Kaps 5th March 2024

Some questions and answers are incomplete, but u can get what came in today's paper. Best of luck

1)Verapamil interaction with following four.....pick least?

Digoxin
Cyclosporin
Carbamazipine
Dabigatran(ans)
2)Fluconazole?
Imidazole
Triazol(ans)
3)To be taken with food:
Isotretinon(ans)
Sertraline
Amoxicillin
Atorvastin
4)Clearance what is not true :
1) depends on t half (ans)
2) required for steady state conc for continuous infusion
3) is the drug removal from a compartment or area
5)Choose the correct statement of acute
cystitisa-A norfloxacin 7 days treatment
b-Hexamine “methenamine” hippurate and Ascorbic acid
c- cephalexine(ans)
6)Coc failure by which
Valproate topiramate bromhexine Omeprazole
Ans topiramate
7)Amiodarone interactions , choose correct ,options very confusing i chose interact with levothyroxin controlled
hypoglycaemia ,
it is inhibitor of cyp3a4/5
reduce digoxin dose to 1/3(ans)
cause qt prolongation with venlafaxine
8)Most hypoglycemia : insulin? Ryt
9)Warfarin more with celecoxib or tramadol? Celecoxib
10)Which side effect leads to stopping of terbinafine
A hepatic toxicity(ans)
B diarrhoea
11)Cyp450 enzymes located in?? Endoplasmic reticulum
12)Not use during fungal or viral
Isotretinoin
Mometasone(ans)
Silver sulfasalazine
Mupriocin
13)Which pair determines css after iv infusion
A. T1/2 and loading dose
B. T1/2 and dose rate(ans)
I chooses B
14)Choice for hypertension for patients already taking digoxin for arrthmia
A. Captopril/ one ace i forgot exact name(ans)
B. Carvidelol
C. Verapamil
D. Hydrochlorothizide
15)Pka of drug
A. Natural logarithm of dissociation constant
B. Logarithm of reciprocal of dissociation constant(ans)
16)Pyrole, pipercille, steroid structure
17)What is streoselective rxn
A. Rxn that favour one type of isomer(ans)
B. Rxn that exclusively form one isomer
Doxepine choose correct
A.Breastfeeding can use
B.Cause dry mouth, blurred vision and bradycardia
Both are not correct. Choose none
18)Sildenafil 100mg or 50mg
Ans 50mg
19)LMW Heparin:
1.Can be used subcutaneously or IM
2.No monitor required (ans)
3.Thrombocytopenia
4......
20)Topical absorption of active ingredient least depend:
Low Mol wt
PH(ans)
Lipid solubility
Partion coefficient
21) Dose of hydrocortisone,Colchine,Phneytoin
22)Prindopril dose in CHF
23)Dehydration not give empglozin
Ryt empagli CI in dehydration.
24)Buprenorphine mixed with
Methadone
Naltrexone(ans)
Fumazenil
Codine
25)Patient on Low sodium diet, substitute salt?
1.Potassium chloride(ans)
2.Calcium chloride
3.Calcium iodide
4......
26)And one more question.
Which of the following statement is leat appropriate.
Allopurinol not used for acute gout.
Pcm is prefered for acute gout attack(ans)
Rest of options were not related.
Here guys
Pls pay attention
Least _____ B
True ____ A
27)Buprenorphine mixed with
Methadone
Naltrexone(ans)
Fumazenil
Codine
Choose B And first choice Naloxone
Its already in product called Suboxone
28)Naloxone used for overdose of
Cocaine
Amphetamine
Heroin(ans)
29)What is least counselling you would give to a patient taking allopurinol
Your doctor may get checked your uric acid levels to monitor the effect of drug.
Take this drug with food to avoid gi upset.
You may not encounter gout attacks within first few months after taking this medication(ans)
Yes right bcz allo give acute attack of gout when used initially.
30)A patient is taking following drugs which drugs can cause photosensitive reaction and u advice patient to use
sunscreen.
Cyclosporin
Trimethoprim(ans)
Haloperidol
31)Pcm least absoroption from : transdermal route? Ryt Yes paracetamol least no transdermal form available
32)Cytchrom require
Oxygen or NaDPh
Ans.nadph
33) Best with digoxin in arrhythmia
A.Perindopril
B.HCTZ
C.verapamil
D.Carvedilol
I choose vera
34)Gram -ve
Penicillin
Amikacin
Ciprofloxacin
I choose amikacin AG
35) What is not true about linezolid.
Covers gram positive bacteria.
