OpenLab CDS

Revision 2.7
Release Notes
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 Contents

Contents

Introduction 4
For our Regulated Customers 4

OpenLab CDS version history 5

Version 2.7 5
Version 2.6 16
Version 2.5 24
Version 2.4 29
Version 2.3 35
Version 2.2 38

Important Support Information 41

OpenLab CDS Release Notes 3

 Version 2.6

Introduction

This document provides a listing of the major feature modifications made in

each release of actively supported OpenLab CDS Software including
selected add-ons.
Please see chapter 3, Important Support Information for references
regarding known issues and workarounds.

For our Regulated Customers

When any change is made to Agilent software, the validation status of the
software needs to be re-established by the user/customer.
Whenever software is changed, a validation analysis should be conducted
not just for the validation of an individual change, but also to determine the
extent and impact of that change on the entire software system.

OpenLab CDS Release Notes 4

 Version 2.7

OpenLab CDS version history

Version 2.7

Infrastructure Support updates

See the OpenLab CDS Requirements and Supported Instruments guide
(CDS_v2.7_Requirements_en.pdf) for full details.

Compatibility updates
Added Support for:
• Windows 11 (64-bit): 21H2 (Enterprise or Professional)
• Windows 10 (64-bit): 20H2 or greater (Enterprise or Professional) 1
• OpenLab Server/ECM XT 2.7, includes Basic Server product
• .NET 4.8 (minimum required)
.NET 6.0 (installed by default without removing previous versions)
• PostgreSQL 14.1 (Shared Services, Content Management, and Data
Repository)
• Amazon Web Services (AWS): Tested releases until April 2022
• Microsoft Azure: Tested releases until April 2022

Removed support of
• Windows 10 (P + E) 2004 and 20H1, and Windows 10 (E) 1909
• Oracle 18C, SQL 2014
• Internet Explorer

1For support of LTSC/LTSB check FAQ on OpenLab CDS product page:

https://www.agilent.com/en/support/software-informatics/analytical-software-suite/chromatography-
data-systems/openlab-cds/faq-openlab-cds-ltsc

OpenLab CDS Release Notes 5

 Version 2.7

Reduced number of firewall ports required open to run an

OpenLab CDS + OpenLab Server/ ECM XT system
With the release of CDS v2.7 and Server/ECM XT 2.7, communication
between various OpenLab Components is moving towards well accepted
standard ports 443 (TLS) and 80. See the OpenLab CDS Requirements Guide
for full details on the required ports.
Note: These changes only apply to OpenLab components version 2.7 or
greater. OpenLab Server/ ECM XT 2.7 maintains backwards compatibility
with previous versions of CDS. The communication requirements for use
with these versions are documented in the respective Requirement guides.

Compatibility with Agilent Software versions

Note: These are independent releases
• OpenLab Server / ECM XT v2.7
• Sample Scheduler for OpenLab v2.7
• OpenLab Shared Services Server 3.6 (with ECM 3.x deployments only)
• Test Services v3.5
• WalkUp 4.2
• RTL Wizard 3.7.x
• NGA-RGA 2.7
• GPC/SEC Software for OpenLab CDS v1.6
• Peak Evaluation 3.7.x
• Allotrope ADFExport for OpenLab v1.3.1

Compatibility prepared for the subsequent product versions that will release
after OpenLab CDS 2.7 (see the respective release notes for detail):
• EZChrom Migration
• SLIMS
• Match compare
• 2D-LC
• Online LC monitoring

OpenLab CDS Release Notes 6

 Version 2.7

Data Integrity Enhancements

Standardized display of usernames with user-ID

• Usernames are displayed in the format Full Name (userid) in all
OpenLab CDS applications, audit trails and activity logs

Improved Audit Trail

• Reviewing or adding a manual entry to the audit trail no longer triggers a
new result version.
• Audit trail logs a 'Saved method' event if a processing method gets
linked to a result set or if a master method is updated.
• File type is provided in the audit trail header
• Rollback of changes in method is logged in audit trail (without updates
of method version)

Sample Prep method (.smx) is now saved with results and can be
included in a report

Improved traceability when exiting Failover mode:

• Change of username from general (System) to machine name of AIC for
activity log entries when reconnecting to system.

