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PREP 1 - Powder

The document outlines the preparation and therapeutic uses of effervescent powders, including their formulation, method of preparation, and recommended storage conditions. It highlights the ingredients involved, such as potassium sodium tartrate, sodium bicarbonate, and tartaric acid, which react to produce carbon dioxide when mixed with water. The document also emphasizes the importance of moisture-resistant packaging to maintain the stability and efficacy of the powders.

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cali k
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4 views

PREP 1 - Powder

The document outlines the preparation and therapeutic uses of effervescent powders, including their formulation, method of preparation, and recommended storage conditions. It highlights the ingredients involved, such as potassium sodium tartrate, sodium bicarbonate, and tartaric acid, which react to produce carbon dioxide when mixed with water. The document also emphasizes the importance of moisture-resistant packaging to maintain the stability and efficacy of the powders.

Uploaded by

cali k
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 17

PREPERATION NO.

COMPOUND
EFFERVESCENCE
POWDER
POST - LABORATORY
OBJECTIVES
To evaluate the therapeutic use and
effectiveness of effervescence powder.

To analyze the method and steps involved


in the preparation of effervescence powder.

To determine the appropriate container


and storage conditions for maintaining
effervescene powders its uniform.
USE OF THE
PREPARATION
Mucolytic

Multivitamins

For Digestive Health

Antacids

Pain reliever
PURPOSES & USAGE:
TABLE OF FORMULA
PHYSICAL
INGREDIENT QUANTITY USE IN FORMULA
DESCRIPTION

Potassium Sodium Enhancing the


15 g Crystalized powder
Tartrate effervesence

White powder
Sodium Bicarbinate 5g Base
crystalline

Combine with
Natural occuring
Tartaric Acid 4.3 g NAHCO3 to produce
organic acid
CO2
CALCULATIONS

Applicable to all powders:


METHOD OF PREPARATION

The method we used involved


mixing sodium potassium
tartrate and sodium bicarbonate
by spatulation method.
APPROPRIATE CONTAINER
Effervescent powders require appropriate packaging to prevent moisture
exposure, maintain stability, and ensure ease of use. The best container
options include:

Moisture-Resistant Containers

Aluminum Foil Sachets/Pouches/Wax papers: Provides excellent moisture


barrier and is ideal for single-use doses.

Plastic or Glass Jars with Tight-Sealing Lids: Prevents humidity entry and
extends shelf life.

.
APPROPRIATE CONTAINER
DESCRIPTION OF FINISHED PRODUCT

Effervescent powders in pharmaceutical preparations are dry


formulations designed to dissolve in water, releasing carbon dioxide
to create a fizzy solution. They typically contain an active
pharmaceutical ingredient (API) such as paracetamol, aspirin, or
vitamins, along with an acid (citric or tartaric acid) and a base
(sodium bicarbonate) that react to produce effervescence.
Additional ingredients like sweeteners, flavors, binders, and anti-
caking agents enhance taste, stability, and solubility.
DESCRIPTION OF FINISHED PRODUCT

This dosage form offers rapid drug absorption, improved patient


compliance, and better bioavailability compared to tablets or
capsules. Effervescent powders are widely used for pain relief,
antacids, and vitamin supplements, providing a convenient and
palatable alternative to traditional oral medications.
FINISHED PRODUCT
RECOMMENDED STORAGE CONDITION
Storage Conditions for Effervescent Powders
Temperature: Store at 15–25°C (59–77°F), away from heat.
Humidity: Keep in a dry environment (<50% RH) to prevent
premature reaction.
Light Protection: Use opaque or amber containers, avoiding direct
sunlight.
Air & Moisture Control: Store in airtight, moisture-resistant
containers with desiccants.
Avoid Contamination: Keep away from strong odors, chemicals, and
reactive substances.
GUIDE QUESTIONS:
1.) What are effervescent granules? Give the composition
of this preparation.

Answer: After learning and making effervescent granules,


we learned that these granules are a type of
pharmaceutical preparation design to dissolve in water,
releasing carbon dioxide and they are often used for oral
administration of medications or supplements, enhancing
their taste & solubility.
GUIDE QUESTIONS:
2. What are the general techniques applied in both manufacturing and extemporaneous
preparation of powders?
Answer: The following general techniques are:

a. Comminution, by reducing the particles size of ingredients using titturation) milling.

b. Blending. by mixing powders uniformly to ensure even the distribution of active ingreclients.

C. Sieving, by passing the powder through a sieve to remove the lumps and achieve uniform
size.

d. Granulation, by converting the powders into granules, for better handling& uniformily.

e. Packaging, it must be properly stored to protect them from moisture and


GUIDE QUESTIONS:

3. What chemical substances do effervescent powders


release when mixed with water?
Answer: it releases carbon dioxide (CO2), due to the reaction
between the acid (tartaric acid) and base (sodium
bicarbonate) in the presence of water.
Thank
you!

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