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Food Drug Interactions

The document provides a comprehensive list of food-drug interactions for various medications, including antibiotics, antifungals, antihistamines, and more. It details specific recommendations for each drug, such as taking certain medications on an empty stomach or with food to optimize absorption and minimize side effects. This information is crucial for patients to ensure effective medication use and avoid adverse interactions.

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Dhrushya Varghese
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66 views6 pages

Food Drug Interactions

The document provides a comprehensive list of food-drug interactions for various medications, including antibiotics, antifungals, antihistamines, and more. It details specific recommendations for each drug, such as taking certain medications on an empty stomach or with food to optimize absorption and minimize side effects. This information is crucial for patients to ensure effective medication use and avoid adverse interactions.

Uploaded by

Dhrushya Varghese
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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LIST OF FOOD DRUG INTERACTIONS

FOOD DRUG INTERACTIONS

Generic Name Brand Name Food – Drug Interaction


ANTIBIOTICS

TETRACYCLINES

Doxycycline Doxy

Doxinate ,

Vibazine -DT

§ Absorption is reduced if taken concomitantly with antacids

containing aluminium, calcium, magnesium, bismuth subsalicylate

and iron containing preparations

§ It is best taken on a empty stomach with a full glass of water 1 hour

before or 2 hours after meals

FLUOROQUINOLONE

ANTIBIOTICS

Ciprofloxacin Ciplox /Cifran tablet

250mg/500mg/750mg

Ciplox TZ

§ Avoid concurrent administration with the following -

-- magnesium/aluminum antacids and other products containing

calcium, iron or zinc

ANTIFUNGALS
Itroconazole Canditral capsule § Take capsule with a full meal since bioavailability is maximal when

taken with a full meal

§ Absorption of capsule formulation can be increased after

Coadministration with a cola by 75%

MACROLIDE ANTIBIOTICS

Azithromycin Azithral

§ Should be taken 1 hour before or 2 hrs after a meal

Erythromycin Erythrocin tablet

250mg/500mg

§ To optimize erythromycin efficacy, take on an

empty stomach, at least 30 minutes before meals since food alters

erythromycin concentrations

ANTIHISTAMINES

Fexofenadine/

Cetrizine

Allegra,

Cetzine syrup

§ Best to take antihistamines on an empty stomach to increase their

effectiveness

ANTIVIRAL – HIV Non-Nucleoside Reverse Transcriptase Inhibitor

Efavirenz Efavir tablet 200mg/600mg

§ Take on an empty stomach preferably at bed time. High fat/low

calorie meals can increase the

bioavailability by 50%

OSTEOPOROSIS
Biphosphonate

Alendronate Osteophos tablet

35mg/70mg

§ Take with a full glass of water upon rising for the day on an empty

stomach. Stay upright for 30min to avoid irritation to food pipe

(oesophagus).

ANTI-THYROID DRUGS

Levothyroxine Eltroxin 100mcg Thyronorm

25mcg/50mcg

§ Take on empty stomach before breakfast

1/3/PHR/L8/012 2

ANTI HYPERTENSIVES

β - blockers

Propranolol Ciplar 10mg/40mg

Ciplar LA

40mg/80mg

§ First pass hepatic metabolism may be decreased when

taken with food, thereby enhancing bioavailability levels

Metoprolol Met XL tablet

12.5mg/25mg/50m

g Metolar XR

tablet 12.5 Mg

Seloken XL tablet

50mg

§ First pass hepatic metabolism may be decreased when


taken with food, thereby enhancing bioavailability

§ Avoid alcohol due to additive effect of lowering blood

pressure

ANTIDEPRESSANTS

Tricyclic

antidepressant

Amitryptyline Tryptamer tablet

10mg/25mg

§ Should be taken with food to reduce the GIside effects

SEIZURE DISORDERS

Phenytoin Eptoin tablet

§ Absorption may increase 27% when taken with a

standard meal

§ Serum phenytoin concentrations may be decreased by

enteral feeding preparations or nutritional supplements

Angina Prevention Medication

Nitrates

Isosorbide Dinitrate Sorbitrate 5mg.10mg § Take on a empty stomach

DIURETICS

Loop Diuretics

Furosemide Lasix Injection

Lasix tablet 4mg

Frusinex tablet

§ May take with food or milk to decrease GIside effects

ANTI-EMETIC
Dopamine receptor

antagonist

Metoclopramide Perinorm

tablet/syrup/injection

§ Take 30mins before food

GOUT

Allopurinol Zyloric tablet 100mg

§ Take after meals with fluids to decrease GIside effects

ACNE VULGARIS

Isotretinoin Sotret capsule 10mg/20mg

Isotroin 10mg/20mg

§ Food increases the absorption of isotretinoin hence take

with food or milk but avoid Vit A supplements

ANALGESICS

Peripherally acting non

narcotic

analgesics:

Ibuprofen/Naproxen Brufen

/ Combiflam

§ To be taken with food because they irritate the

stomach lining.

Centrally acting

narcotic analgesics

Morphine tablet

Durogesic patches
Vermor

Durogesic –d trans

Fentanyl Injection

§ Avoid ,alcohol, cough syrup or sleeping pills since there

will be a n additive CNS depressant effect

§ Drink lot of water to avoid constipation

ELECTROLYTES

Potassium Chloride Kesol Injection § Take with food to decrease gastric upset

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