SAFETY DATA SHEET Version 8.

1
Revision Date 05.02.2022
Print Date 08.07.2024

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : n-Paraffin Mix C18,C20,C22,C24

Product Number : 47108

Brand : Supelco
1.2 Other means of identification
No data available
1.3 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : For R&D use only. Not for pharmaceutical, household or other
uses.
1.4 Details of the supplier of the safety data sheet
Company :

Taiwan Merck & Co. Neihu

Taipei Crest Avenue
6th Floor, Sec 89

Merck KGaA
64271 Darmstadt
Germany
Phone:+49 6151 72-0

1.5 Emergency telephone

Emergency Phone # : +(44)-870-8200418 (CHEMTREC (GB))
+(353)-19014670 (CHEMTREC Ireland)
001-803-017-9114 (CHEMTREC India)

SECTION 2: Hazards identification

2.1 GHS Classification
Flammable liquids (Category 2), H225
Skin corrosion/irritation (Category 2), H315
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
Aspiration hazard (Category 1), H304
Short-term (acute) aquatic hazard (Category 1), H400
Long-term (chronic) aquatic hazard (Category 1), H410
For the full text of the H-Statements mentioned in this Section, see Section 16.

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2.2 GHS Label elements, including precautionary statements
Pictogram

Signal word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapor.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
Prevention
P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No
smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/ eye protection/ face protection.
Response
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/ shower.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor if you feel unwell.
P331 Do NOT induce vomiting.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant
foam to extinguish.
P391 Collect spillage.
Storage
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
Disposal
P501 Dispose of contents/ container to an approved waste disposal
plant.
2.3 Other hazards - none

SECTION 3: Composition/information on ingredients

Substance / Mixture : Mixture
3.2 Mixtures
Formula : C8H18

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 Hazardous ingredients
Component Classification Concentration
n-octane
CAS-No. 111-65-9 Flam. Liq. 2; 2; STOT SE <= 100 %
EC-No. 203-892-1 3; Asp. Tox. 1; Aquatic
Index-No. 601-009-00-8 Acute 1; Aquatic Chronic
1; H225, H315, H336,
H304, H400, H410
M-Factor - Aquatic Acute:
10 - Aquatic Chronic: 1
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary
failure possible after aspiration of vomit. Call a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
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5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water
from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary
measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition.
Store at room temperature. hygroscopic
Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

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8.1 Control parameters
Ingredients with workplace control parameters
Component CAS-No. Value Control Basis
parameters
n-octane辛烷 111-65-9 TWA 300 ppm Standards of Permissible
1,400 mg/m3 Exposure Limits in Workplace
STEL 375 ppm Standards of Permissible
1,400 mg/m3 Exposure Limits in Workplace
8.2 Exposure controls
Appropriate engineering controls
Immediately change contaminated clothing. Apply preventive skin protection. Wash
hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: > 480 min
Material tested:KCL 741 Dermatril® L
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: > 480 min
Material tested:KCL 741 Dermatril® L
required
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following
standards: DIN EN 143, DIN 14387 and other accompanying standards relating to
the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

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SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odor No data available
c) Odor Threshold No data available
d) pH No data available
e) Melting No data available
point/freezing point
f) Initial boiling point 125 - 126 °C at 1,013 hPa
and boiling range
g) Flash point 13 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits
k) Vapor pressure 14.7 hPa at 20.0 °C
l) Vapor density No data available
m) Density No data available
Relative density No data available
n) Water solubility No data available
o) Partition coefficient: No data available
n-octanol/water
p) Autoignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
s) Explosive properties Not classified as explosive.
t) Oxidizing properties none

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
Vapors may form explosive mixture with air.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .

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10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
Strong oxidizing agents, Strong acids
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Mixture
Acute toxicity
LD50 Oral - Rat - male and female - > 5,000 mg/kg
(OECD Test Guideline 401)
Remarks: (in analogy to similar compounds)
The value is given in analogy to the following substances: isooctane
LC50 Inhalation - Rat - male and female - 4 h - > 24.88 mg/l - vapor

(OECD Test Guideline 403)

LD50 Dermal - Rabbit - male and female - > 2,000 mg/kg
(OECD Test Guideline 402)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Skin corrosion/irritation
Mixture causes skin irritation.
Skin - Rabbit
Result: Irritating to skin. - 24 h
(OECD Test Guideline 404)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
(OECD Test Guideline 405)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative
(OECD Test Guideline 406)
Remarks: (in analogy to similar products)
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation

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 Method: OECD Test Guideline 471
Result: negative
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: n-heptaneTest Type:
Chromosome aberration test in vitro
Test system: rat hepatocytes
Method: OECD Test Guideline 473
Result: negative
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: n-heptaneTest Type: In vitro
mammalian cell gene mutation test
Test system: human lymphoblastoid cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctaneCarcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Central
nervous system depression, narcosis, To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly investigated.
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Vomiting, Central
nervous system depression, narcosis
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

Systemic effects:

After uptake of large quantities:

Headache
Dizziness
Nausea
Vomiting
agitation
somnolence
Drowsiness
Unconsciousness
respiratory arrest

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 It generally applies for aliphatic hydrocarbons with 6 - 18 carbon atoms that they may
cause pneumonia, in some cases also pulmonary oedema, upon direct inhalation, i.e. in
conditions that can occur only in very special circumstances (nebulizations, spraying,
inhalation of aerosols and similar). After absorption of very large quantities: narcosis.

Handle in accordance with good industrial hygiene and safety practice.

Components
n-octane
Acute toxicity
LD50 Oral - Rat - male and female - > 5,000 mg/kg
(OECD Test Guideline 401)
Remarks: (in analogy to similar compounds)
The value is given in analogy to the following substances: isooctane
LC50 Inhalation - Rat - male and female - 4 h - > 24.88 mg/l - vapor
(OECD Test Guideline 403)
LD50 Dermal - Rabbit - male and female - > 2,000 mg/kg
(OECD Test Guideline 402)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Skin corrosion/irritation
Skin - Rabbit
Result: Irritating to skin. - 24 h
(OECD Test Guideline 404)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
(OECD Test Guideline 405)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative
(OECD Test Guideline 406)
Remarks: (in analogy to similar products)
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Result: negative
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: n-heptane
Test Type: Chromosome aberration test in vitro
Test system: rat hepatocytes
Result: negative
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: n-heptane

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 Test Type: In vitro mammalian cell gene mutation test
Test system: human lymphoblastoid cells
Result: negative
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: isooctane
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table
3.1/3.2)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.

SECTION 12: Ecological information

12.1 Toxicity
Mixture
Toxicity to fish mortality LC50 - Oryzias latipes - 0.42 mg/l - 96.0 h
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 0.38 mg/l - 48 h
and other aquatic Remarks: (ECHA)
invertebrates
Toxicity to algae Growth inhibition NOEC - Pseudokirchneriella subcapitata
(microalgae) - 5.8 mg/l - 72 h
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 10 d
Result: 70.3 % - Readily biodegradable.
Remarks: (ECHA)

Theoretical oxygen 3,500 mg/g

demand Remarks: (Lit.)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not
conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available

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 Components
n-octane
Toxicity to fish mortality LC50 - Oryzias latipes - 0.42 mg/l - 96.0 h
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 0.38 mg/l - 48
and other aquatic h
invertebrates Remarks: (ECHA)

Toxicity to algae Growth inhibition NOEC - Pseudokirchneriella subcapitata

(microalgae) - 5.8 mg/l - 72 h

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Waste material must be disposed of in accordance with the national and local regulations.
Leave chemicals in original containers. No mixing with other waste. Handle uncleaned
containers like the product itself. See www.retrologistik.com for processes regarding the
return of chemicals and containers, or contact us there if you have further questions. The
chemical must be disposed or recycled in accordance with Waste Disposal Act. See
www.epa.gov.tw for the information of chemical waste disposal companies and their
contacts.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1262 IMDG: 1262 IATA-DGR: 1262
14.2 UN proper shipping name
ADR/RID: OCTANES
IMDG: OCTANES
IATA-DGR: Octanes
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA-DGR: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA-DGR: II
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA-DGR: no
14.6 Special precautions for user
None
14.7 Incompatible materials
Strong oxidizing agents, Strong acids
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
Occupational Safety and Health Act; Regulations on
Occupational Safety and Health Facilities
Waste Disposal Act; Standards for the Storage,
Cleanup, Handling and Disposal of Industrial Waste

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 Regulations on Labelling and Hazard Communication
of Hazardous Chemicals;Exposure Assessment and
Control Banding of Hazardous Ch
Rules on Road Traffic Safety
Standards of Permissible Exposure Limits in
Workplace
Establishment Standards and Safety Control
Regulations for Manufacturing, Storing, Processing
Public Hazardous Substances and Flammable
Pressurized Gases Places

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapor.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Further information
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact [email protected].

Literature references About detail information, please refer to each section The
information contained herein is based on the present
state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not
represent a guarantee of any properties of the product.
Organization that prepared Name:Merck KGaA LS-QH
the SDS Address/Telephone number:64271 Darmstadt
Germany/+49 6151 72-0
Date that the SDS was 05.02.2022 Print Date 08.07.2024
prepared

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