Enhanced OpenLab installer

Usability enhancements
• System Preparation Tool (SPT) launched automatically during
installation.
• Option to navigate between launcher tabs using key "Tab" and
"Shift+Tab"; "Enter" or "Space" to select the tab
• During upgrade, installer shows tiles for installed topology only
• New command keys enhance silent mode:
 Cmd key “CheckStatusOnly" to avoid automatic change of Windows
settings during SPT runs in silent mode
 Ability to set key "DBAdmin", "DBpassword" in cmd or tags
<AdminName>, <ObfuscatedPassword> via configuration file
OpenLab CDS Release Notes 7
 Version 2.7

Branding updates
• Installer UI refresh
• Update Launch Icon, splash screen, and login screens

Online Help updates

• New, additional cloud version of the Help and Learning platform
accessible at https://openlab.help.agilent.com. Adds direct access of
updated English and localized user-guides.
• New help format supports favorites

Product Level Changes for v2.7

Control Panel

Added software status in instrument view

• New optional software status column is available in the instruments
panel: Color codes indicate one of the following SW states:
 Default (ok state)
 Collecting data from instruments
 Waiting for user action
 Paused (because user is doing something)
 Disconnected from hardware
 Error state

Added Privileges
• New Activity Log Access privilege
 Required for view access to the Activity Log.
 Upon upgrade the Activity Log Access role is assigned
automatically to all existing users and groups.

OpenLab CDS Release Notes 8

 Version 2.7

• Other new privileges: (see respective sections on details about the

related functionality)
 Request access
 Cancel my pending runs: Delete pending runs submitted by me
 Run single sample: Control Single injection runs
 Modify instrument configuration in CDS Client

Acquisition

New “Ad Hoc mode” allows instrument-initiated runs

• Controlling user may initiate runs “ad hoc” from the Agilent GC
instrument: CDS is made aware and can acquire data. Ad Hoc mode
restricts access to Agilent LCs and GCs for other users.

Centrally Managed Unattended Printing

• Option to create common, shared folders (“printers”) to use for
centralized, unattended printing if used in conjunction with a 3rd party
print management software package.
• Users may choose from a predefined list of printers to assign for
specific print tasks (e.g., print injection reports) or summary reports
• Option to override the printer specified in the processing method.

New Wait sequence line type.

• Allows the user to specify that the sequence will wait until
 User resumes
 Wait Timeout triggers automatic resume
• Option to specify method for the instrument as part of the wait line (e.g.,
to flush the system when changing methods)
• While acquisition is waiting, additional samples may be added to a
sequence. The user can
 Scan Barcodes while sequence is waiting
 Update & resume sequence with one click

OpenLab CDS Release Notes 9

 Version 2.7

Tokenized result path (structured acquisition result storage)

• Pre-defined tokens may be appended to the result path (e.g., Date,
injection source, instrument name), to enhance data organization and
search for results.

New print/export option for sample prep methods

• Report provides the same options as the Acquisition Method report. It
offers printing or exporting method parameters and audit trail.

Ability to request access to an item that is blocked by another user

• Requires Request access privilege. The original, blocking user can deny
the request. In case of no response after 60 seconds the blocked item is
released automatically.

Change of instrument configuration in the Acquisition Client:

• Requires Modify instrument configuration in CDS Client permission.
Note: Requires LC&CE driver version 3.5 or higher to use the whole
feature set.

Productivity and Usability enhancements

• Easy refresh of an injection list (without closing the tree)
• Option to restrict “Load Data” to the newly acquired data
• Sorting of single-sample data by project or sequence
• Enhanced “Home” project feature for easy access from Data Processing
view
• New “Save and close” option allows easy clean-up of tree-view
• Support large number of files in the Sequence
• User-configurable Run Queue table - persistent per user and per
instrument
• New Active and History tabs display acquiring runs separately from
completed runs.
• Sample/Sequence Stop options are limited to those supported by the
instrument configuration.
• Enable continuous use of snapshot feature for single runs: Supports
faster workflows without need to close and open a new DA instance.

