Oncology Board Review, Second Edition Blueprint Study

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Library of Congress Cataloging-in-Publication Data

Names: Worden, Francis P., editor. | Khoriaty, Rami N., editor. | Cobain, Erin F., editor. | Pearson,
Alexander T., editor.
Title: Oncology board review: blueprint study guide and Q&A / [edited by] Francis P. Worden, Rami N.
Khoriaty, Erin F. Cobain, Alexander T. Pearson.
Other titles: Oncology boards flash review.
Description: Second edition. | New York: Demos, [2017] | Preceded by Oncology boards flash review /
Francis P. Worden, Rami N. Khoriaty, editors. c2013. | Includes index.
Identifiers: LCCN 2016056062 | ISBN 9781620701157 | ISBN 9781617052927 (e-book)
Subjects: | MESH: Neoplasms | Examination Questions | Handbooks
Classification: LCC RC266.5 | NLM QZ 18.2 | DDC 616.99/40076—dc23
LC record available at https://lccn.loc.gov/2016056062

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16 17 18 19 20 / 5 4 3 2 1
Contents

Contributors
Preface
Acknowledgments
Share Oncology Board Review: Blueprint Study Guide and Q&A, Second
Edition

PART I. HEMATOLOGIC MALIGNANCIES

1. Acute Leukemias and Hairy Cell Leukemia
Lyndsey N. Runaas, Rami N. Khoriaty, and Dale Bixby

2. Chronic Lymphocytic Leukemia

Erlene K. Seymour, Rami N. Khoriaty, and Dale Bixby
3. Chronic Myeloid Leukemia and Myeloproliferative Neoplasms
Brittany Siontis and Rami N. Khoriaty

4. Myelodysplastic Syndromes
Rami N. Khoriaty and Dale Bixby
5. Hodgkin Lymphoma
Darren King and Ryan A. Wilcox
6. Non-Hodgkin Lymphoma—Low Grade
Erlene K. Seymour and Tycel J. Phillips

7. Non-Hodgkin Lymphoma—High Grade

Erlene K. Seymour and Tycel J. Phillips
8. Peripheral T-Cell Lymphomas
Sumana Devata and Ryan A. Wilcox

9. Multiple Myeloma and Plasma Cell Dyscrasias

Maryann Shango and Erica Campagnaro

PART II. AERODIGESTIVE MALIGNANCIES

10. Non–Small Cell Lung Cancer

Manali Bhave and Gregory P. Kalemkerian
11. Small Cell Lung Cancer
Dana E. Angelini and Khaled A. Hassan

12. Malignant Pleural Mesothelioma

Jordan K. Schaefer and Gregory P. Kalemkerian
13. Thymoma and Thymic Carcinoma
 Jordan K. Schaefer and Gregory P. Kalemkerian
14. Head and Neck Cancers and Salivary Gland Tumors
Paul L. Swiecicki and Francis P. Worden

PART III. ENDOCRINE MALIGNANCIES

15. Thyroid Cancer

Paul L. Swiecicki and Megan R. Haymart
16. Adrenocortical Carcinoma
Frank C. Cackowski and Tobias Else
17. Pheochromocytomas and Paragangliomas
Frank C. Cackowski and Tobias Else

PART IV. BREAST CANCER

18. Breast Cancer
Kunal C. Kadakia, Erin F. Cobain, and Monika Burness

PART V. GENITOURINARY MALIGNANCIES

19. Bladder Cancer
Sarah Yentz, Alon Weizer, and Ajjai Alva
20. Prostate Cancer
Zachery R. Reichert, Megan E. V. Caram, and Kathleen Ann Cooney
21. Testicular Cancer
Zachery R. Reichert and David C. Smith
22. Renal Cell Carcinoma
Benjamin Y. Scheier and Bruce Redman

PART VI. GASTROINTESTINAL MALIGNANCIES

23. Esophageal Cancer

Raymond M. Esper, Paul L. Swiecicki, and James A. Hayman
24. Gastric Cancer
David B. Zhen and Mark M. Zalupski

25. Colorectal Cancer

Maryann Shango and John C. Krauss
26. Anal Cancer
Maryann Shango and John C. Krauss
27. Pancreatic and Biliary Cancers
David B. Zhen and Mark M. Zalupski

28. Hepatocellular Carcinoma

Paul M. Corsello and Neehar D. Parikh
29. Neuroendocrine Tumors
Sarah Yentz and Vaibhav Sahai

