NUMS BLOCK ONE IMPORTANT GUIDLINE

MATCH THE MARKING WITH BLUE PRINT TO MASTER YOUR FIRST

PROFF WITH GOOD MARKS
QUESTIONS MENTIONED WITH VERY IMPORTANT ARE THE MOST
IMPORTANT QUESTIONS THERE IS NO CHOICE TO LEFT THIS THIS
ARE ASK IN VIVA MCQ SEQ IN EVERY EXAM
BOOK TO BE USED FOR GROSS IS SNELL BUT IF YOU WAN GOOD
MARKS USE KLM FOR CLINICAL ALONG WITH SNELL
1.Shoulder joint stability and movement around the shoulder joint along with
dislocation, rotator cuff muscles with rotator cuff tiredness sometime they give
with axillary nerve injury. Vvv important U.Q
Brachial plexus complete very important for mcq and
2. Clavipectoral Fassi and Structure pierce by it.
3. Lymphatic drainage of breast along with breast carcinoma. Vvvv important
U.Q
4. Axilla content and boundaries
5. Axillary artery relation and branches
6. Anastomosis around scapula and elbow joint
7. Brachial artery with branches
8. Cubidol fossa
9. Radial nerve with wrist drop case Vvv important U.SEQ
10. Median nerve with ape like hand case Vvv important U. SEQ
11. Ulnar with claw hand case Vvv important U. SEQ.
12. Anatomical snuffbox with Radial artery damage case
13. Muscle of anterior compartment of forearm
14. Supination and pronation Vvv important U. SEQ.
15. Palmar arches’ important U. SEQ.

Histology FROM YOUR COLLEGE journal

1.Classification of epithelium
2. Draw the stratified squamous epithelium and transnational epithelium or
any of the squamous epithelium can come for drawing.
3. Classification of glands on the basis of mode and type of secretion and
shape.
4. Tabulate lymphoid organ like spleen, thymus, lymph nodes along with there
diagram important U. SEQ
5. Classification of connective tissue.
10. Tabulate the three types of muscle
11. Differentiate between collagen and elastin
12. Differentiate between elastic cartilage and elastic connective tissue
13. Functions of connective tissue cells
13. Basal apical and lateral domain of epithelium Vvv important U. SEQ.
14. Ulter structure of Cilla flagella and micro-Cilla.
Embryology USE ONLY LANGMAN
Down syndrome.
Turners’ syndrome.
Chromosomes segregation.
Mitosis and meiosis.
Fertilization phase with polyspermy. Vvv important U. SEQ
Spermatogenesis and oogenesis.
Female reproductive cycle (Mcq).
Cleavage.
Summary of 1st week(mcq).
Implantation of blastocyst with clinical for mcq and seq.
Placenta previa.
Why 2nd week is called week of two. Vvv important U. SEQ
Gastrulation with sacrococcygeal teratomas and caudal dysgenesis important
U. SEQ
Development of notochord.
Neurulation and neural crest derivates with neural tube defective important U.
SEQ.
Development of somites and intraembryonic coelom.
Germ layer derivates.

FOR ORDERING OUR CHAPTER WISE MCQ BOOK SCAN THE QR CODE
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 Paper-I (Anatomy)
BLUEPRINT, YEAR I-BLOCK I (Y2 BIV) 2025 (THEORY)
(MCQs + SAQs/ SEQs)

MCQs SEQs
Topic Learning Outcomes (IxF) Category Weightage
(Marks=28) (Marks=12)
Cell Structure and Function
General Anatomy  Demonstrate the anatomical
position

 Name various planes of the Good To 2/2812=

body 21 1
Know 0.85

 Define the terms of position,

movement, and laterality
General Histology  List various cell organelles
 Cell along with their functions
 Epithelial  Explain the structure and
tissue
functions of various
components of cytoskeleton
 Classify epithelium with
examples of each type
 Classify Glands with
examples.
 Define polarity
 List the structural 1
modifications of apical,
lateral and basal domains of
the cell. Must
23 2.5 2
 Classify the apical Know
modifications according to
motility
 Name the component of
cytoskeleton contributing in
each apical modification
 Define metaplasia and
correlate it with its clinical
importance.
 Classify various types of cell
junctions according to
functions, providing
examples of each.

