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Pharmacological and Toxicological Screening Methods

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Gagan Chawla
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598 views2 pages

Pharmacological and Toxicological Screening Methods

Notes help ful for students

Uploaded by

Gagan Chawla
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Examination, 2022-23

MPL103
Course Name: PHARMA
Year: First Year
Branch: M Pharm
Subject: Pharmacological and Toxicological Screening Methods

Time – 3 hours Maximum marks- 75

SECTION A 10X02=20
Attempt all questions
1. Pyloric ligation method is used to study …………………………. Activity in animal.
2. Enlist any two in vivo methods used for diarrhoea evaluation in rat.
3. Simplest and most economic model used for cancer is ……………………..
4. Term Aphrodisiac means ………………………..
5. Plus- maze model is used to detect ……………………… activity in animals.
6. ……………………are called smart drugs because …………………………………
7. Hazelnut extract given by transdermal route cause ………………………….in animals.
8. Give the reason for selection of streptozotoc in over alloxan for induction of diabetes in
rats.
9. Allergic contact dermatitis is-
a) A non-immune response caused by a direct action of an agent on the skin
b) An immediate type I hypersensitivity reaction
c) A delayed type IV hypersensitivity reaction
d) Characterized by the intensity of reaction being proportional to the elicitation dose.
10. Which of the following concerning the use of the "benchmark dose" in risk assessment is
NOT correct?
a) Can use the full range of doses and responses studied.
b) Allows use of data obtained from experiments where a clear "no observed adverse
effect level" (NOAEL) has been attained.
c) May be defined as the lower confidence limit on the 10% effective dose.
d) Is primarily used for analyses of carcinogenicity data and has limited utility for
analyses of developmental and reproduction studies that generate quantal data.

SECTION B
2X10=20
Attempt any two
11. Elaborate immune assay, interpret methods for evaluation of immune assay in relation to
insulin or digoxin.
12. Analyse the applications of transgenic animals in modern pharmacological
experimentation along with their methods of production and maintenance.
13. Interpret different animal models used for neurodegenerative diseases.
SECTION C
Attempt any five questions- (5X7=35)

14. Illustrate the limitations of experimentation in animal models, describe some alternate
for animal experimentation.
15. Quote the principle of bioassay and analyse different methods used in animal
experimentation.
16. Demonstrate in vivo animal models for anti-depressants.
17. Distinguish the methods of extrapolation of in vitro data to preclinical and preclinical
data to humans.
18. Summarize CPCSEA guidelines for maintenance, breeding and conducting
experiments on animals.
19. Extend any two in vitro methods for detection of anti-inflammatory activity.
20. Write a note on general principles of preclinical screening and enlist techniques of
euthanasia used for experimental animals.
21. Enlist and explain any two models for anti-epileptic study.
22. Describe types of animals used in laboratory also mention application of different
species and strains.

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