Epidemiological Problems with key
Epidemiological Problems with key
Epidemiological Exercises
1. (a) What are the various measures of occurrence for a disease? How are the measures of occurrence of a disease related to each
other? (3marks)
(b)A sample of 1500 women in the age group of 70-74 years was selected from the population ofSiddipet.Amongthem,30 were
known cases of Rheumatoid Arthritis. After medical examination, 70 were newly diagnosed as Rheumatoid Arthritis cases.
Calculate the rates of occurrence of Rheumatoid Arthritis in the given sample population?(2marks)
(i) Incidence = Number of new cases of Rheumatoid Arthritis during a given time period X 1000
Population at risk during that period
Incidence=70/1500 x1000=46.6
(ii) Prevalence = Number of all current cases (old and new) of Rheumatoid existing at a given point in time X 100
Population at risk during that period
The above prevalence is 6 units more than the National Prevalence of RA (National Prevalence:1%)
2. (a) What are the various measures for evaluation of a screening test? (3marks)
(b) A Simple and inexpensive screening test was developed to identify person with COPD. To study usefulness of the test,
cases were examined clinically and the results are shown in the following table. Calculate the Positive and Negative
Predictive value of the test. (2marks)
Disease
Yes No Total
Screening Positive 60 20 80
test Result Negative 40 80 120
Total 100 100 200
(i) Sensitivity
(ii) Specificity
(iii)Positive Predictive Value
(iv)Negative Predictive Value
(v)Percentage of False Negatives and False Positives
Disease
Yes No Total
Screening Positive 60 (a) 20 (b) FP 80
test Result TP
Negative 40 (c) FN 80 (d) TN 120
Total 100 100 200
= ax100/a+c = 60x100/60+40
= 6000/100
Sensitivity = 60%
Specificity = 80%.
Positive Predictive value = True Positive X 100
True Positive + False Positive
= ax100/a+b
= 60/60+20 x100
= 80/80+40 x100
= bx100/b+d = 20x100/20+80
= 2000/100
False Positive = 20%
3. A district has a total population 20,00,000. Of this, male population is 10,00,075 & female population is 9,00,025. Total No. of deaths
for the year 2018 in this district were 2935, out of which, 1,375 were male deaths & 1,560 were female deaths.
a) Calculate the Crude Death Rate of this district for the year2018.(2marks)
b) Calculate Sex Specific Death Rates for this district for the year2018.(2marks)
c) Name 2 Sources for Mortality data in India. (1mark)
Ans: Given,
Crude Death Rate of the district = 1.4 deaths per 1000 population
(b) Sex Specific Death Rates:
Male Death Rate = Number of Male Death in an year X 1000
Total Male population in the year
= 1375/10,00,075 x1000
=1.37 male deaths per 1000 male population
= 1560/9,00,025 x1000
=1.73 female deaths per 1000 male population
Ans)
(a) Epidemiological Indices for Malaria
i) Annual Parasite Incidence= Total Positive Slides for Malaria in a year x 1000/ Total Population
ii) Annual Blood Examination Rate= Smears examined in a year x 100 / Total Population
iii) Annual Falciparum Incidence= Total Positive P. falciparum in a year x1000/ Total Population
iv) Slide Positivity Rate=Total Positive Slides for Malaria x 100/ Total Slides Examined.
v) Slide Falciparum Rate =Total Positive Slides of P.falciparum x 100/Slides examined
(b) Given,
(i) Annual Parasite Incidence of year 2018 = Confirmed cases during 1 year X 1000
Population under survelliance
= 268+30 x1000/30000
=293÷30
=9.93 Positive Slides for malarial parasite per 1000 slides
examined.
(ii) Slide Positive Rate = Total Slide Positive for malaria X 100
Total Slides Examined
= 268/5000 x 100
=5.36 Positive Slides for malarial parasite per 100 slides examined
(c) Programme for malaria is National Vector Borne Disease Control Programme(NVBDCP).Vector control
measures:1)Anti-adult measures, 2) Anti-larval measures and 3) Personal protective measures.
