31/01/2025, 20:11 Molecular Basis of Inheritance

Sigma Institute

Sigma Institute
Anmol Sharma
NEET 2025

Molecular Basis of Inheritance

Date: Feb 01, 2025 Time: __mins/hrs Total Marks: 100 X 1 = 100

Topics covered
Biology
Molecular Basis of Inheritence - DNA Fingerprinting, The DNA, Translation, Genetic Code, Transcription, Replication, Human
Genome Project, Regulation of Gene Expression and Lac Operon, The Search of Genetic Material, Packaging of DNA, t-RNA - the
Adapter Molecule, Introduction, Properties of Genetic Material,

(1) 5 srRNA, tRNA & SnRNA

Subject : Biology No. of Questions : 100
(2) mRNA, HnRNA & SnRNA
1. DNA polymorphism forms the basis of : (3) 28 S rRNA, 18 S rRNA & 5 S rRNA
(1) DNA finger printing (4) All types of rRNA & tRNA
(2) Both genetic mapping and DNA finger printing 8. Transcription and translation can be couple in
(3) Translation (1) Yeast
(4) Genetic mapping (2) Paramecium
2. The ratio between purines and pyrimidines in the (3) E.Coli
starting codon (4) Amoeba
(1) 2 : 1
9. Discontinuously synthesized strands of DNA adjacent
(2) 1 : 1 to_____ DNA template are joined together by_______.
(3) 1 : 2
(1) 5 → 3 , DNA endonucleace
(4) 3 : 1
(2) ′ ′
DNA Aase
3 → 5

3. The cellular factory / Organelle responsible for the (3) 5

′
→ 3 DNA ligase
′

synthesis of proteins is (4) 3

′
→ 5 , DNA ligase
′

(1) Ribosome
10. Transcription is intiated by
(2) Nucleus
(1) Only σ (sigma) factor
(3) Golgi body
(2) Only DNA dependent RNA polymerase
(4) Centriole
(3) Only ρ (Rho) factor
4. A coding sequence made of alternating C and U bases (4) RNA polymerase when it associates transiently with σ
would form a polypeptide having ____ (sigma) factor
(1) Either leu or ser residue
11. In a crime investigation, the investigating officer
(2) Alterating leu and ser residues collects different biological samples from the crime
(3) Only ser residues spot for DNA fingerprinting analysis. Which of the
(4) Only leu residues following samples is not helpful in this analysis?

5. Presence of exons and introns is seen in (1) Skin Shreds

(2) Erythrocytes
(1) Secondary transcript
(3) Semen sample
(2) Primary transcript
(4) Hair follicle
(3) t RNA
(4) snRNA 12. What is the role of RNA polymerase III in the process
of transcription in Eukaryotes?
6. DNA-dependent RNA polymerase also catalyse the
polymerisation in only one direction, (1) Transcription of rRNAs (28S, 18S and 5.8S)
(2) Transcription of tRNA, 5S rRNA and snRNA
(1) 3
′
→ 3
′

(3) Transcription of precursor of mRNA

(2) 5
′
→ 5
′

(4) Transcription of only snRNAs

(3) 5
′
→ 3
′

(4) 3
′
→ 5
′ 13. Genetic material of bacteriophage ϕ × 174 and it has
____ nucleotides
7. In eukaryotes, RNA polymerase III catalyses the
(1) ss DNA, 5386
synthesis of
(2) ss RNA, 5386

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(3) ds DNA,5368 21. For transcription the requirements are
(4) ss DNA, 5368 i. DNA
ii.DNA dependent RNA polymerase
14. In a 3.2Kbp long piece of DNA, 820 adenine bases were iii. Nuceloside triphosphate
found. What would be the number of cytosine bases? iv. Helicase
(1) 1560 (1) i,ii,iii
(2) 780 (2) i,ii only
(3) 1480 (3) i,ii,iv
(4) 740 (4) All

