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The chapter discusses Self-microemulsifying drug-delivery systems (SMEDDS), which enhance the bioavailability of poorly soluble drugs through oral delivery. It highlights the challenges of traditional systems, such as in vivo precipitation and handling issues, and suggests solutions like polymeric precipitation inhibitors and solid-SMEDDS to improve stability and functionality. The chapter provides a comprehensive overview of various SMEDDS formulations, their compositions, characterization, and applications.

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17 views

b 9780128144879000090

The chapter discusses Self-microemulsifying drug-delivery systems (SMEDDS), which enhance the bioavailability of poorly soluble drugs through oral delivery. It highlights the challenges of traditional systems, such as in vivo precipitation and handling issues, and suggests solutions like polymeric precipitation inhibitors and solid-SMEDDS to improve stability and functionality. The chapter provides a comprehensive overview of various SMEDDS formulations, their compositions, characterization, and applications.

Uploaded by

R K
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as TXT, PDF, TXT or read online on Scribd
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Kuldeep Rajpoot, Muktika Tekade, Vikas Pandey, SreeHarsha Nagaraja, Susanne R.

Youngren-Ortiz, Rakesh K. Tekade,


Chapter 9 - Self-microemulsifying drug-delivery system: ongoing challenges and
future ahead,
Editor(s): Rakesh K. Tekade,
In Advances in Pharmaceutical Product Development and Research,
Drug Delivery Systems,
Academic Press,
2020,
Pages 393-454,
ISBN 9780128144879,
https://doi.org/10.1016/B978-0-12-814487-9.00009-0.
(https://www.sciencedirect.com/science/article/pii/B9780128144879000090)
Abstract: Self-microemulsifying drug-delivery system (SMEDDS) can be defined as an
isotropic system containing lipid and surfactant as well as cosurfactant that
develop an emulsion in the aqueous fluid after slight agitation. Nearly half of the
newly synthesized chemical molecules show less solubility in the aqueous phase,
which is the major concern to the efficient delivery of drug molecules and hence
decrease the bioavailability of these entities. In addition, SMEDDSs are considered
as a prominent platform in resolving poor bioavailability of hydrophobic drugs
through oral delivery. However, traditional self-emulsifying systems that are being
developed using a liquid phase may exhibit few disadvantages such as in vivo
precipitation of bioactive molecules, product handling problems, and restricted
lymphatic transport. Moreover, these limitations restrict their prominent
applications. In this context the addition of distinct polymeric precipitation
inhibitors may facilitate the keeping of the drug in supersaturation state.
Furthermore, solid-SMEDDS assist in combating both handling of liquid as well as
stability-related issues. In addition the incorporation of medium-chain
triglycerides along with antioxidants may also reduce oxidation-related issues of
some unsaturated fatty acids. This chapter details in-depth report on distinct
kinds of SMEDDS-based formulations via various route, dosage forms, composition,
characterization, and their applications.
Keywords: SMEDDS; self-emulsifying; drug delivery; polymeric precipitation
inhibitors; solid-SMEDDS

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