Rx.

Only use this medication when given prescription - This medication contains propyl paraben and methyl paraben, so it can cause allergic reactions (may appear slowly).
SHINPOONG GENTRI-SONE PREGNANT AND BREASTFEEDING WOMEN
During pregnancy
(Betamethasone dipropionate, Clotrimazole, Gentamicin)
- There is insufficient evidence of the safety of the medication during pregnancy. Clotrimazole does not cause teratogens in animals but can be toxic to
- Topical medications
- Read the instructions manual carefully before use. If you need more information, please consult a doctor. the fetus when taken in high doses.
- Keep out of reach of children. - Topical use of corticosteroids on pregnant animals can cause abnormal fetal development, including clef palate and fetal growth retardation. Therefore,
INGREDIENTS there may be a very small risk of these effects occurring in the human fetus. Therefore, this medication should only be taken during pregnancy if the
Each tube contains: benefits of the medication outweigh the potential risks to the fetus, and if the drug must be take, it should not be used as much as applying a large amount
Active ingredients 10g tube 20g tube of the medication or taking it for a long time.
Betamethasone dipropionate 6.4 mg 12.8 mg During breastfeeding
Clotrimazole 100 mg 200 mg It is not clear whether the components of the drug are excreted in human milk. Therefore, caution should be exercised when giving medication to
Gentamicin (in the form of Gentamicin sulfate) 10 mg 20 mg breastfeeding mothers.
Excipients: Steryl alcohol, cetyl alcohol, propylene glycol, polysorbate 60, mild canopy oil, sorbitan monostearate, EFFECTS ON THE ABILITY TO DRIVE AND OPERATE MACHINERY
methyl paraben, propyl paraben, purified water. The medication does not affect the ability to drive and operate machinery.
FORMULATION DRUG INTERACTIONS
White cream contained in an aluminium tube with a screw cap. There isn’t yet any research on the interactions of this medication with other drugs.
INDICATIONS UNWANTED SIDE EFFECTS
The drug is indicated in cases of atopics dermatitis with bacterial and fungal infections.
- Reduce inflammatory and pruritus episodes of dermatitis and cortiocosteriod-responsive skin allergies: acute and chronic eczema, contact dermatitis, The unwanted side effects of the medication include:
atopics dematitis, hyperseborrheic dermatitis, chronic planar lichen, squamous dermatitis, urticaria, psoriasis, anal itching, vulva, minor burns or insect - Burning and stinging, rashes, edema, paresthesia and other forms of infection on the skin.
bites. - Erythema, blisters, peeling, itching, urticaria, irritated skin, skin irritation, folliculitis, hirsutism, acne, dark or pale skin, perioral dermatitis, allergic
- Treatment of skin fungus caused by Candila albicans and ringworm caused by Malassazeia furfu. Treatment of stem fungus (strabismus, ringworm), skin reactions, waterlogging, skin atrophy, scratching and redness of the skin, skin bruising, blured and sensitive vision.
inguinal fungus, and foot fungus caused by Trichophyton rubrum, T.mentagrophytes, Epidermophyton floccosum, or Microsporum canis. - In children: inhibition of the hypothelamic-potuitary-adrenal axis (HPA), Cushing’s syndrome, and increased intracranial pressure.
- Skin surface infections caused by susceptible strains of bacteria. Immediately notify doctor or pharmacist of any unwanted side effects experienced when using, including side effects not listed in this manual.
DOSAGE AND HOW TO USE OVERDOSE AND HOW TO HANDLE
- Apply a thin layer of cream and gently rub on the damaged skin 2 times a day. - Acute overdose when taking topical drugs almost does not occur and will not lead to life-threatening situations; Of course, corticosteroids when used
- The duration of treatment depends on the severity and location of the disease and the patient’s response. If there is no clinical improvement after 1-2 topically can be absorbed enough to cause systemic effects. In this case, symptomatic treatment measures should be applied.
weeks of using the medication, the disease should be rediagnosed.
- Do not apply bandages to the damaged skin when using the medication. - Poisoning also almost does not occur when accidentally swallowing drugs. Signs of poisoning that appear after accidentally swallowing the drug
- Do not apply the medication to the eyes. should be treated symptomatically.
- Do If used in children, should not be used for more than 5 days in any location on the body. PHARMACODYNAMICS
- Do not apply the drug for more than 5 days on the face, folds of skin (such as the inside of the knee) or on a large area of the skin. Pharmacological subgrouping: drugs for skin diseases.
CONTRAINDICATIONS ATC code: D07AC01 (batamethason), D01AC01 (clotrimazole), D06AX07 (gentamicin).