15. If a geneticist uses the blind approach for sequencing 22. Identify A, B, C, D, E.
the whole genome of an organism, followed by
assignment of function to different segments, the
methodology adopted by him is called as :
(1) Gene mapping
(2) Expressed sequence tags
(3) Bioinformatics
(4) Sequence annotation
16. Select the correct option
i. z gene codes → beta-galactosidase (β-gal )
ii. y gene codes → permease
A = Inhibitor B = Operator
iii. a gene → transacetylase
iv. i gene → repressor of the lac operon (1) C = y gene D = z gene

E = a gene
(1) Only i is correct
(2) Only ii,iii is correct
A = inducer B = Operator
(3) Only i, ii, iii is correct
(2) C = z gene D = y gene
(4) All are correct
E = a gene

17. If the sequence of bases in DNA is AATCCATG, then

the sequence of bases in its transcript will be A = Inhibitor gene B = Operator

(1) UUAGGUAC (3) C = z gene D = y gene

(2) AAUCGAAU E = a gene

(3) UUAGCUUA
(4) AAUCGAUG A = inducer B = Operator

(4) C = y gene D = z gene

18. The radioactive probe used by Taylor to detect E = a gene
distribution of newly synthesized DNA in
chromosomes:
(1) Thymidine 23. During transcription the DNA strand with 3’ →
(2) Adenosine 5’ polarity of the structural gene always acts as
a template because
(3) Guanidine
(1) Enzyme DNA dependent RNA polymerase always
(4) Cytosine
catalyse the polymerisation in 3’ → 5’ direction
19. The year 1953 was known for the Double helical model (2) Enzyme DNA dependent RNA polymerase always
of DNA given by______ , also for discovery of catalyse polymerisation in both the directions
ribosome by_______, also for proposing the semi (3) Nucleotides of DNA strand with 5’ → 3’ are transferred
conservative DNA replication by______ and also for to mRNA
the experiment done on chemical evolution by_______
(4) Enzyme DNA dependent RNA polymerase always
(1) Watson and Crick; G.Palade; Watson and Crick; Urey catalyse the polymerisation in 5’ → 3’ direction
Miller
24. Select the correct statement
(2) Watson and Crick; G.Palade; Messelson and Stahl;
Stanley Miller (1) Two strands of DNA are parallel and complimentary
(3) Watson and Crick; De Duve; Messelson and Stahl; (2) Two strands of DNA are anti- parallel and non-
Stanley Miller complimentary
(4) Watson and Crick; G.Palade; Watson and Crick; (3) Two strands are anti- parallel and complimentary
Stanley Miller (4) All the above
20. UUU, UUC code for which amino acids ? 25. Haploid content of human DNA is ____
(1) Alanine, phenylalanine respectively (1) 1.65 × 10
9
bP

(2) Phenylalanine, alanine respectively (2) 3.1 − 3.3 × 10

9
bP
(3) Phenylalanine, methioninerespectively
(3) 4.6 × 10
9
bP
(4) Phenylalanine, phenylalanine respectively
(4) 3.3 × 10
9
bP

26. Identify the structure.

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31/01/2025, 20:11 Molecular Basis of Inheritance
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(2) B
(3) C
(4) D
31. The following structure represents

(1) Cytosine
(2) Thiamine
(3) Uracil
(4) Thymine
27. In the following identify the name of the process
(1) 'Beads on string' structure of nucleosome in chromatin
(2) 'Beads on string' under electron microscope
(3) 'Beads on string' under compound microscope
(4) Both 1 & 2

32. In the following diagram the direction of anticodon is?

(1) A - Initiation, B - Elongation, C - Termination (1) t-RNA -3'-3'

(2) A - Termination, B - Elongation, C - Initiation (2) t-RNA-3'-5'
(3) A - Elongation, B - Initiation, C - Termination (3) t-RNA-5'-3'
(4) A - termination, B - Initiation, C - Elongation (4) t-RNA-5'-5'

28. The following structure represents. 33. Which experiment is shown in the below figure?

(1) r-RNA
(2) hn-RNA
(3) m-RNA
(4) t-RNA

29. This Diagram indicates

(1) Griffith's experiment (1928)

(2) Hershay and Chase experiment (1952)
(3) Meselson and Stahl experiment (1958)
(4) Watson and Crick experiment
34. The following represents a polysome, how many m-
RNA are represented here ?
(1) DNA replication
(2) Reverse transcription
(3) Transcription
(4) Translation

