refrigerant-r-407c
refrigerant-r-407c
1.2 Relevant identified uses of the substance or mixture and uses advised against
Uses advised against: This product is not recommended for any industrial, professional or consumer
use other than the Intended Uses above and the instructions written in this Safety Data Sheet.
Company/undertaking identification
Supplier/Manufacturer:
e-mail: [email protected]
Emergency Information:
Inside U.S. and Canada: (800)-424-9300 (CHEMTREC)
Outside U.S. and Canada: 1-703-527-3887 (CHEMTREC)
National Emergency Centre (Greece): ++30 210 7793777
1
2. HAZARDS IDENTIFICATION
Physical hazards
Hazard pictograms:
GHS04
Hazard Statements
Precautionary statements
Storage
2
3. COMPOSITION / INFORMATION ON INGREDIENTS
*
See section 16 for the full text of the Hazard Code(s) declared above.
General advice
If unconscious place in recovery position and seek medical advice.
Never give anything by mouth to an unconscious person.
If breathing is irregular or stopped, administer artificial respiration.
First aider needs to protect himself.
If symptoms persist, call a physician.
Inhalation
Move to fresh air. Keep patient warm and at rest.
Remove from exposure, lie down.
Artificial respiration and/or oxygen may be necessary. Call a physician.
Skin contact
Flush area with lukewarm water. Do not use hot water. If frostbite has occurred, call a physician.
Take off contaminated clothing and shoes immediately.
Eye contact
Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes.
Get medical attention.
Ingestion
Is not considered a potential route of exposure.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms
Misuse or intentional inhalation abuse may cause death without warning symptoms, due to cardiac
effects.
Other symptoms potentially related to misuse or inhalation abuse are:, Anaesthetic effects, Light-
headedness, dizziness, confusion, incoordination, drowsiness, or unconsciousness, irregular heartbeat
with a strange sensation in the chest, heart thumping, apprehension, feeling of fainting, dizziness or
weakness.
3
Skin contact may provoke the following symptoms:
Frostbite, Irritation, Discomfort, Itching, Redness, Swelling of tissue
4.3. Indication of any immediate medical attention and special treatment needed
Treatment: Do not give adrenaline or similar drugs.
Difluoromethane
AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA
5
* AEL is DuPont's Acceptable Exposure Limit. Where governmentally imposed occupational
exposure limits which are lower than the AEL are in effect, such limits shall take precedence.
Pentafluoroethane
Type of Application (Use): Workers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 16444 mg/m3
1,1,1,2-Tetrafluoroethane
Type of Application (Use): Workers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 13936 mg/m3
Pentafluoroethane
Value: 0.1 mg/l
Compartment: Fresh water
Value: 1 mg/l
Compartment: Water
Remarks: Intermittent use/release.
1,1,1,2-Tetrafluoroethane
Value: 0.1 mg/l
Compartment: Fresh water
Value: 1 mg/l
Compartment: Water
Remarks: Intermittent use/release.
Value: 73 mg/l
Compartment: Water
Remarks: Sewage treatment plants
6
8.2 Exposure Controls
Engineering measures
Ensure adequate ventilation, especially in confined areas. Local exhaust should be used when large
amounts are released.
Eye protection
Wear safety glasses or coverall chemical splash goggles. Eye protection complying with EN 166. or
ANSI Z87.1 Additionally wear a face shield where the possibility exists for face contact due to
splashing, spraying or airborne contact with this material.
Hand protection
Material: Leather gloves
The suitability for a specific workplace should be discussed with the producers of the protective
gloves.
The choice of an appropriate glove does not only depend on its material but also on other quality
features and is different from one producer to the other. Please observe the instructions regarding
permeability and breakthrough time which are provided by the supplier of the gloves. Also take into
consideration the specific local conditions under which the product is used, such as the danger of
cuts, abrasion, and the contact time.
Protective measures
Self-contained breathing apparatus (SCBA) is required if a large release occurs.
The type of protective equipment must be selected according to the concentration and amount of the
substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice.
Respiratory protection
For rescue and maintenance work in storage tanks use self-contained breathing apparatus. Vapours
are heavier than air and can cause suffocation by reducing oxygen available for breathing.
Respiratory protection complying with EN 137.
Color: Colorless
7
Solubility in Water: Not determined
No data available.
10.1. Reactivity
Decomposes on heating.