5. (a) As per the data recorded in Siddipet,10 women died due to puerperal sepsis, 5 women died during abortion in their
antenatal period, 3 women died in road traffic accidents and 15 women died during labor in the year 2018. There were
8000 live births. Calculate the maternal mortality rate of the town for the year 2018. (2 marks)
(c) Name 2 National Programs or schemes in India directed to reduce maternal mortality. (2marks)
(a) Maternal Mortality Rate= Number of Maternal Deaths of Reproductive Age X 100000
Total Number of live births
= 30/8000 x 100000
1) Hemorrhage
2) Sepsis
3) Eclampsia
4) Obstructed Labor
5) Unsafe Abortion
Calculi
USG
Present Absent Total
Positive 90(TP) a 20(FP) b 110
Negative 10(FN) c 80(TN) d 90
Total 100 100 200
Total Population that underwent in the USG for diagnosis of Calculi=200 Individuals
True Positive Test Results=90Individuals
True Negative Test Results = 80 Individuals
False Positive Test Results = 20 Individuals
False Negative Test Results=10Individuals
=90/90 + 10 x 100= 90 %
= 80/80+20 +100= 80 %
Given test USG is 90% sensitive and 80% specific in detecting renal calculi.
7. In a study of lung cancer, following data was observed. Total population studied was 810. Out of the 125 lung cancer patients
studied, 80 were smokers. Among the non-cancerous group of 685 members used for comparison, Smokers were 325.
(a)
Disease
RISK Lung cancer present Lung cancer absent Total
FACTOR
Smoker 80 (a) 325 (b) 405
Nonsmoker 45 (c) 360 (d) 405
Total 125 685 810
(b)This is a case-control type of epidemiological study.
= (axd)
(bxc)
325 x 45
Comment:
Therefore, the smokers are 1.97 times or twice at risk of developing lung cancer than non-smokers
8. A small town with adult population of 25,000 was followed for 10 years to study risk factors for heart disease. The data obtained at the
end of 10 years is as follows.
Heart Disease
Present Absent Total
Smoker 100 9900 10000
Non-Smoker 50 14950 15000
Total 150 24850 25000
Ans)
(a) Type of epidemiological study design : Prospective Cohort Study
Heart Disease
Present Absent Total
Smoker 100 (a) 9900 (b) 10000
Non-Smoker 50 (c) 14950 15000
(d)
Total 150 24850 25000
(b) Relative risk, Attributable risk, Population-Attributable risk can be calculated using cohort study design.
(c) Relative Risk = Incidence of disease among exposed population
Incidence of disease among unexposed population
100/10000
50/15000
=3.03
Incidence rate of heart disease is 3.03 times or 200% more chance in the smokers when compared with non smokers.
9. The RNTCP data for Siddipet district was recorded as under for 2019 with a population of 50,00,000. Crude death rate of Siddipet is 6
per 1000 Population.
Ans: Given,
(i) Incidence=No. of new sputum positive cases in the year 2019/ Total population at risk in the year 2019 X 1000
= 1500/50,00,000 X 1000
=0.3 per 1000 per year. Or 30 per 1 lakh population
= 150/1500x100
Case Fatality Rate = 10 deaths due to TB per 100 TB cases
= 150/5000000 X 100000
= 3 deaths due to TB per 1 lakh population.
=150/30,000 x 100
= 0.5%
10. (a) In Hyderabad cancer hospital, 4000 patients were operated for Ca-cervix in the year1970. Of them 550 cases survived
upto 1975. Calculate survival rate for ca-cervix? (2 marks)
(b)Name the National Program related to cancer in India. (1mark)
(c)What are the Preventive measures for Cancer Cervix? (2marks)
Ans: Given number of patients operated for Cancer Cervix in the year1970=4000
Number of patients survived for Cancer Cervix till the year 1975=550
(a) 5 – year survival rate = Number of cases alive after 5 years X 100
Number of cases alive at beginning
= 550/4000 x 100
(b) National Program related to cancer in India National Programme for Prevention and
Control of Cancer, Diabetes, CVD and Stroke (NPCDCS)
(i) VaccinationofyoungadolescentsagainstHPVvaccine(CervarixorGardasil)
(ii) Education to reduce high risk sexual behavior
(iii) Avoiding other risk factors like early marriage and childbearing, smoking
(iv) Regular screening of women and treatment of pre-cancerous lesions.
