GPAT Practice QP

Pharmaceutical Inorganic Chemistry

1. As per Bronsted-Lowry concept, acid is defined b. By increasing the sensitivity of tooth

as: enamel
a. Electron pair acceptor c. Decreased acid solubility of enamel
b. Any substance/molecule that can donate a d. Increased acid solubility of enamel
proton 8. The standard solution of arsenic contains
c. Any substance/molecule that can accept a a. Arsenious acid
proton b. (b)Arsenic acid
d. Electron pair donor c. (c) Arsine
2. In which limit test, Thioglycolic acid is used: d. (d) Arsenic oxide
a. Limit test for arsenic 9. One of the following limit test is based on the
b. Limit test for iron comparison of color
c. Limit test for sulphate a. Limit test for sulphate
d. Limit test for chloride b. Limit test for chloride
3. A 2.0 % saline solution is c. Limit test for iron
a. Hypotonic d. A&C
b. Hypertonic 10. Which is both acidifying as well as expectorant:
c. Isotonic a. Ammonium chloride
d. Iso-osmotic b. Potassium iodide
4. Water for injection is prepared by using c. Dil. HCl
distillation d. Sodium potassium tartrate
a. Fractional 11. According to Arrhenius theory base is a substance
b. Molecular which give rise……………. When dissolved in
c. Simple water.
d. Steam a. Hydroxyl ion
5. Limit for the following heavy metal/s is/are b. Hydronium ion
mentioned in the WHO guidelines for herbal drug c. Hydrogen ion
evaluation. d. None of these
a. Cadmium 12. Boric acid is used as:
b. Mercury a. Urinary acidifier
c. Lead b. Antimicrobials
d. Arsenic c. Antioxidants
6. Silver nitrate reagent is used for limit test in d. None of these
Indian Pharmacopoeia for 13. Calcium is essential for:
a. Lead a. Blood purification of whaler bone
b. Iron b. Blood clotting
c. Chloride c. Both of the above
d. Mercury d. All of the above
7. The mechanism by which fluorides inhibit dental 14. The major side effect associated with saline
caries is cathartics is:
a. By increasing susceptibility to acid a. Excessive loss of body fluids in form of
water stools
 b. Convulsions d. Electron accepter
c. Cardiac disorders 23. Boron trifluoride is
d. Constipation a. Acid
15. The category of calcium gluconate is: b. Base
a. Antacid c. Neutral
b. Calcium replenishment d. Amphoteric
c. Antioxidant 24. Carbonic acid is ……………..acid
d. Radiopharmaceuticals a. Strong
16. The concentration of standard iron solution in the b. Weak
limit test for iron as: c. Very strong
a. 10ppm d. None of these
b. 15ppm 25. In parenteral pharmaceutical preparation
c. 20ppm following buffer is used
d. 25ppm a. Borate
17. Limit tests are performed in: b. Phosphate
a. Nessler cylinders c. Chlorate
b. Measuring cylinders d. None of these
c. Kipps apparatus 26. Boric acid having……………..mol. wt.
d. Iodine flasks a. 61.83
18. In Bronsted- lowery concepts acid is: b. 40.1
a. Proton donor c. 45
b. Electron donor d. 50
c. Proton accepter 27. Sodium thiosulphate is titrated
d. Electron accepter with…………..solution
19. In the limit test of sulphate alcohol not allow A. o.1 N iodine
a. Saturation B. 0.5 N iodine
b. Super saturation C. 0.1N HCl
c. Less saturation D. 0.5 N HCl
d. Precipitation 28. Baking soda is known for
20. Limit test are ……………..test designed to a. Na2CO3
identify and control small quantities of impurities. b. NaHCO3
a. Qualitative c. NaOH
b. Quantitative d. K2CO3
c. Imperative 29. Hydrogen peroxide is used as
d. All of these a. Antiseptic
21. Limit test for iron purple color is due to formation b. Acidifying agent
of …………… c. Protective
a. Ferrous sulphate d. Antioxidant
b. Glycolate 30. Compound capable of function as antimicrobial
c. Ferric glycolate agent through oxidative mechanism are
d. Glycolic acid a. H2O2
22. According to Lewis concept acid is b. Halogens
a. Electron pair accepter c. KmnO4
b. Electron pair donor d. All of these
c. Proton accepter 31. Hydrogen peroxide is titrated from
 a. 0.6 N KmnO4 a. Gel
0.1 N KmnO4 b. Potassium acetate
b. 0.5 N KmnO4 c. Zinc Chloride
0.1 N KmnO4 d. Magnesium
32. When……………gas is passed through potassium 40. The first edition of IP got published
permanganate solution, which disappear violet in……………..
