Kaps 4rth March 2024 part 2

With answers

121)Sildenafill taken with?

Can take with Nitrofuratoin
Contraindicated with Nicorandil and Nitrates.
122)Not induce Seizures? Moderate exercise
123) Cetrimide is? Cationic
124)If patch efficacy low then apply heat?
No never apply heat as it may cause toxicity.
125)In which condition dose of digoxin will adjust? Hypokalemia
126)MOA of mebendazole?
Mebendazole
Inhibit microtubules polymerization by binding to beta tubulin in parasites,inhibition of glucose uptake by
parasite.
Or
Mebendazole: It inhibit glucose uptake and transportation in parasites which may leads to death of parasites.
Inhibit microtubules polymerization by binding to beta tubulin in parasites,inhibition of glucose uptake by
parasite
127)MOA of cefoxitin?Cell wall synthesis inhibitor.
128) Toxicity of Pcm by?
Toxic metabolite napqi cellular bind to proteins.
129)Not beta Phentolamine? can't understand this question
130)Linear concentration in?In first order
131)E feacelis ttt? Imipenam,meropenam
132)Hyperphosphatemia concerned with Which ion? Ca, hypocalcemia
133) Tinnitus by? Aspirin
134)Inner Ear equilibrium
135)Glucorticoid --Acth
136) Probenecid inhibit renal clearance of cephalosporin? Ryt
137)Not factor of absorption? Height
138) Carpenter rash ttt Terbinafine
139)Runny nose,fever,soar throat ttt pcm and diphenhydramine.
140) prednisolone? Ketone ring
141)To reduce illegal selling of buprenorphine add naloxone
142) Glycoside contains? Steroid ring
144)Safe in Asthma St John's? Ryt
145)In Cushing syndrome? Cortisol increase
146)Buffer mainly for? Vaginal pessaries
147)Epoprostenol cause?vasodilation
148)Piroxicam is? Non selective
149)empagliflozin CI in?Dehydration
150) Moa b selective ? selegiline
151)Pcm less for transdermal?ryt
152)Ondansetron is? 5HT3 Antagonist
153)Formoterol onset ?1-3 min
154)Butyryl hydro antioxidant
155)Which cause orthostatic hypotension.
1st check alpha blockers then acei,arbs,tca,ssri,maoi,ccb.thiazides loops
There was Amlodipine so Amlodipine correct ans.
156)Not given in absence seizures is? Levetiracetam
157)Leflunamide action after? 4-6 weeks
158) coc rx with hypericum(st John)?coc failure
160) Benzocaine incorrect insoluble in Dil acid.
161)Half life not affected by?absorption
162)Hold in tight containers? High vapor pressure drugs
163) Amitriptyline? Prodrug
164)pH effect on bond rotation, question will be like ,Not factor affect molecular rotation... Ph or temperature.
Ans ph
165)EDTA is ? Chelating agent
166) Tamoxifen Side effect on uterus? Agonist action
167) Sterility not required for?enema
168)Capping? Separation of upper layer
169)Ciclosporin organ rejection
170) Magnesium Stearate? Lubricant
171) Disaccharide is? Sucrose
172) Corticosteroids oral candidiasis
173) Diltiazem is 3A4? Diltiazem is Cyp3A4 substrate and enzyme inhibitor.
174) Epilepsy triggered by? Flash light
175) Codeine 2D6.
176) Neutral drug absorption inc by increasing 0/w partition coefficient
177) Urinary incontinence? Imipramine if not then choose oxybutynin
178)Low maternal plasma drug concentration due to?
Low drug level
179) Apixaban crushed or not?
Apixaban can be crushed.
180)Temazepam act through? GABA
181)Active metabolite allopurinol?
Oxypurinol
182) Tardive dyskinesia --dopamine blockage.
183)ACEIs increase? Brdaykinin
184)Stereoselective Rx
185)Patient taking perindopril and thiazide what not to choose: naproxen pcm tramadol oxycodone
I chose naproxen) triple whammy effect
Ans is naproxen.
186)Scabies: least appropriate: only infected ppl are treated
187)Tonic clonic : valproic acid
188) Paba pasa? decarboxylation
189)Asa? Hydrolysis
190)Many questions about plasma proteins and binding
Saturation due to inc affinity
Binding not affected by plasma conc
191)Also renal excretion drug should be polar.
192)Sc and Im abs : what is correct:
I chose: not limited by SC drug absorption in interstitial fluid?
193)What does not affect transdermal abs : molecular size
193)Tramadol longest duration of action.
194)Most on g -ve? Aminoglycoside
195)E. Faecialis ttt imipenem
196)There was a graph related to linear choose first order in it.
197)venlafaxine or CBZ not require monitoring? Cbz require, venlafaxine no monitoring required.
198)Lisinopril dose? 40mg and sildenafil choose 50mg.
199)Naproxen not racemic mixture
200)Counselling for doxepin: safe in bf
Or tell pt that it is causes your dry mouth brady cardia
201)Digoxin’s t half calculations
Nahpo4
Steady state 95% : 4.3 t 1/2
202)Digoxin and arrhythmia: choose vera
203)Olanzapine causes? hyperglycemia
204)Least in terbinafine : thyroid monitoring.
205)Theophylline+smoking
Decrease theophylline level
206)Famotidine+Itraconazole
Decrease Itraconazole
207)Asprin toxicity? Don't give EDTA give urine alkalinizers
208)Warfarin+spironolactone?
No rx
209)Warfarin+phenytoin?
Increase bleeding
210)Simvastatin+cholchine?
Myopathy
211)Dose of donepezil? 10mg

