Abstracts Nephrology Dialysis Transplantation

Hazard ratio of droping out due to fluid overload. was to perform a feasibility study with the CLS UF device in order to evaluate 1) the
ability of the device to maintain the intraperitoneal glucose concentration 2) ultrafiltra-
tion and total fluid output and 3) patient tolerability.
HR 95%CI P
METHODS: Five ESRD patients on stable PD therapy were treated with the CLS UF
Na Sieving 0.47 0.21-1.02 0.06 device for two eight hour study sessions. After an initial pre-fill with two litres of a
CA125 0.27 0.09 - 0.78 0.01 standard 2.27% glucose PD solution, the CLS UF was set at a rate of 9 g/h of glucose for
medium transporters and 11 g/h for high transporters. IP glucose concentration was
CA125*Na Sieving 1.08 1.01 - 1.15 0.02
measured hourly. IP fluid was drained regularly during the treatment session. Data is
Age 1.03 0.95-1.12 0.44 expressed as mean 6 STDEV.
Sex 0.10 0.00-2.50 0.16 RESULTS: The glucose concentration in the intraperitoneal fluid stabilized after about
In another multivariate model, the 2nd and 3rd tertiles of CA125 were associated with two hours at approximately 1.27% (average 1.27 6 0.21). The average IP glucose con-
less dropouts relative to the 1st tertile (p¼0.04), adjusted for age, sex and UF failure. centration, UF volume, urine volume and total fluid output (UF volume þ urine) are
CONCLUSIONS: Higher CA125 levels in the peritoneal effluent appear to be associ- presented in Table 1. All patients tolerated the treatment well and no discomfort associ-
ated with a longer durability in PD and less dropouts due to fluid overload, especially ated with the intermittent transfer of IP fluid was experienced. Table 1.
when accompanied by high sodium sieving. Despite this, our data seems to show these
biomarkers are insufficient to predict inadequate dialysis dose or UF failure.
Patient IP glucose UF volume Urine Total fluid

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concentration# (ml/8h) (ml/8h) output (ml/
SP528 CLINICAL MANIFESTATIONS RISK FACTORS AND (%) 8h)
PROGNOSIS OF ENCAPSULATED PERITONEAL SCLEROSIS 1 1.1460.01 729624 25635 75461
Yener Koc4, Taner Basturk3, Tamer Sakaci4, Feyza Bayrakdar Caglayan4, Nuri 2 1.1060.01 144666 11206141 1264648
Baris Hasbal4, Elbis Ahbap4, Mustafa Sevinc4, Ayse Sinangil1, Zuhal Atan Ucar2, 3 1.4760.16 2696144 5906651 8596853
Perin Nazif4, Mahmut Islam4, Abdulkadir Unsal3 4 1.4260.04 16886562 138653 18266848
1
Internal Medicine/Nephrology, Istanbul Bilim University, Istanbul, Turkey, 2Nephrology,
Omer Halisdemir University, Nigde, Turkey, 3Internal Medicine/Nephrology, Saglik
5 1.2660.20 99623 16106113 1709681
#
Bilimleri University, Istanbul, Turkey and 4Nephrology, Sisli Hamidiye Etfal Training and Average glucose concentration 2-8 hour time points
Research Hospital, Istanbul, Turkey

