcytic hypocromic D. Macrocytic hypocromic
23. What would be the possible blood group and type in the table given below:

A. Blood group A, RhD positive

B. Blood group B, RhD positive

C. Blood group B, RhD negative

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D. Cannot be determined

Unknown cells with Unknown serum with Interpretation

Anti-A Anti-B Anti-D A1 cells B cells Group

0 +4 +2 +4 0 ?

Note: Interpretation of test results: + (agglutination) 0 (no
agglutination)

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