Appropriate Antibiotic Selection MRSA

Gram Positive ( + ) Gram Negative ( - ) PsMo Anaerobes (*) Atypical (~)

For the Most Common Bacterial Organisms
VANCOMYCIN
DAPTOMYCIN (VISA, VRSA,VRE)
(+ ) Gram Positive
(-) Gram Negative * Guidelines per Organ System LINEZOLID (PO) (VISA, VRSA,VRE)
Meningitis http://www.idsociety.org/Organ_System
(*) Anaerobes
PIPERCILLIN—TAZOBACTAM (ZOSYN)
Young Adults: (+)
(~) Atypical N. meningitidis
Strep. pneumoniae
AMPICILLIN/SULBACTAM (UNASYN)
Older Adults:
Strep. Pneumoniae
AMOXICILLIN/CLAVULINIC ACID (AUGMENTIN)
N. meningitidis
L. monocytogenes (+) (*)
AZTREONAM
CAP
S. pneumoniae Otitis S. pneumoniae, H. influenzae, IMIPENEM, MEROPENEM, DORIPENEM
H. influenzae Pneumonia * M. catarrhalis Strep. pyogenes
M. catarrhalis Sinusitis Staph. aureus, Strep viridans,
Group A Strep (+) ( - ) (*) (~) Pharyngitis Anaerobes COLISTIN
S. pyogenes
Staph. aureus
Strep viridans HAP/HCAP VAP CEFAZOLIN (1G)
Anaerobes E.coli Stentotrophomonas
Klebsiella Klebsiella MRSA CEFOXITIN, CEFOTETAN (2G)
Pseudomonas Enterobacter Pseudomonas
CEFOX; TETAN (2G)
Acinetobacter Pseudomonas Acinetobacter
S.aureus MRSA CEFTRIAXONE , CEFOTAXIME, CEFPODOXIME (3G)
Atypical
Legionella
MRSA
Streptococci
(+) (~) ( - ) CEFTAZIDIME (3G)
Mycoplasma HCAP Bacterial Endocarditis*
Follow Guidelines:
Strep. viridans (50%–80%) CEFEPIME (4G)
CAP: IDSA/ATS 2007 Guidelines for CAP Staph. Aureus (50% acute), MRSA
HAP: Am J Respir Crit Care Med ; 2005 Staph. epidermidis (20%–30%)
Enterococci (5%–15%) BACTRIM (TMP-SMX)
HACEK :
H. parainfluenza, H. aphrophilus,
Actinobacillus actinomycetemcomitans
Cardiobacterium, Eikenella, Kingella
MOXIFLOXACIN MOXIFLOXACIN
Cholecystitis ( - ) (~) Brucella , Enterococci, Coxiella burnetii
LEVOFLOX
LEVOFLOXACIN
Enterobacter spp; E. coli, Follow Guidelines:
Klebsiella, E. faecalis Circulation.2005; 111: 3167-3184 CIPROFLOXACIN CIPROFLOX
Enterococcus, Salmonella doi: 10.1161/
Clostridium, Bacteroides, CIRCULATIONAHA.105.165563
Vibrio vulnificans DOXYCYCLINE DOXYCYCLINE
(+) ( - ) (*) (~) TIGECYCLINE TIGECYCLINE
Gastroenteritis Osteomyelitis
Salmonella, (-)
(*) Most Common: Staph. aureus AZITHROMYCIN AZITHRO
Shigella,
Foreign Body: Coag-neg
Campylobacter,
Staph, Propionibacterium
Aeromonas
Nosocomial: Pseudomonas,
ERYTHROMYCIN
Yersinia enterocolitica
Enterobacteriaceae,
E. coli (EHEC)
E. coli (EAEC)
Human mouth, Diabetic foot, CLINDAMYCIN CLINDAMYCIN
Decubitus ulcers:
E. coli (EPEC)
Streptococci, Anaerobes
E. coli (VTEC :O157) E. coli ( 75%) Urinary Tract Cellulitis (+) ( - ) (*) Sickle cell disease:
GENTAMYCIN
Clostridium diff. Klebsiella, Proteus, Streptococcus pyogenes (65%)
Infection Salmonella, Pneumococcus
Enterobacter (10-15%) Staphylococcus aureus (35% ) HIV: Bartonella henselae
Pseudomonas, Serratia, (-) (+) (*) (~) Rare: Pseudomonas aeruginosa, Human or animal bites: TOBRAMYCIN
Citrobacter, Staph. Aureus Haemophilus influenza Pasteurella , Eikenella
Staph. saprophyticus (5 to 10%) Human Bites: Anaerobes,
E. faecalis (GDS), Strep. agalactiae (GBS) Eikenella, Strep. viridans
Immunocompromised: AMIKACIN
Aspergillus, MAC, C.albicans
Rare: Anaerobes, Salmonella, Leptospira Cat or Dog: Pasteurella multocida Geographic: MTB, Brucella,
Mycoplasma, Chlamydia, Salt Water Injury: Vibrio vulnificus Coxiella
METRONIDAZOLE
Morganella morgagni Fresh water injury: Aeromonas
Beta-Lactam’s Cephalosporins Fluoroquinolones Tetracyclines Macrolides Aminoglycosides Kartik A. Valluri M.D. ©
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