Laks Bio Project
Laks Bio Project
ACKNOWLEDGEMENT
1
INDEX
3 Types of Allergies 5
4 Environmental Allergies 7
5 Drug Allergies 8
6 Insect Allergies 9
7 Other Allergies 10
8 Pathophysiology of Allergic Reactions 11
9 Immediate Phase 13
10 Role of Mediators 14
11 Common Allergens 16
2
Introduction
3
The Immune System's Role in Allergies
4
Types of Allergies
Food Allergies
Food allergies occur when the immune system mistakenly identifies
certain proteins in food as harmful, leading to an allergic reaction. Some
of the most common food allergens include:
5
Seafood: Shellfish (including shrimp, crab, and lobster) and fish
allergies are common, especially among adults. These allergies can lead
to severe reactions, and individuals may need to avoid all forms of
seafood, including cross contamination with cooking utensils or
equipment.
6
Environmental Allergies
Environmental allergies are triggered by allergens found in the
environment. They can be classified into two categories: seasonal and
perennial allergies.
Seasonal Allergies
Seasonal allergies, also known as hay fever or allergic rhinitis, are often
caused by pollen from trees, grasses, and weeds. These allergens are
prevalent during specific seasons, leading to symptoms such as
sneezing, nasal congestion, itchy eyes, and fatigue. Common pollen
triggers include:
• Tree Pollen: Generally, peaks in spring.
• Grass Pollen: Most common in late spring and early summer.
• Weed Pollen: Common in late summer and fall.
Perennial Allergies
Perennial allergies occur year-round and are often caused by indoor
allergens such as:
• Dust Mites: Microscopic organisms found in bedding, carpets,
and upholstered furniture. Dust mite allergies are prevalent, with
studies indicating that approximately 20 million Americans are
affected.
• Mold: Fungi that thrive in damp environments, both indoors and
outdoors. Mold spores can trigger allergic reactions, particularly
in individuals with asthma.
7
Drug Allergies
8
Insect Allergies
Insect allergies are triggered by stings or bites from specific insects, and
they can result in serious allergic reactions. Common insect allergens
include:
• Bees: Honeybee and bumblebee stings can cause severe allergic
reactions in sensitive individuals, potentially leading to
anaphylaxis. Approximately 2 million Americans are at risk of
life-threatening reactions to insect stings.
• Wasps and Hornets: Stings from wasps and hornets can also
provoke allergic reactions, and individuals allergic to one type of
stinging insect may be allergic to others.
• Fire Ants: In some regions, fire ant stings are particularly
problematic, causing painful reactions and potential anaphylaxis.
Individuals with insect allergies are often advised to carry epinephrine
auto-injectors and wear medical identification to alert others in case of
an emergency
9
Other Allergies
10
Pathophysiology of Allergic Reactions
Mechanisms of Sensitization
Sensitization is the process by which the immune system becomes
overly reactive to a typically harmless substance, known as an allergen.
The sensitization process can be divided into several key steps:
1. Initial Exposure: The individual is first exposed to an allergen,
such as pollen, pet dander, or certain foods. During this exposure,
the allergen is processed by antigen-presenting cells (APCs),
which are primarily dendritic cells.
2. Activation of T-helper Cells: The APCs present the allergen to
naïve T-cells, leading to their differentiation into T-helper (Th) 2
cells. These cells play a critical role in promoting the allergic
response by producing cytokines.
11
3. IgE Production: In response to cytokines produced by Th2 cells,
B-cells are activated and differentiate into plasma cells that
produce Immunoglobulin E (IgE) antibodies specific to the
allergen. This IgE binds to the surface of mast cells and basophils,
sensitizing them to the allergen.
4. Re-exposure: Upon subsequent exposure to the same allergen,
the allergen cross-links the IgE on the surface of mast cells and
basophils, leading to their activation.
12
Immediate Phase
Delayed Phase
The delayed phase occurs several hours after re-exposure and involves
a more sustained response. Key features include:
Recruitment of Inflammatory Cells: The immediate release of
mediators leads to the recruitment of additional inflammatory cells,
including eosinophils, neutrophils, and T-cells to the site of allergen
exposure.
Sustained Symptoms: The delayed phase can result in prolonged
symptoms, such as:
o Prolonged nasal congestion
o Skin rashes
o Asthma exacerbations
13
Role of Mediators
Various mediators play crucial roles in the allergic response. Key
mediators include:
Histamines
Histamines are stored in mast cells and are among the first mediators
released during an allergic reaction. They cause:
• Vasodilation: Increased blood flow to the area leads to redness
and warmth.
• Increased Vascular Permeability: This causes fluid leakage,
resulting in swelling and enema.
• Smooth Muscle Contraction: Histamines can lead to
bronchoconstriction, causing difficulty breathing in individuals
with asthma.
Leukotrienes
Leukotrienes are lipid mediators produced by mast cells, eosinophils,
and other immune cells. They contribute to:
• Bronchoconstriction: Similar to histamines, leukotrienes can
cause constriction of airway smooth muscles.
• Increased Mucus Production: They promote mucus secretion,
leading to airway obstruction.