color a. 1956
a. Hydrogen sulphide b. 1955
b. Chloride c. 1965
c. Carbon dioxide d. 1985
d. Oxygen 41. …………… is not class of topical agents
33. Ammonium chloride is titrated a. Antibiotic
with………………solution b. Protectives
a. Sodium fluoride c. Antimicrobial
b. Sodium hydroxide d. Astringents
c. Sodium carbonate 42. Magnesium sulphate is used as…………..
d. Silver nitrate a. Astringents
34. Copper sulphate is titrated with b. Dental products
a. Sodium fluoride c. Cathartics
b. Sodium iodide d. Epectorant
c. Sodium thiosulphate 43. Alum is assayed by …………..method
d. Sodium hydroxide a. Oxidation reductions
35. ……………is used as an antidots in cyanide b. Complexometric
poisoning c. Precipitations
a. Sodium fluoride d. Gravimetric
b. Sodium iodide 44. What should be applied to get relief from the bite
c. Silver nitrate of honeybee?
d. Sodium thiosulphate a. Baking soda
36. Expectorant drug is………….. b. Washing soda
a. Copper Sulphate c. Lemon soda
b. Potassium iodide d. Vinegar
c. Ferrous sulphate 45. Which enzyme become active in stomach during
d. Zinc sulphate low value PH?
37. Dentifrices is used for…….. a. Melittin
a. Antacid b. Pepsin
b. Emetics c. Thyroxine
c. Dental product d. Adrenaline
d. Antimicrobial 46. The outer layer of teeth is made up of…..
38. …………..is a sources of impurities a. Calcium sulphate
a. Raw material b. Calcium carbonate
b. Method of manufacturing c. Calcium phosphate
c. Both a and b d. Calcium nitrate
d. None of these 47. When a strong acid combines with a strong base,
39. …………….compound is used as desensitizing the nature of aqueous salt solution will be……
agent a. Neutral
 b. Acidic a. Chlorinated lime
c. Basic b. Aluminium acetate solution
d. Slightly basic c. Nitrous oxide
48. What is the molecular formula of sodium zincate? d. Chlorobenznylidine malononitrile
a. NaZn(OH)3 56. Measurement of radiation by:
b. Na2ZnO2 a. Those depend on collection of ions.
c. Na2Zn(OH)4 b. Those depend on collection of photons.
d. NaZnOH c. Both
49. What is formed by reaction of non-metal oxide d. None of these
with water? 57. The use of sodium rose Bengal (1-131) in-
a. Acid a. Study of K ion exchanges
b. Base b. Liver scanning
c. Salt c. Plasma volume determination
d. Metal d. Brain Scanning
50. What will be the nature of a solution having PH 2 58. Which of the following in not of type of gas filled
as compared to the one having PH 4? detector.
