YEAR 5 MBChB

Professional Practice Block

Prescribing Case Studies

2015/16

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 Prescribing Tutorial

This workbook contains a variety of prescribing scenarios. There will not be time
during the tutorial to cover all the cases but students should attempt to complete the
workbook in private study time. Separate workbook has blank prescription and
medicine reconciliation sheets.

Admission Cases Pages 3 – 5

Discharge Cases Pages 5 – 14
Anticoagulation Cases Pages 15 – 16
DVT case Page 17
Peri-operative cases Page 17
Sedation Cases Page18
Acute Pain cases Page 19
Alcohol Withdrawal Case Page 19
IV Fluids Cases Pages 20 -23
Diabetes Cases Pages 24 – 27
Chestpain Case Page 27

Online BNF resource http://www.evidence.nhs.uk/formulary/bnf/current

NHS Grampian Protocols:
 Reversal of anticoagulation with warfarin
http://www.nhsgrampian.com/grampianfoi/files/WOA_560_0113.pdf
 Peri-op guide:
http://www.nhsgrampian.com/grampianfoi/files/PeriOp_697_0714.pdf
 Tranquillisation Policy NHS Grampian
http://www.nhsgrampian.com/grampianfoi/files/NHSGRapTranq.pdf
 Diabetes Guidance www.nhsgrampian.org/guidelines/diabetes

NICE Guidelines on IV Fluids https://www.nice.org.uk/guidance/cg174
NICE pathway ACS http://pathways.nice.org.uk/pathways/acute-coronary-syndromes

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ADMISSION CASE 1

It’s Saturday afternoon. Mr Tom Smith is a 76 year old man being admitted to a
medical ward with a raised INR. His GP checked it yesterday after Mr Smith noticed
some bruising and the laboratory called GMEDs today as the INR was 8.2. The
warfarin is prescribed for atrial fibrillation and previous TIAs. He is well with no
obvious bleeding. He is currently being treated for a urine infection which is
improving.

He tells you that these are his current medicines:

Warfarin usual dose 3mg once daily

Ramipril 10mg once daily
Amlodipine 10mg once daily
Simvastatin 20mg once daily
Ciprofloxacin 500mg twice daily for last 3 days

Tasks:

1. Complete the medicines reconciliation form, including action plan for each
medicine.
2. Write up the prescription sheets for continuing medicines
3. Make a decision regarding how you will deal with the raised INR, what you will do
about his warfarin dose and when you will check his INR again

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 ADMISSION CASE 2

It’s 8pm on Wednesday.

Jessie Kesson is an 80 year old lady admitted to the orthopaedic ward with a right
fractured neck of femur. She has a past history of ischaemic heart disease,
osteoarthritis, COPD and recent DVT. Her AMT is 7/10. Your registrar thinks she
will need an operation.
Medication history:
Information Information from Information from the ambulance
from Jessie Jessie’s daughter crew who found the following
medicines in Jessie’s House, so
brought them in
“Puffers” “water pills” Salbutamol inhaler 2 puffs if
required for wheeze
“Wee white “blood thinner” Tiotropium inhaler 18mcg daily
pills”
Pain “killers” Heart pills Rivaroxaban 20mg once dialy
Might be able to bring in Atenolol 50mg once daily
note from house
Questions whether Jessie Felodipine 5mg once daily
has been taking her
medicines properly
Furosemide 20mg once daily
Co-dydramol 2 tabs as required for
pain

Task:

Write up the medicines reconciliation form, complete the medicine action plan on this
form and then write up the prescription sheet

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ADMISSION CASE 3

Mrs Middleton (aged 60) arrives in the AMAU from A&E on a Saturday morning.
She has had an episode of chest pain which the registrar thinks may be due to gastro-
oesophageal reflux, but is waiting for a 12 hour troponin. She has taken along all her
drugs in a carrier bag. This is what it contains:

3 empty packets of aspirin – 75mg tablets, dated 12, 8 and 3 months ago, 56 tablets
per pack
1 half full packet of co-codamol (30/500), dated 4 months ago, 112 tablets
2 packets of paracetamol – 1 empty, 1 half full - no date
1 half full packet of co-dydramol, dated 2 months ago (for James Middleton)
1 half full bottle of lactulose, dated 4 months ago
1 empty packet of clopidogrel, dated last year
1 GTN spray, dated 19 months ago
2 strips of sertraline, each containing 14 tablets, unopened
3 salbutamol MDI inhalers, 2 almost empty
2 seretide accuhalers
1 half strip of clarithromycin 250mg tabs dated 7 months ago
1 half packet of benson and hedges
1 packet of atenolol 50mg dated 1 month ago
1 half used grotty tube of betnovate (no instructions or date)

Tasks:

1. Please complete the medicines reconciliation form, action plan and prescription
chart for continuing medicines.
2. What medicines related problems might this patient have?