• Recruitment of Inflammatory Cells: Leukotrienes attract
eosinophils and other inflammatory cells to the site of allergen
exposure.
Cytokines
Cytokines are signalling proteins produced by immune cells that play
diverse roles in the immune response. In allergies, Th2 cytokines, such
as IL-4, IL-5, and IL-13, are particularly important:
14
• IL-4: Promotes B-cell class switching to produce IgE antibodies.
• IL-5: Stimulates the growth and activation of eosinophils, which
are involved in chronic allergic inflammation.
• IL-13: Contributes to mucus production and airway
Anaphylaxis
Anaphylaxis is a severe, life-threatening allergic reaction that occurs
rapidly and requires immediate medical attention. Key points include:
Causes
Anaphylaxis can be triggered by various allergens, including:
• Foods (e.g., peanuts, tree nuts, shellfish)
• Medications (e.g., penicillin, nonsteroidal anti-inflammatory
drugs)
• Insect stings (e.g., bees, wasps)
• Latex exposure
Symptoms
Symptoms of anaphylaxis can occur within minutes and may include:
• Skin reactions (hives, swelling)
• Respiratory issues (shortness of breath, wheezing)
• Cardiovascular symptoms (rapid heartbeat, low blood pressure)
• Gastrointestinal symptoms (nausea, vomiting)
15
Common Allergens
Food Allergens
Food allergies are immune responses to specific proteins found in certain
foods. The major food allergens, often referred to as the "big eight,"
include:
1. Peanuts
• Source: Peanuts are legumes that grow underground. They are
commonly found in snacks, candies, and sauces.
• Allergic Reactions: Reactions can range from mild symptoms,
such as hives and swelling, to severe anaphylaxis.
2. Tree Nuts
• Source: Common tree nuts include almonds, walnuts, hazelnuts,
cashews, pistachios, and Brazil nuts. They are often found in
baked goods, granola bars, and trail mixes.
• Allergic Reactions: Similar to peanut allergies, reactions can be
severe, with symptoms like difficulty breathing and anaphylaxis.
3. Milk
• Source: Cow's milk is the primary allergenic source, commonly
found in dairy products such as cheese, yogurt, and butter.
16
4. Eggs
• Source: Eggs, particularly egg whites, are found in many baked
goods, dressings, and may be present in vaccines.
• Allergic Reactions: Reactions may manifest as skin rashes,
respiratory problems, or gastrointestinal symptoms.
5. Wheat
• Source: Wheat is a common ingredient in bread, pasta, and many
processed foods.
• Allergic Reactions: Symptoms can include hives, asthma, and
anaphylaxis, although many people may have gluten intolerance
or celiac disease, which are different from wheat allergies.
6. Soy
• Source: Soybeans are found in various forms, including tofu, soy
milk, and as an ingredient in processed foods.
• Allergic Reactions: Symptoms can range from mild to severe,
similar to other food allergies.
7. Fish
• Source: Common fish allergens include salmon, tuna, and cod.
Fish is often found in seafood dishes and fish sauces.
• Allergic Reactions: Fish allergies can cause severe reactions,
often leading to anaphylaxis.
8. Shellfish
• Source: Shellfish include crustaceans (e.g., shrimp, crab) and
molluscs (e.g., clams, oysters). They are prevalent in seafood
cuisine.
• Allergic Reactions: Shellfish allergies are often severe and can
trigger anaphylaxis.
17
Environmental Allergens
Environmental allergens are substances in the environment that can
trigger allergic reactions. They can be categorized into pollen and indoor
allergens.
Pollen Allergens
Pollen is a common environmental allergen, particularly during specific
seasons.
1. Tree Pollen: Trees such as oak, cedar, and birch release pollen in
the spring. Symptoms include sneezing, itchy eyes, and nasal
congestion.
2. Grass Pollen: Grass pollen is prevalent in late spring and early
summer. Common grasses include Bermuda, Timothy, and
Kentucky bluegrass.
3. Weed Pollen: Weeds like ragweed, sagebrush, and pigweed
release pollen in late summer and fall, causing similar allergic
symptoms.
Chemical Allergens
18
Chemical allergens are substances commonly found in household
products that can provoke allergic reactions. Key examples include:
1. Fragrances: Many personal care products, air fresheners, and
cleaning products contain fragrances that can trigger allergic
reactions and asthma symptoms.
2. Preservatives: Some preservatives used in food and cosmetics
(e.g., sulphites, parabens) can cause allergic reactions in sensitive
individuals.
3. Latex: Natural rubber latex, found in gloves, balloons, and some
medical devices, can cause allergic reactions ranging from mild
skin irritation to anaphylaxis.
4. Household Cleaners: Chemicals in cleaning products (e.g.,
bleach, ammonia) can cause skin irritation, respiratory problems,
and allergic reactions in some individuals.
19
Summary of common symptoms
Examples of
Category Common Symptoms
Allergens
20
Symptom Overview
Allergic reactions can lead to a wide range of symptoms that can be
categorized into three main types: respiratory, skin, and
gastrointestinal.