Can be used for severe cases of Mrsa
Can cause myelosupression.
Only available In Iv dosage form(ans)
36) Dose dependent effect of chemotherapy drugs.
Myelosupression(ans)
Alopecia
Nausea and vomiting.
37)A patient is on chemotherapy regimen and he experience epistaxis.what could be the reason.
Leukopenia
Thromobocytopenia(ans)
Leuckocytosis.
38)Drug of choice for terminal neurelgia.
Cbz
39) Which of the following is not a concern for amiodarone?
A) development of hypo hyperthyroidism
B)need for multiple doses(ans)
C) development of liver toxicities
D)Long half life
40)What is least true about cyp system.
Cyp1A2 responsible for 50% of metabolic reactions.(ans)
Differnt cytochrome have different activities.
A few cytochromes metabolize drugs slower than other.
41)Efalizumab stored at 2-8c
42)Good choice for psoriatic arthritis.
D pencillamine.
Mtx(ans)
43)Terbinafine monitoring least(thyroid)
44)Most hypoglycemic SU, if insulin not in option choose SU.
45)Penicillin and cephalosporin cross sensitivity ?4-10%
46)What not related to tablet test
1. Friability
2. Disintegration
3. Dissolution
4 difference in weight not more than 2.5%
Ans.4 (please confirm this
47)Carpenter rash? Terbinafine
48)Colchiine dose(1000 mcg then after 1 hr 500mcg ,max 1.5 mg or 1500 mcg
49)Hydrocortsisone dose
100 mg every 6 hourly
50)Sore thorat runny nose pt on lisin and statin
Benzrym + pcm
51)Oral candiasis by ? Corticosteroids
52)Cbz most hepatic ? Ryt
53)Not used in absence seizures? levetiracetam
54)What inc MI ldh and cpk both given
I chose cpk
55)Skin layers stratum 3 given and dermis
Which rate limiting barrier
Ans stratum
56)Oleic acid? anionic
57)Cetrimide? Cationic
58)cefaclor class
59)lh (testosterone)& fsh(spermatogenesis)
60)diltiazim cyp? Cyp3A4 inhibitor
61)codeine cyp? Cyp2D6 substrate
62)clarithro cyp? Cyp3A4 inhibitor
63)prazosin? Alpha blocker
64)Buffer for most? Vaginal
65)Legionella ? treated with doxycycline
66)acidic urine low excretion in acidic medicine? Ryt acid in acid is absorbed so less excretion will take place.
67)cyclosporin graft rejection
68)white blood cells after chemotherapy?10-14 days
69)for fungal & viral infection less used is?iso or mometa or silver
Ans mometasone.
70)I got the Isotretinoin hair thining or constipation question too
Isotretinoin cause thinning
71)Mycoplasma tx
Clarithro or doxy not available
I go for Azithro
72)Grape fruit juice.. dilitiazam..st john wart interactions(please go through their rxs)
73)Rebound salivation and hypo hypertension by which class?
Ans{((Nicotinic receptors blockers will cause hyposalivation and hypertension(sympathetic))}
Whereas nicotinic receptors agonist will cause hypersalivation and hypotension (parasympathetic)
74)Erythromycin which cyp? Cyp3A4 inhibitor
75)Thyroid toxicity which combination
Lithium and amiodarone.
76)PASA ?decarboxylation
77) tachycardia not symptom of NMS?fever, tachycardia is NMS
78)Tiotropium what is correct(LAMA)
79)UTI causative agent(e.coli)
80)Vancomycin SE?
Red men syndrome,Nephrotoxicity, Ototoxicity.
81) in Paper 1 Pyrole,Pipiracillin structure
82)Volume Of distribution decrease due to what?? increase plasma binding and low tissue binding, vice versa,
renal failure, hepatic failure?
83)Psoriatic arthritis ttt?? Methotrexate(ans)
HCQ
84)Aspirin rx least with?? citalopram, naproxen, mtx, propranolol
Ans
85)Glucocorticoid related- What condition occurs on long term use.
86)Not symptoms of Cushings syndrome
88)Type of Anemia seen in Chronic Kidney Failure? Normocytic Normochromic Anemia.
89)Precursor of thyroxine(tyrosine )and serotonin(tryptophan)
90)Symptoms seen in overdose of levothyroxine? Seizures
91)Symptoms not included in organophosphate poisoning
92)Alcohol not use?? Griseofulvin, itra, flu,
Ans griseofulvin
93) Rifampicin with Theophylline Rx?
Dec Theophylline level
94)Ethanol and water what type of isomer
95)Defnition of isomer
96)Diasteriomer
97) All Nsaids are anti-inflammatory, analgesic??