General  Explain the sequence of Must

32 2.5 2
Embryology events of mitosis and meiosis Know

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Gametogenesis with the help of illustrations
and models.
 Elucidate the morphological
changes in male and female
gametes during their
maturation
 Define the following terms in
relation to spermatogenesis
and oogenesis: Haploid,
Diploid , Euploid

Chromosomal Aberrations:
 List numerical and structural
chromosomal disorders,
Aneuploid, Triploid,
Polyploid, Nondisjunction,
Monosomy,
 Trisomy, Mosaicism,
Translocation
 Explain the embryological
basis and clinical
presentation of following
syndromes: Down’s,
Kleinfelter, Turner,
Angelman, Pradar Willi, Cri
du chat
Ovulation,
Fertilization,  Correlate the menstrual and
development 1st ovarian cycles with each other
week,  Describe the process of
ovulation
 Define corpus luteum and
corpus albicans
 Define fertilization.
 Describe and illustrate the
steps, and outcomes of
fertilization
 Describe the basic principles 32
Must
2.5 2
behind various techniques of Know
Second week of in vitro fertilization
Development  Describe the process of
implantation.
 List the sites of abnormal
implantation and describe
their clinical significance.
 Define cleavage, morula,
blastula
 Define Gastrulation

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  Describe the formation of
notochord and the
Third week establishment of body axes.
development  Recognize the embryological
basis of sacrococcygeal
teratoma,
Holoprosencephaly, caudal
dysgenesis, Situs inversus
General Histology Connective tissues
Connective
 List the components of 22
Good To
1.7 2
tissue connective tissue. Know
 List various CT cells and fibers
 Classify connective tissue
 Describe the characteristic
features of each type
 Explain the role of fibroblasts
in wound contraction
 Elucidate the role of
macrophages in defense

Lymphoid Tissues
Must
 Correlate the microstructure 33 3.8 3
Know
of lymphoid organs with their
functions and dysfunctions
 Identify the histological
features of lymphoid organs
under light microscope
 Describe the light
microscopic features of
lymph node, thymus, spleen,
palatine tonsil on slides
Block I
Module III
Musculoskeletal System – I (MSK – I)
Topic Learning Outcomes (IxF) Category Weightage MCQs
GENERAL  Comprehend general
ANATOMY concept of structure of skin,
fascia, bones, muscles and
joints
 Skin, fascia,
 Describe the organization of
bones,
nervous system. Nice to
muscles and 12 1.1 1
joints  Enumerate components of know
central and peripheral
nervous system & describe
their general features
 Describe the origin, course,
and distribution of a typical

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 spinal nerve with the help of
a diagram.
 Define: Dermatomes,
Receptors, and effectors

Histology of  Describe the light

microscopic characteristics
Muscular tissue of skeletal, cardiac, and Good to
smooth muscles 22 know 2.2 2
 Tabulate the microscopic
differences between three
types of muscles
Gross Anatomy Determine the side of clavicle, Nice to
21 1.1
 Bones of scapula, humerus, radius ulna Know 1
upper limb  Identify important bony
landmarks on these bones
 Locate attachments of major
muscles and ligaments
attached on these bones
 Discuss the clinical
implications in fractures of
these bones at different sites
 Comprehend the structure of
breast tissue
 Justify the importance of
fibrous septa in breast in
relation to its carcinoma
 Describe the blood supply
and lymphatic drainage of
breast
 Justify the clinical
Must
Pectoral region importance of sentinel lymph 3 3 5.1
Know
node
 Trace the possible routes of
metastasis of breast cancer
5
 Tabulate the attachments,
nerve supply and actions of
muscles attaching upper limb
to thoracic wall.
 Describe attachments of
pectoral fascia
Scapular region
Tabulate the attachments, nerve
supply and actions of muscles
attaching upper limb to Must
33 9 2
vertebral column Know
 Tabulate the attachments,
nerve supply and actions of

