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Tissue_Engineering_Slide_by_Slide_Explanation

Tissue engineering is an interdisciplinary field focused on creating tissue-like structures using cells and biomaterials to restore tissue function. It involves processes like scaffold development, cell seeding, and tissue integration, with applications in various medical fields. Key challenges include material selection, vascularization, and immune rejection.

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5 views

Tissue_Engineering_Slide_by_Slide_Explanation

Tissue engineering is an interdisciplinary field focused on creating tissue-like structures using cells and biomaterials to restore tissue function. It involves processes like scaffold development, cell seeding, and tissue integration, with applications in various medical fields. Key challenges include material selection, vascularization, and immune rejection.

Uploaded by

tacc6352
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Tissue Engineering – Slide-by-Slide

Explanation
Slide 1: What is Tissue Engineering?
Tissue engineering is an interdisciplinary field using cells, biomaterials, and signals to
generate tissue-like structures. It aims to provide biological substitutes that restore or
improve tissue function.

Slide 2: Introduction and History


Combines genetic and chemical engineering to develop lab-grown tissues/organs. The term
'tissue engineering' was coined in 1988. First FDA approval: Integra Artificial Skin (1996).

Slide 3: Examples of Tissue Engineered Products


Bioartificial liver, artificial pancreas, engineered cartilage, airways, vessels, skin, bone
marrow, bone.

Slide 4: Basic Principles of Tissue Engineering


1. Start with scaffold material
2. Shape and seed with cells
3. Add growth factors
4. Grow tissue in 3D
5. Implant and integrate with host body.

Slide 5: Cell Types in Tissue Engineering


Autologous (same individual), Allogeneic (same species donor), Xenogenic (different
species), Isogenic (genetically identical).
Includes primary, secondary cells and stem cells (multipotent, pluripotent, totipotent).

Slide 6: Role of Stem Cells


Stem cells are undifferentiated cells that can divide and specialize. They are ideal for tissue
engineering due to their regenerative capacity.

Slide 7: Scaffolds – Structure and Role


Scaffolds support 3D tissue growth. Must allow cell attachment, migration, and nutrient
transport. Should be biodegradable and biocompatible.

Slide 8: Scaffold Properties and Materials


Desirable properties: high porosity, proper pore size, mechanical strength. Materials
include natural (collagen, fibrin) and synthetic (PLA).
Slide 9: Scaffold Fabrication Methods
Methods: Nanofiber self-assembly, textile tech, solvent casting, gas foaming, electrospinning,
laser bioprinting, etc.

Slide 10: Bioreactors in Tissue Engineering


Devices simulating physiological conditions to promote cell/tissue growth. Control
temperature, gases, mechanical forces, and more.

Slide 11: Tissue Engineering vs. Cloning


Cloning creates identical organisms via nuclear transfer. Tissue engineering regenerates
tissues using patient’s cells, not for reproduction.

Slide 12: Step-by-Step Tissue Engineering Process


1. Cell selection and isolation
2. Scaffold development
3. Seeding and culturing
4. Tissue formation and integration

Slide 13: Applications of Tissue Engineering


Used for therapeutic cloning, cardiovascular, neurological, orthopedic, urological, and organ
transplantation applications.

Slide 14: Challenges in Tissue Engineering


Challenges include: appropriate scaffold materials, vascularization, nutrient transport,
immune rejection, mass production, and quality control.

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