(b) Verbal Autopsy, Civil Registration of Death, Hospital Records, Sample Registration System, Mortality survey
, Health Surveillance data, Post Mortem Records, Burial Ground Records.
(c) Given,
Mid-Year Population=3,00,000
Live births =2000
Infant deaths=65
Total deaths=1100
= 65/2000 X 1000
12. Calculate requirement of bleaching powder for disinfection of well having height of 7meters, height of water column 5.5
meters and diameter 2.5meters.
of well =
𝜋𝑑2h X 1000
Ans: Volume
4
=3.14x2.5x2.5x5.5/4x1000
=26984lit
13.In a Primary School in certain village having 300 students of which 07 students developed diphtheria and 12 students from the
same class having contact with the cases developed diphtheria. Out of 300, 200 students are immunized. Calculate secondary attack
rate. What is the importance of SAR? Mention the SAR of any two diseases.
Ans: Secondary Attack Rate = No. of persons developing disease within a range of IP x 100
Total number of susceptible persons
= (12/93)x100=12.9%
=Secondaryattackrateofdiphtheriainthatprimaryschoolis12.9%.
DISEASE SECONDARY
ATTACKRATE
SMALLPOX 30-45%
MEASLES >80%
MUMPS ~86%
PERTUSIS ~90%
The above graph has one peak and it is a point source epidemics. Examples: Food poisoning
1. The epidemic curve rises and falls rapidly with no secondary waves.
2. Theepidemictendstobeexplosivewithclusteringofcaseswithinanarrowintervaloftime.
15. A circular well with diameter of 2m & depth of water Column 3.6m is to be chlorinated. On doing Horrock’s test, blue colour was
developed in third cup. Calculate the amount of bleaching powder required for disinfection of well. Explain double pot method of
disinfecting well.
= 45.2/4=11.304X1000=11304litres
=149gms
DOUBLE POT METHOD: National Environment Engineering Research Institute, Nagpur-introduced Double Pot method
Requirements: -2 cylindrical pots- one placed inside the other, inside height and diameter is 30cm and 25cm respectively,
for the outer pot. The inner pot with a hole of 1cm diameter in the upper portion and outer pot has hole with same
diameter above 4cm from bottom.
Procedure: A mixture of 1kg bleaching powder + 2kg coarse sand the inner pot filled with mixture and placed inside the
outer pot and outer pot mouth covered with polyethylene foil. The double pot is lowered into the well with rope 1m below
the water level
Advantages: Can be used for 2-3 wks satisfactorily for a small house hold
Can disinfect wells with 4500 liters of water with a draw flow rate 360-450 liters per day.
16. A community block area with mid near population of 95000 there were 2800 live births in the year 2018 following word the
number of deaths:
Number of deaths(>28weeks of gestation)=21Deaths
within7days of birth=33
Deaths within 7-28 days of birth=57
Deaths during 29 days to less than 1 year of age =55
Maternal deaths =4
Under 5 deaths=180
Calculate MMR, still birth rate, perinatal mortality rate, neonatal mortality rate, infant mortality rate and under 5mortality
rate
Ans:
=4/2800X 100000
Deaths of individuals less than 1year of age per 1,000 live births:
=145/2800X1000
=51.7 per1000 live births
17. The no. of children under 1 year of age in the area served by your primary health centre is 2,500, you are currently half way
through a supply period of one month. The stock records show that you have a stock of 1500 doses of measles vaccines
with you. (Measles Wastage Multiplying Factor is 2 for that PHC)
Solution
No. of doses required per month= No. of Beneficiaries X No. of Doses X Measles Vaccine Wastage Factor
b) POSSIBLECAUSESARE
c) Action
• Distributing remaining doses to other centers or returning back to Vaccine Cold storage.