Calculation
Determination of Na in NACL solution
Determination of K in C6H6K3O7.H2O
Determintaion of t1/2 of drug after 72hours. (t1/2 was 24 hours)
Initial conc 2gm after 72 hours

212)Weak acid
Options was: acetic acid, lactic acid, tartaric acid, 4th one forget
Ans Boric acid is weak acid

213)DOC in for giardiasis

Tinidazole metronidazole.
All were anti fungal except mebendazole
214)Cholinergic agonist drugs?
Pilo,Physos,Physio,Neoo,Ecthio
215)Classification of SABA(salbutamol , terbutaline)and LABA(Formoterol ,salmeterol) SAMA(ipratropium)
LAMA (tiotropium)

Questions about microorganisms

Renal clearance of drugs,
Asthma drugs
Interactions of famotidine rivaroxaban itroconazole , warfarin interactions 3,4 , councelling with rifampicin use in
women, side effects of tcas , serotonin syndrome symptoms, gentamicin

216)Not used in viral bacterial infections? Mometasone.

217)Benzoyl peroxide 10% used for ... Acne
218)Apixaben can be crushed and taken with food,juice? ryt
219)Cephalosporins penicillin resistance percentage 4-10%
230)WBCS Platelets start to reduce after chemotherapy after 6-8 days
231)Cystitis 1st line ttt? cephalexin
232)Broad-spectrum penicillin? amoxicillin
233)Asthma not triggered by? warm Air
234)Sildenafil safe to take with nitrofurantoin ?ryt
235)Drug used in bph? prazosin
236)Cause postural hypotension? terazosin.
237)Dose of GTN
238) questions related to epilepsy
Phenytoin dose in status epilepticus
Least use of levetriacetam among all epilepsy types , absence seizure ,topic clonic etc
1st line therapy for generalized seizure sodium valproate
Least induce convulsive seizure moderate exercise ( other were flickering lights , fever , mental status )
Antiepileptic interaction as inducer except cbz and phenytoin ( levetriacetam , valproate , tiagabine )
239)Not to take with estradiol coc i chose hypericum also there was fenugreek in option
240)Estradiol failure as coc with drugs ( all were new options i think antiepileptic drugs were there)
241)Clavulanic acid ?inhibit penicillinase
242)Hepatotoxic antiepileptic ?cbz
243)Reduce chances of stroke , decrease infarction in MI patient is ?beta blocker atenolol
244)Which enzyme is used to determine MI? Ans is CPK
As No troponin in option also there was LDH , alk phosphatase , ALT
245)Epoprostenol , dilate vascular smooth muscles
246)Esomeprazole? cause hypomagnesemia
247)Penicillin allergy after 30 min , what to avoid in future , cephalosporins cefazolin.
248)Bacterioid fragilis resistant to cephalexin what to use ?cefoxitin
249)Dephthariae organism belong to class? corynebacterium Diptheria
250)Warfarin rx with metronidazole? bleeding
251)Buprenorphine and methadone comparison but chose the option buprenorphine not to take in pregnancy
252)Drug used for urinary urgency?oxybutynin if imipramine not present
253)Amiodarone interactions , choose correct ,options very confusing i chose interact with levothyroxin
controlled hypoglycaemia , others were it is inhibitor of cyp3a4/5 , reduce digoxin dose to 1/3 , cause qt
prolongation with venlafaxin
254)Diltiazem with simvastatin? myopathy
255)Rivaroxaban rx with ketoconazole? toxicity bleeding
256)Grapefruit rx with felodipine?