OpenLab CDS Release Notes 10

 Version 2.7

Data Analysis and Reporting

Enhanced Calibration
• Calibration may be based on time-based group as reference (if using
linear curve models or fixed response factors)
• Calibration Coefficient of determination (r2) calculations can be
validated for all calibration modes

Added option to scale detector response for peak area or height

before calibration and quantification
• Facilitates �𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 𝑎𝑎𝑎𝑎𝑎𝑎𝑎𝑎, �𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 ℎ𝑒𝑒𝑒𝑒𝑒𝑒ℎ𝑡𝑡 , log10 (𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 𝑎𝑎𝑎𝑎𝑎𝑎𝑎𝑎),
log10 (𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 ℎ𝑒𝑒𝑒𝑒𝑒𝑒ℎ𝑡𝑡)
• Use of area correction for CE
• Scaled responses are shown in the injection results, custom calculation,
and reports

Extended token list in Injection Reports

• New token Result Path (e.g., year/month/day/instrument name etc.)
allows for structures defined at acquisition time to be used for report
copy operations.
• Option to include the new result path token in processing method
enables to structure exported reports and exported data.

Different detectors can use the same compound name in compound

table of the processing method
• A compound may be identified with the same name in multiple signals.
It is possible to create results for dual column confirmation applications.

Possibility to define calibration level specific ISTD amounts in the

processing method to simplify sequence setup.
• Option to choose for method level amounts to override those from the
sequence table and in the injection list.

OpenLab CDS Release Notes 11

 Version 2.7

Enhanced Integration Optimizer

• Added option for fine tune of the integration using timed events
• Added time programming and advanced functions, such as Overlays,
fine tune existing processing methods, or the option to optimize
different retention time ranges independently for timed events

Enhanced support of 2D-LC (may require additional product)

• Support Custom Calculation for 2D-LC
• Support 2D-LC and 2D-GC data with integration optimizer
• Store and use 2D column information
• Peak Purity provided for 2D peaks
• Support in AMX method import

Extended custom calculations and reports

• Compound specific multiplier

Mass Spec related improvements

Enhanced Automatic Spectrum Extraction

• Added ability to use either identified peaks or all peaks.

Enhanced the MS Peak Purity

• Changed the graphical presentation in Peak Details to show
components. This applies to both Separate and Overlaid modes.

Add\Update now adds compounds to the compound table with a TIC

SCAN signal instead of an EIC signal.

OpenLab CDS Release Notes 12

 Version 2.7

Enhanced method-import from EZChrom

• Improved DA methods import now includes calibration curves, timed
groups, and history points.

Expanded support of Capillary Electrophoresis (CE)

In conjunction with LC&CE Driver 3.5 the following workflows are supported:

Acquisition
• Configure the 7100 Agilent CE or CE/MSD instruments using instrument
type Agilent LC & LC/MS.
• Connect to the CE instrument, create methods, and run analyses using
CE specific soft configuration options.
• Review CE analytic data with same feature set as for LC.
• Create reports from CE data with same feature set as for LC.
• Capillary Zone Electrophoresis (CZE) workflow (with or without
corrected area and CE specific calculations).

Data Analysis updates

• Data Analysis allows for scaled responses using various options.
• Audit trail is supported with CE.

Automation for method developments, including user vials/sequence

overwrite.

OpenLab CDS Release Notes 13

 Version 2.7

Sample Scheduler for OpenLab integration with CDS

Balance integration - from Sample Scheduler to Data Analysis:

• Digital transfer of weighing results from balance (LabX balance) to
OpenLab CDS, via lab balance bridge
• Barcode-driven balance workflow with Sample Scheduler integration
• Meta Data transfer with or linked to results from Sample Scheduler to
OpenLab CDS Data Analysis
• Audit trails provide seamless documentation of entire workflow

Instrument dashboard that is integrated with OpenLab CDS is

available in localized versions:
• Provides overview of instruments from a mobile device or PC

Enhancements to Backup and Restore for Workstation Plus

• Temporary files are now stored in the database backup location.
• Added retries mechanism for backup finalization
• Added detailed progress tracking for the verification procedure
• Created a console application for PostgreSQL customization to support
incremental backups
• Added installation of the Restore Utility and launch icon. Restore utility
may be launched from the Start menu
• Updated launch icons for Backup and Restore utilities

