The WEF Nexus Journey_2022
The WEF Nexus Journey_2022
This paper describes the beginning of the WEF Nexus Journey in the classroom and
shows how the Nexus emerged into the discipline that it is today. The paper offers
definitions, shares some success stories from around the world, reflects on future
opportunities, and provides a few concluding remarks.
Keywords: WEF Nexus, sustainability triangle, food security, Nexus tradeoffs, WEF analytics, WEF interlinkages,
hotspots, stakeholder engagement
THE JOURNEY
In late 1990, interest in agricultural engineering was declining among students entering colleges
of engineering and of agriculture. Departments across the nation changed their names to include
environmental, biosystems, and other natural resource terminologies. My own department at
Purdue was part of both colleges. I requested the department chair to include me in its student
recruitment team for our colleges of agriculture and engineering so that, as a member of the team,
I could work to recruit freshmen from both colleges into the agricultural engineering department.
Edited by:
My recruitment strategy was focused on including non-traditional students who typically did not
Olcay I. Unver, see agriculture as part of their future career. I introduced the department by focusing on the
Arizona State University, United States threatened, interconnected water, energy, and food systems; on how an agricultural engineer might
Reviewed by: contribute to this grand challenge of water, energy, and food security. My presentation introduced
Tafadzwanashe Mabhaudhi, what I called the “sustainability triangle” (Figure 1). We witnessed a significant spike in interest
University of KwaZulu-Natal, around this grand challenge among rural and urban students of diverse ethnic backgrounds.
South Africa In 2008, as the inaugural director of Purdue’s Global Engineering Program, I had the opportunity
*Correspondence: to further develop these concepts and incorporated them into the academic programs we offered.
Rabi H. Mohtar In 2009, I was invited to join the Water Security Council of the World Economic Forum and
[email protected] discovered that term WEF (water, energy, food) for worked well for both the Nexus and the World
Economic Forum, where I further developed this systems approach to water security. The water
Specialty section: security council included members from public and private sectors, international organizations,
This article was submitted to
non-governmental organizations, and some academics. The WEF Nexus concept was adopted by
Water-Smart Food Production,
the Council in January 2011 at the annual meeting of the World Economic Forum in Davos and
a section of the journal
Frontiers in Sustainable Food Systems published for the first time (Mohtar, 2011).
Thus, the Nexus took off on the global stage. What began with the water security
Received: 01 December 2021
publication of the World Economic Forum (Davos, January 2011) was followed in November
Accepted: 18 April 2022
Published: 26 May 2022 with the Bonn 2011 Conference, focused on the interdependencies of water, energy, food
securities and explicitly identifying the role of decision making (Hoff, 2011). In June
Citation:
Mohtar RH (2022) The WEF Nexus
2012, the Rio+20 United Nations Conference on Sustainable Development recognized and
Journey. highlighted the WEF linkages to nutrition, sustainable agriculture, sustainable cities, health,
Front. Sustain. Food Syst. 6:820305. biodiversity, and desertification. At COP18, the United Nations Climate Change Conference of
doi: 10.3389/fsufs.2022.820305 Parties in Doha, the food-water-energy nexus was presented as describing the “human face”
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Mohtar WEF Nexus Journey
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Mohtar WEF Nexus Journey
looked at thematic and geographic applications, beginning with export, which competes for local resources in the region
the launch of Qatar’s National Food Security Program in 2011. (Degirmencioglu et al., 2019). In Lebanon, we took a health
When Qatar was struggling to find a solution to its food security centered approach that places health at the center of the Nexus
challenges, our application allowed an analytical platform that (Bachour et al., 2020).