30. Mention in which test-tube did Avery et al found

transformation

(1) Only one

(2) As many as polypeptides are present
(3) It can be variable
(4) None of these

35. In the following experiment identify the labelled parts

(1) A

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(1) P - Phosphate group, Q-Deoxyribose sugar, R-

Nitrogen base
(2) P-Nitrogen base, Q-Deoxyribose sugar, R-Phophate
group
(3) P-Nitrogen base, Q-Ribose sugar, R-Phosphate group
(4) P-Phosphate group, Q-Ribose sugar, R-Nitrogen base

39. In the following diagram, depicting the Messelson &

Stahl expt. Identify the type of DNA A, B & C.
(1) A - Infection, B - Blending, C - Centrifugation
(2) A - Centrifugation, B - Infection, C - Blending
(3) A - Blending, B - Infection, C - Centrifugation
(4) A - Centrifugation, B - Blending, C - Infection

36. Choose the correct option for the below figure

(1) A − N
14
N
14 15
, B − N
14
N
15
,C − N N
15

(1) A - nucleotide; B - nucleoside; C - Phosphate (2) A − N

15
N
15 15
, B − N
14
N
14
,C − N N
14

(2) A - nucleoside; B - nucleotide; C - Phosphate (3) A − N

14
N
14 14
, B − N
14
N
15
,C − N N
15

(3) A - Phosphate; B - nucleotide; C - nucleoside (4) A − N

15
N
15 15
, B − N
15
N
14
,C − N N
14

(4) A - nucleoside; B - Phosphate; C - nucleotide 40. In the diagram how many histone proteins are depicted
37. Identify the purine out of the structure.

(1) 9
(2) 8
(1) B - Adenine (3) 10
(2) A - Adenine (4) 11
(3) C - Adenine
41. Identify the structure & labelled parts A, B.
(4) A - Guanine

38. Identify P, Q, R.

(1) Nucleus − A − H1 B − Octamer

(2) Nucleus − A − Octamer B − H1

(3) Nucleosome A − H1 B − Octamer

(4) Nucleosome − A Octamer B − H1

42. Identify the process showed in the process diagram

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31/01/2025, 20:11 Molecular Basis of Inheritance
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Column I Column II
DNA-dependent DNA Replication is
A P
polymerase continuous
Average rate of
(1) Capping Deoxyribonucleoside
B Q polymerisation 2000
triphosphates
(2) RNA splicing bp per second
(3) Poly adenylation Polarity 3 → 5 of′ ′

C R Dual prupose
parental strand
(4) All of these
Polarity 5 → 3 of′ ′
Replication is
D S
43. Identify the diagram. oarental strand discontinuous

(1) A – R, B – P, C – Q, D – S
(2) A – Q, B – R, C – P, D – S
(3) A – P, B – R, C – Q, D – S
(4) A – Q, B – P, C – R, D – S

47. Match the columns I and II.

Column I Column II
A Promoter P Provides binding site for DNA
B Terminator Q Flanked portion
(1) Lac operon (switched on) Structural End of the process of
C R
(2) Lac operon (switched off) gene transcription
(3) Try operon (switched on) (1) A − R, B − P, C − Q

(4) Trp operon (switched off) (2) A − Q, B − R, C − P

44. Identify the structure that contains codon (B) chain of (3) A − P, B − R, C − Q

amino acid, (A) large (C) small ribosomal unit (D) (4) A − Q, B − P, C − R

ribosomal unit in a prokaryote

48. Match the columns I and II WRT Translation.

Column I Column II
Recognised only by the initiator
A Ribosome P
tRNA
Release
B Q Moves from codon to codon
factor
C Start codon R Binds to the stop codon
Present at the both 5’ -end and
D UTRs S
3’ -end

