TEACHING PLAN: Pharmaceutical Organic Chemistry-I

SCHOOL: (SOL)
SCHOOL OF
LAW ACADEMIC SESSION: 2021 – 2022 FOR STUDENTS’ BATCH:
Course
1
No. BP202T
Course
2
Title Pharmaceutical Organic Chemistry-I
3 Credits 4
Theory hours 45
Tutorial 8
Learning Preparation and Exam 4
4
Hours Flipped 4
SL/Al 4
Total hours 65
1. The students will be well acquainted with the Knowledge about structure, name and
Course the type of isomerism of the organic compound and reaction, name the reaction and
5
Objective orientation of reactions.
2. Understand reactivity/stability of compounds, reactivity/stability of compounds
1. write the structure, name and the type of isomerism of the organic compound
Course 2. write the reaction, name the reaction and orientation of reactions
6
Outcomes 3. account for reactivity/stability of compounds,
1. 4. identify/confirm the identification of organic compound
7 Outline syllabus:
Introduction Page Lectu
Paper
7.01 Numbers res
Code
Unit hours
Unit I Unit-1:
12
Classificati Classification of Organic Compounds
on, Common and IUPAC systems of nomenclature of organic
nomenclatu compounds
re and (up to 10 Carbons open chain and carbocyclic compounds)
isomerism Structural isomerisms in organic compounds

Unit II SP3 hybridization in alkanes, Halogenation of alkanes, uses

18
Alkanes*, of paraffins.
Alkenes* Stabilities of alkenes, SP2 hybridization in alkenes
and E1 and E2 reactions – kinetics, order of reactivity of alkyl
Conjugated halides, rearrangement of
dienes carbocations, Saytzeffs orientation and evidences. E1 verses
BP202T E2 reactions, Factors affecting E1
and E2 reactions. Ozonolysis, electrophilic addition
7.02
reactions of alkenes, Markownikoff’s orientation, free
radical addition reactions of alkenes, Anti Markownikoff’s
orientation.
Stability of conjugated dienes, Diel-Alder, electrophilic
addition, free radical addition reactions of conjugated
dienes, allylic rearrangement
Unit III SN1 and SN2 reactions - kinetics, order of reactivity of
16
Alkyl alkyl halides, stereochemistry and rearrangement of
halides and carbocations. SN1 versus SN2 reactions, Factors affecting
alcohols SN1 and SN2 reactions, Structure and uses of ethylchloride,
Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform
Alcohols*- Qualitative tests, Structure and uses of Ethyl
alcohol, Methyl alcohol, chlorobutanol, Cetosteryl alcohol,
Benzyl alcohol, Glycerol, Propylene glycol

1
 Nucleophilic addition, Electromeric effect, aldol
16
Unit IV condensation, Crossed Aldol condensation, Cannizzaro
reaction, Crossed Cannizzaro reaction, Benzoin
Carbonyl
condensation, Perkin
compounds
condensation, qualitative tests, Structure and uses of
(Aldehydes
Formaldehyde, Paraldehyde, Acetone, Chloral hydrate,
and
Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
ketones)
7.03 Unit V Acidity of carboxylic acids, effect of substituents on
13
Carboxylic acidity, inductive effect and qualitative
acids. tests for carboxylic acids ,amide and ester
Aliphatic Structure and Uses of Acetic acid, Lactic acid, Tartaric
Amines acid, Citric acid, Succinic acid. Oxalic
acid, Salicylic acid, Benzoic acid, Benzyl benzoate,
Dimethyl phthalate, Methyl salicylate and
Acetyl salicylic acid
8 Course Evaluation
8.1 Continous Mode 10M (25%)
Attendanc
8.11
e 4M (10%)
quiz,
assignment
open book
test, field
8.12 work,
group
discussion
and
seminar 6 Assignments and 3M (7.5%)
Student –
8.13 Teacher
interaction 3M (7.5%)
8.3 End-term examination: 75%
9 Text Books & References
1.Organic Chemistry byMorrison and Boyd
9.1 Text book 2. Organic Chemistry by I.L. Finar , Volume-I
3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
4. Organic Chemistry by P.L.Soni
5. Practical Organic Chemistry byMann and Saunders.
Reference 6. Vogel’s text book of Practical Organic Chemistry
9.2
s 7. Advanced Practical organic chemistry by N.K.Vishnoi.
8. Introduction to Organic Laboratory techniques by Pavia, Lampman and Kriz.
9. Reaction and reaction mechanism by Ahluwaliah/Chatwal.
https://www.youtube.com/watch?v=BRCc8BrUMwI
https://nptel.ac.in/courses/104/103/104103071/
http://www.freebookcentre.net/chemistry-books-download/Basics-of-Organic-Chemistry-
Video
and-Mechanism.html
9.3 Reference
https://organicchemistrydata.org/links/
s
https://www.organic-chemistry.org/
https://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm

2
Course Outcome Mapping with Programme Outcomes

CO’s/PO’s PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11
CO1 M M S L M M L M S
CO2 M M S S L M M L M S
CO3 M M S S L M M L M S
CO4 M M S S L M M L M S
CO5 M M S S L M M L M S

QUESTION BANK
1. Write increasing order of priority of functional groups
2. Classify the functional groups
3. Explain in details about the isomerism?
4. Define and explain on structural isomerism with suitable examples?
5. Describe and write on hybridization, halogenation of alkanes
6. Explain on hybridization, halogenation of alkenes
7. Elaborate in about stability of alkenes
8. Write about reaction, mechanism kinetics, Factors effecting of E2 Reaction?
9. Write about reaction, mechanism kinetics, Factors effecting of E1 Reaction?
10. Write about reaction, mechanism of Markownikoff’s reaction?
11. Write about reaction, mechanism of anti Markownikoff’s reaction?
12. Write a note on Stability of conjugated dienes?
13. Write a note on free radical addition reactions of conjugated dienes?
14. Write about allylic rearrangement in conjugated dienes?
15. Write a note kinetics, order of reactivity of stereochemistry and rearrangement factors
affecting alkyl halides in SN2 reactions?
16. Write a note kinetics, order of reactivity of stereochemistry and factors affecting alkyl
halides in SN1 reactions?
17. Describe Structure and uses of ethylchloride, Chloroform, trichloroethylene,
tetrachloroethylene?
18. Explain structure and uses of dichloromethane, tetrachloromethane and iodoform
19. Write a note on Qualitative tests of alcohols?
20. Write a about Structure and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol,
Cetosteryl alcohol,
21. Write a about Structure and uses of Benzyl alcohol, Glycerol, Propylene glycol?
22. Classify the carbonyl compounds?
23. Descibe the nomenclature ans structure of carbonyl compounds?
24. Write a note in Nucleophilic addition and mechanism of carbonyl compounds?
25. Describe reaction and mechanism involved in aldol condensation,
26. Describe reaction and mechanism involved in Crossed Aldol condensation,
27. Describe reaction and mechanism involved in Cannizzaro reaction,
28. Describe reaction and mechanism involved in Crossed Cannizzaro reaction?
29. Write a note on reaction and mechanism involved in Benzoin condensation, Perkin
30. Condensation?
31. write a note on qualitative tests for carbonyl compounds?
32. Write a about Structure and uses of Formaldehyde, Paraldehyde, Acetone,
Chloral hydrate?

3
 33. Write a about Structure and uses of Hexamine, Benzaldehyde, Vanilin,
Cinnamaldehyde?
PROJECTS (To be given to group of students)

1. Practice the IUPAC Nomenclatures on the Organic compounds?

2. Demonstrate the models for the structural models using the Molecular models
3. Perform the synthesis of organic molecules using the SN1 and SN2 reactions?
4. Perform the synthesis of organic molecules using the elimination reactions?
5. Perform the synthesis of organic molecules using the nucleophilic addition
reactions?
6. Perform the synthesis of organic molecules using the dehydration Alcohols?
7. Complete a MOOC certification program on Organic synthesis in NPTEL,
Coursera and Udemy