considered the implications of achieving food security in Qatar Morocco’s phosphate industry posed a special challenge in
(Mohtar and Daher, 2014). water-scarce Morocco: phosphate production has a high-water
In Abu Dhabi, the group worked with the International footprint. We looked at the tradeoffs between the water used
Renewable Energy Agency (IRENA) to help produce a by the industry vs. the water used by other sectors, such as
comprehensive study on the steps needed for promoting agriculture (Lee et al., 2020). In Morocco, we also looked
renewable energy as part of the energy portfolio mix and how it at the tradeoffs between Nexus and the different sustainable
interfaces with other energy sources, conditions, and limitations development goals (SDGs) for water, energy, and food as part of
to this energy (International Renewable Energy Agency, 2015). the national plans for resource management (Daher and Mohtar,
There are additional examples of energy deployment, 2021).
including the sustainable energy portfolio of Texas, where the In two unpublished studies, one in the Mekong Basin and the
group worked on the projected water gap, critical when hydraulic second in Nigeria, we looked at the Nexus tradeoffs between the
fracturing was at its peak and the water needed for this process hydropower industry (hydraulic energy), agricultural irrigation,
was taken from other sectors, mainly domestic and agriculture community livelihood, and food security. Each of these case
(Daher et al., 2019). This work focused on the tradeoffs between studies shares a common element of quantification of the
energy, water, and transportation. The transportation lifeline for interlinkages and the tradeoffs that exist in the analysis and
water used in the hydraulic fracturing process are the roads, validates the conclusion that the Nexus systems approach can
which also provide the transportation lifeline for communities offer economic benefits to multiple sectors.
and impact traffic and the safety of transport (Mohtar et al., 2019).
As addressed more specifically below, the research group also
considered the WEF Nexus in the San Antonio region (Mohtar, A WEB BASED WEF NEXUS TOOL
2019), and a specific issue in Matagorda County, which neighbors
Houston and has a large nuclear power plant whose need for The tool developed for implementing these concepts was first
cooling water competes with water needs of other sectors (Kulat released in Qatar (Mohtar and Daher, 2012) and provided a user
et al., 2019). interface that allows entering the portfolios and questions about
A comprehensive study conducted in the Gediz Basin of scenario components (food self-sufficiency, water sources and
Turkey looked at the tradeoffs between planting food for quantities, energy sources) and impact (import countries and
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the relative risks of importing commodities from that country). so are both energy demand and the financial burden. In
An administrative interface and a science component provide a conclusion, the tradeoffs that we identified and quantified must
“behind the scenes” look at local data characteristics. The Tool’s be considered before making the appropriate decisions presented
output is the entire footprint of water, energy, land, carbon in these national plans. The Nexus framework and Tool allow
emission, financial constraints, and other elements. Combined, identification of these issues and is essential for such analysis to
the policy and the science allowed us to produce a sustainability be accomplished.
index, which, in turn, allowed comparison and ranking of various The second version of the Tool, released to assess food
scenarios. Further development of the tool was later completed security in Qatar (Mohtar and Daher, 2012, 2014; Daher and
and published (Daher and Mohtar, 2015). Mohtar, 2015), allows users to create scenarios for a given
location by defining the inputs of the water, the food, and the
Implementation of the SDGs energy portfolios. Users create scenarios and the Tool generates
The Tool allows us to look at the tradeoffs of implementing a the sustainability index for each and quantifies the tradeoffs.
series of interventions. The interconnected SDGs 2, 6, and 7 This index is a measure of how sustainable the scenario is
(zero hunger, clean water and sanitation, affordable and clean based on water, energy, land, environmental footprint and
energy) represent our first attempt to create a consortium considering user preferences. For example, Qatar does not have
promoting the use of Nexus within the SDG community. sufficient land to independently ensure complete food security,
Texas A&M led the effort in collaboration with World so solutions requiring extensive land resources will not rank
Wildlife Fund (WWF), International Union for Conservation high on the sustainability index. The WET Tool (water-energy-
of Nature (IUCN), Swedish Environmental Institute (SEI), transportation) used scenarios related to oil price, natural gas,
The World Bank, International Food Policy Research Institute and lateral drill length. We quantified tradeoff analysis for
(IFPRI), Global Water Partnership (GWP), Deloitte, Asian the scenarios and determined which is most site-specific and
Development Bank (ADB), International Water Management appropriate scenarios (Daher et al., 2019).