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 muscles attaching scapula to
the humerus
 Identify the boundaries and
contents of quadrangular
and triangular spaces
 Trace the route and
anatomical relationships of
arteries and nerves present
in this region
 Describe the structure of
acromioclavicular and
sternoclavicular joints
 Justify the stability of
clavicular joints in case of
direct blow to clavicle and
resultant fracture
 Describe type, ligaments,
articular surfaces, blood
supply and nerve supply of
shoulder joint
 Elucidate the movements at
shoulder joint with reference
to axis and muscles
producing them
 Justify the clinical
presentation of shoulder
joint dislocation on
anatomical basis
 Justify the stability of the
shoulder joint in spite of wide
range of movements it offers
by describing the factors
responsible
 Define rotators cuff and list
its components
 Justify the clinical
presentation of rotator cuff
injuries, frozen shoulder and
calcific supraspinatus
tendinitis based on the
anatomical knowledge
 Illustrate the anastomosis
around shoulder
joint/scapula
 Appraise the shape and 33 Must 9
Know
Axilla extent of axilla
 Enumerate different
structures forming various

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 walls of axilla and identify
their inter-relationship
 Enumerate different
contents of axilla
 Describe the relations and
distribution of vessels of
axilla
 Describe the formation and
name the branches of
brachial plexus
 Illustrate the brachial plexus
 Elucidate the drainage area
of each group of axillary
lymph nodes
 Analyze the anatomical basis
of clinical presentation in
case of injury to long thoracic
nerve
Tabulate the attachments, nerve
supply and actions of muscles of
arm and forearm
 Trace the route and relations 23
3
of the neurovascular Must
3.4
structures of arm and Know
forearm
 Analyze the anatomical basis
of clinical presentation in
case of injury to various
nerves of arm and forearm
 Describe the type, capsule
and ligaments of elbow,
superior and inferior radio-
Arm & Forearm
ulnar joints
 Explain the movements of
these joints with reference to
axis and muscles performing
these movements
 Describe the blood supply
and nerve supply of elbow
joint
 Justify the anatomical basis
of carrying angle
 Correlate the anatomy of
these joints with clinical
presentations of their
dislocation

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  Outline the boundaries and
contents of cubital fossa in a
sequential order
 Justify the clinical
importance of blood vessels
present in cubital fossa
 Recognize the boundaries of
anatomical snuff box and
bony landmarks in its floor
 Describe the attachments of,
and structures passing deep
to flexor and extensor
retinacula in a sequential
order
 Elucidate the anatomical
basis of clinical presentation
of compartment syndrome of
forearm, Volkmann’s
ischemic contracture,
rupture of various tendons
and tennis elbow.
 Highlight the clinical
significance of radial artery
with reference to pulse and
BP monitoring and coronary
angiography

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  Explain the clinical
significance of injury to
scaphoid and hamate
Hand  Elucidate the salient features
of skin of palm and dorsum
of hand and discuss its
cutaneous innervation
 Describe palmar aponeurosis
 Enumerate the small
muscles of hand with their
actions and nerve supply
 Describe the fibrous and
synovial flexor sheaths of
the hand
 Explain the carpal tunnel
with reference to its
formation and contents
 Analyze the anatomical basis
of Dupuytren’s contracture,
carpal tunnel syndrome, Good To
22 2.2
trigger finger and Know
tenosynovitis of synovial
sheaths of flexor tendons
 Describe boundaries &
2
contents of spaces of palm
 Analyze the anatomical basis
of palmar, Parona and pulp
spaces in case of wound,
resultant infections, and
route of surgical drainage.
 Revisit the insertion of long
flexor and extensor tendons
 Describe the blood supply of
hand
 Trace the pathway and
distribution of radial,
median, and ulnar nerves in
hand and correlate with
clinical presentation of their
injuries
Wrist Joint Describe the type, capsule, and
ligaments of wrist joint
 Explain the movements of
wrist joint with reference to Nice to
11 0.5
axis and muscles responsible Know
 Describe the blood supply
and nerve supply of wrist
joint

