Long Duration Spaceflight Problems
Long Duration Spaceflight Problems
Jeffrey A. Hoffman
MIT
Nature of Space Radiation
(outside the Earth’s radiation belts)
•Solar Radiation
•Flares
•Coronal Mass Ejections
•Induced Radiation
(spallation, etc.)
30 day max 25 75 37 13
•Solar Radiation
•Flares
•Coronal Mass Ejections
•Induced Radiation
(spallation, etc.)
= 1 rad/rem
Passive Shielding against Radiation:
1. What are the carcinogenic risks following irradiation by protons and HZE particles?
2. How do cell killing and induction of chromosomal aberrations vary as a function of the
thickness and composition of shielding?
3. Are there studies that can be conducted to increase the confidence of extrapolation from
rodents to humans of radiation-induced genetic alterations that in turn could enhance
similar extrapolations for cancer?
4. Does exposure to heavy ions at the level that would occur during deep-space missions of
long duration pose a risk to the integrity and function of the central nervous system?
5. How can better error analyses be performed of all factors contributing to estimation of
risk by a particular method, and what are the types and magnitude of uncertainty associated with
method? What alternate methods for calculation of risk can be used to compare with
conventional predictions in order to assess absolute uncertainties? How can these analyses
and calculations be used to better determine how the uncertainties in the methods affect
estimates of human risks and mission costs?
6. How do the selection and design of the space vehicle affect the radiation environment in
which the crew has to exist?
7. Can solar particle events be predicted with sufficient advance warning to allow
crewmembers to return to the safety of a shielded storm shelter?
LOWER-PRIORITY RESEARCH QUESTIONS
1. What are the risks of reduced fertility and sterility as a result of exposure to radiation on
missions of long duration in deep space?
2. What are the risks of clinically significant cataracts being induced by exposure to radiation at
the levels that will occur on extended space flights?
3. Can drugs be used to protect against the acute or carcinogenic effects of exposure to
radiation in space?
4. Is there an assay that can provide information on an individual's sensitivity to radiation-
induced mutagenicity and that can be predictive of a predisposition for susceptibility to
cancer?
5. Are there differences in biological response arising from exposure to particles with similar
LET, but with different atomic numbers and energies?
Prof. Jeffrey A. Hoffman
MIT
Lec
Parts of lecture originally developed by:
Spatial Orientation
Photo NASA
Mental Rotation
A well-known
person is not
easily
recognized
when
upside-down
Elvis Presley
Who’s That Girl ?