Difluoromethane (HFC-32)
Pentafluoroethane
1,1,1,2-Tetrafluoroethane
Skin irritation
Difluoromethane (HFC-32)
1,1,1,2-Tetrafluoroethane
Rabbit
Classification: Not classified as irritant
Result: No skin irritation
Eye irritation
Difluoromethane (HFC-32)
1,1,1,2-Tetrafluoroethane
Rabbit
Classification: Not classified as irritant
Result: No eye irritation
Sensitisation
9
Difluoromethane (HFC-32)
Skin sensitization: Does not cause skin sensitisation. Not tested on animals
Not expected to cause sensitization based on expert review of the properties of the substance.
There are no reports of human respiratory sensitization.
Pentafluoroethane
Human
Classification: Does not cause respiratory sensitisation.
Result: Does not cause respiratory sensitisation.
1,1,1,2-Tetrafluoroethane
Guinea pig
Classification: Does not cause skin sensitisation.
Result: Does not cause skin sensitisation.
Rat
Classification: Does not cause respiratory sensitisation.
Result: Does not cause respiratory sensitisation.
Difluoromethane (HFC-32)
Inhalation
Rat: -
No toxicologically significant effects were found.
Pentafluoroethane
Inhalation Rat
No toxicologically significant effects were found.
1,1,1,2-Tetrafluoroethane
Inhalation Rat
No toxicologically significant effects were found.
Mutagenicity assessment
Difluoromethane (HFC-32)
Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures
did not show mutagenic effects.
Pentafluoroethane
Animal testing did not show any mutagenic effects. Evidence suggests this substance does not cause
genetic damage in cultured mammalian cells. Did not cause genetic damage in cultured bacterial
cells.
1,1,1,2-Tetrafluoroethane
10
Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures
did not show mutagenic effects.
Carcinogenicity assessment
The carcinogenicity classifications for this product and/or its ingredients have been determined
according to HazCom 2012, Appendix A.6. The classifications may differ from those listed in the
National Toxicology Program (NTP) Report on Carcinogens (latest edition) or those found to be a
potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs (latest
edition). None of the components present in this material at concentrations equal to or greater than
0.1% are listed by IARC, NTP, or OSHA, as a carcinogen.
Pentafluoroethane
Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is
not carcinogenic.
1,1,1,2-Tetrafluoroethane
Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is
not carcinogenic.
Difluoromethane (HFC-32)
Pentafluoroethane
1,1,1,2-Tetrafluoroethane
Assessment teratogenicity
Difluoromethane (HFC-32)
Pentafluoroethane
1,1,1,2-Tetrafluoroethane
Further information
Avoid skin contact with leaking liquid (danger of frostbite).
Difluoromethane (HFC-32)
11
Further information: Cardiac sensitisation threshold limit: > 735000 mg/m3
12.1. Toxicity
Toxicity to fish
Difluoromethane (HFC-32)
Pentafluoroethane
LC50 / 96 h / Oncorhynchus mykiss (rainbow trout): 450 mg/l
Information given is based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
LC50 / 96 h / Oncorhynchus mykiss (rainbow trout): 450 mg/l
Difluoromethane (HFC-32)
Pentafluoroethane
ErC50 / 96 h / Algae: 142 mg/l
Information given is based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
ErC50 / 96 h / Algae: 142 mg/l
Information given is based on data obtained from similar substances.
Difluoromethane (HFC-32)
Pentafluoroethane
EC50 / 48 h / Daphnia magna (Water flea): 980 mg/l
Information given is based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
EC50 / 48 h / Daphnia magna (Water flea): 980 mg/l
12
Biodegradability
Difluoromethane (HFC-32)
Pentafluoroethane
Not rapidly biodegradable.
1,1,1,2-Tetrafluoroethane
Not biodegradable.
Bioaccumulation
No data available.
No data available.
This mixture contains no substance considered to be persistent, bioaccumulating and toxic (PBT). /
This mixture contains no substance considered to be very persistent and very bioaccumulating
(vPvB).
Component information
Pentafluoroethane
UN/IPCC. Greenhouse Gas Global Warming Potentials (IPCC Fourth Assessment Report, Climate
Change - Table TS.2 - Global warming potential: 3500 100-yr
General information
Do not discharge into any place where its accumulation could be dangerous. Vent to atmosphere in a
well ventilated place. Avoid discharges to atmosphere.
13
Disposal methods
Refer to the EIGA code of practice (Doc.30 "Disposal of Gases", downloadable at
http://www.eiga.org) for more guidance on suitable disposal methods. Dispose of container via
supplier only. Discharge, treatment, or disposal may be subject to national, state, or local laws.