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  Correlate the anatomical
knowledge with clinical
presentation of wrist joint
dislocation
 Enumerate the structures
endangered in case of fall on
outstretched hand
Cutaneous Cutaneous innervation of upper 22 Good to 2.2
innervation of limb Know
upper limb  Correlate the dermatomes
with the cutaneous
innervation of specific
nerves in
Arm & forearm
 Illustrate cutaneous
innervation and dermatomes
of upper limb
 Identify the area of sensory
loss in case of injury to
different nerves
Injuries to brachial plexus and 22 Good to 2.2
its branches Know
Injuries to brachial
plexus and its
 Revisit the formation and
branches branches of brachial plexus
 Identify the points of injury
and justify peculiar positions
of upper limb in cases of 2
Klumpke paralysis & Erb-
Duchenne palsy with
anatomical reasoning
 Identify the anatomical sites
where different branches of
brachial plexus are
vulnerable to injury /
compression
 Correlate the lesion of
following nerves with
respective areas of sensory
and motor loss and peculiar
positions of different parts of
upper limb:
 Axillary, Long thoracic,
Musculocutaneous, Ulnar,
Median, Radial
Venous and Venous and lymphatic drainage 11 Nice to 0.5
lymphatic of upper limb Know
drainage of upper  Recap the veins in various
limb
parts to describe the venous

MBBS Curriculum Year-I (Version-IV) (2025) Page | 121

 drainage of upper limb as a
whole
 Identify the veins commonly
used for cannulation
 Discuss the lymphatic
drainage of upper limb in
detail in correlation with
infection and malignant
spread
TOTAL 28 3

MBBS Curriculum Year-I (Version-IV) (2025) Page | 122

physiology USE ONLY GUYTON AND SOME FLOW CHART
SHAREWOOD
peroxisomes and lysosome difference.
Difference between negative and positive feedback.
Fluid mosaic model.
glycocalyx function.
Active and passive transport with example or carrier mediated transport Viv
important U. SEQ.
Feedback principle and gain formula.
Rest membrane potential and Action potential Vvv important U. SEQ.
NA+ and K+ pumps.
Difference between apoptosis and necrosis Vvv important U. SEQ.
Extrinsic and intrinsic pathway Vvv important U. SEQ.
Thrombocytopenia. pathophysiology Vvv important U. SEQ.
Haemophilia pathophysiology Vvv important U. SEQ.
Types of helper t cell Vvv important U. SEQ.
Cytotoxic t cell.
Anticoagulant Vvv important U. SEQ.
Hormonal and cell mediated immunities.
Type of anemia and its pathophysiology Vvv important U. SEQ.
Blood group typing.
erythroblastosis fetalis Vvv important U. SEQ.
Rh blood group.
Platelets plug formation.
Action of antibodies direct and indirect action.
Allo and iso and other grafts.
Clotting Factors and role of vitamin k in it.
 Paper-I (Physiology)
BLUEPRINT, YEAR I-BLOCK I (YI BI) 2025 THEORY
(MCQs + SAQs/ SEQs)
Total MCQs SEQs
Topic Learning Outcomes (I x F) Category
Weight (Marks=28) (Marks=12)
Cell Structure and Functions
Homeostasis,  Appreciate the role of homeostatic
Cell Organelle, feedback mechanisms in maintaining
the functional organization of the
Cytoskeleton Human Body and Control of the Must
and cell "Internal Environment" 3x2 1.05 1
Know
locomotion  Relate the structure of cell and its
various components to metabolic
processes and locomotion
Genetic  Comprehend Genetic control of cell
Control of cell functions and cell division
 Compare and contrast apoptosis &
function Good to
necrosis 2x2 0.7 1
 Explain the pathophysiology of cancer
Know
and aging (General disorders),
polycystic kidney disease.
Cell  Describe the composition of a human
membrane cell membrane
and transport  Differentiate the different type of Must
transport mechanism across the cell 3x2 1.05 1
of substances Know
membrane for the movement of
through cell micro & macromolecules.
membrane 02
Active  Differentiate the different type
Transport of of active transport mechanism
substances across the cell membrane with Must
3x2 1.05 1
through example of each mechanism. Know
membranes
Composition  Describe the cellular and fluid
& Functions of composition and general
Good to
blood functions of blood. 2x2 0.7 1
Know
 Describe the genesis of blood
cells.
Erythropoiesis  Describe the Morphology and
in bone Genesis of Red Blood Cells
marrow  Identify the factors in regulation
Must
of erythropoiesis and 3x3 1.58 2
Know
maturation of RBC with relative
importance of hypoxia in
inducing erythropoiesis.