- Hypersensitivity to any of the ingredients of the medication, to other corticosteroids or imidazole. The drug contains betamethason, a glucocorticoid that carries the common properties of corticosteroids; clotrimazol antifungal of the imidaxol group and
- Viral infections such as small pox simplex, singles, chickenpox, molluscum contagiosum, warts, measles and rubella, hand-foot-mouth disease,… gentamicin - aminoglycoside antibiotics.
- Tuberculosis, syphilis, Behcet disease - Topical corticosteroids are effective in treating many skin diseases due to their anti-inflammatory, anti-itching and vasoconstrictive properties.
- Second-degree burns or more - Clotrimazole has antifungal effects due to inhibition of ergosterol biosynthesis. The inhibition of ergestrol biosynthesis leads to a deterioration in the
PRECAUTIONS
- Local and systemic toxicity often occurs, especially when the medication is used for a long time on a large area of skin, folded skin or bandaged skin. structure and function of the cytoplasmic membrane of the fungus. Clotrimazol has a broad spectrum of antifungal properties, including
If the medication is used for children or applied to the face, it should only be used for 5 days. Avoid taking medication continuously for a long time in dermatopathogenic fungi, fungus, mildew, etc. Clotrimazole also has an effect on Streptococci, Staphylococci, Gardnerella vaginalis and Bacteroides.
people who are sick, regardless of age. - Gentamicin has several effects on the cells of susceptible bacteria. The drug affects the integrity of cell membranes and the metabolism of ANT, but
- Topical corticosteroids can be detrimental in the treatment of psoriasis for a number of reasons, including rebound due to icnreased tolerance, risk of the most important is the inhibition of protein biosynthesis at the 30S ribosomal site. Gentamicin-susceptible strains include susceptible strains of
development purulent psoriasis, increased systemic or local toxicity due to impaired skin protective function. It is necessary to monitor the patient Streptococci (alpha and beta group A hemolytics), Staphylococcus aureus (coagulase-positive or negative, and some penicillinase-based strains), and
carefully. Gram-rich bacteria, Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, and Kiebsiella pneumoniae.
- Topical absorption of corticosteroids into the bloodstream may cause retrograde inhibition of the hypothalamic-pituitary-adrenal axis (HPA), causing PHARMACOKINETICS
glucocortisteroid deficiency after discontinuation of treatment. Cushing’s syndrome can also occur. Periodic monitoring of signs of HPA axis inhibition - This drug is used in the treatment of skin diseases and is used for topical application. Therefore, the pharmacokinetics
should be performed in patients who receive high doses of strong steroids and apply over a large area of skin. If HPA axis inhibition occurs, efforts should associated with the bioavailability of the drug at the impact site are minimal.
be sought to discontinue the drug, reduce the number of doses, or to replace it with a weaker corticosteroid. HPA axis function usually recovers
immediately and completely after discontinuation. Occasionally, signs and symptoms of steroid withdrawal may occur, requiring systemic corticosteroid - Clotrimazole is distributed into the epidermis after topical application but absorption into the general circulation (if any) is minimal.
supplementation. - The level of transcutaneous absorption of topical corticosteroids depends on many factors, including the carrier, skin integrity, and dressing. Topical
- Visual disturbances may occur with topical corticosteroids (including rectal, nasal, or ocular placement) or systemic catheterization. If you have corticoseroids when absorbed into the general circulation bind to plasma proteins and are metabolized in the liver and excreted through the kidneys. Some
symptoms such as blurred vision or other visual disturbances, you should see a specialist to evaluate the cause, which may be due to cataracts, glaucom, corticosteroids and metabolites are also excreted through the face.
or rare diseases such as central serous chorioretinopathy (CSCR), which appear after intracorporal or systemic corticosteroids. PRESENTATION: Box containing 1 tube of 10g. Box containing 1 tube of 20g.
- All systemic corticosteroid side effects, including adrenal snow suppression, may occur with topical corticosteroids, especially in infants and young PRESERVATION: Stored in a cool, dry place with temperature below 30oC.
children. EXPIRY DATE: 36 months from the date of manufacture.
- Young children are often more susceptible to systemic toxicity than adults due to the larger ratio of skin area to body weight. Manifestations of adrenal QUALITY STANDARDS: TCCS (Manufacter standards)
suppression in young children include developmental delay, delayed weight gain, decreased plasma cortisol levels, and non-response to ACTH stimuli. MANUFACTURER: SHINPOONG DAEWOO PHARMA CO., LTD
Factory: Number 13, 9A Street, Industrial area Bien Hoa II, An Binh Ward, Bien Hoa City, Dong Nai Province, Vietnam.
Manifestations of increased intracranial pressure include palpitations, headaches, bilateral visual edema.
Office: Number 29, Ba Vi Street, Ward 4, Tan Binh District, Ho Chi Minh City.
- Knowledge in using this medication for children under 12 years old is still limited. Phone number: 028-222 50683 Fax: 028-222 50682 Email: [email protected].