Institute (IWMI), and the OCP Policy Center. The take-away The San Antonio case studies focused on Region L of the
lessons showed that improving access to electricity can negatively Texas Water Plan (Mohtar, 2019) and used a system of systems
impact ambient water quality, water availability, and ecosystem approach. Thematic teams (Energy for Water, Water for Food,
health. Ensuring universal access to affordable, reliable, modern and Water for Energy) worked with stakeholders to collect data
energy services means substantially increasing the share of for modeling, governance, financing, and tradeoff analysis. A
renewable energy in the global energy mix, doubling the circular approach that circled some data back to stakeholders
global rate of improvement in energy efficiency, enhancing improved decision making. The goal was to better understand the
international cooperation to facilitate access to clean energy Texas water gap projected over the next 20 years. By focusing on
research and technology (including renewable energy, energy three subregions, each representing a distinct hotspot, we used a
efficiency, and advanced, cleaner fossil-fuel technology, and holistic systems approach to identify ways to bridge the projected
promoting investment in energy infrastructure and clean energy 40% water gap for Texas.
technology). This would be done by expanding infrastructure and We discovered that solutions are different for each zone
upgrading the technology to supply modern, sustainable energy or hotspot. In the Lubbock area, which has a declining water
services for all those living in developing countries, particularly table due to over pumping by farmland, we encouraged dryland
the least developed countries, in accordance with their respective farming: different sources of water and fresh investment in the
programs of support. sector were needed for agriculture. In San Antonio, a growing
First in Morocco, we looked at the analytics of how water, area with high demand for municipal water, solutions included
energy, and food are interconnected in the national plan and then implementation of low impact development solutions, which
identified the associated tradeoffs. Morocco’s green water plan requires investment and could carry potential for both ground
sets targets for introducing income such as increasing production water recharge and urban agriculture. The Eagle Ford shale
of olive, citrus, fruits, and vegetables. The effort to generate region produces a lot of energy and developing shale production
income resulted in reducing cereals production by 20% and increases ground water consumption. One unique aspect of shale
moves from a self-sufficiency model into an economic model for gas production is its very intense consumption of water, in both
agriculture. Morocco’s 2030 water strategy includes desalination space and time. The wells are very localized and require a lot of
and treated wastewater (TWW); its energy strategy includes water at certain peaks, which presents a particular challenge that
increasing renewable energy by up to 42%. After quantifying must be addressed in terms of total quantity of water needed and
the interlinkages, we realized that these three plans compete for in terms of the spatial location and time so as not to coincide
the same resources, mainly those needed for capital resources. with other peak demand times for water, whether for agriculture
Thus, if one looks at food, the tradeoff involves increasing or municipal.
the water-land-energy factor at the expense of food security.
Regarding energy: reduced emissions come at the expense of
finance, land, and water. Increasing the quantity of renewable IMPACT OF WEF NEXUS SOLUTIONS
energy means changing the allocation of land and water from
agricultural production into energy production. Additionally, Three tools can highlight the impact of WEF Nexus solutions.
while water security is improved with added water and TWW, The Water-Energy-Transportation (WET) Tool, designed to
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quantify the relations and tradeoffs between the water, energy, FUTURE OPPORTUNITIES
and transportation sectors for different scenarios, using factors
like increased oil and gas production, market prices, lateral Future opportunities begin with a sustainable business model for
lengths of wells, and input amounts of water. The tool allows us agricultural systems: the current food and agriculture system is
to look at the scenarios and promote the best options as we move not sustainable. While food production has provided real success
forward (Daher et al., 2019; Mohtar et al., 2019). stories in terms of producing enough food globally for the world’s
The Matagorda County Tool shows that annual income could population, some questions have been ignored such as nutritional
increase by as much as $32 million dollars above the current value relative to water and energy use, as well as air quality
“business as usual” scenario, mainly in the agriculture sector that and impact on soil health. In the future, we will not have the
is currently suffering from a lack of water (Kulat et al., 2019). same quantity of water allocated to agriculture, thus, we need a
The Energy Portfolio Assessment Tool (EPAT) allows options different model. One that allows the use of multiple and different
for the energy portfolio and shows that some energy policies sources of water; one that considers the human and ecosystem
can mitigate carbon emissions, even after capacity increase, by values of this water. Here is where the Nexus can contribute.