PART VII. SARCOMA

30. Sarcoma
Elizabeth J. Davis and Rashmi Chugh

PART VIII. MELANOMA

31. Melanoma
Darren King and Christopher Lao

PART IX. CENTRAL NERVOUS SYSTEM MALIGNANCIES

32. Central Nervous System Tumors
Erin F. Cobain, Aaron Mammoser, and Larry Junck

PART X. GYNECOLOGIC MALIGNANCIES

33. Cervical, Vulvar, and Vaginal Cancers

Kari E. Hacker and Karen McLean
34. Ovarian Cancer
Lan G. Coffman and Ronald J. Buckanovich
35. Endometrial Cancer
Lan G. Coffman and Ronald J. Buckanovich

PART XI. CANCER OF UNKNOWN PRIMARY

36. Cancer of Unknown Primary

Benjamin Y. Scheier and Laurence H. Baker

PART XII. GENETICS AND TUMOR BIOLOGY

37. Genetics and Tumor Biology
Carlos J. Gallego, Jessica N. Everett, Shawna Kraft, and Elena M. Stoffel

PART XIII. SUPPORTIVE AND PALLIATIVE CARE

38. Oncologic Emergencies and Supportive Care
Angel Qin, Francis P. Worden, and Maria Silveira

PART XIV. BONE MARROW TRANSPLANTATION

39. Bone Marrow Transplant
Lyndsey N. Runaas and Mary Mansour Riwes

PART XV. BIOSTATISTICS

40. Biostatistics
Alexander T. Pearson and Emily Bellile
Index
Contributors

Ajjai Alva, MBBS, Assistant Professor, Division of Hematology/Oncology,

Department of Internal Medicine, University of Michigan Medical School,
Ann Arbor, Michigan

Dana E. Angelini, MD, Associate Staff, Department of Hematology and

Medical Oncology, Cleveland Clinic–Taussig Cancer Center, Cleveland, Ohio

Laurence H. Baker, DO, Collegiate Professor, Cancer Developmental

Therapeutics, Professor of Internal Medicine and Pharmacology, Division of
Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Emily Bellile, MS, Statistician, Center for Cancer Biostatistics, Department

of Biostatistics, University of Michigan School of Public Health, Ann Arbor,
Michigan

Manali Bhave, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Dale Bixby, MD, PhD, Clinical Associate Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Ronald J. Buckanovich, MD, PhD, Associate Professor, Internal Medicine,

Division of Medical Oncology, Department of Obstetrics and Gynecology,
University of Michigan Medical School, Ann Arbor, Michigan

Monika Burness, MD, Clinical Lecturer, Division of Hematology/Oncology,

Department of Internal Medicine, University of Michigan Medical School,
Ann Arbor, Michigan

Frank C. Cackowski, MD, PhD, Hematology and Oncology Fellow, Division

of Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Erica Campagnaro, MD, Associate Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Megan E. V. Caram, MD, MSc, Clinical Lecturer, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School; Staff Physician, Department of Medicine, Ann
Arbor Veterans Affairs, Ann Arbor, Michigan
Rashmi Chugh, MD, Associate Professor, Division of Hematology/Oncology,
Department of Internal Medicine, University of Michigan Medical School,
Ann Arbor, Michigan

Erin F. Cobain, MD, Clinical Lecturer, Division of Hematology/Oncology,

Department of Internal Medicine, University of Michigan Medical School,
Ann Arbor, Michigan

Lan G. Coffman, MD, PhD, Clinical Lecturer, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Kathleen Ann Cooney, MD, H.A. and Edna Benning Presidential Endowed
Chair and Department Chair, Department of Internal Medicine, University
of Utah School of Medicine, Salt Lake City, Utah

Paul M. Corsello, MD, Gastroenterology Fellow, Division of

Gastroenterology, Department of Internal Medicine, University of Michigan
Medical School, Ann Arbor, Michigan

Elizabeth J. Davis, MD, Assistant Professor of Medicine, Division of

Hematology/Oncology, Department of Internal Medicine, Vanderbilt
University Medical Center, Nashville, Tennessee

Sumana Devata, MD, Clinical Assistant Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Tobias Else, MD, Assistant Professor, Division of Metabolism,

Endocrinology and Diabetes, Department of Internal Medicine, University
of Michigan Medical School, Ann Arbor, Michigan