(1) A − R, B − P, C − Q, D − S

(2) A − Q, B − R, C − P, D − S

(3) A − P, B − R, C − Q, D − S

(4) A − Q, B − P, C − R, D − S

(1) m-RNA, polypeptide, 50 S, 30 S

49. Match Column- I with Column- II
(2) r-RNA, polypeptide, 50 S, 30 S
Choose the correct answer from the options given
(3) m-RNA, polypeptide, 60 S, 40 S below:
(4) m-RNA, polypeptide, 60 S, 40 S
Column I Column II
45. The diagram represents the central dogma of A Gene ‘a’ P β-galactosidase
molecular biology. Choose the correct combination of
B Gene ‘y’ Q Transacetylase
labelling.
C Gene ‘i’ R Permease
D Gene ‘z’ S Repressor protein

(1) A-Q, B-P, C-S, D-R

(2) A-Q, B-R, C-S, D-P
(3) A-R, B-S, C-P, D-Q
(4) A-R, B-P, C-S, D-Q
50. Match the columns I and II.

Column I Column II
(1) A-DNA B-RNA C-Protein D-DNA Purine: pyrimidine ratio
A Friedrich Meischer P
(2) A-RNA B-DNA C-Protein D-RNA equal one
(3) A-DNA B-Protein C-Protein D-DNA James Watson &
B Q Nuclein
Francis Crick
(4) A-Protein B-DNA C-DNA D-Protein C Erwin Chargaff R 1953
46. Match the columns I and II.
(1) A − R, B − P, C − Q

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(2) A − Q, B − R, C − P 56. Match the columns I and II.
(3) A − P, B − R, C − Q
Column I Column II
(4) A − Q, B − P, C − R
DNA-dependent Joining of discontinuously
A P
51. Match the columns I and II wrt HGP. DNA polymerase synthesized fragments
Polymerisation only in one
B DNA ligase Q
Column I Column II direction 5 → 3
′ ′

Caenorhabditis C Origin of replication R Initiate replication

A P Plant
elegans
Genes that are expressed (1) A − R, B − P, C − Q

B Arabidopsis Q (2)
as RNA A − Q, B − R, C − P

A free living non-pathogenic (3) A − P, B − R, C − Q

C EST R
nematode (4) A − Q, B − P, C − R

Assigning different regions

Sequence 57. Match the columns I and II.
D S in the sequence with
annotation
functions
Column I Column II
(1) A − R, B − P, C − Q, D − S Process of making RNA from Human genome
A P
(2) A − Q, B − R, C − P, D − S DNA project
(3) A − P, B − R, C − Q, D − S
B Process of protein synthesis Q Transcription
Determination of complete
(4) A − Q, B − P, C − R, D − S C R Translation
nucleotide sequence
52. Match the columns I and II wrt HGP.
(1) A − R, B − P, C − Q

Column I Column II (2) A − Q, B − R, C − P

A Human genome P 3000 bases (3) A − P , B − R, C − Q

B Average gene Q 3164.7 million nucleotide (4) A − Q , B − P, C − R
C Chromosome I R 2968 genes
D Y chromosome S 231 genes 58. Match the columns I and II.

(1) A − R, B − P, C − Q, D − S Column I Column II

(2) Some amino acids are coded by
A − Q, B − R, C − P, D − S A Unambigous P
more than one codon
(3) A − P, B − R, C − Q, D − S
B Degenerate Q AUG
(4) A − Q, B − P, C − R, D − S
Dual One codon codes for only one
C R
53. Match the columns I and II. functions amino acid
From bacteria to human UUU
D Universal S
Column I Column II would code for phenylalanine
A Exons P Absent in RNA
(1) A − R, B − P, C − Q, D − S
B Introns Q Functional unit of inheritance
C Gene R Processed RNA (2) A − Q, B − R, C − P, D − S

(3) A − P, B − R, C − Q, D − S

(1) A − R, B − P, C − Q
(4) A − Q, B − P, C − R, D − S

(2) A − Q, B − R, C − P
59. Match the columns I and II.
(3) A − P, B − R, C − Q

(4) A − Q, B − P, C − R Column I Column II

54. Match the columns I and II with respect to DNA. A AUG P Phenylalanine
B UUU Q Methionine
Column I Column II C UUC R Phenylalanine
A Base pairing P Sugar of DNA D UAG S Non-sense codon
B Deoxyribose Q Unique property
C Thymine R Nitrogen base of DNA (1) A – R , B – P , C – Q, D – S
(2) A – Q , B – R , C – S, D –P
(1) A − R, B − P, C − Q (3) A – P , B – R , C – Q, D – S
(2) A − Q, B − R, C − P (4) A–Q,B–P,C–R,D–S
(3) A − P, B − R, C − Q
60. Match the columns I and II.
(4) A − Q, B − P, C − R