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Anemia &  Classify anemia based on their
Polycythemia morphological findings, RBC
indices & etiology.
 Classify polycythemia into
primary and secondary Must
3x3 1.58 1
polycythemia and discuss its Know
effects on circulatory system
 Explain the effect of anemia and
polycythemia on circulatory
system.
WBCs  Enlist different types of white
Leukocytosis / blood cells and discuss their
Leucopenia physiological characteristics.
Must
 Describe the role and functions 3x2 1.05 1
Know
of white blood cells in providing
protection to the body against
invading organism.
Inflammation  Discuss causes, cellular features
and Innate and five cardinal signs of
immunity + inflammation.
complement  Define innate immunity. Discuss
Must
system the mechanisms involved in 3x3 1.58 1
Know
innate immunity.
 Appraise the composition and
functions of reticulo-
endothelial system.
Acquired  Concept of T & B lymphocytes
Immunity Active & passive immunity
 Discuss the mechanisms
through which antibodies
Must
directly attack an invading 3x3 1.58
Know
agent.
 Explain role of helper T cells,
cytotoxic T cells and suppressor
T cells in T cells immunity. 2
Autoimmunity  Define autoimmunity. Discuss
& Transplant the pathophysiological process
rejection involved in development of
autoimmunity Good to
2x2 0.7
 Discuss the pathophysiological Know
process involved in transplant
rejection of tissues by human
body.

MBBS Curriculum Year-I (Version-IV) (2025) Page | 124

  Discuss the mechanisms
involved in immune tolerance.
Allergy /  Explain different types of
Hypersensitivi allergies.
Must
ty  Discuss the mechanism 2x3 1.05 1
Know
involved in development of an
allergy & hypersensitivity.
Blood groups  Describe the principles of blood
grouping and cross matching.
Must
 Tabulate the genotype & 3x2 1.05 1
Know
phenotypes of ABO blood group
system.
Rh blood  Comprehend different Rh blood
group system group systems and their
significance Must
2x3 1.05 1
 Discuss the pathophysiology of Know
Erythroblastosis Fetalis, its
treatment and precautions.
Hemostasis  Discuss the four steps involved
in blood coagulation.
 Coagulation pathway
 Comprehend the physiology of
Must
clotting factors and mechanism 3x3 1.58 2
Know
of blood clotting.
 Compare & contrast intrinsic
and extrinsic pathway of
clotting.
Bleeding  Discuss the effect of deficiency
disorder of platelets and clotting factors
in hemostasis.
 Discuss the pathophysiology of
blood dyscrasias like Vitamin K
deficiency, Hemophilia and
Thrombocytopenia Must
3x3 1.58 2
 Compare & contrast Know
Hemophilia with
Thrombocytopenia.
 Correlate deficiencies of
clotting factors VIII & IX with its
varied clinical manifestations
(Hemophilia)
MSK - 1

MBBS Curriculum Year-I (Version-IV) (2025) Page | 125

Neuron &  Review the physiological
Synapse structure and working of
neuron and synapse Must
3x3 1.58 2
 Elucidate structural and Know
functional changes taking place
in nerve fibers after injury.
RMP- Resting  Explain the ionic and
Membrane mechanical mechanisms of
Potential generation of resting
membrane potential in
excitable tissue (nerves & Good to
2x2 0.7 1
muscle). Know
 Explain how the abnormal
function of ion channels
(channelopathies) can alter the
resting membrane potential
Action  Explain different phases of
Potential action potential and ionic &
electrical changes occurring
during each phase of action
potential
 Differentiate between absolute 01
Must
and relative refractory periods 3x2 1.05 1
Know
 Understand the concept of all or
nothing principle in
propagation of an action
potential
 Explain the concept of saltatory
conduction
Neuromuscula  Illustrate neuromuscular
r Junction junction, sequence of events
taking place during
neuromuscular transmission Must
2x3 1.05 1
and factors affecting this Know
process
 Explain pathophysiology of
myasthenia gravis.
Skeletal  Illustrate the physiologic
muscle anatomy of skeletal muscle
morphology  Tabulate macroscopic, Nice to
2x1 0.35 1
microscopic, functional Know
differences of various types of
muscles

