DERMATOLOGY

BY
DR VAIBHAV JAIN
TOPICS-
1.Basics of Dermatology
2. Skin Appendages
3.Papulosquamous Disorders
4.Infections
5.STDs
6.Vesicobullous Disorders
7.Pigmentory Disorders
8.Miscellaneous topics
Anatomy of skin
->
Largest organ of Body.
weight 4-5kg.
--

173 -2m2
Area ->

Layers of skin- Epidermis

BM2IDE]
permis
E
hypodermis, subcutis.
Epidermis -
St. Corneum
I
e
come
M
->

Y St. Lucidum V
lets.
-

Grab -
St. Granulosum -
-

-
some -
St. Spinosum - ⑧
-
St. Basale.
Burger.
-
Cells of Epidermis-
V abundent cells
keratinocytes -> most

⑦
In all layer.

perived from - Ectoderm

-

-
Melanocytes - secreting Melanosomes
↓
*
It
St. 695al2
Melanin
--
↓I
0
⑧ sumelanin pheomelanin
G
Black whe
[ -

melanocyte.
Derived from 36keratinocytes. I
-
v
St. spinosum. Prickle Relllayer.
Langerhans cells -
⑭

APL phagocytic an
nature.
↑

->Bm
-> mesodermal. i

Derived from e

Tennis racquetappearance.
↑

hallmark -

Birbeck Granules.
CDC
Markers
-
CD20
S100

Type slow
L
I
touch Receptor.
adapting.
-
Merkel cells
-

derived from -> Ectoderm

-
r
 Layers- &

flat-
dIIS
W

E
-

L
-

...
-
S

E
· ~
I

↑ "
-

-3
-

-
-

a >
-
↑
Desmosomes
--

Rete
ridges.
 St. Corneum
⑦
an

⑦
LBWIPreten
-
=

neuceus.
--
-
a
↑ plorneum.
Basale
Epidermal
war we
-> layer. transisttime.
st. Lucidum
->
-

Eledin Gvanules
Pa Im
-
--

-3
-

sole &

Icthyo sis vulgaris

Granules
-
rst.Granulosum -> -
-

I Keratohyaline profillagrin Ellagrin

-> -

e winter Eczema
-
2. Membrane Coating Granules -

upid Asteotic
Bodies / Camellar -C222m9 -
odland
Bodies.
st. Spinosum ->
price all
layer.
DSg.
⑧
Desmosomes
DSC

DP
[S
PG

st. Basale
-
eatinocytes
Man
52-15days.
⑭ Epidermal
turnover
Time Bas
-

8. Sedeum
20. 1 stibasale.
Disorders-
nucleus in St. corneum.
⑦ o
Parakeratosis -
Y

P > Psoriasis
E Eczema
A
-
keratosis
Actinic
s ->seborunic dermatitis
Swi sil. Co
-

Dyskeratosis -Y Abnormal keratinisation.

duran - Varley Hauler

Benign parrier disease.
Premalignantcondition
Bowen disease.
 ↑ separation of Keratinocytes.
Acantholysis

srmigus-8,
D
phemphigus vulgaris ->
D593-
O
O

Barrier's Hailey Halley Ca2

-
ATPase

microabscesses

Papillary tip
Microabscss-Dermatitis perpetiformis
Psoriasis
->

Mynero microabscess

Patrier's Michoabscess
- Mycosis fungoides.
Kogg pustules. ->

Psoriasis
Basement membrane zone -
↓
/

Protein Hemidesmosomes.
-

I Bullowhemphigod
e
-

&

-
-

plectin

Integrin.
 I
Dermis – Papillary collagen >
dermis acid
Gyaluronic
Reticular. fibroblast. -
Dermis.

I =

Subcutaneous layer - , Hypodermis

Panniculas - panniculitis
-

d
subutaneous
quflammation of
layer.
TYPES OF SKIN LESIONS-
-
Lesion
- W -
↓

- - develop due to
i disease
-
U
b
-
-
2Lesions
~ #
~ to elesion
converted -

-
~

~
unfilled sesion fat Y

- - clear- fluid
-
-

-
-
>
-

sup resiste
solid C --

Lesion
- Size 4 Ass
v- v
-

erosion
D Epidermis
I -
v
Y
Loss ot
-

4,2er: Spidermis
v
Denis
-
- -
W
Skin appendages-
-

Glands
Nails
fars
--
-

-
-

- -
sebaceous
Sweat Gland
Gland.
-
 e

Keration
W
NAILS – shaped nice

ase
17
III M
SOPD
- -
- -

-
-

trauma
-

m - =
-

↑
94
-
O -
-
Mr. MC
-
-
Chiness-
- -

000->
>
= >
>

- -
8 Ground Glass.
-
-
-
-
e
⑧
-
-

v-
④
-
-

Depatic faster
HAIR FOLLICLES
-

Ors
ha 2-6y23-
Loss q
↑ q
Alopecia
Growing -Y Resting,
phase.
phase. - -
females
- -