55. Match the columns I and II.

Column I Column II
mRNAmessenger In ribosomes in
A P
Column I Column II RNA cytoplasm
A Capping P 5’ -end of hnRNA From nucleus to
B tRNATransfer RNA Q
B Splicing Q 3’ -end of hnRNA cytoplasm
C Tailing R Removal of introns C rRNAribosomal RNA R In cytoplasm

(1) A − R, B − P, C − Q
(1) A − R, B − P, C − Q

(2) A − Q, B − R, C − P
(2) A − Q, B − R, C − P

(3) A − P, B − R, C − Q
(3) A − P, B − R, C − Q

(4) A − Q, B − P, C − R
(4) A − Q, B − P, C − R

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61. The codon on mRNA are:
CAU-CCU-AAA-CUG. Column I Column II
Identify the correct sequence of amino acids. 5’ -end (upstream) of the
A Promoter P
structural gene
(1) His-Pro-Lys-Leu
Upstream or downstream
(2) Pro-His-Lys-Leu B Terminator Q
to the promoter
(3) His-Pro-Leu-Lys Additional
3’ -end (downstream) of
(4) Pro-Leu-Lys-His C regulatory R
the coding strand
sequences
62. Match the columns I and II.
(1) A − R, B − P, C − Q
Column I Column II (2) A − Q, B − R, C − P
Increases permeability of
A Repressor P (3) A − P, B − R, C − Q
lactose
Hydrolysis of the (4) A − Q, B − P, C − R
B Betagalactosidase Q
disaccharide 67. Match the columns I and II.
C Permease R Acetylation of galactosides
D Transacetylase S Binds to the operator Column I Column II
A Replication fork P Polyploidy
(1) A − R, B − P, C − Q, D − S
Small opening of
(2) B Replication of DNA Q
A − S, B − Q, C − P, D − R the DNA helix
(3) A − P, B − R, C − Q, D − S Failure in cell division S-phase of the cell
C R
(4) A − Q, B − P, C − R, D − S after DNA replication cycle

63. Match the columns I and II. (1) A − R, B − P, C − Q

(2) A − Q, B − R, C − P
Column I Column II
(3) A − P, B − R, C − Q
Streptococcus
A Frederick Griffith P (4)
pneumoniae A − Q, B − P, C − R

Alfred Hershey & Matha 68. Match the columns I and II wrt tRNA.
B Q E.coli
Chase
Mathew Messelson & Column I Column II
C R Bacteriophages
Franklin Stahl It binds to specific amino
D Taylor S Vicia faba A Anticodon loop P
acids
Amino acid acceptor
(1) B Q Clover-leaf
A − R, B − P, C − Q, D − S
end
(2) A − Q, B − R, C − P, D − S C Secondary structure R Complementary
(3) A − P, B − R, C − Q, D − S D Actual structure S Inverted L
(4) A − Q, B − P, C − R, D − S
(1) A − R, B − P, C − Q, D − S

64. Match the columns I and II. (2) A − Q, B − R, C − P, D − S

Column I Column II (3) A − P, B − R, C − Q, D − S

mRNA (4) A − Q, B − P, C − R, D − S
A P Structural & catalytic role
messenger RNA 69. Match the columns I and II.
tRNA- Transfer
B Q Template for translation
RNA Column I Column II
rRNA- ribosomal Brings aminoacids and reads N-glycosidic
C R A P Linkage of two nucleotides
RNA the genetic code linkage
Phosphoester Nitrogenous base is linked
(1) A − R, B − P, C − Q B Q
linkage to the C-1 of pentose sugar
(2) A − Q, B − R, C − P
Phosphodiester Phosphate group is linked to
C R
(3) A − P, B − R, C − Q bonds the OH group of the 5-C
(4) A − Q, B − P, C − R 2 Hydrogen
D S Between C & G
bonds
65. Match the columns I and II. 3 Hydrogen
E T Between A & T
bonds
Column I Column II
A Cistron P Eukaryotes (1) A − R, B − P, C − Q, D − T, E − S

