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BE5230 - Ch1 - Introduction Slides

The document is a syllabus for the course BE 4230, Stem Cell and Tissue Engineering, at Michigan Technological University. It outlines course objectives, key topics such as cell biology, tissue dynamics, and applications in regenerative medicine, and includes required textbooks. The syllabus also highlights the significance of tissue engineering in developing artificial implants and therapies for various medical conditions.

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Noorunnisa CAIE Social teacher
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5 views

BE5230 - Ch1 - Introduction Slides

The document is a syllabus for the course BE 4230, Stem Cell and Tissue Engineering, at Michigan Technological University. It outlines course objectives, key topics such as cell biology, tissue dynamics, and applications in regenerative medicine, and includes required textbooks. The syllabus also highlights the significance of tissue engineering in developing artificial implants and therapies for various medical conditions.

Uploaded by

Noorunnisa CAIE Social teacher
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Stem Cell and Tissue Engineering (BE 4230)

Class syllabus
• BE 4230 (2023 Spring) textbooks
– Tissue Engineering, 1st Edition, Prentice Hall
Introduction Bernhard O. Palsson, Sangeeta N. Bhatia
– Principles of Tissue Engineering, 4th Edition, Academic Press
Robert Lanza, Robert Langer, Joseph P. Vacanti

Hyeun Joong Yoon


Biomedical Engineering
Michigan Technological University

1 2

Class syllabus Class syllabus


• Introduction
• Course objectives
• Overview of cell biology 1
– To provide the students with an overview of fundamental concepts • Overview of cell biology 2
in tissue engineering and regenerative medicine • Cell culture 1
– To provide students with an understanding of critical evaluation of • Cell culture 2
scientific literature and scientific and engineering research and • Tissue dynamics
development in this field • Morphogenesis
• Cell differentiation
– To integrate materials science, chemistry, biology, and
• Cell migration, cell division, cell death
transplantation medicine in order to provide potential solution to
• Extra cellular matrix (ECM)
human disease or medical problems. • Cell and tissue properties
• Stem cell 1
• Stem cell 2
• Presentation
• Final

3 4

Biomedical engineering What is tissue engineering


• Bioinformatics • Biomechanics
• Tissue engineering is a technique which uses combining of
cells, scaffolds (biomaterials) or signals (growth factors,
biologically active molecules) into functional damaged
tissues.
• Tissue Engineering • Neural Engineering

• Medical Imaging • Genetic Engineering

5 6
What is tissue engineering What is tissue engineering
• Tissue engineering is the development and manipulation of • Regenerative medicine
artificial implants, laboratory-grown tissues, genetically - Replacing diseased or injured tissues with tissue constructs
engineered cells and/or molecules to replace or support the designed and fabricated for the specific needs of each individual
function of defective or injured part of the body. patient.

7 8

Tissue engineering market Tissue engineering application


• Cell-based therapy

• Knee
• Liver
• Pancreas
• Skin

2001: $600 Millions


2010: $8.3 Billion

9 10

Knee Cartilage and chondrocytes


• Knee pain may be the result of an injury, such as a ruptured • Cartilage is a resilient and smooth elastic tissue, a rubber-like
ligament or torn cartilage. padding that covers and protects the ends of long bones at the
joints.
• Cartilage is composed of specialized cells called chondrocytes
that produce a large amount of collagenous extracellular matrix,
abundant ground substance that is rich in proteoglycan and
elastin fibers.

Cartilage tissue Human chondrocytes culture

11 12
Cartilage and chondrocytes Liver
• The Liver provides a
diverse array of vital
functions, including
metabolism (protein,
fat, and carbohydrate),
detoxification of
foreign compounds,
production of vital
serum proteins (clotting
factors and albumin),
and production of bile
for digestion.

13 14

Liver (Bioartificial liver device) Pancreas

• Challenges: adequacy of cell source to sustain a patient


stability of cell functions on the time scale of therapy
cell preservation
clinical implementation

15 16

Pancreas/beta-islet cells Pancreas/beta-islet cells


• Encapsulation of
islets is used to
“immunoisolate”
the donor cells by
blocking the
transport of key
immune molecules.

Construction of perfused,
semipermeable conduit for high
blood flow surrounded by cells

17 18
Skin Skin
• Skin is the soft outer tissue.
• It consists of two layers.
(dermis, epidermis)

BioSurface Technologies for the treatment of patients with deep


dermal or full thickness burns (Epicel)

19 20

Bone-marrow Bone-marrow
• Bone marrow is soft, gelatinous tissue that fills the medullary
cavities, the centers of bones.

21 22

Bone-marrow transplantation (BMT) Bone-marrow transplantation (BMT)


• Allogeneic transplant process • Autologous transplant process

23 24
Bone-marrow transplantation (BMT)

25

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