MBBS Curriculum Year-I (Version-IV) (2025) Page | 126

Skeletal  Discuss the morphology and
muscle physiological processes of the
contraction skeletal muscle contraction.
and relaxation  List the steps in excitation-
contraction coupling in skeletal
Good to
muscle 2x2 0.7
Know
 Appreciate the characteristics
and differences between
isometric and isotonic
contraction with the help of
examples.
Properties of Explain the motor unit and its
muscle physiological importance. Explain
contraction the concept of:
 Summation
 Treppe Must
3x3 1.58 1
 Skeletal muscle tone Know
 Muscle fatigue
 Tetanization
 Contracture remainder
 Muscle dystrophy
Muscle  Enlist types of muscle
remodeling + remodeling
Rigor mortis  Summarize the effects of
hypertrophy, hyperplasia & Good to
2x2 0.7 1
atrophy on the skeletal muscle Know
structure and function
 Explain the physiological basis
of rigor mortis
Smooth  Correlate characteristics of
muscle smooth muscle contraction Must
2x3 1.05
morphology & with their physiological Know
characteristics functions
Smooth  Illustrate the sequence of
muscle events leading to smooth 1
contraction muscle contraction and
Nice to
and relaxation relaxation. 2x1 0.35
Know
 Give an account on the
physiological anatomy of
smooth muscle NMJ
TOTAL 28 3

MBBS Curriculum Year-I (Version-IV) (2025) Page | 127

BIOCHEMISTRY TOPICS USE Lippincott and satyanarayana
If there would be issues in finding figure let me know
Oxidative step in HMP shunt pathway.
Gluconeogenesis.
G6PD deficiency.
How G6PD is synthesis in RBC.
Glycogen synthesis and degradation and how it's regulated.
Glycogen storage disease.
lactose intolerance.
Glycolysis Regulation.
Anaerobic glycolysis.
Fate of pyruvate.
TCA Regulation.
Glucose transporters.
2nd Messager system.
PDH deficiency.
TCA enzymes.
3 irreversible steps of gluconeogenesis.
Glycogen synthesis figure 11.5 and 11.8 v imp. Hormonal regulations of
glycogen synthesis.
Glycogen storage diseases.
Fructose metabolism 12.2 and fig12.3.
Sources of NADPH. Cytochrome 450 systems.
Synthesis and functions of NO.
Hurlers and hunter's syndrome fig 14.2.
GAGS 14. 4.
Figure 3.4 and figure 3.5 difference is important.
Significance of sigmoidal dissociation curve.
Effect of 2,3 BPG.
3.11 v.v.v important.
Hemoglobinopathies is very important for scenario base questions.
Enzyme chapter is very important expect mechanism of enzyme action may
face confirm seq from here in any of your exam.
Immunoglobulin structure.
Cell Membrane structures.
Heme synthesis and heme degradation.
Different type of jaundice.
Figure 21. 8 read for mcq.
Figure 6.8.
Chemiosmotic hypothesis with 6.13.
Figure 6.17 in best way.
 Paper-I (Biochemistry)
BLUEPRINT CELL STRUCTURE & FUNCTION (MODULE II) + MSK-I (MODULE III)
YEAR I-BLOCK I 2025 THEORY
(MCQs + SAQs/SEQs)
Total MCQs 3 x SEQs
Learning Outcomes (I x F) Category (Marks=28) (Marks=12)
Weight
CELL STRUCTURE & FUNCTION
 Identify the basic elements of 1
biochemistry and the significance of
the Human Genome Project
 List various biomolecules and their 3×1=3 GK 0.04
roles in cellular function
 Identify methods for separating
biomolecules
Explain the fluid mosaic model, detailing 1
the biochemical composition and
functions of cell membrane components, 3×2=6 MK 0.09
and identify various cell biomarkers
relevant to cellular structure and function
Compare the biochemical significance of
different types of membranes and analyze
the biochemical composition and 3×3=9 MK 0.14
functions of various cell organelles in 2
maintaining cellular processes
Apply biochemical functions of cellular
2
biomarkers in clinical context
2×1=2 NK 0.03
Correlate associated disorders of various
cell organelles
Explain the chemistry and signaling
mechanisms of cell surface and
intracellular receptors, and compare the
biochemical bases of various membrane 3×3=9 MK 0.14
transport mechanisms, as well as
receptor-mediated endocytosis and ATP- 2
sensitive K+ channels
Elaborate the role of signal transduction in
health and disease
2×1=2 NK 0.03
Elaborate the role of membrane transport
mechanisms in health and disease
Explain enzyme classification,
mechanisms, components, kinetics, 1
3×2=6 MK 0.09
regulation, and inhibition with their
biomedical significance