B Monocistronic Q DNA coding for a polypeptide (2) A − Q, B − R, C − P, D − T, E − S

C Polycistronic R Bacteria (3) A − S, B − R, C − P, D − T, E − Q

(1) A − R, B − P, C − Q (4) A − Q, B − T, C − P, D − R, E − S

(2) A − Q, B − R, C − P
70. Match the scientists of Column I with their
(3) A − P, B − R, C − Q contributions in Column II
(4) A − Q, B − P, C − R

66. Match the columns I and II.

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(4) A-1,B-3,C-2,D-4
Column I Column II
A Griffith P Lac operon 75. Match the columns I and II.
B Jacob & Monad Q DNA is the genetic material
Meselson & Column I Column II
C R Transforming principle
Stahl A RNA polymerase I P Transcribes snRNAs
Hershey and DNA replicates semi- B RNA polymerase II Q Transcribes rRNAs
D S
Chase conservativelys. C RNA polymerase III R Transcribes hnRNA

(1) A - P; B - Q; C - R; D - S (1) A − R, B − P, C − Q

(2) A - P; B - S; C - Q; D - R (2) A − Q, B − R, C − P

(3) A - R; B - P; C - S; D - Q (3) A − P, B − R, C − Q

(4) A - R; B - Q; C - P; D - S (4) A − Q, B − P, C − R

71. Match the columns I and II with respect to nucleosome. 76. Match the following.

Column I Column II Column I Column II

Typical A VNTR P Largest gene
A P Negatively charged
nucleosome B Introns and exons Q DNA fingerprinting
B Histones Q 200 bp C Dystrophin R Bulk DNA
Basic amino acid lysine and D Satellite DNA S Splicing
C DNA R
arginines
(1) A - Q; B - S;C - P;D - R

(1) A − R, B − P, C − Q
(2) A - S; B - P;C - Q;D - R

(2) A − Q, B − R, C − P
(3) A - R;B - S;C - P;D - Q

(3) A − P, B − R, C − Q
(4) A - Q;B - P;C - S;D - R

(4) A − Q, B − P, C − R
77. Match the columns I and II.
72. Match the columns I and II.
Column I Column II
Column I Column II A Taylor & colleagues P Protein coat
A Bacteriophage ϕ × 174 P 5386 nucleotides Cesium chloride density
B Q 1958, Visia faba
B Bacteriophage lambda Q 4.6 × 10 bp 6
gradient centrifugation
C Escherichia coli R 48502 base pairs Semi-conservative
C Radioactive sulphur ( 35
S ) R
D Human DNA haploid S 3.3 × 10 bp 9 replication of DNA

(1) A − R, B − P, C − Q, D − S (1) A − R, B − P, C − Q

(2) A − Q, B − R, C − P, D − S (2) A − Q, B − R, C − P

(3) A − P, B − R, C − Q, D − S (3) A − P, B − R, C − Q

(4) A − Q, B − P, C − R, D − S (4) A − Q, B − P, C − R

73. Match the columns I and II. 78. Match Column I with Column II
Choose the correct answer from the options
Column I Column II given below:
A Frederick Griffith P 1952
British bacteriologist
Column I Column II
B Oswald Avery Q A Frederick Griffith P Genetic code
- 1928
Alfred Hershey & Matha Radioactive Francois Jacob & Semi-conservative mode of
C R B Q
Chase thymidine Jacque Monod DNA replicatione
D Taylor S 1958 Har Gobind
C R Transformation
Mathew Messelson & Khorana
E T 1933 - 34 D Meselson & Stahl S Lac operon
Franklin Stahl

