CSF Shunts for Idiopathic Normal Pressure Hydrocephalus
CSF Shunts for Idiopathic Normal Pressure Hydrocephalus
Background:
Cerebrospinal fluid (CSF) shunts are medical devices used to treat hydrocephalus, a condition characterized by an abnormal
accumulation of cerebrospinal fluid within the brain's ventricles. These shunts help to divert excess fluid away from the brain to
another part of the body where it can be absorbed.
1. Shunt Material: Shunts can be made of different materials, including silicone, polyurethane, and other biocompatible
materials.
2. Valve Mechanism:
o Pressure-Regulated Shunts: These shunts have a valve mechanism that regulates the flow of CSF based on
the pressure within the ventricles. They can be further classified into:
▪ Programmable Shunts: These shunts allow adjustment of the opening pressure externally,
typically through the use of a magnet.
▪ Fixed-Pressure Shunts: These shunts have a predetermined opening pressure that cannot be
adjusted externally.
o Gravitational Shunts: Gravitational shunts, also known as siphon-control valves, utilize the gravitational
force to regulate CSF flow. They are designed to prevent over-drainage of CSF when the patient is in certain
positions, such as upright or lying down.
3. Shunt Components:
o Ventriculoperitoneal (VP) Shunts: These shunts divert CSF from the cerebral ventricles to the peritoneal
cavity.
o Ventriculoatrial (VA) Shunts: In these shunts, CSF is redirected from the ventricles to the atria of the heart.
o Ventriculopleural (VPL) Shunts: CSF is drained from the ventricles to the pleural cavity.
o Lumboperitoneal (LP) Shunts: These shunts connect the lumbar subarachnoid space to the peritoneal
cavity.
4. Shunt Functionality:
o Standard Shunts: These shunts maintain a constant flow rate of CSF drainage.
o Adjustable Shunts: As mentioned earlier, these shunts allow for the adjustment of the opening pressure,
either externally (programmable) or internally (adjustable).
5. Implantation Technique:
o Open Surgery: Historically, CSF shunts were implanted through open surgical procedures.
o Minimally Invasive Techniques: These include endoscopic procedures where the shunt is implanted using
minimally invasive techniques.
6. ONGOING TRIALS: Minimally Invasive CSF Shunting System for the Treatment of Idiopathic Normal Pressure
Hydrocephalus
• https://www.ynhh.org/services/neurology-neurosurgery/normal-pressure-hydrocephalus
• https://clinicaltrials.gov/search?cond=Normal%20Pressure%20Hydrocephalus&intr=eShunt%20
PubMed
Ventriculoperitoneal shunts
• https://thejns.org/doi/10.3171/2023.9.JNS23668
• https://doi.org/10.1227/NEU.0000000000000155
• https://pubmed.ncbi.nlm.nih.gov/19812934/
• https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(09)00050-2
• https://pubmed.ncbi.nlm.nih.gov/19388302/
• https://pubmed.ncbi.nlm.nih.gov/16671489/
• https://pubmed.ncbi.nlm.nih.gov/12134935/
• https://thejns.org/doi/10.3171/jns.2002.97.1.0073
Ventriculopleural shunts
• -
Ventriculoatrial shunts
• https://www.sciencedirect.com/science/article/abs/pii/S0303846716300531
• https://www.sciencedirect.com/science/article/abs/pii/S0303846717300793?via%3Dihub
#preview-section-abstract
Lumboperitoneal shunts
• https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(20)31728-8
• https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(12)00022-7
• https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29688482/
• https://linkinghub.elsevier.com/retrieve/pii/S1474-4422(15)00046-0
• https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35978079/