a. More acidic a. Proportional counter
b. More basic b. Semiconductor detector
c. Neutral c. GM counter
d. None of these d. Ionization Chamber
51. The strength of a Bronsted acid depends upon its 59. Beta particles penetration tissue up to
tendency to……..a proton. a. 100cm
a. Gain b. 1000cm
b. Donate c. 1cm
c. React with d. 10cm
d. None of these 60. Gamma ray are electromagnetic radiation with a
52. All cations and molecules that are short of an wave length.
electron pair act as……… a. Much longer than those of light
a. Lewis acids b. Much shorter than of light
b. Lewis bases c. Equal to light
c. Bronsted acids d. None of these
d. Bronsted base 61. Isotopes are characterized as
53. The strength of an acid depends upon a. Identical atomic number
a. The concentration of H+ ions in aqueous b. Identical mass number
solution c. Identical atomic number and identical
b. The concentration of electron pair in mass number
aqueous solution d. Identical atomic number and different
c. The tendency to release the electron pair mass no.
d. The tendency to gain the electron pair 62. Radioactive isotopes in decay by
54. Hypo is synonym for? a. Zero order kinetics
a. Calcium hydroxide b. Pseudo Zero order kinetics
b. Sodium thiosulphate c. First order Kinetics
c. Bentonite d. Second Order Kinetics
d. Talc 63. Which types of radiation having high penetration
55. Tear gas (CS gas) composition? power?
 a. Alpha radiation b. Freely soluble
b. Beta radiation c. Sparingly soluble
c. Gamma Radiation d. Slightly soluble
d. UV radiation 72. “Role of lead acetate is to trap any hydrogen
64. Unit of radioactivity is sulfide gas that may be produced alongside the
a. Poise arsine gas”. This statement justifies to which limit
b. Ohm test
c. Curies a. Arsenic
d. Dyne/cm b. Chloride
65. Radiopharmaceuticals compounds stored in: c. Sulphate
a. Refrigerator d. Lead
b. Lead container 73. According to Arrhenius concept an acid is
c. Warm temperature substance which
d. Glass Container a. Gives H+ ion
66. Which method is used for the Limit test for b. Gives OH- ion
arsenic? c. Donate
a. Gutzeit method d. Red litmus blue
b. Oswald method 74. The electron acceptors which have high positivity
c. Arrhenius method and small size are
d. Karl-Fischer method a. Hard Bases
67. The agent used to prevent the dental carries is:- b. Hard Acids
a. Sodium fluoride c. Soft Base
b. Strontium chloride d. Hard Acids
c. chloride 75. What is H+ ion concentration for distilled water
d. Dicalcium phosphate a. 10-14
68. As per USP, test limit for treated soda lime glass b. 10+14
with container size of 200 ml is:- c. 10-7
a. 0.70ml of 0.02N Acid d. 10+7
b. 1.0ml of 0.2N Acid 76. The pH of a solution equals to
c. 0.20ml of 0.02N Acid a. Positive logarithm of OH- ion
d. 0.70ml of 0.2N Acid b. Negative logarithm of OH-ion
69. Buffer capacity is also referred to as:- c. Positive logarithm of H+
a. Buffer index d. Negative logarithm of H+ ion
b. Buffer value 77. Which statement is correct about pH of acid
c. Buffer efficiency a. Above 7
d. All of these b. Between 8-9
70. Which of the following is a suitable antidote for c. Below 7
mercury poisoning? d. 7
a. Atropine 78. A strong acid has large
b. Dimercaprol a. Ka
c. Naloxone b. Kb
d. Nalorphine c. PKa
71. As per I.P, if the solubility range of a solute is 30 d. pKb
to 100 parts, it will be 79. The pH of solution having hydrogen ion
a. Soluble concentration 4.2 x 10-4 is
 a. 3. 88. The amount of acid or base that must be added to
b. 2.5 buffer to produce a unit change of pH is
c. 4.7 a. Buffer Solution
d. 5.89 b. Buffer Action
+ -
80. As the pH increases pOH ion c. Buffer Capacity
a. increases d. None of above
b. decreases 89. Acidifiers are the drugs which
c. neither increase nor decrease a. decrease the acidity
d. none of the above b. increase the acidity
81. According to Lewis Concept c. first increase then decrease
a. Acid is proton donor d. no effect on acidity
b. Acid is electron pair donor 90. Water is having ______ as impurities as very
c. Base is electron pair donor small quantity
d. Base is electron accepter a. calcium
82. Which of the following represents property of Soft b. potassium
Bases c. Cl
a. High positive charge d. both a and c
b. Low positive charge 91. Limit test for arsenic is based on which test?