Autoimmune ·us Transient D

-

excanige
olsen
Hatton Ludwig i x a
bee
phase. 3 mos
u -
: y
-

appearance.
Swarm
- 3WKS-
⑧

-
>
- >

sch
- Growing Rx.
Pe
- -
- -

adiation chemotherapy.
·

↓
GLANDS - sweats
-
Sweat glands -

Apocrine
e Eccrine

↓Together
--

Hair
-

1 the
Everywhere follicle.
control
cholinergic Adrenergic
b control
Disorder.
I
Rubra
-

--
-
-

-
 Sebaceous gland
sebur
B -

open with Hair follicle-

unit.
6 pilosebaceous

[ 36
-
-

ACNE
formation.
-
 Acne
A

- -
-
- -

Topical A
B
topical
I

Retinoids.Topical
comedons
9 sotretinoin
-

Retinoid retion
-
-
-
t
by
-

Black -
open t
>
= >
AbX.
Topical
-

white cosed
-
-

-
> Adaplever Abx. t
Retinain clinda Being
acterium mycin peide
Propionit - Anh
-

-
 * PAPULOSQUAMOUS DISORDERS Deep regular
Autogmmune disorder
piling.
Psoriasis- -
--

I
?
MC sites -
i Extensor Alopecia areata.

MC
type
i
-

psoriasis vulgan's (me)

-
-

O
pitting.
⑥
P
->

0 -
oil drop sign => onchyolysis

L
I onchyolysis
0 ⑧
I ->
irregular. Berke
Membrane

silver scaling,
S ->
subungual drop
I
oil

4
myperkeratosis sign
⑰ =>>
-

-
 Neucus
-
~.bost.cor
neutrophetartrneum
w 0 psoriasi's
[
-

- r -

- -

(u
-

I
>

v
-> -

·trat
on
↓
MTX.
Steroids
U

Al Cycle
-, ..
-

Sin

q
- -

-
-
-
-
9

=>
-
... -

->
-

Guttate. Redness
Psoriasis
~ -

AbX.
-

Ly URTI
-
-
MTX.
Lichen planus
Mycosal involvement
5P7
plane Topped ⑧
O
q
polygonal -
=

pruritic
Lichen planus
papule.
--

purple.
-
- 6. A

colloid bodies.
=o
-
"I w
=

-
⑦
 9 Isomorphic phenomenon
True koebner
-
false
-
- -
Koebner's Ishenomenon koebnar
-

↓
W Lichen planus
-
- -
-
wants

rais =
Mollscum

contagiosum
↑

--
--

vitgo autoquoculation
Lichen nitidus
minien
I
-

BAl 94 claw
appearance.
-
 patch
mother
Pityriasis rosea
Herald patch.
scaling.
firtree pattern.
christmas tree palten

t collarate
of scale.

scale.
liggrate
paper

Psoriasis
silvers white scales-
fishlikescales- Icthyosis
Greasyscales Seborrhic Dermatitis,
->

Branny pityriasis versou

scalls
Rice Grain scales
7 x
 INFECTIONS
Bacterial infections -
minutissimum- Loral Red
Erythrasma- C.
appearance.
Keratolytic enzyme. L
-

woodlamp -

Examination - -

Ecthyma- E.
pyogenicum s.
pyogens
-Y
- --
-

Pseudomonas
2.
-
GraneoSum ->

3.
Contagiosum ->
parapovious
-
 Honey
- colored strepto-Sh
impetigo-
-
crusting.

i
staph
qureUS.
-

Staph
~ GrowAiee I

I
aureus streptococ
↑

I fi
Deep superficial.
Margin.
-
--

Diffuse year cut

 finevice scale
Fungal- T sales- Branny-
scall

pityriasis versicolor

M. 4106059
2.A W

sphagetti
-x

furter.
Meatball

Microscopy-
Apple
Green.
A Bananal Grapes Appearance.
mic-site -
trunk wood
Lamp selenium sulphide.
RX y
-

