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dopamine

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4 views

dopamine

Uploaded by

Muhammad Naqi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Dopamine

Introduction:
Dopamine is a naturally occurring catecholamine neurotransmitter that plays a key role in
several critical physiological processes such as mood regulation, motor control, and the
regulation of blood pressure.

Therapeutic Class:

Cardiac stimulant

vasopressor

Pharmacological class:

Adrenergic agonist
MOA
Dopamine exerts its effects by stimulating dopaminergic, alpha-adrenergic, and beta-
adrenergic receptors, depending on the dose:

• Low doses (1-5 mcg/kg/min):

Primarily stimulates dopamine receptors, causing vasodilation in renal improving blood flow
to this areas.

• Moderate doses (5-10 mcg/kg/min):

Stimulates beta-1 adrenergic receptors, increasing heart rate, contractility, and cardiac
output.

• High doses (above 10 mcg/kg/min):

Stimulates alpha-1 adrenergic receptors, causing vasoconstriction and increasing blood


pressure.
Indication:
Dopamine is indicated for:

• Shock (e.g., cardiogenic, septic, or hypovolemic shock)

• Hypotension (low blood pressure)

• Cardiac arrest

• Heart failure

• Bradycardia (slow heart rate)


Pharmacokinetics
Absorption Distribution Metabolism Elimination

Widely distributed in the


body, with high
concentrations in the Metabolised by MAO
Given
brain, kidneys, and heart and COMT
IV
Volume of distribution Main metabolite
Bioavailability
0.29-0.48 L/kg Dihydroxyphenylacetic Renal excretion
100%
acid (DOPAC)
Plasma Protein binding
Half Life
50-80% Homovanillic acid
2-5min
(HVA)
Blood brain barrier
NO crossing
Drug details
Generic name Brand name Dosage form Dose Route of administration

For Adults:
Initial dose: 2-5 mcg/kg/
min IV infusion

For Infants and


Children:
Intropin Initial dose: 1-5 mcg/kg/
Dopamine Injectible min IV infusion IV
Dopastat
For Elderly:
Dosing in the elderly is
typically similar to adult
dosing but should be
started at the lower end
of the dose range
Drug detail
Frequency ADR’s Drug Interactions Contra-Indications Precaution

Tachycardia
Pramipexole
Continuous IV infusion Arrhythmias
Haloperidol Hypertension Pregnancy
with dosage adjusted Nausea
Cocaine Tachyarrhythmias Hypovolemia
based on clinical Vomiting
Selegiline Pheochromocytoma Renel Impairment
response. Headache
Tolcapone Ventricular fibrillation Hypertension
Anxiety
Hyperglycemia
Any Questions

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