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Activity 5- Linkage and Recombination

The document is an activity set for a genetics course, focusing on linkage and recombination problems. It includes various problems related to genetic crosses, phenotypic ratios, recombination frequencies, and the distinction between sex-linked recessive traits and sex-influenced traits. The activity requires students to show their solutions and calculations for each problem presented.

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Mark Joseph Pulintan
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25 views

Activity 5- Linkage and Recombination

The document is an activity set for a genetics course, focusing on linkage and recombination problems. It includes various problems related to genetic crosses, phenotypic ratios, recombination frequencies, and the distinction between sex-linked recessive traits and sex-influenced traits. The activity requires students to show their solutions and calculations for each problem presented.

Uploaded by

Mark Joseph Pulintan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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BSCI 1006 Activity 5 Genetics

Name MARK JOSEPH B. PULINTAN Date


Section BSED 2-2 SCIENCE Score

Activity 5
Linkage and Recombination
(Problem Set)

Answer the following problems and show your solution.


1. The trihybrid AaBbCc is crossed to the triple recessive, aabbcc, and
the following phenotypes are obtained in the progeny: 64 abc, 11
aBc, 18 aBC, 14 AbC, 17 Abc, 3 ABc, 71 ABC, 2 abC
a. Which of these loci are linked?
b. Determine the map distance between these genes.
BSCI 1006 Activity 5 Genetics

2. The homozygous mutant a, an allele of the albinism gene in the


mouse, has a white coat and dark eyes. The homozygous mutant p
has pink eyes. Mice of genotype a+/+p are testcrossed with mice
homozygous for the two mutations. The progeny obtained are
shown below. Calculate the recombination frequency and map
distance between the two genes.

Phenotype of Progeny Number


White coat, dark eyes 240
White coat, pink eyes 31 31
Dark coat, white eyes 34 34
Dark coat, pink eyes 474 474

3. A pair of genes AB are completely linked together, so they are


tightly linked. Give the genotypic ratio of the cross between a
heterozygous and recessive parents.

4. Why is coefficient of coincidence a basis for strength of linkage?


BSCI 1006 Activity 5 Genetics

5. Red-green colorblindness in humans is recessive and x-linked. if a


woman, heterozygous for colorblindness marries a colorblind man,
what is the probability that they will have colorblind daughter?

6. Vermillion eye color in Drosophila sp. is a sex-linked recessive trait.


What phenotype would be found in this progeny of a cross between
a vermillion female and a wild type male?
BSCI 1006 Activity 5 Genetics

7. How would you distinguish a trait caused by a sex-linked recessive


allele from one caused by a sex-influenced gene that is dominant?
Sex-linked diseases are passed down through families via the
X or Y chromosome. The X and Y chromosomes are sex
chromosomes. When an abnormal gene from one parent causes
disease, even if the matching gene from the other parent is normal,
this is referred to as dominant inheritance. The abnormal gene takes
precedence. However, in recessive inheritance, both matching
genes must be abnormal for disease to occur. If only one of the two
genes is abnormal, the disease does not occur or is mild. A carrier is
someone who has one abnormal gene but no symptoms. Carriers
are able to pass on abnormal genes to their children.

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