c. High electronegativity (a) Gutzeit test
d. Low electronegativity (b)Fehling's test
83. The normal human blood pH is (c)Benedict's test
a.5.5-6.5 (d)None
b.8.8-9.6 92. Limit test for iron purple color is due to formation
c.7.35-7.45 of-
d.2.35-3.78 (a)ferrous sulphate
84. Buffers are mixture of (b)Ferrous mercaptoacetate
a. Strong acid & Strong base (c)Citric acid
b. Weak base & Weak acid (d)None
c. Weak acid & salt 93. Limit test of iron is based upon the reaction of Fe
d. None of above with________in of a solution buffered with
85. Role of buffers in pharmacy is related to ammonium citrate.
a. Stability (a)Thioglycollic acid
b. Solubility (b)Acetic acid
c. Color (c)Sodium hydroxide
d. All of the above (d)thioglyconate
86. pH of buffer solution depend upon 94. In limit test for arsenic, temperature should be
+
a. acid(H ) maintained at
b. conjugate base a. 70 degree
c. Salt b. 50 degree
d. Both a & b c. 40 degree
87. HCl can be prepared by reacting NaCl with d. 30 degree
a. H2SO4 95. Limit test for lead is based upon reaction
b. NaHSO4 between__________and_________to form
c. Both a & b complex.
d. None of the above a. Pb , Dithizone
 b. Pb , Ammonia 103. Which of the following values of pH will change
c. both (a) and (b) blue litmus paper red?
d. none a. 3.4
96. In limit test for iron , ferrous thioglycolate has b. 12.6
stable pink to reddish purple colour in which c. 8.2
medium? d. 7.0
a. acidic 104. Distilled water will
b. alkaline a. not change red or blue litmus paper
c. neutral b. cannot be tested using litmus paper
d. None c. change blue litmus paper to red
97. In limit test for arsenic, __________is converted d. change red litmus paper to blue
to arsenous acid/arsine gas. 105. In human body the main thing act as a buffer
a. arsine is……….
b. arsenide a. Blood
c. both (a) and (b) b. Water
d. none c. Leukocytes
98. The chief source of lead impurity are d. None of the above
a. sulphuric acid 106. The impurities which are having a toxic effect on-
b. lead lined apparatus a. Chloride
c. both (a) and (b) b. sulphate
d. none c. lead and arsenic salts
99. Arsine gas is carried and comes in contact d. iron
with________in produces a yellow or brown e. The impurity which cannot be detected by
stain. senses
a. Mercuric chloride f. odour
b. Zinc g. phenolic impurity
c. both (a) and (b) h. colour
d. none i. taste
100. What is pH a measure of? 107. Impurity which is not present in raw material is
a. Density a. water
b. ion concentration b. lead
c. hydrogen-ion concentration c. arsenic
d. solute concentration d. heavy metals
101. A solution with a pH of 6.0 is 108. Copper turnings are known to have impurities of -
a. acidic a. lead
b. strongly basic b. iron and arsenic
c. neutral c. silver
d. weakly basic d. aluminium
102. Which of the following values of pH will change 109. Tap water does not contain which impurity
red litmus paper blue? a. calcium
a. 8.5 b. magnesium
b. 3.1 c. chloride
c. 7.0 d. sulphate
d. 6.2 110. Limit tests have been prescribed for cyanides in -
a. potassium iodide
 b. ammonium chloride d. United States Pharmacopeia
c. sodium sulphate 119. Which of the following pharmacopoeias is
d. barium hydroxide published by the United States Pharmacopeial
111. Limit test of Arsenic is also known as …….... Convention (USP)?
a. Gutzeit test a. International Pharmacopoeia
b. Kjeldahl’s test b. European Pharmacopoeia
c. None of the above c. Japanese Pharmacopoeia
d. Both a and b d. United States Pharmacopeia
112. ………… paper is used in limit test of Arsenic. 120. Which of the following is the most common
a. Mercuric chloride source of impurities in pharmaceutical
b. Calcium chloride substances?