OpenLab CDS Release Notes 14

 Version 2.7

Driver Updates
Agilent Instrument driver packages shipped with OpenLab CDS 2.7:
RC.NET Instrument Driver Driver Software Installed by
Revision default
Agilent LC & CE 3.4 * 
Agilent LC/MS SQ 2.5 
Agilent ELSD 1.8
Agilent GC 3.7 
Agilent GC/MS SQ 1.4 
Agilent Micro GC 2.3
Agilent Gas Analyzer 2.7
Agilent G1888 Headspace B.01.09.2
Agilent 7697A-8697 Headspace 3.3
Agilent 35900E A/D Converter 2.3 
Agilent SS420X A/D Converter 1.2 
Agilent Data Player 2.4 
Agilent CTC PAL 3 2.5
Agilent CTC PAL-xt B.01.08
* LC&CE driver version 3.5 or higher is required to use the extended CE
workflow, for non-RC.Net Method Import (2DLC), and the whole feature set
provided by the Modify instrument configuration in CDS Client
permission.
See the OpenLab CDS media for more details on final component versions.

Non-Agilent Instrument Control Drivers

Support for non-Agilent instruments in OpenLab CDS continues to expand.
For the most current list of supported non-Agilent instruments visit the FAQ
page “What instruments are supported in OpenLab CDS?” on the Agilent web-
site www.agilent.com.

OpenLab CDS Release Notes 15

 Version 2.6

Version 2.6

Infrastructure Support updates

Cloud Services supported:

Agilent OpenLab with ECM XT as backend can run in an Amazon Web
Services (AWS) or Microsoft Azure cloud environment.
For details see your Agilent representative.

Compatibility updates
Workstations, Clients, and Instrument Controllers (AICs) are now
supported on:
• Windows 10 64-bit, Enterprise (1909 or greater), or
Professional (2004 or greater) 2
• OpenLab Server / ECM XT 2.6, includes new Basic Server product

See the CDS Requirements guide for full details.

Communication port and protocol changes

OpenLab CDS with OpenLab Server or OpenLab ECM XT now utilizes secure
https communication protocols between clients (e.gs OpenLab CDS Clients,
AICs, and web browsers) and the server application. To ensure appropriate
authentication of the applications, Agilent OpenLab can utilize any existing
commercially signed digital certificate OR supplied OpenLab self-signed
certificate as part of system configuration.

2 For support of LTSC/LTSB, and the most current versions check with your Agilent representative.

OpenLab CDS Release Notes 16

 Version 2.6

System / Installation

Enhanced System Preparation Tool (SPT)

• This SPT is now integrated in the installer and runs as the first step. It
may still be launched prior to installation
• SPT steps and progress shown in installer UI
• Mandatory settings are checked, and OS settings are updated if possible
or identified as requiring manual correction before installation proceeds
• The user can choose the recommended actions
• SPT report provides instructions how to update the setting manually
before installation of the CDS

New dedicated installation workflow for Shared Services Server

• New workflow is used specifically for deployments connected to
OpenLab ECM 3.x

Updated data integrity features

• Updated wording or category of audit trail and activity log entries
• Added entries to the audit trail

OpenLab Control Panel updates

Added Privileges for OpenLab CDS

• Disable/enable calibration points
(default in built-in role Chemist, Technician, Everything)
• Use integration optimizer
(default in built-in role Chemist, Everything)
• Integration optimizer: Display peak results
(default in built-in role Everything)

OpenLab CDS Release Notes 17

 Version 2.6

Added Privileges and Roles for Workstation Plus

New Privilege:
• Delete Content Of Project

New Roles:
• Project Content Deletion
• Content Management Administrator

Sample Scheduler for OpenLab delivered on OpenLab CDS

media

Sample Scheduler for OpenLab is installed via OpenLab installer

Instrument dashboard available with OpenLab CDS (C/S only)

 Provides overview of instruments from a mobile device or PC
 Displays available instruments
 Shows status information and instrument errors

By activating the software and adding instrument licenses the

instrument dashboard is turned into a full Sample Scheduler for OpenLab
installation: This management tool includes a simple user interface for
submitting analyses, time scheduling capabilities for unattended
maintenance and calibration procedures, and more productivity
features.