SS Ardes
-
Azoles

piedra- ⑧ Black piedra Piedra nort

#>-
al
-
-

Trichosporan
Shira
G

-
0
-
Y
Bejeille
--
 Dermatophytes.
skin, Nails, nois
Tichophytow Y
-

4x -skin mails
Epidermophyton->
-

is
#

->
skin
NX
Microsporon- -

pitis
-
-
--

0 0
0

Painfully I Hi
tender boggy swelling.
↓
scutula Black dot Greaten
Kerion favus
↓
↑. Mengrophyte ↑Schem Rx Griseoulvin.
>

↑ Verucossum
 Y corboris
↑cruris
T. Ungum.

⑤
--
-
↑. pedis
athelete
GOOt-
central
clearing Tinia
->

Perbinafine
-

Rx
scarring
-
central
-
->
Lupus
-
vulgan's V

central
crusting Leishmania
->
gtracamole
sporotrichosis
Parasitic -
Viral -
HPV

Deep I
D
->

2
s
->
superficial

-
plane 3, 10

- common
C 4

Epidermo dysplasia
E 5,&
verruciformis

A- >
Anogenital warts 6, 11

B -> 7
Butcher's
Mycobacterial infections -

.
n
&

u
 M. Lapral
->
Leprosy

paribaullary
Mutbaullary

Rx.

Rifampicin 600mg/month
->

Mofazamine ->
3rong/mouth
someday
DAPSONe
->
loomg/day.
↑
 Lepra reactions

Ridley Classification
soppling
T

BT -
Y Me lesions
in india I satellite
lesions
BB ->
anverted sauces shaped lesion/Geographical
BL

LL
↑
 STDs- HSV chancroid Syphilis Donovanosis (GY

Inters)
K. Granulomati's chlamydiar
-

MSU n.
Dyckey; T.pallidum
organism
3-7 days 3-5day 9-90 days 30days 10-30day
I.P
⑦
⑦ ⑦
pain ⑰ ⑰

Edge
>

undermined Rubbry
-

Lymph BIL Rubbry Pseudo BIL

BIL UIL 6460S, buboS painful
Acknopathy shoty painless
painful
painful
Transient.
uncer multiple multiple single single
Beefy Red
We.
 kits
STD

P.
Urethral
discharge
-
NGU
Gonococcal
(neisserial (chlamydial
A
mucoid
purulent A
b
ceftriaxone Doxy
I
t

Azithromycin
Azithromycin
19t -
-
Areyong.
 2. Vaginal discharge
candidiasis
Trichomonas B.
Vaginosis
b ↓
b
Metrol
fluconazole metronidazole saccinidazole

(150mg)
fluconazole
1297 -2 ->
(150mg)
secinidazole (29)

3.
Genital ulcers
-
syphillis kit 3

(non perpetic)
Donovanosis

chanceoid
I->
Penelleene
(non-Grouped)
 kit-4
4. to
Allergic
-

peniclin Doxycycline
Azithromy n

5. Herpetic -> Acyclovir yoorg TDs x

days

cefixime
PID -
6. metronidazole

7.
BUbOS ->
Doxycycline
Azithromycin
STD kitS
 VESICOBULLOUS DISORDERS
Phempighus #>
phemphigoid-

Antibodies

Tensebullal
flaced bullae
 phemphigus
↑folaceous p. vulgaris

St. Spinosum
St. Granulosum
subcorneal Suprabasal

Buccal
Seborhic Mucosa
areas. scalp
signs -> Nikolsky
Abose nausen

Histology Acanthocytes
->

DIF -

Rx -
Steroids

Dyclophosphamide.
 Bullous
phemphigoid
IgG BRAg2;
->
I

Linear deposition
IgG
on BM2

Pensebulae are formed.

Rx steroids.
->

Linear disease BOL DAPSONE

IgA
string of
IgA on BM2
Pearl appearance
-
 Alw celiac ds.
->

Dermatitis perpetiformis BO BR2 CR3

Ab HLA
=

Anti ando

Antigliadin
AntiTiG
Microabscess
papillary tip
IyA
deposit
DOC- Dasone

ROC -
Avoid Brow
I
PIGMENTORY DISORDERS
 MISCELLEANEOUS
AD

I
Melanin
&
Melanocytes OMelanocytes Synthesis
⑦
!
⑦
tyrosinase
&
Rodent uncer

pitting I
scaring
wrs
I
Thankyou