Scribd
Upload
3 views

BT302_2_Fall 2024_Solved (1)

Uploaded by

Sannan Ahmed
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
3 views

BT302_2_Fall 2024_Solved (1)

Uploaded by

Sannan Ahmed
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 4

BT302

Assignment 2,Fall 24
Total Marks: 10

Due date: 6th-Dec-2024

Instructions:

• Make sure that you upload the solution before due date. No assignment will be accepted through
e-mail after the due date.

Formatting guidelines

• Use the font style “Times New Roman” and font size “12”.
• Use black and blue font colours only.
Solution guidelines

• To solve this assignment, you should have good command over lectures 11 to 14
• This is not a group assignment; it is an individual assignment so be careful and avoid copying others’
work
• Give the answer according to question only and avoid irrelevant details.

Please note that your assignment will not be graded if:

• It is submitted after due date


• Cheating or copying of assignment is strictly prohibited. The cheated or copied assignment will be
marked ‘Zero’.
-----------------------------------------------------------------------------------------------------------------------

Question:
Create a visual representation of how SARS-CoV-2 (Coronavirus) antigens are
processed and presented through the MHC. The diagram should be specific to
SARS-Cov-2 and not any other virus.
• Text-only answers, hand-drawn diagrams, AI-generated diagrams and diagrams taken
from the internet will receive a zero.
• Use insert image to paste it in solution.
SARS-CoV-2 Antigen Processing and Presentation via MHC
Class I(Tentative Illustration)
1. Viral Entry

• Receptor Binding: SARS-CoV-2 binds to the ACE2 receptor on the host cell surface.
• Entry Mechanism: The virus enters the cell through endocytosis or membrane fusion.

2. Viral Protein Synthesis

• RNA Release: The viral RNA genome is released into the cytoplasm.
• Protein Production: Host ribosomes translate viral RNA into structural and non-structural
proteins.

3. Proteasomal Processing

• Degradation: Viral proteins are degraded by the proteasome into short peptides (8–10 amino
acids) suitable for MHC class I binding.

4. Peptide Transport to the ER

• TAP Transporter: Peptides are transported into the endoplasmic reticulum (ER) via the
Transporter Associated with Antigen Processing (TAP).

5. MHC Class I Loading

• Peptide Binding: Peptides bind to MHC class I molecules in the ER.


• Complex Stabilization: The binding stabilizes the MHC class I-peptide complex for
transport.

6. Transport to the Cell Surface

• Golgi Apparatus: The MHC class I-peptide complex passes through the Golgi apparatus.
• Surface Presentation: The complex is presented on the host cell surface.

7. Recognition by CD8+ T Cells

• Immune Activation: CD8+ cytotoxic T lymphocytes (CTLs) recognize the viral peptides
through their T cell receptors (TCRs).
• Response: CTLs target and destroy infected cells, limiting viral replication.

Key Components

• ACE2 Receptor: Facilitates viral entry.


• Proteasome: Processes viral proteins into peptides.
• TAP Transporter: Delivers peptides to the ER.
• MHC Class I Molecules: Present peptides on the cell surface.
• CD8+ T Cells: Recognize the antigen and initiate immune responses

Touch at Book Emoji below yo Join our Whatsapp Group


👇
📖

You might also like