Launch Sample Scheduler for OpenLab (C/S only)

• New launch button for fast access from within the Acquisition client or
the Windows start menu

Migration Tools for OpenLab

• No longer part of the OpenLab installer.
It is now available on the media in Setup > Tools > Migration

OpenLab CDS Release Notes 18

 Version 2.6

QualA
New QualA 3.4 release (Test Services) delivered with OpenLab CDS. See
separate QualA Release Notes for details on feature updates

Updated Branding
Redesigned launch Icons, splash screens and login screens, to adjust to new
Agilent branding

Product Level Changes for v2.6

Acquisition

Changes to Run Queue and Sequences

• Option to save each sample in a sequence as unique result set
• Edit currently running sequence when run queue is paused
• Sequences in progress can now be stopped to add priority samples or
address a tray loading mistake
• Runs are shown separately on Active or History tab

Changes to the dual simultaneous injection workflow

• Unique table fill down possible for front and back injections
• Sequence table can be filtered to display only the front or back channel
• Option to save front and back samples to separate result sets
• Option to save each sample in a dual simultaneous sequence as unique
result set

Improved snapshot and result review feature

Once opened from the online signal window or sequence table, a
snapshot/review instance can remain open for further snapshots taken in
the context of the same sequence.

OpenLab CDS Release Notes 19

 Version 2.6

Added Reference Chromatogram in Acquisition

• Allows to visualize the reference chromatogram within the real time plot

Data Analysis and Reporting

Unique calibration curve handling

• A new quantification mode for calibration runs. When acquiring new
sequences, the new function provides the option to post-pone
processing and reporting until an uninterrupted series of calibration
injections is finished. This mode needs to be activated in the project.
When reprocessing data acquired with immediate processing or data
acquired with an earlier version of OpenLab CDS, the quantification
results for the intermediate calibration injections will be different
• In addition to the back quantification of calibration standards, de-
activation of a single calibration point now gets automatically applied to
all loaded calibration and sample injections where the corresponding
calibration was used

New Integration Optimizer Wizard

• The integration optimizer helps find a suitable set of integration events.
It allows integration parameters to be tuned via sliders (peak width,
slope sensitivity, height reject, peak separation modes) and the resulting
integration to be previewed in real-time in the Chromatograms window
• It enables easy deployment of integration settings to the lab

Reference Chromatogram
• Added option to define a reference chromatogram in the processing
method and display up to 5 signal specific reference chromatograms in
the chromatogram window

Enhanced compound management in the calibration tab

• New column in compound table provides the option to sort compounds
by signal names and retention times

Enhanced visualization of sample types

• Added coloring in the injection list analogous to Acquisition context
OpenLab CDS Release Notes 20
 Version 2.6

Miscellaneous updates to reporting

• User can choose separate acquisition method parameters to use in both
Acquisition and DA reports
• Added ability to report MS Peak Table via a new snippet

Mass Spec related improvements

Update to Sample Purity

• Updated design of results table for sample purity analysis, to allow
faster screening of results
• Added signal column: sample purity results can be viewed by signal
• Added sample purity results filter
• Added copy and export capabilities from the sample purity table
• Updated sample purity report to reflect the updated sample purity
results table
• Added columns to the target table to show RT and Adducts.

Update to MS spectrum window

• Added a movable threshold selection to hide unwanted m/z values
• Added maximum abundance window to identify the most abundant m/z

Added MS Spectral Smoothing

• Option to apply the Gaussian smoothing algorithm to an MS Spectrum
displayed in profile mode

Enhanced SIM data functionality

• Extract Chromatogram
• Add ion as compound to the method
• Add ion as qualifier to the compound

Added support for NIST/EPA/NIH EI-MS Library, 2020 release

(NIST20)

OpenLab CDS Release Notes 21

 Version 2.6

Enhancements to Backup and Restore

• Added automated Restore for Workstation Plus. Restore Utility is
available from the Start Menu and provided on the media (Setup >
Tools)
• New tools for all-in-one and 2-server topologies of OpenLab Server and
ECM XT will allow users with limited technical skills to automate a
scheduled back up and perform a restore when necessary
• Incremental backups are supported

Added basic CE and CE/MS Support

OpenLab CDS v2.6 supports basic CE release with LC & CE Driver 3.2 or
higher
• Configure the CE instrument as part of the instrument type "Agilent LC"
• Connect to the CE instrument, create methods, and run analyses
• View CE monitor signals in Online Plot
• Review CE analytic data with same feature set as for LC
• Create reports from CE data with same feature set as for LC

