Physics of Ultrasound
Physics of Ultrasound
Physics of Ultrasound
J. Anthony Seibert
Imaging systems using ultrasound have attained a large contraction of the crystal surface by an external power
presence as point-of-care (PoC) devices across many source introduces energy into the medium as a series of
clinical domains over the past 10 years. The success compressions and rarefactions, traveling as a wave front
of ultrasound for this purpose is attributed to several in the direction of travel, known as a longitudinal wave,
characteristics, including the low cost and portability as shown in Fig. 1.1.
of ultrasound devices, the nonionizing nature of ultra-
sound waves, and the ability to produce real-time Wavelength, Frequency, Speed
images of the acoustic properties of the tissues and tis- The wavelength (λ) is the distance between any two
sue structures in the body to deliver timely patient care, repeating points on the wave (a cycle), typically mea-
among many positive attributes. An understanding of sured in millimeters (mm). The frequency (f) is the num-
the basic physics of ultrasound, in addition to hands-on ber of times the wave repeats per second (s), also defined
training, practice, and development of experience are of in hertz (Hz), where 1 Hz = 1 cycle/s. Frequency identi-
great importance in its effective and safe use. This chap- fies the category of sound: less than 15 Hz is infrasound,
ter describes the characteristics, properties, and produc- 15 Hz to 20,000 Hz (20 kHz) is audible sound, and
tion of ultrasound; interaction with tissues, acquisition, above 20 kHz is ultrasound. Medical ultrasound typi-
processing, and display of the ultrasound image; the cally uses frequencies in the million cycles/s megahertz
instrumentation; achievable measurements, including (MHz) range, from 1 to 15 MHz, with some specialized
blood velocity; and safety issues. ultrasound applications beyond 50 MHz. The period is
the time duration of one wave cycle and is equal to 1/f.
The speed of sound, c, is the distance traveled per unit
CHARACTERISTICS OF SOUND time through a medium and is equal to the wavelength
Sound is mechanical energy that propagates through a (distance) divided by the period (time). As frequency is
continuous, elastic medium by the compression (high inversely equal to the period, the product of wavelength
pressure) and rarefaction (low pressure) of particles and frequency is equal to the speed of sound, c = λf. The
that comprise it. Compression is caused by a mechani- speed of sound varies substantially for different mate-
cal inward deformation by an external force, such as an rials, based on compressibility, stiffness, and density
expanding and contracting transducer crystal composed characteristics of the medium. For instance, air is highly
of multiple elements in contact with the medium. During compressible and of low density, with a relatively low
transducer surface expansion, an increase in the local speed of sound; bone is stiff and dense, with a relatively
pressure at contact occurs. Contraction of the crystal very high speed of sound; and soft tissues have com-
follows, causing a decrease in pressure. The mechanical pressibility and density characteristics with intermedi-
energy imparted at the surface is transferred to adjacent ate speeds, as listed in Table 1.1. Of importance are the
particles of the medium, which travels at the speed of average speeds for “soft tissue” (1540 m/s), fatty tissue
sound through the medium. Continuous expansion and (1450 m/s), and air (330 m/s). To relate time with depth
2
CHAPTER 1 Physics of Ultrasound 3
Contraction
Expansion Compression Wavelength, λ
(mm)
Pressure amplitude
1 cycle
Transducer Rarefaction
Fig. 1.1 Mechanical energy is generated from an expanding and contracting crystal in contact with a medium,
introducing high-pressure (compression) and low-pressure (rarefaction) variations of the constituent particles
that transfer the energy to adjacent particles as a longitudinal wave.
θi =θr
θi θr
Reflection Reflection
(echo return to (echo away from
transducer) transducer)
z1 = p1c1
Boundary
z2 = p2c2
Direction Refraction
c2 >c1
unchanged
Transmission θt
c2 <c1
c2 = c1
Fig. 1.3 A boundary separating two tissues with different acoustic impedances demonstrates (A) perpendic-
ular (normal) incidence of an ultrasound wave with reflection of an echo back to the source (transducer) and
transmission to greater depths in a straight line and (B) incidence of the wave at a nonperpendicular angle,
with the incident angle measured relative to the normal incidence and the reflected echo at an angle opposite
but equal to the incident angle. The transmitted ultrasound wave is refracted if the speed of sound is differ-
ent in the two tissues, with the angle of refraction also referenced to the normal direction. Refraction angle
depends on the relative speed differences and the change in the wavelength at the boundary.