Increase felodipine
257)Diltiazem?cyp3a4 substrate.
258)Surfactant definition
surfactant, substance such as a detergent that, when added to a liquid, reduces its surface tension, thereby
increasing its spreading and wetting properties. In the dyeing of textiles, surfactants help the dye penetrate the
fabric evenly.
259)Anionic surfactant oleic acid , sorbitan mono oleate ? Oliec acid is anionic.
260)Optical rotation least affected by pH
261)Benzocaine structure , pick incorrect insoluble in mineral acids
262)Not property of water soluble ointment base , anhydrous
Least correct about ointment base , made up only of hydrocarbons
263)Incorrect about ion trapping?acidic drug remain ionized in acidic compartment and reabsorbed.
264)About cystitis, cephalexin 1st choice or methenamine hippurate taken with ascorbic acid ( i chose 1st) since
cephalexin is used in cystitis.
265)Testosterone secreted regulated by FSH ,LH ,Ovaries?
Ans LH
266)Mineralocorticoid example fludrocortisone .
267)Corticosteroids synthesized in? In adrenal cortex and controlled by ACTH
268)Hyperkalemia is caused by salbutamol , atenolol ,irbesartan
Ans Salbutamol
269)About digoxin , dose is reduced to half in hypokalemic patient?ryt since dec potassium will increase digoxin
toxicity.
270)Prodrug famciclovir?ryt
271)Neutropenia by? ganciclovir
272)Acyclovir least use in? ( HS1, HS2, VZ ,vaccinia )
Ans vaccinia
273)Potassium is reabsorbed from? proximal tubule
And excretion through? Dct
274)Not a benefit of lmwh over heparin, renal impairment related option rest were , decrease HIT , decreased
osteoporosis,
275)Most acidic salicylic acid ( in options least pka option was this , others were lactic acid , boric acid )
Ans Choose salicylic acid as it is more acidic with lower pka.
276)Azathioprine , with deficiency of metabolising enzyme dpmt cause myelosupression
277)MTX toxicity with ,hydroxychloroquine , trimethoprime
Ans trimethoprime as no rx with hcq.
278)Buffer essential for vaginal pessaries ( other were oral tab, subcutaneous, nail tinctures)
279)IV , topical antifungal? Itraconazole nystatin, amphotericin , griseofulvin
Ans amphotericin.
280)Nystatin used by ( thrush recurs every month , 60 year old lady , 12 year old girl , after using antibiotics)
Ans after using antibiotics.
281)Rate limiting in topical preparation stratum corneum
281)Daunorubicin cause?cardiotoxicity
282)Cushing disease what is high? Cortisol is high
283)Phase 2 metabolism , demethylation acetylation phosphorylation
Ans acetylation
284)Combination affect thyroid function is by? lithium and amiodarone both
285)Warfarin INR affected by quinolone?ryt
286)Common feature of NSAID all are antipyretic.
( also there was inhibit cox1 )
287)Initial direct response in cell mediated immune response by? T cells
288)No need TDM for metronidazole?ryt
Resolution of racemate , to separate enantiomers
Enantiomers what is wrong , enantiomers are non superimposable mirror images of same compound ,
enantiomers of same compound have different physicl properties )2 options in same question

Calculations from mosm , meq, suppositories,ph pka , dosing , LD, area under curve , clearance etc few were
difficult