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Chronic cough

Chronic cough, lasting eight weeks or more, significantly impacts quality of life and is often linked to cough hypersensitivity syndrome (CHS) and various underlying conditions. Recent advancements in diagnostic tools and understanding of the condition's mechanisms are paving the way for innovative treatments, including neuropharmacological interventions and cognitive-behavioral therapies. Ongoing research is expected to further enhance diagnosis and management strategies for chronic cough.

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13 views2 pages

Chronic cough

Chronic cough, lasting eight weeks or more, significantly impacts quality of life and is often linked to cough hypersensitivity syndrome (CHS) and various underlying conditions. Recent advancements in diagnostic tools and understanding of the condition's mechanisms are paving the way for innovative treatments, including neuropharmacological interventions and cognitive-behavioral therapies. Ongoing research is expected to further enhance diagnosis and management strategies for chronic cough.

Uploaded by

Shami Christo A
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Chronic cough: new insights and future prospects

Chronic cough is a common and debilitating symptom that can have a significant impact on a person's
quality of life. It is defined as a cough lasting for eight weeks or more, and it can be caused by a variety
of underlying conditions. In recent years, there have been significant advancements in our
understanding of chronic cough, leading to new insights and future prospects for its diagnosis and
management.

New insights of chronic cough

 Chronic cough is often triggered by low levels of thermal, mechanical or chemical exposure,
reflecting a common etiology, known as cough hypersensitivity syndrome (CHS). CHS is
characterized by dysregulation of neural pathways and receptors in the central nervous system,
vagal afferent sensory nerves, and ganglia.
 Misdiagnosis of the underlying cause of the cough also adds to patient burden since patients
are unnecessarily exposed to inappropriate investigations or ineffective treatments. A number
of conditions, including irritable bowel syndrome, obstructive sleep apnoea ,obesity , thyroid
disease, neuropathic syndromes , GORD, asthma and allergic rhinitis, are common in patients
with chronic cough, contributing to the disease burden.
 New Diagnostic Tools- Advances in diagnostic tools, such as cough monitoring devices and
ambulatory cough recorders, have enabled more accurate and objective assessments of chronic
cough. These tools help healthcare professionals better understand the frequency and triggers
of cough episodes, aiding in diagnosis and treatment planning.
 A high prevalence of psychological effects is associated with chronic cough.

Future prospects of chronic cough

 Researchers are exploring the use of neuropharmacological interventions to modulate the


cough reflex. Understanding the neural pathways involved in coughing may lead to the
development of drugs that can specifically target these pathways.
 Some studies have suggested that up to 85% of the efficacy of cough medicines is due to a
placebo effect. This effect derives partly from “physiological” actions relating to the formulation
or taste of the preparation, and possibly a specific effect of a sweet taste, independent of any
active ingredient
 Cognitive-behavioral therapies and other psychological interventions may play a more
prominent role in managing chronic cough in the future.
 There is a large healthcare burden associated with CC as well as decreased quality of life
(QOL). Improved decision making will allow pharmacists to educate people with CC and provide
resources to enhance their cough-related QOL.

In summary, chronic cough is a multifaceted condition with diverse underlying causes and complex
mechanisms. Advances in research are shedding light on its pathophysiology, allowing for more accurate
diagnosis and innovative treatment approaches. As research in this field continues to evolve, new
insights and treatments will likely continue to emerge.

https://err.ersjournals.com/content/30/162/210127

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