18. As a Medical Officer of PHC of Telangana State, with a population of 30,000 you have to order for right quantities of vaccines
required for one year. How will you estimate the vaccine requirements based on number of beneficiaries. (2011 Telangana Census -
Birth rate = 17.8/1000 & IMR = 47/1000) (Estimate vaccine requirement for following vaccines only;
• Estimateofactualvaccinedosesneededforvariouspercentagetargetsforimmunizationcoverageforestimated509infantsin30000p
opulation.
= 2259.96
=509x100/100x3x1.11
= 1694.97 /10.
= 509x100/100x1x1.33
= 676.97 / 10
19.In a study, left mid arm circumference(MAC) of 500 children aged 3to5 year, attending different anganwadi centers of a taluk
was measured. Data obtained is given here:
Number of Children
MAC (in cm)
14 100
13.5 150
13 150
12.5 50
12 50
Total 500
How you will interpret the nutritional status of children and give your advice?
Solution:
• Mid arm circumference (MAC) measurement is the easiest method of assessing malnutrition status in children
of 2 to 5 year.
Number of
Nutritional status MAC(in cm) Anganwadi percentage
Children
Satisfactory >13.5 250 50%
Mild to moderate
malnutrition 12.5-13.5 200 40%
Total 500
Interpretation
b. Regular nutritional supplementation providing 300 Kcal and 10 gm of protein is continued for normal children.
c. Additional supplementary nutrition of 300 Kcal (i.e. 300 + 300 kcal and 10 + 5-10 gm of protein) protein is provided
to borderline and severely malnourished children.
b. Vitamin A solution
c. De-worming treatment
1. The district public health laboratory has analyzed a sample of water from an area. The analysis report gave the following
details of the water sample. Compare with the acceptable standards and comment on there port.
Answer:
Comparison of the Analysis Report and Acceptable Standards (BIS,India2012):
Maximum permissible
Acceptable Value
Parameter Observed value limits(in the absence of an
alternate source of water)
Turbidity 1NTU 1NTU 1NTU
Comments:
• Turbidity; total dissolved solids and fluoride content are within acceptable limits.
• The given water sample contains E.coli, which must not be present in any 100-mL sample of protected water. Usually,
it indicates faecal contamination. To prevent further contamination of water, the cause(s) should be identified and
measures should be taken to protect the water supply. Chlorination of water should be done.
• Total hardness level is high. High level of hardness may cause scale deposition in the water distribution system and
will result in excess soap consumption and scum formation. Hardness of water should be removed by boiling / by
adding lime or sodium carbonate.
• Nitrate is high in amount. It may be due to excess free ammonia in water. Excess nitrate may be due to the use of
nitrogenous fertilizers and manures in agriculture, waste water disposal and contamination of water with human and
animal excreta. Biological denitrification is required for removal of high nitrate levels in surface water.
Possiblesourceofcontaminationshouldbefoundandpreventivemeasuresshouldbeapplied.
Conclusion: This water is not suitable for drinking.
2.Comment with recommendations on the following water quality report of a water sample from a village.
Answer:
Comparison of the Analysis Report and Acceptable Standards (BIS,India2012):
Maximum permissible
Acceptable Value
Parameter Observed value limits(in the absence of an
alternate source of water)
Turbidity 8NTU 1NTU 1NTU
Comments:
• Turbidity of water is high. Drinking water must be free from turbidity. The turbidity or muddiness is due to the presence of
mud, clay, silt and such other particulate matters. Turbidity interferes with disinfection of water.
• Total dissolved solids, fluoride content and Nitrates are with in acceptable limits.
• Total hardness level is with in acceptable limits .
• The given water sample contains E.coli, which must not be present in any 100-mL sample of protected water. Usually,
it indicates faecal contamination. To prevent further contamination of water, the cause(s) should be identified and
measures should be taken to protect the water supply. Chlorination of water should be done.
Conclusion: This water is not suitable for drinking.