DISCHARGE CASE 1

Margaret MacPherson is a 77 year old woman who has been in hospital for a vaginal
hysterectomy. This has all been straightforward.
See following 4 pages which are the medicine reconciliation form and prescription
chart. Please write her discharge flimsy.

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DISCHARGE CASE 2
Melvin Stuart is a 75 year old man with non-small cell lung cancer. He was admitted
with chest pain. His primary cancer has infiltrated the surrounding tissues and he has
bony metastases. He has been started on opiates for analgesia to good effect.
Patient’s prescription chart is as follows (4 pages)
Please write his discharge (IDL – Immediate Discharge Letter) prescription, using one
sheet for all the controlled drugs and one for the other medicines.

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ANTICOAGULATION CASE 1

Jennifer McRobert is a 62 year old woman who was admitted to the medical ward 2
weeks after getting an elective left hip replacement. She has no past medical history
other than osteoarthritis of her hips. She was prescribed aspirin as DVT prophylaxis
but has complained of 3 days of a more swollen left leg and today experienced sudden
onset right sided pleuritic chest pain and shortness of breath. She mentions that her
brother had a post operative PE.
She weighs 68 kg.
Following a high probability V/Q scan, a pulmonary embolism is diagnosed.
Please prescribe low molecular weight heparin (dalteparin is local choice) and start
warfarin. Please write down your plan for warfarinisation.

ANTICOAGULATION CASE 2

Martin McKendrick is a 36 year old man who has recently had an aortic valve
replacement (metallic valve) for endocarditis. He was initially treated with
intravenous heparin and has now been started on warfarin.
Today his INR is 3.2.
Please write his discharge prescription, including all the information that the GP
needs. See warfarin prescription chart on next page.
You will need to make decisions about the target INR and length of treatment – this
can been deliberately left off the following chart, but in reality this information must
be included on the chart.

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DVT PROPHYLAXIS CASE

A 64 year old woman is admitted for an abdominal hysterectomy. She is obese.

Otherwise she is well with no past medical history. Her current medicines are:
tranexamic acid when required and dihydrocodeine. Her HRT was stopped 4 weeks
ago.
She weighs 90kg.

Tasks:

1. Name her risk factors for VTE

2. Name her risk factors for bleeding
3. What prophylaxis would you consider? Please prescribe this on the prescription
sheet provided.

PRE-OPERATIVE MANAGEMENT CASE 1

A 72 year old man is admitted with a fractured neck of femur. He has a past medical
history of hypertension and atrial fibrillation. These are his usual medicines:

Amlodipine 10mg daily

Atenolol 50mg daily
Warfarin – usual dose 4mg daily at 18:00 hours; INR today is 2.2.

He is put on the theatre list tomorrow morning. Consider which of his medicines you
should write up on his prescription chart and any other necessary action.

PRE-OPERATIVE MANAGEMENT CASE 2

A 45 year old woman with type II diabetes mellitus is admitted for an elective
cholecystectomy. These are her usual medicines:

Metformin 2g daily in divided doses

Glipizide 5mg once daily
Apixaban 5mg twice daily
Felodipine 5mg once daily
Atorvastatin 40mg daily
Ramipril 10mg daily

Consider which of his medicines you should write up on prescription chart and any
other necessary action.

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SEDATION CASE 1

Alexander Ewing is an 89 year old man who normally lives in a nursing home due to
dementia. He is admitted to an orthopaedic ward following a fall in which he
sustained a fractured neck of femur. He has very poor vision and is almost deaf.
Nursing staff report that Mr Ewing is agitated and distressed at times, and they are
struggling to stop him trying to climb out of bed. He has not had any treatment for
agitation. When you arrive he is staggering around his room and in danger of falling.

His current drugs are:

Paracetamol 1g four times daily

Senna 2 tabs at night
Tolterodine MR 4mg once daily
Chlorphenamine 4mg three times daily
Prochlorperazine 5mg 6 – 8 hourly if needed nausea

Tasks:
1. List the possible causes of Mr Ewing’s agitation and consider non-pharmacological
measures that could be used.
2. Prescribe once off sedation to deal with the current issue on the prescription chart.

SEDATION CASE 2

Jessie McDougall is a 55 year old woman who has been admitted with a pneumonia
(CURB 2). She is concerned that she will not sleep in hospital and you have been
asked to write up a sleeping tablet for her. She is haemodynamically stable and her
oxygen saturations on 2 litres oxygen by nasal cannula is 96%.

Prescribe (or not) an appropriate medicine.

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ACUTE PAIN CASE 1

A 20 year old man presents to A &E after falling off his bike. He is alert and
conscious but in obvious distress and states that he is in “absolute agony”. You
suspect that he has a simple fracture of the tibia but are awaiting an Xray to confirm.
Your registrar asks you to prescribe some parenteral analgesia.

Tasks:

1. Consider the issues around administering parenteral analgesia.

2. Prescribe a one off dose of your drug of choice on the prescription chart.

Part 2
The fracture is confirmed and the registrar decides it does not need fixation. A plaster
cast is applied. The nursing staff approach you and ask you to prescribe him some
oral analgesia for when the IV analgesia wears off.

