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Computational
Hydrodynamics of
Capsules and
biological Cells
Series Editors
N. F. Britton
Department of Mathematical Sciences
University of Bath
Xihong Lin
Department of Biostatistics
Harvard University
Hershel M. Safer
Mona Singh
Department of Computer Science
Princeton University
Anna Tramontano
Department of Biochemical Sciences
University of Rome La Sapienza
Proposals for the series should be submitted to one of the series editors above or directly to:
CRC Press, Taylor & Francis Group
4th, Floor, Albert House
1-4 Singer Street
London EC2A 4BQ
UK
Edited by
C. Pozrikidis
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
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Preface xi
v
vi
Index 309
Preface
Computational biofluid-dynamics addresses a diverse family of problems in-
volving fluid flow inside and around living organisms, organs and tissue, bi-
ological cells, and other biological materials. Numerical methods combine
aspects of computational mechanics, fluid dynamics, computational physics,
computational chemistry and biophysics into a framework that integrates a
broad range of scales. The goal of this edited volume is to provide a com-
prehensive, rigorous, and current introduction to the fundamental concepts,
mathematical formulation, alternative approaches, and predictions of compu-
tational hydrodynamics of capsules and biological cells. The book is meant
to serve both as a research reference and as a teaching resource.
Scope
The numerical methods discussed in the following eight chapters cover
a broad range of possible formulations for simulating the motion of rigid par-
ticles (platelets) and the flow-induced deformation of liquid capsules and cells
enclosed by viscoelastic membranes. Although some of the physical problems
discussed in different chapters are similar or identical, the repetition is de-
sirable so that solutions produced by different numerical approaches can be
compared and the efficiency of alternative formulations can be assessed. The
consistency of the results validates the procedures and offers several alterna-
tives.
Boundary-integral formulations
The first three chapters present boundary-integral formulations. In
Chapter 1, the editor of this volume discusses a boundary-element method
for computing the flow-induced deformation of idealized two-dimensional red
blood cells in Stokes flow and provides a pertinent MATLAB R code. In Chap-
ter 2, Barthès-Biesel, Walter & Salsac discuss highly accurate boundary-
element methods for simulating capsules with spherical unstressed shapes
based on direct and variational formulations. Their work delineates the oc-
currence of membrane wrinkling due to local compression. In Chapter 3,
Freund & Zhao present an advanced boundary-integral formulation based on
Fourier expansions and discuss the results of simulations for cellular flow in
domains with complex geometry. A snapshot of their simulations with thirty
periodically repeated cells is featured on the cover of this volume. In the
past, such depictions have been possible only by artist rendition or schematic
illustration.
xi
xii
Immersed-boundary formulations
Discrete models
Platelet motion
Summary
C. Pozrikidis
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