decreasing water withdrawal volume by almost 10% and, that A second future opportunity lies in the circular food and
CPP technology policy increases water consumption by 5%, land agriculture system. Inputs to such a system include renewable
use by 143%, and cost by 18% (Mroue et al., 2019). water, renewable energy, and nutrients. A circular system would
have reduced carbon emissions, reduced chemical and biological
pollutants, and reduced food wastes and loss. If we look at the
Tradeoffs of Wastewater Reuse in tradeoffs in the outcomes of such a model, keeping in mind the
Agriculture human and ecosystem resource nexus, the choices for a circular
The benefits of wastewater reuse in agriculture are clearly food and agriculture system changes and are site specific. Making
translated into economic growth, coastal and riparian protection, such a transition requires appropriate technologies and policies
reduction of climate variability and risk, and food security (Dare but more importantly behavioral changes.
et al., 2013, 2017). Trade-offs carry some negative aspects: farmer Another future opportunity is the water-food-health nexus,
and consumer perceptions, carbon emissions, treatment and where “one health” is promoted through the interconnections of
conveyance costs, public, and environmental health risks. The water and human health. Drinking water, sewage, seas, and rivers
tradeoffs need to be facilitated through supportive public policy, are considered with their interconnections among water, animals,
good governance, and viable economic models. The potential and food. This includes irrigation water, farm aquaculture, food
of water reuse for agriculture must consider all the principles poisoning, and especially antibiotics and antibiotic resistance. All
identified in a water-energy-food nexus approach and then these lead to a “one-health” system that allows real focus on the
simulate these to begin assessing the different scenarios and human ecosystem and animals in the food supply chain, i.e., the
their tradeoffs. food system as a single unit.
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FUNDING control principles, and that this discipline can go beyond military
applications and be applied to natural and human systems.
The papers referenced in this overview cite specific award And to all those at the American University of Beirut for their
numbers for given projects; nevertheless, the author would inspiration and early career mentorship. I gratefully acknowledge
generally express appreciation for support from the following those who have joined the journey of the last 20 years, from
organizations: Food and Agriculture Organization of the United Purdue University, to Qatar, Texas A&M, and most recently, the
Nations (UN-FAO), National Academy of Sciences, National American University of Beirut. Without their contributions we
Science Foundation, Texas A&M Energy Institute, Texas A&M would not be here today. Likewise, the WEF Nexus Research
Water-Energy-Food (WEF) Resource Nexus Initiative, Texas Team who helped make this happen through their dedicated
A&M University System, and the International Renewable hard work, including Eric Braudeau, Bassel Daher, Amjad
Energy Agency. Assi, Adnan Degirmencioglu, Sandra Yanni, Martin Keulertz,
SangHyun Lee, and the many, many students whose dedicated
ACKNOWLEDGMENTS work over the years produced the results we see. Special thanks
to Mary Schweitzer, the WEF Nexus Research Group program
I gratefully acknowledge Dr. Sharma for spearheading the effort manager for her dedication and tireless effort to support all
of the ACS Symposium, and its organizers: Drs. Daher, Sharma, members of the team over the last 15 years. Mary has been
Laspidou, and Kim. Thank you, Colleagues, for acknowledging editor, administrator, and friend to all of us. She has been the
the work we are doing. Special thanks to my mentors for the glue for the team over all these years. Finally, I offer a special
inspiration that has contributed to my professional journey. acknowledgment to the soul of my mother, for grounding me and
From Michigan State University: Dr. Larry Segerlind, for instilling her values; and to my life partner Samia, whose love,
instilling my love of analytics and systematic thinking, and the support, sharing the joy, tears, and satisfaction of the journey are
late Dr. Thomas Menetsch, for teaching me systems theory, immeasurable.
