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ECE795_final_supplied

The document contains a series of equations and models related to diffusion, electrical currents, and stimulation in biological systems, authored by Drs. I. C. Bruce and H. de Bruin. Key topics include Fick's law, Ohm's law, Nernst-Planck equations, Hodgkin-Huxley models, and cable equations. It serves as a comprehensive reference for understanding the mathematical principles governing cellular and membrane potentials.

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6 views

ECE795_final_supplied

The document contains a series of equations and models related to diffusion, electrical currents, and stimulation in biological systems, authored by Drs. I. C. Bruce and H. de Bruin. Key topics include Fick's law, Ohm's law, Nernst-Planck equations, Hodgkin-Huxley models, and cable equations. It serves as a comprehensive reference for understanding the mathematical principles governing cellular and membrane potentials.

Uploaded by

DOOAMADAA
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 11

Page 2 of 12

Supplied Equations and Tables

Fick’s law of diffusion:

Ohm’s law of drift:

Einstein’s equation:

Nernst-Planck equation (ion flux):

Nernst-Planck equation (electric current density):

Continued on page 3 December 12, 2006 Drs. I. C. Bruce & H. de Bruin


Page 3 of 12
Nernst equation:

Isopotential membrane patch response to an intracellular current step:

Strength-duration relationship for intracellular stimulation:

Chronaxie for intracellular stimulation:

GHK transmembrane potential equation:

Drs. I. C. Bruce & H. de Bruin December 12, 2006 Continued on page 4


Page 4 of 12
Hodgkin-Huxley potassium channel model:

Continued on page 5 December 12, 2006 Drs. I. C. Bruce & H. de Bruin


Page 5 of 12
Hodgkin-Huxley sodium channel model:

Cable equation intracellular axial resistance per unit length:

Cable equation membrane resistance times unit length:

Cable equation membrane capacitance per unit length:

Drs. I. C. Bruce & H. de Bruin December 12, 2006 Continued on page 6


Page 6 of 12
Cable equation extra- and intra-cellular axial electric potential gradients:

Cable equation intra- and extra-cellular axial current gradients:

Cable equation total axial current:

Cable equation membrane potential vs. transmembrane and applied currents:

Cable equation intracellular potential vs. transmembrane current:

Linear cable equation for extracellular current injection:

Continued on page 7 December 12, 2006 Drs. I. C. Bruce & H. de Bruin


Page 7 of 12
Space constant and time constant:

Steady-state solution to homogeneous infinite linear cable equation:

Steady-state solution to infinite linear cable equation with extracellular current


injection at the spatial origin:

General time-varying solution to infinite linear cable equation with intracellular


current step at the spatial origin:

Centroid of temporal waveform:

Transfer delay:

Drs. I. C. Bruce & H. de Bruin December 12, 2006 Continued on page 8


Page 8 of 12
Progagation delay:

Local delay for isopotential membrane:

Delays for infinite linear cable:

Nominal propagation velocity for infinite linear cable:

Hodgkin-Huxley cable equation:

Continued on page 9 December 12, 2006 Drs. I. C. Bruce & H. de Bruin


Page 9 of 12
Hodgkin-Huxley propagating action potential equation:

Postsynaptic current equation:

Postsynaptic conductance alpha equation:

Steady-state response of a finite cable:

Input impedance for semi-infinite cable:

Steady-state solution to infinite linear cable equation with extracellular current


injection at the spatial origin:

Drs. I. C. Bruce & H. de Bruin December 12, 2006 Continued on page 10


Page 10 of 12
Steady-state solution with extracellular current injection at the spatial origin for
a finite linear cable with a sealed-end termination:

Steady-state solution with extracellular current injection at the spatial origin for
a finite linear cable with a killed-end termination:

Steady-state solution with extracellular current injection at the spatial origin for
a finite linear cable with an arbitrary-impedance termination:

Extracellular field produced by a fiber:

Continued on page 11 December 12, 2006 Drs. I. C. Bruce & H. de Bruin


Page 11 of 12
Approximate extracellular field produced by a cylindrical fiber:

Monopole source density for a cylindrical fiber:

Dipole source density for a cylindrical fiber:

Quadrupole source density for a cylindrical fiber:

Lumped dipole strength for a cylindrical fiber:

Lumped monopole strength for a cylindrical fiber:

Drs. I. C. Bruce & H. de Bruin December 12, 2006 Continued on page 12


Page 12 of 12
Extracellular field produced by a monopolar point current source:

Strength-duration relationship for extracellular stimulation:

Chronaxie for extracellular stimulation:

END OF SUPPLIED EQUATIONS

December 12, 2006 Drs. I. C. Bruce & H. de Bruin

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