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The document contains a series of multiple-choice questions and answers related to biochemical processes, particularly focusing on the Krebs cycle, oxidative phosphorylation, and electron transport chain. Key topics include the number of carbon molecules in the Krebs cycle, components of ATP synthase, and the role of various complexes in cellular respiration. Each question is followed by the correct answer, providing a concise review of essential concepts in biochemistry.

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2 views

Questions (2)

The document contains a series of multiple-choice questions and answers related to biochemical processes, particularly focusing on the Krebs cycle, oxidative phosphorylation, and electron transport chain. Key topics include the number of carbon molecules in the Krebs cycle, components of ATP synthase, and the role of various complexes in cellular respiration. Each question is followed by the correct answer, providing a concise review of essential concepts in biochemistry.

Uploaded by

baylasanayman22
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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1. In Krebs cycle, starting from isocitrate and ending with fumarate, how many
4-carbon molecules are there?
A) One molecule
B) Three molecules
C) Two molecules
D) Four molecules
Answer: B

2. Ubiquinone is a component of ______


A) None of the above
B) Complex II
C) Complex III
D) Complex I
Answer: D

3. How many oxidative decarboxylation reactions (steps) in the degradation of one


molecule of glucose?
A) Four
B) Two
C) One
D) Three
Answer: D

4. Which of the following is not an intermediate of TCA Cycle?


A) oxaloacetate
B) Citrate
C) a-ketoglutarate
D) acetyl-CoA
Answer: D

5. In TCA cycle, starting from citrate and ending with fumarate all the following
reactions occur except:
A) Condensation
B) Isomerization
C) Substrate level phosphorylation
D) Decarboxylation
Answer: A

6. Riboflavin prosthetic group can be found in:


A) Complex II only
B) Complex I only
C) Complex I & II & III
D) Complex I & II
Answer: D
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7. Which of the following is the correct order of ATP synthesis in ATP


synthase?<br/>I. ATP is synthesized<br/>II. ADP and Pi bind to L site<br/>III. ATP is
released as the T conformation converts to an O conformation
A) II -> III -> I
B) II -> III -> I
C) II -> I -> III
D) I->III->II
Answer: C

8. The conversion of pyruvate to acetyl-CoA is known as


A) Oxidative phosphorylation
B) Oxidative decarboxylation
C) Reductive decarboxylation
D) Oxidative carboxylation
Answer: B

9. Antimycin was used to inhibit ETC, what is its effect?


A) Increase oxygen levels in mitochondria
B) Decrease oxygen levels in mitochondria
C) No change in the amount of oxygen
D) Increase in H2O
Answer: A

10. Which product of glucose degradation is necessary for Oxidative


Phosphorylation?
A) NADH
B) O2 and NADH
C) O2
D) Acetyl-CoA
Answer: A

11. How many NADH is formed per glucose in the mitochondrial matrix?
A) 8
B) 10
C) 6
D) 4
Answer: A

12. Products of oxidative phosphorylation:


A) Oxygen
B) ATP + H2O
C) ADP
D) NADH
Answer: B
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13. Which compound in the citric acid cycle of the following has thioester bond?
A) Fumarate
B) Alpha keto glutarate
C) Malate
D) Succinyl-CoA
Answer: D

14. Which of the following is correct about chemiosmotic theory?


A) pH levels decrease in weakly buffered mitochondria while actively respiring
B) All of the following is true
C) Uncouplers and ionophores disrupt the proton gradient , inhibiting ATP synthase
D) Disruption of inner membrane stops respiration
Answer: B

15. Name of complex III


A) Cytochrome cb1 complex
B) Cytochrome bc1 complex
C) Cytochrome c oxidase
D) Cytochrome ab1 complex
Answer: B

16. Name of complex IV


A) Cytochrome ubiquinone reductase
B) Cytochrome c oxidase complex
C) NADH dehydrogenase
D) Succinate dehydrogenase
Answer: B

17. Below is the net reaction for Krebs Cycle. Find X<br/>Acetyl-CoA + 3NAD z +
FAD z + GDP + Pi + <mark>X</mark>H2O !’ 2CO2 + 3NADH + FADH2 + CoASH + GTP
+ 3H z
A) 1
B) 3
C) 2
D) 0
Answer: C

18. Which of the following is a product of hydration


A) Succinate
B) Fumarate
C) Malate
D) Isocitrate
Answer: C
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19. Which of the following is correct about the reversible reaction done by malate
dehydrogenase?
A) OAA is oxidized to form malate, producing a third NADH
B) Malate is reduced to form OAA, producing a third NADH
C) OAA is reduced to form malate, producing a third NADH
D) Malate is oxidized to form OAA, producing a third NADH
Answer: D

20. Function of proton gradient in oxidative phosphorylation


A) Oxidize NADH to NAD z
B) Creates a pore inside the membrane
C) Reduce O2 to H2O
D) Induces conformational change in ATP synthase
Answer: D

21. ATP synthase which of the following is correct:


A) The F1 motor converts the protonmotive force into rotational force rotating the central
shaft (³ and µ) to synthesize ATP
B) F0 has 5 subunits (a3:ß3:³:´:µ)
C) F1 has 3 subunits (a:b:c12)
D) none of the above
Answer: D

22. Which shuttle moves glycolytic NADH into the inner membrane/oxidative
phosphorylation(?)
A) Glyceraldehyde-dihydroxyacetone shuttle
B) Malate-Glutamate shuttle
C) Malate-Pyruvate shuttle
D) Glycerol-3-phosphate shuttle
Answer: D

23. Oxidative phosphorylation is in


A) Mitochondrial matrix
B) Cytoplasm
C) Intermembrane space of mitochondria
D) inner membrane of mitochondria
Answer: D

24. Which of the following activates citrate synthase?


A) ATP
B) succinyl-CoA
C) NADH
D) None of the above
Answer: D
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25. Uncoupling agent that mammals use to generate heat


A) Cytochrome c
B) High proton levels
C) High electrons levels
D) Gramicidin A
Answer: D

26. In the reaction from succinate to fumarate which of the following happens
A) Pi was used for substrate-level phosphorylation
B) GTP is released
C) FADH2 is generated
D) All of the following is correct
Answer: C

27. All of the following is true regarding pyruvate dehydrogenase complex except?
A) It contains 3 enzymes
B) Multi-enzyme complex
C) Catalyzes the reversible reaction
D) Uses thiamin, niacin and riboflavin derivatives as coenzymes
Answer: C

28. Which of the following is a coenzyme of pyruvate dehydrogenase enzyme?


A) FADH2
B) Vitamin B12
C) Lipoic acid
D) Biotin
Answer: C

29. Movement of electrons causes proton pumping in ETC which generates


A) Electron gradient
B) Protonmotive force
C) Oxygen motive force
D) None of the above
Answer: B

30. Which of the following is true regarding complex IV in ETC?


A) It pumps protons from the intermembrane space to the mitochondrial matrix
B) It accepts electrons from O2
C) It donates electrons to cytochrome c
D) None of the above
Answer: D

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