Raymond M. Esper, MD, PhD, Physician, Florida Cancer Specialists and

Research Institute, Fort Myers, Florida

Jessica N. Everett, MS, CGC, Clinical Assistant Professor, Department of

Internal Medicine, Molecular Medicine and Genetics, University of
Michigan Medical School, Ann Arbor, Michigan

Carlos J. Gallego, MD, MS, Assistant Professor, Department of Genetics

and Genome Sciences, Case Western Reserve University School of
Medicine, Cleveland, Ohio

Kari E. Hacker, MD, PhD, Gynecologic Oncology Fellow, Department of

Obstetrics and Gynecology, University of Michigan Medical School, Ann
Arbor, Michigan

Khaled A. Hassan, MD, MS, Assistant Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan
James A. Hayman, MD, MBA, Professor, Associate Chair for Clinical
Activities, Department of Radiation Oncology, University of Michigan
Health System, Ann Arbor, Michigan

Megan R. Haymart, MD, Assistant Professor of Medicine, Division of

Metabolism, Endocrinology and Diabetes, University of Michigan Medical
School, Ann Arbor, Michigan

Larry Junck, MD, Professor of Neurology, Department of Neurology,

University of Michigan; Co-Director, Neuro-Oncology Program, University
of Michigan Comprehensive Cancer Center, University of Michigan Medical
School, Ann Arbor, Michigan

Kunal C. Kadakia, MD, FACP, Clinical Assistant Professor of Medicine, UNC,

Department of Medical Oncology, Levine Cancer Institute, Charlotte, North
Carolina

Gregory P. Kalemkerian, MD, Professor of Medicine, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Rami N. Khoriaty, MD, Assistant Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Darren King, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Shawna Kraft, PharmD, Clinical Specialist, Division of

Hematology/Oncology, Department of Pharmacy; Clinical Assistant
Professor, Department of Clinical Pharmacy, University of Michigan College
of Pharmacy, Ann Arbor, Michigan

John C. Krauss, MD, Assistant Professor of Internal Medicine, Division of

Hematology/Oncology, University of Michigan Medical School, Ann Arbor,
Michigan

Christopher Lao, MD, Associate Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Aaron Mammoser, MD, MS, Associate Professor, Department of

Neurosurgery, Louisiana State University Health Sciences Center, New
Orleans, Louisiana

Karen McLean, MD, PhD, Assistant Professor, Gynecologic Oncology,

Department of Obstetrics and Gynecology, University of Michigan Medical
School, Ann Arbor, Michigan
Neehar D. Parikh, MD, MS, Clinical Lecturer, Medical Director, Liver Tumor
Program, Division of Gastroenterology, University of Michigan Medical
School, Ann Arbor, Michigan

Alexander T. Pearson, MD, PhD, Clinical Lecturer, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Tycel J. Phillips, MD, Assistant Professor, Division of Hematology/Oncology,

Department of Internal Medicine, University of Michigan Medical School,
Ann Arbor, Michigan

Angel Qin, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Bruce Redman, DO, Professor of Internal Medicine, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Zachery R. Reichert, MD, PhD, Hematology and Oncology Fellow, Division

of Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Mary Mansour Riwes, DO, Clinical Assistant Professor of Medicine, Division

of Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Lyndsey N. Runaas, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Vaibhav Sahai, MBBS, MS, Assistant Professor of Internal Medicine,

Division of Hematology/Oncology, Department of Internal Medicine,
University of Michigan Medical School, Ann Arbor, Michigan

Jordan K. Schaefer, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Benjamin Y. Scheier, MD, Staff Physician, Department of

Oncology/Hematology, Kaiser Permanente, Lafayette, Colorado

Erlene K. Seymour, MD, Assistant Professor, Department of

Hematology/Oncology, Karmanos Cancer Institute/Wayne State University,
Detroit, Michigan

Maryann Shango, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan
Maria Silveira, MD, Fellow, Division of Geriatric and Palliative Medicine,
Department of Internal Medicine, University of Michigan Medical School,
Ann Arbor, Michigan

Brittany Siontis, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

David C. Smith, MD, Professor of Medicine and Urology, Associate Chief for
Clinical Services, Division of Hematology/Oncology, Department of Internal
Medicine, University of Michigan Medical School, Ann Arbor, Michigan