3. Consider the options and prescribe suitable analgesia.

ACUTE PAIN CASE 2

A 63 year old man is admitted to a medical ward with crushing retrosternal chest pain.
His ECG shows ST depression and a NSTEMI is suspected. The nurses ask you to
prescribe something for his pain.

Prescribe your choice of analgesia on the prescription chart.

ALCOHOL WITHDRAWAL CASE

A 58 year old man is admitted to the medical ward with diarrhoea and vomiting. He
is admits to drinking a couple of vodkas a day. He last had a drink 2 days ago and is
quite shaky although he denies any issue. Both you and the nursing staff suspect he
drinks more than he admits to (his GGT and MCV are noticeably raised). The nurses
are keen that you write up something to prevent the DTs.

Prescribe an appropriate regime for this man (he is managing oral intake).

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IV FLUIDS CASE 1

Mark Smith is a 45 yr old man is admitted at 0800 to a general surgical ward for a
hernia repair and he is first on the list. He has been admitted electively and has been
fasting since midnight. You receive a phone call from the anaesthetist to say that the
operating list has been changed and this patients operation has been delayed to 4pm.

The nursing staff bleep you to ask you to prescribe some fluids for this patient.

Prescribe appropriate fluids on the IV infusion prescription chart.

IV FLUIDS CASE 2

Mary McPherson is an 80 year old lady with history of 3 previous MI’s. She is
admitted to medicine for the elderly with a urinary tract infection (confused and off
legs). Her drugs include furosemide and antihypertensives. On examination she
looks dry, HR 70 BP 90/40.

Her bloods are:

Na 154
K 3.7
Urea 21.2
Creat 173

Tasks:

1. Please prescribe initial IV fluids on the prescription chart.

2. Make a plan for further monitoring and fluids.

IV FLUIDS CASE 3

A 34 year old man (Andrew Wright) has had a short section of his distal ileum
excised for Crohn’s disease. He is 2 days post-op and will probably not be able to eat
and drink for another 2 days. He is stable.
There are no blood results for today yet.

This is his fluid chart. The nurses ask you to prescribe today’s fluids.

Prescribe the fluids on the chart.

He had 2 bags of normal saline on this chart (6 hourly).

See IV fluids 3 overleaf

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IV FLUIDS CASE 4

A 78 year old man (Duncan Robertson) has been admitted to the surgical ward with a
subacute obstruction. He has no cardiac or renal history that you know about. He is
initially treated conservatively with a large bore NG tube. He needs I.V fluids as he is
nil by mouth.
On examination, he looks a little dry, with a HR of 100bpm, BP 120/56.

Bloods today are:

Na 144
K 5.2
Urea 15.3
Creat 120

These are his charts – urine output 200 mls today; NG output 500mls (until about
15:00, admitted at 06:00)
Has had 1 bag of saline over 8 hours so far

See IV fluids chart overleaf

Please prescribe appropriate fluids.

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DIABETES PRESCRIBING

DIABETES PATIENT ONE

Mr David King (CHI 2307752209) has Type 1 Diabetes Mellitus and has presented
into the AMAU with shortness of breath and cough. He has been diagnosed with
pneumonia and is able to eat and drink. He is on a basal bolus regimen. Novorapid 6
units before breakfast, 8-10 units before lunch and 10-12 units before teatime. He
takes his Levemir 12 units at bedtime.

Hours 1 - 2
All his medications have been written up apart from his diabetes chart. Prescribe his
diabetes medication. His blood sugar is currently 17. What other information do you
want to know?

Hours 3 - 4

David was commenced on antibiotics but he began to vomit and was unable to keep
anything down. It turns out he had also missed his morning insulin. His blood glucose
was now 22 and he had 3 plus ketones and 4.2 blood ketones.

Task 1: What should be the next step in his management? Signs?

Task 2: As suspected he has developed DKA – see the protocol attached. Prescribe
fluids and insulin treatment regime on DKA prescription pathway sheet.

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DIABETES PATIENT TWO

Sally Smith (CHI 3001472271) has Type 1 Diabetes she is due to have a
hysterectomy the following day on ARI Ward 43. Her usual insulin is Novomix 30 at
doses of 26 units before breakfast and 14 units before tea. She is listed for surgery in
the morning.
Please prescribe her insulin and discuss the next step of her management.

When do you recommence her insulin and what do you do?

CHESTPAIN CASE

Mr Michael Mouse (65) has no significant previous medical history. He is admitted to

ARI Ward 101 with chest pain. Serial ECGs show no ST changes but a significant rise
on Troponin-1 and he has been diagnosed with an NSTEMI. Following consultation
with seniors it was decided not to proceed to PCI.
eGFR>60mls/min, BP 165/90 mmHg, Pulse 66/min in SR.

1. Prescribe initial treatment for Mr Mouse

2. Prescribe secondary prevention medications

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