UN number: 3340
ADR class: 2
RID-class: 2.2
Packing group: N/A
Labeling: 2.2 - Non-flammable gas
UN number: 3340
IMDG class: 2.2
IMDG packing group: N/A
Labeling: 2.2 - Non-flammable gas
EmS: F-C, S-V
UN number: 3340
IATA/ICAO class: 2.2
Packing group: N/A
Labeling: 2.2 - Non-flammable gas
Shipping Containers
Tank Cars
Cylinders
Ton Tanks
14.6 GENERAL
Gas cylinders must be equipped with valve protection caps during transportation.
14
15. REGULATORY INFORMATION
15.1 Safety, health and environmental regulations/legislation specific for the substance or
mixture
EU Regulations
Directive 96/61/EC: concerning integrated pollution prevention and control (IPPC): Article 15,
European Pollution Emission Registry (EPER):
National Regulations
Management of Health and Safety at Work Regulations (1999 No. 3242). The Regulatory Reform
(Fire Safety) Order 2005 (2005 No. 1541). Control of Substances Hazardous to Health Regulations
(COSHH, 2002 No. 2677). Provision and Use of Work Equipment Regulations (PUWER, 1998 No.
2306). Personal Protective Equipment Regulations (1992 No. 2966). Control of Major Accident
Hazards Regulations (COMAH, 2015 No. 483). Pressure Systems Safety Regulations (PSSR, 2000
No. 128). Only products that comply with the food regulations (EC) No. 1333/2008 and (EU) No.
231/2012 and are labelled as such may be used as food additives. This Safety Data Sheet has been
produced to comply with Regulation (EU) 453/2010.
ADR: Accord européen sur le transport des marchandises dangereuses par Route (European
Agreement concerning the International Carriage of Dangerous Goods by Road).
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de
fer (Regulations Concerning the International Transport of Dangerous Goods by Rail).
IMDG: International Maritime Code for Dangerous Goods.
IATA: International Air Transport Association.
ICAO: International Civil Aviation Organization.
bw: Body weight.
Carc.: Carcinogenicity.
CAS number: Chemical Abstracts Service number.
CLP: Classification Labelling Packaging Regulation.
CSA: Chemical Safety Assessment.
CSR: Chemical Safety Report.
DNEL: Derived No Effect Level.
dw: Dry weight.
15
EC number: EINECS and ELINCS number.
EC: European Commission.
EC50: Half maximal effective concentration.
EINECS: European Inventory of Existing Commercial Chemical Substances.
ELINCS: European List of Notified Chemical Substances.
EmS: Emergency Schedule.
ERC: Environmental Release Category.
ES: Exposure scenario.
food: oral feed.
GHS: Globally Harmonized System of Classification and Labelling of Chemicals.
Irrit.: Irritation.
LC50: Lethal concentration, 50 %.
LD50: Median Lethal dose.
LOAEC: Lowest Observed Adverse Effect Concentration.
LOAEL: Lowest Observed Adverse Effect Level.
MK value: Maximum Concentration value.
NCO: An international corporation that provides customer service contracting.
NOAEC: No Observed Adverse Effect Concentration.
NOAEL: No Observed Adverse Effect Level.
NOEC: No Observed Effect Concentration.
OECD: Organisation for Economic Cooperation and Development.
PBT: Persistent, Bioaccumulative and Toxic.
PNEC: Predicted No Effect Concentration.
PROC: Process category.
REACH: The Registration, Evaluation, Authorisation and Restriction of Chemicals.
Resp.: Respiratory.
Sens.: Sensitization.
STEL value: Short Term Exposure Limit value.
STOT RE: Specific target organ toxicity — repeated exposure.
STOT SE: Specific target organ toxicity — single exposure.
STOT: Specific Target Organ Toxicity.
STP: Sewage Treatment Plant.
SU: Sector of use.
Tox.: Toxicity.
TWA value: Time Weighted Average value.
vPvB: Very Persistent and Very Bioaccumulative.
All information, instructions and statements contained in this Material Safety Data Sheet are
compiled in accordance with European Directives, corresponding national legislation and on the
basis of information given by our suppliers.
The information disclosed in this Material Safety Data Sheet (which supersedes all previous
versions) is believed to be correct, at the date of issue, to the best of our current knowledge and
experience. It only relates to the specific product designated herein and it may not be valid when said
product is used in combination with any other products or in any processed form, unless specified in
the text. This document aims to provide the necessary health and safety information of the product
and is not to be considered a warranty or quality specification. It is the responsibility of the recipient
of this Material Safety Data Sheet to ensure that information given here is read and understood by all
who use, handle, dispose of or in any way come in contact with the product.
Also, it is the responsibility of the user to comply with local legislation relating to safety, health,
environment and waste management. Data and information provided concerning the product are
informative, exclusively presented to the customer.
16