Elena M. Stoffel, MD, MPH, Assistant Professor, Department of Internal

Medicine, Director, Cancer Genetics Clinic, University of Michigan Health
System, Ann Arbor, Michigan

Paul L. Swiecicki, MD, Hematology/Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Alon Weizer, MD, Associate Professor of Urology, Associate Chair, Surgical

Services, Department of Urology, University of Michigan, Ann Arbor,
Michigan

Ryan A. Wilcox, MD, PhD, Assistant Professor, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Francis P. Worden, MD, Clinical Professor of Medicine, Director of

Hematology/Oncology Fellowship Program, Division of
Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Sarah Yentz, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

Mark M. Zalupski, MD, Professor of Internal Medicine, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan

David B. Zhen, MD, Hematology and Oncology Fellow, Division of

Hematology/Oncology, Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan
Preface

Preparation for board examinations can be a daunting and overwhelming

process for many of us. As trainees, we are often busy with research
projects, manuscripts, and a large clinical volume, making it difficult to find
time to study for board examinations. As practicing physicians, we find it
hard to keep up on material needed for board recertification.
Questions on the board examinations are drawn from well-established,
validated medical literature and widely accepted clinical guidelines. That
said, the University of Michigan Hematology/Oncology Fellowship Program
designed this board review book to summarize information that is most
pertinent for testing. The Oncology Board Review: Blueprint Study Guide
and Q&A, Second Edition expands upon the excellent question-based
review by providing key updates in all chapters that will be reflected in the
medical oncology boards. This book is not intended to be an all-
encompassing review. Rather, it is intended to help summarize the
important facts that one might need to know for his or her examination,
similar to taking notes of pertinent information that one would like to
memorize. We created each chapter to cover all of the topics listed in the
blueprint provided by the American Board of Internal Medicine as material
one should know for the Medical Oncology Board Examination. The authors
have endeavored to provide the most accurate and up-to-date information,
including well-established chemotherapy regimens for a variety of
malignancies. New to this edition, we have also written board review
questions to accompany each chapter, providing over 230 multiple choice
questions with answers and detailed rationales to those seeking practice
questions ahead of their certification or recertification exams.
We hope that fellows and practicing medical oncologists preparing for
their certification or recertification will find Oncology Board Review:
Blueprint Study Guide and Q&A, Second Edition a useful tool. Our goal is to
help our readers summarize and solidify many important clinical facts and
to help them build confidence in their exam preparation about their
knowledge.
As the Hematology/Oncology Fellowship Program director and the chief
fellow at the University of Michigan (Ann Arbor, Michigan), we engaged our
fellows and faculty to develop Oncology Board Review: Blueprint Study
Guide and Q&A, Second Edition. Each chapter was written by a fellow and
edited by an expert faculty member or an ancillary staff clinician. We
gratefully acknowledge the dedication of our fellows, faculty, and medical
staff. The successful completion of this project was made possible by the
editorial and publishing staff of Demos Medical Publishing, especially David
D’Addona, senior editor, and Joseph Stubenrauch, the managing editor
who moved the project seamlessly through production.
Finally, we dedicate this book to Michelle Reinhold for her continued
devotion and immeasurable service to the University of Michigan
Hematology/Oncology Fellowship Program as program coordinator.
Francis P. Worden, MD
Rami N. Khoriaty, MD
Erin F. Cobain, MD
Alexander T. Pearson, MD, PhD
Acknowledgments

The editors would like to acknowledge and thank the contributors from the
previous edition for their contributions:

Dawit Aregawi, MD
Grace Chen, MD
Stephanie Daignault-Newton, MS
Irina Dobrosotskaya, MD, PhD
Marwan Fakih, MD
Scott D. Gitlin, MD
Petros D. Grivas, MD, PhD
Maha Hussain, MD
Sadakatsu Ikeda, MD
Mark S. Kaminski, MD
Daniel Lebovic, MD
Binu Malhotra, MD
Jorge Marrero, MD
Kevin McDonnell, MD, PhD
Meaghan W. O’Malley, MD
Phillip Palmbos, MD, PhD
Brian Parkin, MD
Joshua M. Ruch, MD
Igor Rybkin, MD, PhD
Assuntina G. Sacco, MD
Ann W. Silk, MD, MS
Moshe Talpaz, MD
Eduardo Vilar-Sanchez, MD, PhD
Alissa Weber, MD