REFERENCES Hoff, H. (2011). Understanding the Nexus. Background Paper for the Bonn 2011
Conference: The Water, Energy and Food Security Nexus. Stockholm: Stockholm
Bachour, R., Yanni, S., Daher, B., Jaafar, H., Ajour, S., and Mohtar, R. (2020). Environment Institute. Retrieved from https://www.sei.org/publications/
Final Report: Water-Energy-Food-Health Nexus; Case Study: Lebanon. Pilot understanding-the-nexus/ (accessed November, 2021).
Study on Evapotranspiration and Trade-Offs in the Water-Energy-Food Nexus International Renewable Energy Agency (2015). Renewable Energy in the Water,
in the Beqaa valley in Lebanon. Project Number 339628. Food and Agriculture Energy & Food Nexus, eds R. Ferroukhi, D. Nagpal, A. Lopez-Peña, T. Hodges,
Organization of the United Nations (UN FAO) and Faculty of Agricultural and R. H. Mohtar, B. Daher, S. Mohtar, M. Keulertz (Abu Dhabi: International
Food Sciences, American University of Beirut (FAFS-AUB), Beirut, Lebanon. Renewable Energy Agency).
Daher, B., Lee, S., Kaushik, V., Blake, J., Askariyeh, M. H., Shafiezadeh, H., Kulat, M. I., Mohtar, R. H., and Olivera, F. (2019). Holistic water-
et al. (2019). Towards bridging the water gap in Texas: a water-energy-food energy-food nexus for guiding water resources planning: Matagorda
nexus approach. Sci. Total Environ. 647 449–463. doi: 10.1016/j.scitotenv.2018. County, Texas Case. Front. Environ. Sci. 7, 3. doi: 10.3389/fenvs.2019.
07.398 00003
Daher, B., and Mohtar, R. H. (2021). “Water-energy-food sustainable development Lawford, R., and Mohtar, R. H. (2015). TAMUS/Future Earth Water-Energy-Food
goals in morocco,” in Clean Water and Sanitation. Encyclopedia of the UN Nexus Workshop. Washington, DC: TAMUS-Futureearth Research Gaps in
Sustainable Development Goals, eds W. Leal Filho, A. M. Azul, L. Brandli, A. the Integrated Observations and Improved Governance for the W-E-F Nexus
Lange Salvia, T. Wall (Cham: Springer). doi: 10.1007/978-3-319-70061-8_133-1 (ExecSumm). Retrieved from https://wefnexus.tamu.edu/files/2016/02/June-
Daher, B., Mohtar, R. H., Lee, S., and Assi, A. T. (2017). “Modeling the water- 2105-TAMUS-Futureearth-ExecSumm.pdf (accessed November, 2021).
energy-food nexus: a 7-question guideline,” in Water-Energy-Food Nexus: Lee, S. H., Assi, A. T., Daher, B., Mengoub, F. E., and Mohtar, R. H. (2020).
Principles and Practices, Vol. 229, eds P. A. Salam, S. Shrestha, V. P. Pandey, and A Water-Energy-Food Nexus approach for conducting trade-off analysis:
A. K. Anal (John Wiley and Sons, Inc), 57–66. doi: 10.1002/9781119243175.ch6 Morocco’s phosphate industry in the Khouribga region. Hydrol. Earth Syst. Sci.
