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3 views

Document (11)

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jobekara9
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Make a brief write up about the need for bioinformatics

in your preferred subject area


Topic : Need for bioinformatics in Biofilm producing
genes.
Bacterial biofilms are complex and highly antibiotic-
resistant aggregates of microbes that form on surfaces in
the environment and body including medical devices.
They are key contributors to the growing antibiotic
resistance crisis and account for two-thirds of all
infections.
Bioinformatics, as related to genetics and genomics, is a
scientific subdiscipline that involves using computer
technology to collect, store, analyze and disseminate
biological data and information, such as DNA and amino
acid sequences or annotations about those sequences.
Scientists and clinicians use databases that organize and
index such biological information to increase our
understanding of health and disease and, in certain
cases, as part of medical care.
Thus, there is a critical need to develop anti-biofilm
specific therapeutics. Here we discuss mechanisms of
biofilm formation, current anti-biofilm agents, and
strategies for developing, discovering, and testing new
anti-biofilm agents. Biofilm formation involves many
factors and is broadly regulated by the stringent
response, quorum sensing, and c-di-GMP signaling,
processes that have been targeted by anti-biofilm agents.
Developing new anti-biofilm agents requires a
comprehensive systems-level understanding of these
mechanisms, as well as the discovery of new
mechanisms. This can be accomplished through omics
approaches such as transcriptomics, metabolomics, and
proteomics, which can also be integrated to better
understand biofilm biology. Guided by mechanistic
understanding, in silico techniques such as virtual
screening and machine learning can discover small
molecules that can inhibit key biofilm regulators.

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