OpenLab CDS Release Notes 22

 Version 2.6

Driver Updates
Agilent Instrument driver packages shipped with OpenLab CDS 2.6:
RC.NET Instrument Driver Driver Software Installed by
Revision default
Agilent LC & CE 3.3 
Agilent LC/MS SQ 2.4 
Agilent ELSD 1.8
Agilent GC 3.5 
Agilent GC/MS SQ 1.4 
Agilent Micro GC 2.2
Agilent Gas Analyzer 2.6
Agilent G1888 Headspace B.01.09.1
Agilent 7697A-8697 Headspace 3.1 *
Agilent 35900E A/D Converter 2.3 
Agilent SS420X A/D Converter 1.2 
Agilent Data Player 2.4 
Agilent CTC PAL 3 2.3
Agilent CTC PAL-xt B.01.08
* Both HSS drivers may be co-installed on a system. Installing 3.1 or higher will
upgrade both B.01.09 and B.01.10 drivers. To keep G1888 control install B.01.09.1
after the upgrade.
See OpenLab CDS Requirement guide (CDS_Requirements.pdf) for details.

Non-Agilent Instrument Control Drivers

Support for non-Agilent instruments in OpenLab CDS continues to expand.
For the most current list of supported non-Agilent instruments visit the FAQ
page “What instruments are supported in OpenLab CDS?” on the Agilent web-
site.

OpenLab CDS Release Notes 23

 Version 2.5

Version 2.5

Infrastructure Support

OpenLab CDS version 2.5 is supported in the following configurations:

Workstation Plus, Workstation with file-based storage, and Client/Server.
Workstations, Clients and Agilent Instrument Controllers (AICs) are
supported on:
• Windows 10, Enterprise or Professional, 64-bit (version 1809 or higher 3)
Additionally, for networked deployments, clients 4 and AICs 5 are supported
on:
• Windows Server 2016, Standard or Datacenter, 64-bit
• Windows Server 2019, Standard or Datacenter, 64-bit
Windows 7 and Windows Server 2012 are no longer supported

Russian Language Support

• OpenLab CDS Workstation with file-based storage and OpenLab
Workstation Plus now support Russian language.

Systems Management Software Support

• Supports installation and updates deployment of select components of
OpenLab CDS using systems management software, such as Microsoft
System Center Configuration Manager (SCCM).

3 For support of the most current versions check with your Agilent representative.
4 In virtual environments
5 AICs are supported but not recommended on Windows Server 2016 or 2019, Standard or Data Center

OpenLab CDS Release Notes 24

 Version 2.5

System Preparation Tool

• Performs an automatic check of PC requirements required to use
OpenLab CDS, identifies errors encountered, and provides associated
warnings. Automatically updates most required Windows settings as
needed and generates an outcome report.

Product Level Changes

Introduction of core purification workflows

• OpenLab CDS now supports the use of Agilent Purification LC systems
with fraction collection.
 Includes UV signal triggered collection; time and volume-based
collection and manual.
 Includes delay volume collection calibration.
 Includes pooling and recovery collection.
Note does not support Mass based purification.

Support for Single Sign-on

• Support for SSO on OpenLab CDS Systems using Windows domain
authentication including card key access. Eliminates the need for
multiple logins from valid users once they have logged in with their
Windows credentials.

Introduction of Method Status labels to ensure that only approved

methods can be used to acquire and process data.
• Ability to configure and enforce which methods are available for use
within a project according to designated method status label.
 Generic = default status. Users can be restricted from using this
type of method.
 Approved = Select users can be restricted to only see and “use
Approved” methods.
 Obsoleted = marked as no longer in use. Users cannot use this
method type if Method Status is active for a project.

• New privileges introduced to define who can

 change the associated status label of a method
 use generic status methods

OpenLab CDS Release Notes 25

 Version 2.5

Automatic Collection and Storage of Column Information

• OpenLab CDS now collects and saves column information as provided
by instrument. This includes columns using RFID column tags. Column
tags used in Agilent hardware and consumables will now auto-
propagate information into the result set data available for search and
reporting. Certain information may be automatically populated for
further data analysis calculations
 For LC: Use of RFID column tags requires an Agilent Infinity II LC
series column compartment and appropriate columns.
 For GC: Requires an Agilent 8890 or Intuvo 9000 GC with a J&W
column with Smart ID Keys.