c. Lactate a. Raw materials
d. Potassium oxide b. Manufacturing process
113. Acids acidifiers are used as c. Packaging
a. Refineries d. Storage
b. Pharmaceutical aid 121. Which of the following is not a type of impurity in
c. Limit test pharmaceutical substances?
d. Antacids a. Inorganic impurities
114. A compound having foreign matter is b. Organic impurities
a. Pure c. Residual solvents
b. Impure d. Microbial impurities
c. Qualitative analysis 122. Which of the following organic impurities is
d. None of the above formed during the synthesis of aspirin?
115. Acid used in limit test of chloride a. Salicylic acid
a. H2SO4 b. Acetic anhydride
b. HCl c. Salicylic anhydride
c. HNO3 d. Acetic acid
d. MgO 123. Which of the following inorganic impurities is
116. Acid used in limit test of sulphate commonly found in pharmaceutical substances?
a. BaCl2 a. Heavy metals
b. BaSO4 b. Chlorides
c. HCl c. Sulphate
d. HNO3 d. All of the above
117. Which of the following is the oldest 124. Which of the following residual solvents is limited
pharmacopoeia in the world? in pharmaceutical substances by the ICH Q3C
a. London Pharmacopoeia guideline?
b. Chinese Pharmacopoeia a. Water
c. Indian Pharmacopoeia b. Ethanol
d. United States Pharmacopeia c. Methanol
118. Which of the following pharmacopoeias is d. Toluene
published by the World Health Organization 125. What is the principle of the limit test for chloride
(WHO)? using silver nitrate?
a. International Pharmacopoeia a. Chloride ions form a white precipitate
b. European Pharmacopoeia with silver nitrate.
c. Japanese Pharmacopoeia
 b. Chloride ions form a yellow precipitate d. Lead ions do not form a precipitate with
with silver nitrate. hydrogen sulphide.
c. Chloride ions form a red precipitate with 130. What is the principle of the limit test for heavy
silver nitrate. metals using the sulphide test
d. Chloride ions form a black precipitate a. Heavy metal ions form a black precipitate
with silver nitrate. with hydrogen sulphide.
126. What is the principle of the limit test for sulphate b. Heavy metal ions form a yellow
using barium chloride? precipitate with hydrogen sulphide.
a. Sulphate ions form a white precipitate c. Heavy metal ions form a red precipitate
with barium chloride. with hydrogen sulphide.
b. Sulphate ions form a yellow precipitate d. Heavy metal ions do not form a precipitate
with barium chloride. with hydrogen sulphide.
c. Sulphate ions form a red precipitate with 131. What is the advantage of the modified limit test
barium chloride. for chloride over the traditional limit test using
d. Sulphate ions form a black precipitate silver nitrate?
with barium chloride. a. It is more sensitive.
127. What is the principle of the limit test for iron b. It is less specific.
using ammonium thiocyanate? c. It is less expensive.
a. Iron ions form a red precipitate with d. It is easier to perform.
ammonium thiocyanate. 132. What is the principle of the modified limit test for
b. Iron ions form a yellow precipitate with chloride?
ammonium thiocyanate. a. Chloride ions form a white precipitate
c. Iron ions form a white precipitate with with silver nitrate in the presence of nitric
ammonium thiocyanate. acid.
d. Iron ions form a black precipitate with b. Chloride ions form a yellow precipitate
ammonium thiocyanate. with silver nitrate in the presence of nitric
128. What is the principle of the limit test for arsenic acid.
using Gutzeit’s test? c. Chloride ions form a red precipitate with
a. Arsenic forms a yellow stain on silver silver nitrate in the presence of nitric acid.
nitrate paper. d. Chloride ions form a black precipitate
b. Arsenic forms a red stain on silver nitrate with silver nitrate in the presence of nitric
paper. acid.
c. Arsenic forms a black stain on silver 133. What is the advantage of the modified limit test
nitrate paper. for sulphate over the traditional limit test using
d. Arsenic does not form a stain on silver barium chloride?
nitrate paper. a. It is more sensitive.
