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Lec_09. PET

The document provides an overview of Positron Emission Tomography (PET) as a non-invasive medical imaging technique, detailing the process of synthesizing and injecting radiotracers, measuring gamma-ray emissions, and reconstructing images. It discusses the principles of positron decay and the resulting annihilation that produces gamma rays, along with the available geometries for PET detectors and clinical routines. Additionally, it highlights new developments in multimodality imaging and specialized applications in various medical fields.

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Md Abu Kawser Sajib
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8 views18 pages

Lec_09. PET

The document provides an overview of Positron Emission Tomography (PET) as a non-invasive medical imaging technique, detailing the process of synthesizing and injecting radiotracers, measuring gamma-ray emissions, and reconstructing images. It discusses the principles of positron decay and the resulting annihilation that produces gamma rays, along with the available geometries for PET detectors and clinical routines. Additionally, it highlights new developments in multimodality imaging and specialized applications in various medical fields.

Uploaded by

Md Abu Kawser Sajib
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Physics & Instrumentation in

Positron Emission Tomography

Prepared By Dr. Mehdi Hasan Chowdhury, EEE, CUET 1


Non-invasive Medical Imaging
Techniques
Anatomical CAT MRI

• X-ray
• CAT
• MRI
• Ultrasound
X-Ray

Functional
• “nuclear medicine” - SPECT, PET
• Optical fluorescence, …
2
PET Imaging Overview

- Synthesize radiotracer
- Inject radiotracer
- Measure gamma-ray
emissions from isotope
(~20-60 min)
- Reconstruct images of
radiotracer distribution
(nCi/cc)

3
FDG

4
Positron (+) Decay

Nucleus

18F-FDG Neutrons
+ +
+
Protons

Electrons

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Positron (+) Decay…

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Positron (+) Decay…

7
Positron (+) Decay…

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Positron (+) Decay…

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Positron (+) Decay…

Annihilation gives
• 2x 511 keV gamma rays
• 180 degrees apart
• Line of response
511 keV
e+
Scanner is just a photon e-
counter!
511 keV

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Raw Data & Image Reconstruction

90 projection
image

reconstruction

0 projection
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Available Geometries for PET Detectors

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Clinical PET Scan Routine

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Example

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Example

➢ Low Resolution in
Structural Information
➢ High Resolution in
Functional Information

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New Developments

• Multimodality imaging
• PET/CT
• PET/MRI

• Specialized applications
• Brain, breast, prostate
• Small animal - microPET
• Arterial input function
• Humans - wrist scanner
• Animals - microprobe
• Awake rat brain - RatCAP

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Supplementary Reading

PET Imaging Physics and Instrumentation


Christopher J Thompson, D.Sc. FCCPM
Montreal Neurological Institute

1 Formation of PET Images


2 Components of a PET System
3 PET Detector and Collimator Configurations

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T h a n k Yo u

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