(1) A − R, B − P, C − Q, D − T, E − S (1) A - R, B - Q, C - P, D - S

(2) A − Q, B − R, C − P, D − T, E − S (2) A - R, B - S, C - P, D - Q

(3) A − S, B − R, C − P, D − T, E − Q (3) A - Q, B - R, C - S, D - P

(4) A − Q, B − T, C − P, D − R, E − S (4) A - S, B - P, C - Q, D - R

74. Match the following: 79. Match the columns I and II.

Column I Column II Column I Column II

A t-RNA 1 Linking of amino-acids A E.coli DNA lengths P 1.36 mm
B m-RNA 2 Transfer of genetic information B Human DNA length Q 1 µm
C r-RNA 3 Nucleolar organising region C E.coli area R 2.2 m
Transfer of amino acid from D Human nucleus area S 5 µm
D Peptidyl 4
transferase cytoplasm of ribosome
(1) A − R, B − P, C − Q, D − S

(1) A-4,B-2,C-3,D-1 (2) A − Q, B − R, C − P, D − S

(2) A-1,B-4,C-3, D-2 (3) A − P, B − R, C − Q, D − S

(3) A-1,B-2,C-3, D-4 (4) A − Q, B − P, C − R, D − S

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31/01/2025, 20:11 Molecular Basis of Inheritance
Sigma Institute
80. Match the columns I and II. (4) A − Q, B − P, C − R

Column I Column II 85. Match the columns I and II.

Non-histone
Loosely packed Column I Column II
A chromosomal (NHC) P
chromatin
proteins A George Gamow P Physicist
Higher level Har Gobind Cell-free system for protein
B Q
B Euchromatin Q packaging of Khorana synthesis
chromatin Marshal
C R Homopolymers & copolymers
Transcriptionally Nirenberg
C Heterochromatin R
inactive Polynucleotide
D Severo Ochoa S
phosphorylase
(1) A − R, B − P, C − Q

(2) A − Q, B − R, C − P (1) A − R, B − P, C − Q, D − S

(3) A − P, B − R, C − Q (2) A − Q, B − R, C − P, D − S

(4) A − Q, B − P, C − R (3) A − P, B − R, C − Q, D − S

(4) A − Q, B − P, C − R, D − S
81. Match Column I with Column II:
Choose the correct answer from the options given 86. Match the columns I and II.
below :
Column I Column II
Column I Column II X-ray diffraction
A Friedrich Meischer P
A RNA polymerase III P snRNPs data
B Termination of transcription Q Promotor Maurice Wilkins & Rosalind
B Q Thymine
C Splicing of Exons R Rho factor Franklin
D TATA box S SnRNAs, tRNA C 5-methyl uracil R 1869

(1) A - Q, B - S, C - P, D - R (1) A − R, B − P, C − Q

(2) A - R, B - Q, C - S, D - P (2) A − Q, B − R, C − P

(3) A - R, B - S, C - P, D - Q (3) A − P, B − R, C − Q

(4) A - S, B - R, C - P, D - Q (4) A − Q, B − P, C − R

82. Match the columns I and II 87. Match the columns I and II wrt HGP.

Column I Column II Column I Column II

A i gene P Transacetylase Development of a new area in
A 1990 P
B z gene Q Repressor of the lac operon biology
C y gene R Permease Address the ethical, legal and
B 2003 Q
D a gene S Betagalactosidase social issues
C ELSI R HGP was completed
(1) A − R, B − P, C − Q, D − S D Bioinformatics S HGP was launched
(2) A − Q, B − R, C − P, D − S
(1) A − R, B − P, C − Q, D − S
(3) A − P, B − R, C − Q, D − S
(2) A − Q, B − R, C − P, D − S
(4) A − Q, B − S, C − R, D − P
(3) A − S, B − R, C − Q, D − P

83. Match the columns I and II. (4) A − Q, B − P, C − R, D − S

Column I Column II 88. Match the processes of Column I with the enzyme
A H1 Histones P Inner core of nucleosom involved in Column II and select the correct options
B H3 Histones Q Connects two nucleosome among the following
Present once per 200 base Select the code for the correct answer from the
C Linker DNA R options given below
pairs
Human nucleus
D S 5 µm Column I Column II
area
A DNA replication P RNA polymerase
(1) A − R, B − P, C − Q, D − S B Translation Q DNA polymerase
(2) A − Q, B − R, C − P, D − S C Transcription R Reverse transcriptase
(3) A − P, B − R, C − Q, D − S
D Reverse transcription S Aminoacyl synthetase
(4) A − Q, B − P, C − R, D − S
(1) A - Q; B - S; C - R; D - P