129. What is the principle of the limit test for lead b. It is less specific.
using the sulphide test? c. It is less expensive.
a. Lead ions form a black precipitate with d. It is easier to perform
hydrogen sulphide. 134. What is the principle of the modified limit test for
b. Lead ions form a yellow precipitate with sulphate?
hydrogen sulphide. a. Sulphate ions form a white precipitate
c. Lead ions form a red precipitate with with barium chloride in the presence of
hydrogen sulphide. hydrochloric acid.
 b. Sulphate ions form a yellow precipitate c. The impurity’s presence in natural sources
with barium chloride in the presence of d. The impurity’s potential toxicity and
hydrochloric acid. safety concerns
c. Sulphate ions form a red precipitate with 140. Which of the following statements about limit
barium chloride in the presence of tests for impurities is accurate?
hydrochloric acid. a. Limit tests are used to detect all possible
d. Sulphate ions form a black precipitate impurities in a sample.
with barium chloride in the presence of b. Limit tests involve analyzing impurities at
hydrochloric acid. concentrations higher than the acceptance
135. What is the primary purpose of a pharmacopoeia criteria.
in the field of pharmaceutical analysis? c. Limit tests are a qualitative analysis
a. To establish dosage recommendations for technique.
specific drugs d. Limit tests are primarily used for assessing
b. To provide a comprehensive list of all drug efficacy.
available medications 141. What is the primary purpose of limit tests for
c. To set standards for the quality and purity heavy metals?
of pharmaceutical substances a. To assess the solubility of heavy metals in
d. To outline regulatory procedures for pharmaceuticals
clinical trials b. To identify heavy metal impurities based
136. In the context of pharmacopoeias, what does on their color
“USP” stand for? c. To ensure that heavy metal impurities are
a. United States Pharmacology within safe limits
b. Universal Standard Procedure d. To determine the chemical structure of
c. United States Pharmacopeia heavy metal impurities
d. Uniform Substance Protocol 142. In the context of limit tests, if a sample’s
137. Which of the following is NOT a common source measured concentration of a specific impurity is
of impurities in medicinal agents? below the established acceptance criteria, what
a. Manufacturing processes does this indicate?
b. Environmental contaminants a. The sample is free from impurities.
c. Intentional additives b. The impurity concentration is within the
d. Storage conditions specified limits.
138. When conducting a limit test for a specific c. The sample is contaminated beyond
impurity in a pharmaceutical substance, what is acceptable levels.
the primary purpose of the test? d. The impurity is not detected by the test
a. To determine the total impurity content method.
b. To identify the impurity’s chemical 143. Which organization publishes the European
structure Pharmacopoeia, a compendium of quality
c. To quantify the impurity at or below a standards for pharmaceutical substances and
specified level dosage forms in Europe?
d. To establish the impurity’s therapeutic a. United States Pharmacopeia (USP)
value b. World Health Organization (WHO)
139. In the context of limit tests for impurities, what is c. European Directorate for the Quality of
the acceptance criterion typically based on? Medicines & HealthCare (EDQM)
a. The impurity’s pharmacological effects d. International Organization for
b. The impurity’s color and odor Standardization (ISO)
144. In the context of limit tests for impurities, which
of the following is true about the acceptance
criteria?
a. Acceptance criteria are uniform for all
impurities.
b. Acceptance criteria are typically specified
in terms of percentage purity.
c. Acceptance criteria are established based
on the impurity’s therapeutic value.
d. Acceptance criteria may vary depending
on the impurity and its potential toxicity.
145. When was the ninth edition of IP got published?
a. 2012
b. 2015
c. 2022
d. 2024