Daher, B. T., and Mohtar, R. H. (2015). Water–energy–food (WEF) Nexus tool 24, 4727–4741. doi: 10.5194/hess-24-4727-2020
2.0: guiding integrative resource planning and decision-making. Water Int. 40, Mohtar, R. H (2019). Opportunities in the Water-Energy-Food Nexus Approach:
748–771. doi: 10.1080/02508060.2015.1074148 Innovatively Driving Economic Development, Social Wellbeing, and
Dare, A. E., Mohtar, R. H., Boukchina, R., Rabi, A., and Shomar, B. (2013). Environmental Sustainability. Available online at: https://www.sciencedirect.
Limitations of treated wastewater reuse in the Middle East and North com/journal/science-of-the-total-environment/special-issue/10K1703WP3V
Africa: work-in-progress. Am. Soc. Agric. Biol. Eng. 2013, 131618128. (accessed November, 2021).
doi: 10.13031/aim.20131618128 Mohtar, R. H. (2002). Agriculture 102 Lectures. Purdue University (Unpublished).
Dare, A. E., Mohtar, R. H., Jafvert, C. T., Shomar, B., Engel, B., Boukchina, R., et al. Mohtar, R. H. (2011). “An integrated sustainability index for effective water policy,”
(2017). Opportunities and challenges for treated wastewater reuse in the west in Water Security: The Water-Food-Energy-Climate Nexus. World Economic
bank, Tunisia, and Qatar. Trans. ASABE 60, 1563. doi: 10.13031/trans.12109 Forum, Water Initiative, ed D. Waughray (Washington, DC; London: Island
Degirmencioglu, A., Mohtar, R., Daher, B. T., Ozgunaltay-Ertugrul, G., and Press), 271.
Ertugrul, O. (2019) Assessing the sustainability of crop production in the gediz Mohtar, R. H., and Daher, B. (2012). “Water, energy, and food: the ultimate
basin, Turkey: A water, energy, and food nexus approach. Fresenius Environ. nexus,” in Encyclopedia of Agricultural, Food, and Biological Engineering, 2nd
Bull. 28, 2511–2522. Available online at: https://wefnexus.tamu.edu/files/2019/ Edn, eds D. R. Heldman, C. I. Moraru (Abingdon: Taylor & Francis), 1–15.
04/Degirm_etal_GedizBasin.pdf doi: 10.1081/E-EAFE2-120048376
EastWest Institute (2014). Annual Report 2014. EastWest Institute. Retrieved Mohtar, R. H., and Daher, B. (2014). A Platform for Trade-off Analysis and Resource
from https://www.eastwest.ngo/idea/2014-annual-report (accessed November, Allocation: The Water Energy Food Nexus Tool and its Application to Qatar’s
2021). Food Security. London: Chatham House.
Frontiers in Sustainable Food Systems | www.frontiersin.org 6 May 2022 | Volume 6 | Article 820305
Mohtar WEF Nexus Journey
Mohtar, R. H., and Daher, B. (2016). Water-Energy-Food World Economic Forum (2012). Global Risks 2012, Seventh Edition Insight Report.
nexus framework for facilitating multi-stakeholder dialogue. Geneva: World Economic Forum. Retrieved from: https://www3.weforum.org/
Water Int. 41, 655–661. doi: 10.1080/02508060.2016. docs/WEF_GlobalRisks_Report_2012.pdf (accessed November, 2021)
1149759
Mohtar, R. H., Shafiezadeh, H., Blake, J., and Daher, B. (2019). Economic, Conflict of Interest: The author declares that the research was conducted in the
social, and environmental evaluation of energy development in the eagle ford absence of any commercial or financial relationships that could be construed as a
shale play. Sci. Total Environ. 646, 1601–1614. doi: 10.1016/j.scitotenv.2018. potential conflict of interest.
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Mroue, A. M., Mohtar, R. H., Pistikopoulos, E. N., and Holtzapple, Publisher’s Note: All claims expressed in this article are solely those of the authors
M. T. (2019). Energy portfolio assessment tool (EPAT): sustainable and do not necessarily represent those of their affiliated organizations, or those of
energy planning using the WEF nexus approach—Texas case.
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Water Papers. Washington, DC: World Bank. Available online at: https://
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