background signal. Scattered echo signals are more prev- Ultrasound attenuation
alent relative to specular echo signals when using higher µ ≅ 0.5 dB/cm per MHz
1
ultrasound frequencies. 0.9
0.8
Absorption and Attenuation
Relative intensity
0.7
Attenuation is the loss of intensity with distance trav- 0.6
eled, caused by scattering and absorption of the incident 0.5
beam. Scattering has a strong dependence on increasing 0.4
ultrasound frequency. Absorption occurs by transferring 0.3 2 MHz
energy to the tissues that result in heating or mechanical 0.2 5 MHz
disruption of the tissue structure. The combined effects 0.1 10
MHz
of scattering and absorption result in exponential atten- 0
0 5 10 15 20
uation of ultrasound intensity with distance travelled as Depth of tissue (cm)
a function of increasing frequency. When expressed in Distance traveled = 2 x depth
decibels (dB), a logarithmic measure of intensity, atten- Fig. 1.5 Attenuation and relative intensity of ultrasound remain-
uation in dB/cm linearly increases with ultrasound fre- ing as a function of depth for 2-, 5-, and 10-MHz beams.
quency. An approximate rule of thumb for ultrasound
attenuation average in soft tissue is 0.5 dB/cm times the TABLE 1.2 Attenuation Coefficient μ (dB/
frequency in MHz. Compared with a 1-MHz beam, a cm-MHz) for Tissues*
2-MHz beam will have approximately twice the attenu-
ation, a 5-MHz beam will have five times the attenuation, Tissue μ (1 MHz)
and a 10-MHz beam will have ten times the attenuation Air 1.64
per unit distance traveled. Therefore higher-frequency Blood 0.2
ultrasound beams have a rapidly diminishing penetration Bone 7–10
depth (Fig. 1.5), so careful selection of the transducer fre- Brain 0.6
quency must be made in the context of the imaging depth Cardiac 0.52
needed. The loss of ultrasound intensity in decibels can Connective tissue 1.57
be determined empirically for different tissues by mea- Fat 0.48
suring as a function of distance travelled in centimeters
Liver 0.5
(cm) and is the attenuation coefficient, μ, expressed in
Muscle 1.09
dB/cm. For a given ultrasound frequency, tissues and
Tendon 4.7
fluids have widely varying attenuation coefficients chiefly
resulting from structural and density differences, as indi- Soft tissue (average) 0.54
cated in Table 1.2 for a 1-MHz ultrasound beam. Water 0.0022
*For higher-frequency operation, multiply the attenuation coef-
ficient by the frequency in MHz.
THE ULTRASOUND SYSTEM
PoC ultrasound systems are available from many ven-
dors and come with different features and options, Ultrasound Transducer Operation and Beam
which depend on acquisition capabilities, number of Properties
transducer probes, durability, software functionality, size Ultrasound is produced and detected with a transducer
and weight, battery longevity for handheld units, power array, composed of hundreds of ceramic elements with
requirements, and other considerations. Although all electromechanical (piezoelectric) properties. Ultrasound
ultrasound systems have unique instrumentation, soft- transducers for medical imaging applications employ a
ware, and user interfaces, common components include synthetic piezoelectric ceramic, lead–zirconate–titanate
transducer probes, pulser, beam former, scan converter, (PZT), with a crystal structure that generates a sur-
processor, display, and user interface for instrumenta- face charge of either negative or positive polarity when
tion adjustments and controls. its thickness is expanded under negative pressure or
CHAPTER 1 Physics of Ultrasound 7
Transducer wiring
Housing
Absorber
Damping block
Side view
Transducer array
Matching layer
Edge view
Composite structure
Ultrasound beam direction
A
pulse, the process repeats along a slightly different direc- are received from the greatest depths, the next pulse is
tion to ultimately cover the volume of interest defined by created by activating another subelement group that is
the field of view (FOV). incrementally shifted along the transducer array, and
For a given transducer, multifrequency operation the process repeats on the order of thousands of times
allows flexibility of the sonographer to interactively per second to generate a rectangular image format with
choose the appropriate frequency to emphasize the real-time video image capture. Linear arrays are typi-
spatial resolution or depth of penetration based on the cally composed of 256 to 512 transducer elements, are