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Explain the biochemical role of
isoenzymes in clinical enzymology and
2×1=2 NK 0.03
their significance in disease diagnosis and
treatment 1
Summarize the roles of minerals as
cofactors and vitamins (B1, B2, B3, B6,
2×2=4 GK 0.06
biotin, and pantothenic acid) as
coenzymes in biochemical processes
Give a brief account of chemistry of
2×1=2 NK 0.03
Porphyrins
Discuss the biochemical aspects of
1
porphyrias, hyperbilirubinemia, and
jaundice, and provide an overview of the 2×2=4 GK 0.06
roles of iron, vitamins B9, B12, C, and K in
nutritional anemia and bleeding disorders
Explain the process of heme biosynthesis, 1
its degradation into bile pigments, and
analyze the types, transport, and excretion 3×2=6 MK 0.09
of bile pigments in biochemical and clinical
contexts
Describe the structure, classification, and 1
biochemical functions of Plasma proteins 3×2=6 MK 0.09
& Immunoglobulins
Describe the clinical disorders associated
with Plasma Proteins and 2×1=2 NK 0.03
Immunoglobulins
MSK I
Discuss the structure and functions of
monosaccharides, disaccharides,
oligosaccharides, and polysaccharides,
3×3=9 MK 0.1
including their derivatives, and analyze
their biochemical roles in cellular and
physiological processes
Comprehend the clinical significance of 2
Monosaccharides, disaccharides and
2×1=2 NK 0.02
Polysaccharides: Sorbitol, Mannitol,
Inulin, Dextran, Hyaluronic acid & Heparin
Overview of digestion and absorption of 1
3×2=6 MK 0.06
Carbohydrates
Describe the fundamental processes of 0.1 2
carbohydrate metabolism and explain 1
3×3=9 MK
their importance in energy production and
regulation in the body

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Outline the phase reactions of glycolysis 0.1 2
and explain the regulation of key enzymes,
while comparing and contrasting aerobic
3×3=9 MK
and anaerobic glycolysis, highlighting their
bioenergetics and biochemical
significance.
Describe the HMP shunt (pentose 1
phosphate pathway), its role in producing
NADPH and ribose sugars, and explain its 3×2=6 MK 0.06
importance in protecting cells from
oxidative damage
Explain the fate of pyruvate and lactic acid 1
in the context of metabolic pathways,
3×2=6 MK 0.06
including their role in energy production
and the Cori cycle
Outline the reactions of the citric acid 0.1 2
cycle, describe its role in cellular
respiration and ATP production, and
discuss its energetics, regulation, and
significance, focusing on its anaplerotic 3×3=9 MK
and amphibolic functions
Explain the clinical relevance of the citric
acid cycle (TCA) and its involvement in
metabolic disorders
Explain the processes of gluconeogenesis, 0.1 2
glycogen metabolism (glycogenesis and
glycogenolysis), and the metabolism of
fructose, galactose, and lactose,
emphasizing key reactions, regulatory
3×3=9 MK
mechanisms, and their roles in
maintaining blood glucose levels.
Describe the clinical significance of
gluconeogenesis, focusing on disorders
related to this pathway
Describe the structure and metabolism of 0.1 2
glycosaminoglycans, proteoglycans, and
glycoproteins, emphasizing their 3×3=9 MK
biological functions and importance in
cellular communication and structure.
Discuss the clinical significance of 1
glycolysis, including conditions such as
2×1=2 NK 0.02
pyruvate kinase deficiency, arsenic
poisoning, and lactic acidosis

MBBS Curriculum Year-I (Version-IV) (2025) Page | 130

Discuss biochemical basis of Hemolytic
2×2=4 GK 0.04
anemia (G6PD deficiency)
Correlate the metabolism of fructose, 1
galactose, and lactose with relevant
2×2=4 GK 0.04
metabolic disorders and enzyme
deficiencies
Discuss disorders of glycogen
metabolism, specifically, glycogen storage 2×1=2 NK 0.02
diseases and their clinical manifestations
TOTAL 28 3

MBBS Curriculum Year-I (Version-IV) (2025) Page | 131