Inclusion of the eMethod software tool with OpenLab CDS

• Allows the import of available eMethods from Agilent to OpenLab CDS.

Acquisition
Added injection types for GC dual injection sequence
• Ability to run samples with "Manual/External" or "No
Injection/Instrument Blank" as injection sources in the same dual
sequence.

Data Analysis and Reporting

Integration parameters for individual MS signals
• Ability to setup integration parameters for individual MS signals similar
to existing chromatographic signals.
 Total Ion Chromatogram (TIC) Single Ion Monitoring (SIM), TIC
Scan, SIM and EIC (Extracted Ion Chromatogram).

Normalized amount calculations

• Ability to easily apply NORM calculation using custom calculator.
Supports % and ppm calculation corrected for different sample volume
inputs.

Enhanced report generation and export capabilities.

• Ability to generate more than 2 reports automatically using a Data
Analysis method.
OpenLab CDS Release Notes 26
 Version 2.5

• Reports can now be named and saved to locations using tokens

allowing for automated routing /printing using 3rd party applications.

MS spectrum overlay
• Ability to overlay several color-coded MS Spectrum to compare MS
Spectrum from different samples.

Split TIC SIM signal by Polarity, Fragmentor, and Gain for MS data
• Ability to view separate TIC SIM signals based on Polarity, Fragmentor,
and Gain to provide unique information for each of these different
analytical conditions.

Data exported in AIA. NetCDF standard format now includes MS spectra.

Export of files in Analytical Studio Reviewer (ASR) file format

• Ability to generate files in ASR format to allow OpenLab CDS data to be
viewed in MassHunter Analytical Studio Reviewer. Plate view is not
currently supported.

Backup tool for WorkStation Plus

New utility provides users with enhanced data backup and restore
including the ability to:
• Set up scheduled data backups
• Perform immediate data backup
• Supports cold backup or hot backup

New PowerShell script enables one step data restore

Hot backup support for Client/Server

New procedure for hot backup and restore of the OpenLab Server and ECM
XT system. Hot backup can be performed while the system continues to
acquire and analyze data.

OpenLab CDS Release Notes 27

 Version 2.5

Driver Updates

Agilent Instrument driver packages shipped with OpenLab CDS 2.5

RC.NET Instrument Driver Driver Software Revision Installed by

default with
OpenLab
CDS 2.5
Agilent LC 3.1 x
Agilent ELSD 1.8
Agilent LC/MS SQ 2.4 x
Agilent GC 3.2 x
Agilent Micro GC 2.1
Agilent Headspace B.01.09
Agilent GC/MS SQ 1.4 x
Agilent 35900E A/D Converter 2.3 x
Agilent SS420X A/D Converter A.01.01 x
Agilent Data Player 2.3 x
Agilent CTC PAL 3 2.1
Agilent CTC PAL-xt B.01.08

Non-Agilent Instrument Control Drivers

For the most current list of supported Non-Agilent instruments visit the
OpenLab CDS product page at: www.agilent.com/chem/openlabcds

OpenLab CDS Release Notes 28

 Version 2.4

Version 2.4

Infrastructure Support
OpenLab CDS version 2.4 is supported in the following configurations:
Workstation Plus, Workstation with file-based storage, and Client/Server.
Workstations, Clients and Agilent Instrument Controllers (AICs) are
supported on:
• Windows 10, Enterprise or Professional, 64-bit (version 1703, 1709, or
1803) 6
• Windows 7 SP1, Enterprise or Professional, 64-bit
Additionally, for networked deployments, clients and AICs are supported on:
• Windows Server 2012 R2, Standard or Datacenter, 64-bit
• Windows Server 2016, Standard or Datacenter, 64-bit
New support for OpenLab ECM as networked security repository for
OpenLab CDS. Supported OpenLab ECM software:
• OpenLab ECM Version 3.5 Update 6 or later is required
• OpenLab ECM Version 3.6
No operating system support has been removed since v2.3.

Acquisition

Priority sample submission

• Ability to add priority sample. Users can submit priority samples that will
acquire after the current injection is completed.