84. Match the columns I and II. (2) A - Q; B - S; C - P; D - R

(3) A - Q; B - R; C - S; D - P
Column I Column II (4) A - Q; B - S; C - R; D - P
A RNA P Expression
B Mendelian characters Q Nitrogen base of RNA 89. Statement A : DNA as an acidic substance present in
C Uracil R QB bacteriophage nucleus was first identified by Friedrich
Meischer in 1869.
(1) A − R, B − P, C − Q Statement B : The base pairing confers a very unique
(2) A − Q, B − R, C − P
property to the polynucleotide chains.
(3) A − P, B − R, C − Q (1) Statement A is correct but Statement B is incorrect.

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Sigma Institute
(2) Statement A is incorrect but Statement B is correct. (3) Positively charged proteins
(3) Both statements are correct. (4) Histone proteins
(4) Both Statements are incorrect.
96. If both the strands copied during transcription, then
90. Matthew Meselson and Franklin Stahl grew_____ in a what will happen?
medium containing NH Cl ( N is the ___ isotope of
15
4
15
(1) The segment of DNA would be coding for two different
nitrogen) as the only nitrogen source for many proteins
generations. The result was that______ was (2) Two RNA will be produced simultaneously
incorporated into newly synthesised DNA (as well as complementory to each other.
other nitrogen containing compounds).
(3) There will be formation of double helical RNA
(1) E. coli, heavy, 15
N (4) All of the above
(2) bacteriophage, heavy, 15
N
97. Statement A : The unequivocal proof that DNA is the
(3) E. coli, radioactive, N 15

genetic material came from the

(4) bacteriophage, radioactive, 15
N experiments of Alfred Hershey and Martha
Chase (1952).
91. Sequences prior to the start point of transcription are
Statement B : They worked with viruses that infect
called
bacteria called bacteriophages.
(1) Non coding sequences
(1) Statement A is correct but Statement B is incorrect.
(2) Upstream sequences (2) Statement A is incorrect but Statement B is correct.
(3) Coding sequences
(3) Both statements are correct.
(4) Downstream sequences (4) Both Statements are incorrect.
92. Statement A : Griffith concluded that the S strain bacteria 98. Name the nucleotide added to 5' end of hnRNA in
had somehow been transformed by the capping.
heatkilled R strain bacteria.
Statement B : Some 'transforming principle', transferred (1) Ethyl guanosine monophosphate
from the heatkilled S strain, had enabled (2) Ethyl guanosine triphosphate
the R strain to synthesise a smooth (3) Methyl guanosine triphosphate
polypeptide coat and become virulent.
(4) Methyl guanosine monophosphate
(1) Statement A is correct but Statement B is incorrect.
99. When mRNA is synthesized on DNA, the unwanted
(2) Statement A is incorrect but Statement B is correct.
mRNA regions are removed and regions coding for
(3) Both statements are correct. amino acids are joined together, this process is called
(4) Both Statements are incorrect. as
93. Statement A : A single-strand of mRNA is capable of (1) Splicing
forming different polypeptide chains in (2) Lysogeny
prokaryotes. (3) Replication
Statement B : Termination codons occur in polypeptide.
(4) Central dogma
(1) Statement A is correct but Statement B is incorrect.
100. With respect to ribosome what does A & P represent.
(2) Statement A is incorrect but Statement B is correct.
(3) Both statements are correct.
(4) Both Statements are incorrect.
94. The single stranded DNA of phage ϕ × 174 has 5400
nucleotides. If average protein contains 200 amino
acids, how many different proteins could this phage
DNA code ?
(1) 100
(2) 90
(3) 9
(4) 27
95. In prokaryotes, DNA is held together by which
(1) A - Peptidyl site P - t-RNA binding
proteins?
(2) A - tRNA-binding site P - peptidyl site
(1) Negatively charged proteins
(3) A - m - RNA site P - peptidyle site
(2) Non-histone chromosomal proteins
(4) A - t-RNA binding site P - ATP site

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