✅
98)Prodrugs??
Prodrugs:
Morphine
Clopidegrol
Tramadol
All ace except lisonopril and captopril
Prednisone.
Atrcuraium.
Aspirin
ibuprofen
alluporinol
diazepam
azathioprine
sulidac
femcyclovir
Valacyclovir
Valganciclover
99)Nms causing agents??
Antipsychotics,CNS stimulants, anaesthetics
100)TDM required??
AGAIN!

Drugs need TDM;

Carbamazepine
Clonazepam
Lamotrigine
Phenobarbital
Phenytoin
Valproate
Aminoglycosides
Vancomycin
Theophylline
Amiodarone
Digoxin
Perhexiline
Amitriptyline
Imipramine
Lithium
Ciclosporin
Everolimus
Sirolimus
Tacrolimus
101)Clozapine cause what??
Low plate let
Low calcium
low white blood(ans as it cause agranulocytosis)
102)What is epistaxis??
Chemotherapy dec platelets lead to epistaxis(nose bleeding)
103)E fecalis treated with meropenam imipenam and resistant to??
104)Renal excretion of drug??
90%excreation
10% absorption
105)Amino acid structure
106)Ne to E? Methylation
107)Tetrachyclen apmhiteric+ chelation
108)Dystonia is due to??
109)Gentamicin toxicity?? Ototoxicity, nephrotoxicity.
200)Which drug is using to and avoid uv to avoid skin cancer ciclosporin(ans), aspirin, metoprolol
201) Aminoglycoside avoided in??
202)Cellulitis cause by bacteria?? Pyogenes, aureginesia, fragilis,
203)Not gram - influenza, enteroccis klebsella, ecoli??
205)Post menopausalhormone for what??
Ans Hot flushes(vasomotor)
Glucocorticoids secreten from what??
206)Function of glucocorticoids,
207)Newotonin, psuodoplastic, thixotropic, dilatent defination
208)Pryntal for what?? Tinea oedis, thread worm(ans), lice
209)Sulfonylureas with what increase hypoglycemia??
210)Wrong about donurubucin
211)Esomperazole cause ?hypomagnesia
212)Fentanyl patch counselling
213)LABA(salmeterol, Formoterol), SABA(salbutamol, terbutaline)
SAMA(ipratropium)
LAMA(Tiotropium)
214)Angina +HTN?? (felodipine, propronol, nodalol, carvedilol)
Ans nifedipine in not in option choose CCB here choose felodipine.
215)Carvedilol is what?? Alhpha beta??
Ans beta blocker
216)Inhibition of Lipoxygenase does what??
217)Leflunimide?? Continue for 4 week
218)Asthma not triggered by??warm air
219)Rifampicin +COC??
Coc failure
220) Creatinine clearance depends upon what??
221)Serum creatinine depends upon what??
222)HmgcoA reductase?? Statins
223(Allopurinol Moa?? xanthine oxidase inhibitor
224)Enantiomer??
225)Epoprostanaol do what?? vasodilation
226)Heroin antagonist??
227)HTN preg?? Labetalol
228)Hemolytic anemia?? Methyldopa
229)Moa of penicillins? Cell wall synthesis inhibitor
230)Clavulanate do what?? Inhibit penicillinase enzyme
231)Acei do what?? Creatinine and k increase
232)Doc of trigeminal neuralgia?cbz
233)Least cause aspirin??
Tinitus, urticaria with dipyridamol, decrease bleeding events
Ans Tinnitus

Weak acid what happen in water?? PC decrease if pH of water increase.

Rna to dna
Chelating agent
Oleaic acid
Chemotherapy most common adverse effect?? Mylosup
Tamoxifen?? Uterus agonist.
Cyp 450 where?? Mito or ER.
Sterioselective
Renal failure exoprain
Patch fentanyl choose correct
Drug release less due to heat
Other was wrong
And one was effect teeminate after removing patch
Covlant bond def
Surfactant def
Guaopenasien
Pcm + anti allergic for fever and allergy
Water and ethanol mixing??
Endothermic reaction increase with?? Inc in temp?? Dec in temp??
Safest or heart? Valproc acid
Ab sense seizure?? Ethusuximide
Combinitaion therapy whau to use??
Asthma is not increased by??
Not inallergic rhinitis?? Sinus oain
Not symptom of cardiotoxicity
Nystatin use?? Swallow
Not Tru about cyp 450??
Vitamin Not for eyes??
Not affect alendronate??
Mt monitor?? Trasnaminase level.
Not omega 3??

16 Calculations mostly repeated

Dilution, allegation, %, and the calculation with ans 35.7, mmol
Css in IV depends on
Saturation related question ask which one fulfill the meaning
Lactic acidosis by
Verapamil rx wrong: increase excretion of digoxin
Amiodarone rx wrong: need to increase digoxin
Autoinjector wrong: entire dose
Plasma protein binding least affected by
SC and IM choose correct: need high lipophilic, not related to solubility of drug in intestinal fluid
Mostly can be seen in past recalls but take some time to think.
If ask not official testing in tablet then frability n hardness testing for tabs.
Urea hume
Bha antioxidant
Partial less effect than agonist
Tendancybto bind with revptor affinity
Buprenorphine
Leflunmide
Fursomide
Digoxin
Correct or incorrect data
And was deep datab
phentolamine
Mostly recalls, focus Nov recalls
VD related very confusing and difficult questions 3-4
Clearance confusing question 3
Statin + grape fruit??
Warfarin interaction