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Carofit Plus

The document outlines a dietary supplement containing various antioxidants, including carrot extract, beta-carotene, lycopene, resveratrol, and astaxanthin, which are believed to provide protection against UV-induced skin damage and promote skin health. It emphasizes the importance of carotenoids in mitigating oxidative stress and suggests the need for oral supplementation to combat skin aging and general weakness. The recommended dosage is one tablet daily.

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Rutuja Vedpathak
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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11 views

Carofit Plus

The document outlines a dietary supplement containing various antioxidants, including carrot extract, beta-carotene, lycopene, resveratrol, and astaxanthin, which are believed to provide protection against UV-induced skin damage and promote skin health. It emphasizes the importance of carotenoids in mitigating oxidative stress and suggests the need for oral supplementation to combat skin aging and general weakness. The recommended dosage is one tablet daily.

Uploaded by

Rutuja Vedpathak
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Composition

Carrot extract powder 100 mg

Beta carotene 40 mg

Lycopene 2000 mcg

Resveratrol 25 mg

Astaxanthin 2 mg

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Carotenoids & Beta-Carotene

❖ Carotenoids, naturally occurring lipophilic


micronutrients

❖ Possess an antioxidant activity associated with


protection from damage induced by free radicals
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Carotenoids & Beta-carotene

❖ Beta-carotene - Carrots, fruits and green leafy


vegetables is a powerful antioxidant

❖ In a study using human skin cells, the researchers found


that beta-carotene suppressed UVA-induction of the
matrix metalloprotease enzymes (MMP-1,MMP-3, and
MMP-10), which are key to degradation of the
extracellular matrix during premature skin aging

Free Radic Biol Med. 2004 Sep 1;37(5):654 -70.


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Am J Clin Nutr. 2012 Nov;96(5):1179S-84S.

β-Carotene and other carotenoids in protection from


sunlight

❖ Scavenging of reactive oxygen species is considered to be a


MOA of carotenoids

❖ Absorption of same covers the UVB and UVA range


respectively, thus potentially contributing to photo protective
effects of carotenoid-rich food

PMID: 23053552 9
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Mol Biotechnol. 2007 Sep;37(1):26-30

Carotenoids and flavonoids contribute to nutritional


protection against skin damage from sunlight

❖ Beta-Carotene and lycopene prevent UV-induced erythema


formation

❖ After about 10-12 weeks of dietary intervention, a decrease


in the sensitivity toward UV-induced erythema was observed
in volunteers

PMID: 17914160 10
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Lycopene

❖ Bright red carotenoid pigment

❖ Phytochemical found in tomatoes and other red fruits

❖ Makes up at least 50 % of the carotenoids in the human body,


accentuating its importance.

Wikipedia ; www.tandfonline.com/doi/full/10.1080/10408398.2011.623799?src=recsys
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J Nutr. 1995 Jul;125(7):1854-9

Skin lycopene is destroyed preferentially over beta-carotene


during ultraviolet irradiation in humans

❖ The amounts of lycopene in plasma and skin are comparable


to or even greater than those of beta-carotene

❖ When skin is subjected to UV light stress, more skin lycopene


is destroyed compared with beta-carotene, suggesting a role
of lycopene in mitigating oxidative damage in tissues

PMID: 7616301 13
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Resveratrol

❖ Natural antioxidant - Red wine and many plants

❖ According to a study by the University of Pittsburgh


School of Medicine, when altered with acetyl, resveratrol
administered before radiation exposure proved to protect
cells from radiation in mouse models
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Photochem Photobiol. 2008 Mar-Apr;84(2):415-21

Resveratrol imparts photoprotection of normal cells and


enhances the efficacy of radiation therapy in cancer cells

❖ Useful for prevention of UVB-mediated damages including


skin cancer and enhancing the response of radiation
therapies

PMID: 18221451 17
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ASTAXANTHIN

❖ Major pigment of crustaceans, and is the most widely


distributed xanthophyll in the animal kingdom

❖ It exhibit a pronounced photo protective effect and counteract


UVA-induced damage in the skin to a significant extent

❖ Scavenges the ROS in the skin surface, which ultimately helps


reduce moisture loss and keeps skin smooth
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Indications

General weakness

Photo ageing

Wrinkle

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Need for Oral Supplementation

❖ UVA radiation is known to trigger both the creation of


reactive oxygen species (ROS) and deplete the
antioxidant defense system

❖ For this reason supplementing the system with


antioxidants can help protect against UV damage,
explained by the researchers

Published in Formulation & Science 30-Oct-2008


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Need for Oral Supplementation

❖ Despite, the use of sunscreens and protective clothing as


preventive strategies, the incidence of skin cancer and
other skin-related disorders are on the rise……

❖ Above point suggests that its need of Oral


Photoprotectant

Photochem Photobiol. 2008 Mar-Apr;84(2):415-21.


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Dosage

❖ 1 tablet once daily

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