examination, as shown in Fig. 1.9. of smaller form factor, and generally operate at higher
frequency ranges (5–15 MHz). Because of the higher
Transducer Arrays operating frequency and limited FOV, these transducers
Three basic transducer types for PoC ultrasound are suitable for imaging superficial structures such as the
include linear, curvilinear, and phased arrays, as shown eyes, joints, muscles, and proximal blood vessels and for
in Fig. 1.10. Linear array transducers activate a sub- performing ultrasound-guided procedures. Curvilinear
set of elements, producing a single transmit beam at array transducers have 256 to 512 elements in a convex
one location, and then listen for echoes in the receive geometry, with a subset of elements activated sequen-
mode. Within a fraction of a second, when all echoes tially, like the linear array, producing a trapezoidal
CHAPTER 1 Physics of Ultrasound 9
General
Penetration (Center frequency) Resolution
Selective
transducer
Response
bandwidth
Overall
transducer
bandwidth
4 5 6 7 8 9 10
Frequency (MHz)
Fig. 1.9 Multifrequency transducer transmit and receive response to operational frequency bandwidths
allows the operator to select an appropriate transmit and receive frequency, depending on the type of exam-
ination, type of transducer, transducer bandwidth range, and need for penetration depth (selecting a lower
frequency) or spatial resolution (selecting a higher frequency). The transducer response shown has a select-
able frequency range of 4 to 10 MHz.
image format with increased FOV at both proximal and at a predetermined depth (or depths), which is oper-
distal depths. These transducers are ideal for imaging ator selectable. After excitation, beam direction, and
intraabdominal organs such as the liver, spleen, kidneys, beam formation, the phased array is placed in receive
and bladder. Lower frequencies (2–5 MHz) are used for mode to listen for echoes. The sequence then repeats
depth visualization, but spatial resolution can be lim- along a slightly different beam direction, ultimately
ited as a result. Phased array transducers with 64, 128, creating a sector-shaped image format at a frame rate
and up to 256 elements use all transducer elements in dependent on the number of lines, depth, and FOV. In
the formation of the ultrasound beam. Beam direction the receive mode, returning echoes are detected by all
is determined by relatively large incremental delays active transducer elements used in the formation of the
for sequential excitation of elements from one side of beam. Phased array transducers typically operate at low
the array to the other, effectively steering the beam in frequencies (1–5 MHz), have flexible selection of a nar-
a perpendicular direction to the excitation pattern. row to wide FOV by the operator, and provide efficient
Along a given direction, small incremental excitation two-dimensional (2D) imaging for heart and thoracic
delays in a concave pattern focus the beam diameter imaging requiring small acoustic windows.
10 SECTION 1 Principle of Ultrasound
Spatial Resolution
In ultrasound, the visibility of image detail is determined
by three separate factors: (1) in-plane resolution along
the direction of beam travel, known as axial resolution;
(2) in-plane resolution perpendicular to the direction of
beam travel, known as lateral resolution; and (3) out-of-
plane resolution perpendicular to the in-plane resolution, Lateral
known as elevational or slice-thickness resolution. These
constituents of spatial resolution are illustrated in Fig. 1.12. Elevational
Axial resolution represents the ability to distinctly
separate closely spaced objects in the direction of the
ultrasound beam. Returning echoes from adjacent Axial
boundaries to be resolved as separate are dependent
on the spatial pulse length (SPL), which is the average
wavelength times the number of cycles in the pulse.
Because distance travelled for a pulse-echo interacting Fig. 1.12 The three components of spatial resolution in the
between two adjacent reflectors is twice the separation ultrasound image are shown. Axial, along the beam direction,
is constant with depth. Lateral, in-plane and perpendicular to
distance, echoes to be recorded as separate signals need the beam direction, varies substantially with depth. Elevational,
a spacing just greater than one-half SPL. For example, a perpendicular to the lateral and axial directions, is the slice
5-MHz frequency pulse has a wavelength of 0.31 mm in thickness and varies with depth.