INTRODUCTION AND AIMS: Encapsulated peritoneal sclerosis (EPS) is a multifac- CONCLUSIONS: Treatment for eight hours with CLS UF was well tolerated by the
torial chronic intra-abdominal inflammatory disorder affecting the peritoneum dif- patients without adverse events. Administration of 9-11 g glucose/hour resulted in a
fusely. The aim of this study was to evaluate the rates of EPS in our peritoneal dialysis stable intraperitoneal glucose concentration. The measured ultrafiltration volumes var-
(PD) population, to perform a general assessment of the clinical presentation and to ied both between individual patient sessions and within the cohort as a whole, with a
determine the outcome of affected patients and risk factors. total fluid output between 750 and 1800 ml during the eight hour treatment. In sum-
METHODS: The medical records of consecutive 384 patients who started PD therapy mary, a stable and safe glucose concentration can be maintained with the CLS UF
between January 2001 and November 2016 were evaluated. Socio-demographic charac- device. Further studies are necessary in order to understand the relationship between
teristics, comorbidities, PD therapy details and infectious complications were recorded. the stable IP glucose concentration, ultrafiltration and individual patient
Medical records were examined to make sure cases met the ISPD criteria for EPS diag- characteristics.
nosis including clinical features and either radiological and/or histopathological confir-
mation. Patients diagnosed with EPS were identified, and the incidence, clinical
presentation, treatments and recent status of the patients were reviewed. Factors that
may be associated with EPS diagnosis and mortality were investigated. SP530 COMPARISON OF CONTINUOUS AMBULATORY PERITONEAL
RESULTS: Two hundred one of 384 patients were female, mean age was 45.9615.6 DIALYSIS (CAPD) VERSUS AUTOMATED PERITONEAL
years, mean PD follow up time was 42.6635 months. EPS was developed in 26 patients DIALYSIS (APD) CONSIDERING TREATMENT ADEQUACY,
and EPS development rate was 6.7%. PD follow-up period and duration of hypertonic ANEMIA, INFLAMMATION AND MINERAL BONE DISEASE
solution usage were longer in patients with EPS (p<0.001 and 0.017 respectively).
Patients with and without EPS were similar in terms of modality (p:0.21) but treatment Masa Knehtl4, Eva Jakopin3, Martin Hren1, Nina Hojs4, Sebastjan Bevc4,
duration with APD modality was longer in patients with EPS (p<0.001). The PD fol- Robert Ekart2, Radovan Hojs4
low-up period was found to be a predictor of EPS formation (p<0.001, RR:1.034 1
Department of Dialysis, Clinic for Internal Medicine, University Medical Centre, Maribor,
(%95CI:1.020-1.047)). Age (p<0.001, RR:1.039 (%95CI:1.024-1.053)) and use of Slovenia, 2Department of Dialysis, Clinic for Internal Medicine, Faculty of Medicine,
hypertonic dialysis solution (p:0.007, RR:0.979 (%95 CI:0.965-0.994)) were the factors University of Maribor, University Medical Centre, Maribor, Slovenia, 3Department of
affecting survival in EPS patients. Nephrology, Clinic for Internal Medicine, University Medical Centre, Maribor, Slovenia
CONCLUSIONS: EPS is a relatively rare but fatal complication of peritoneal dialysis and 4Department of Nephrology, Clinic for Internal Medicine, Faculty of Medicine,
and extension of PD duration is a risk for EPS formation. Younger age and usage of University of Maribor, University Medical Centre, Maribor, Slovenia
hypertonic dialysis solution affects mortality in patients with EPS.
INTRODUCTION AND AIMS: The aim of our retrospective analysis was to evaluate
the difference in treatment adequacy, erythropoietin requirements, serum haemoglo-
bin, serum C-reactive protein (CRP) and serum intact parathyroid hormone (i-PTH)
SP529 PERITONEAL ULTRAFILTRATION WITH A STABLE GLUCOSE levels in patients switching from continuous ambulatory peritoneal dialysis (CAPD) to
V
CONCENTRATION USING THE CARRY LIFE UF SYSTEM
R
automated peritoneal dialysis (APD).
METHODS: From May 1998 to November 2017, we retrospectively reviewed 26
Ann-Cathrine Johansson1, Magnus Braide3, Charlotte de Leon2, Eva Persson2, patients (21 males and 5 females, mean age at the introduction of peritoneal dialysis
Lars Wramner2 47.4611.6 years), who switched from CAPD to APD. We compared the two periods
1
Department of Nephrology, Scania University Hospital, Malmö, Sweden, 2Clinical, regarding peritoneal treatment adequacy number (Kt/V), erythropoietin requirements,
Triomed AB, Lund, Sweden and 3Department of Biomedicine, University of Gothenburg, serum haemoglobin, CRP and i-PTH levels.
Gothenburg, Sweden RESULTS: The average time spent on CAPD was 491.76737.2 days, and the average
time spent on APD was 980.861066.0 days. For the CAPD period, the mean Kt/V was
V
R
INTRODUCTION AND AIMS: Carry Life System UF (CLS UF) is a new portable 1.8161.1, mean haemoglobin value was 115.968.3 g/l, mean erythropoietin require-
device intended to achieve a gentle and efficient peritoneal ultrafiltration in patients ment was 4927.163595.8 IU/week, the mean CRP value was 10.8613.0 mg/l, and the
requiring fluid removal. The therapeutic concept is that a stable glucose concentration mean i-PTH value was 414.86347.8 pg/ml. For the APD period, the mean Kt/V was
at an adequate level will achieve a more efficient ultrafiltration compared to standard 1.6960.55, the mean haemoglobin value was 114.969.0 g/l, the mean erythropoietin
PD methods. A stable glucose concentration is obtained by administering glucose to requirement was 3937.463986.5 IU/week, the mean CRP value was 9.0610.0 mg/l, and
the intraperitoneal fluid throughout the treatment, at a rate which compensates for glu- the mean i-PTH value was 420.26311.3 pg/ml. When comparing the two modalities
cose absorption. The device administers glucose via a standard PD catheter, and con- with a paired samples test, we found no significant differences regarding time spent
sists of two separate parts, the cycler and line set. During treatment, a portion (~180ml) (p¼0.063), Kt/V (p¼0.622), haemoglobin level (p¼0.605), CRP (p¼0.463), and i-PTH
of the intraperitoneal fluid (IP) is transferred into the device four times per hour and (p¼0.927). However, we found a significant difference between modalities regarding
20% glucose is added and diluted before the fluid is returned to the patient. The aim erythropoietin requirement (p¼0.035).

i526 | Abstracts