1. Respiratory Symptoms
Respiratory symptoms are among the most common manifestations of
allergies, particularly in cases of allergic rhinitis and asthma. Key
symptoms include:
• Sneezing: A reflex action to clear irritants from the nasal
passages.
• Nasal Congestion: Swelling of nasal passages, leading to
difficulty breathing through the nose.
• Runny Nose (Rhinorrhoea): Increased mucus production that
can lead to a clear or coloured nasal discharge.
• Itchy Eyes (Allergic Conjunctivitis): Irritation of the eyes,
often accompanied by redness and tearing.
• Coughing: A reflex to clear airways, often caused by post-nasal
drip or asthma.
• Wheezing and Shortness of Breath: Common in asthma, these
symptoms result from airway constriction.
2. Skin Symptoms
Skin-related allergic reactions can vary in severity and presentation.
Common skin symptoms include:
• Hives (Urticaria): Raised, itchy welts that can appear anywhere
on the body, often triggered by food allergies or insect stings.
• Eczema (Atopic Dermatitis): A chronic skin condition
characterized by dry, itchy, and inflamed skin, often exacerbated
by environmental allergens.
21
• Angioedema: Swelling beneath the skin, often around the eyes
and lips, that can occur with hives.
3. Gastrointestinal Symptoms
Gastrointestinal symptoms are particularly relevant in cases of food
allergies. Key symptoms include:
• Nausea and Vomiting: Common reactions to food allergens,
which can occur shortly after ingestion.
• Diarrheal: Frequent, watery stools can result from food
allergies.
• Abdominal Pain or Cramping: Discomfort that can accompany
nausea or diarrhoea.
Understanding these symptoms helps individuals identify potential
allergic reactions and seek appropriate medical attention.
22
Diagnostic Methods
Accurate diagnosis of allergies is essential for effective treatment.
Several diagnostic methods are commonly used:
1. Skin Prick Tests
• Procedure: A small amount of allergen extract is applied to the
skin (usually the forearm or back) using a prick or scratch. If the
person is allergic, a raised, red bump (wheal) will develop at the
site within 15-20 minutes.
• Uses: Skin prick tests are commonly used to diagnose allergies
to pollen, pet dander, dust mites, and certain foods.
• Advantages: This test is quick, relatively inexpensive, and
provides immediate results.
2. Blood Tests (IgE Levels)
• Procedure: A blood sample is taken and analysed for specific
IgE antibodies to various allergens. Elevated levels of IgE
specific to a particular allergen indicate sensitization.
• Uses: Blood tests are useful when skin testing is not feasible
(e.g., in cases of severe eczema, or when a person is taking
antihistamines).
• Advantages: They provide a more comprehensive view of
allergen sensitivities and can measure IgE levels quantitatively.
3. Patch Tests
• Procedure: Allergen substances are applied to patches that are
placed on the skin (usually on the back) for 48 hours. The skin is
then examined for reactions.
• Uses: Patch tests are primarily used to diagnose contact
dermatitis, a delayed allergic reaction to substances such as
nickel, fragrances, and preservatives.
• Advantages: This test helps identify specific allergens causing
skin reactions.
23
Challenges in Diagnosis
24
Management and Treatment
25
• Topical Corticosteroids: Hydrocortisone cream can relieve
localized skin symptoms, such as hives or eczema.
• Oral Corticosteroids: Prednisone may be prescribed for severe
allergic reactions or exacerbations, but long-term use is
generally avoided due to potential side effects.
3. Bronchodilators
Bronchodilators are primarily used for asthma management and can
help relieve wheezing and shortness of breath associated with allergic
reactions.
• Short-acting Beta-Agonists (SABAs): Ibuterol (Proventil) is a
commonly used inhaler that provides quick relief during an
asthma attack.
• Long-acting Beta-Agonists (LABAs): Medications like
salmeterol (Serevent) may be used for long-term asthma control
but are not effective for immediate relief.
26
Lifestyle Modifications
27
Avoidance Techniques
28
preparation methods. It’s advisable to choose restaurants
known for accommodating allergies.
• Seasonal Allergies: Individuals should monitor pollen counts
through local weather reports. On high pollen days, it’s best to
stay indoors, keep windows closed, and use air conditioning to
filter indoor air.
o Indoor Allergens: Regular cleaning can help minimize
dust mites, Mold, and pet dander. Using HEPA filters in
vacuum cleaners and air purifiers can effectively reduce
airborne allergens. Washing bedding and curtains in hot
water frequently can also help eliminate dust mites.
• Chemical Allergens:
o Product Selection: For those allergic to certain
chemicals, selecting hypoallergenic and fragrance-free
products can minimize exposure. It’s essential to check
labels on personal care items and household cleaners for
potential allergens.
o Ventilation: Proper ventilation during the use of
household cleaners and chemicals can help reduce
inhalation of airborne irritants.
29
Education and Awareness
30
Public Health Initiatives
31
Final Thoughts
32
BIBLIOGRAPHY
• https://www.niaid.nih.gov
• https://www.mayoclinic.org
• https://e-aair.org
• NCERT Books Class 12
33