6 for support of the most current versions check with your Agilent representative

OpenLab CDS Release Notes 29

 Version 2.4

Edit pending sequences

• Ability to edit pending sequence. Users can preview the pending
sequence and modify all pending lines of the sequence without
disruption to the run queue.
Support for multiple gain acquisition with LC/MSD
• Ability to acquire data with different gain settings for the same mass to
allow increased throughput (see LC/MS Driver Update for details).
SIM ion override
• Allows users to specify target SIM Ion other than what is currently
defined in the acquisition method at time of sequence submission.
Reasons for aborting (see Data Integrity Enhancements for details)

Control client (see Data Integrity Enhancements for details)

Data Analysis and Reporting

Support for MS profile mode

• Acquire and view MS data in profile mode with quantitation through
extracted chromatograms from spectrum peak.
Improvements to custom calculator expression editor
• Adoption of common scripting standards to provide improved
readability
• Autofill and error highlighting
• Indenting and inline help
Multi MS library searching
• Ability to select up to 10 libraries in processing method to search
spectrum in the NIST format Library

OpenLab CDS Release Notes 30

 Version 2.4

Automated batch export functionality of CSV file

• CSV file includes mass, peak area, peak height and retention time.
Automatic calculation of UV purity sensitivity value
• Ability to have the purity threshold calculated automatically for all
compounds in the method based on the sensitivity set for a compound.
Signature order and locking results on sign (see Data Integrity
Enhancements)

Data Integrity Enhancements

Improved signature workflow support

• Ability to enforce customizable signature paths
• Ability to approve/reject multiple at the same level
Signature order and Locking results on sign
• Administrators now have the ability to configure and enforce a signature
order. When enabled, signatures in Data Analysis will have to follow the
order and meaning as prescribed in the project’s signature settings. An
additional enhancement in the Signature Settings page allows for all
results to be automatically locked upon the first signature.
Reasons for aborting
• If reasons are enabled for Results modification, the user will now be
prompted for a reason when they intentionally abort a run queue item.
Obscure Locked Windows
• If OpenLab CDS is locked, the text in the application is blurred in the
event that it may be displaying confidential or sensitive information in its
tests or descriptions.

OpenLab CDS Release Notes 31

 Version 2.4

Control Client
• In a multi-user environment, users with the privilege to manually control
an instrument can “take control” of an instrument to modify its
settings. Other users can still submit runs to the instrument run queue,
but only one user can be modifying these settings at a time. This
reduces mistakes in user overlap and allows changes to the instrument
settings to be correctly attributed to the person who is in-control.

Add-ons
Introduction of QualA add-on for OpenLab CDS WorkStation Plus and
Client/Server
• New software qualification tool allowing customers to self-perform
software qualification assessments for future minor software releases.
Version 1.4 of Migration Tools for OpenLab add on to support workstation to
workstation upgrades to CDS 2.4 from the following software:
• ChemStation C.01.05, C.01,06 or C.01.07
• EZChrom A.04.05, A.04.06 or A.04.07

Support for creation and automated export of Allotrope files in OpenLab CDS
WorkStation and Client/Server software. The Allotrope Data Format (ADF)
files are a universal data format, a detailed description of the Allotrope Data
Format and its structure is available on the Allotrope Foundation web site
(https://www.allotrope.org).
• Automated creation of Allotrope Data Format when result
set/injection completes. Consists of the LC-UV analytical raw data
(chromatograms + spectra) plus metadata and the original OpenLab
CDS files.
• Manual export of result set or sequence

OpenLab CDS Release Notes 32

 Version 2.4

Driver Updates
Agilent Instrument driver packages shipped with OpenLab CDS 2.4
RC.NET Instrument Driver Driver Software Revision Installed by
default with
OpenLab
CDS 2.4
Agilent LC A.02.19 SR3 x
Agilent ELSD A,01.07 (build 12)
Agilent LC/MS SQ 2.2.2260 x
Agilent GC 3.0.532 x
Agilent GC/MS SQ 1.3 (build 54) x
Agilent 490 Micro GC B.01.12.1.2125
Agilent Headspace B.01.07.3
Agilent 35900E A/D Converter 2.3 (build 53) x
Agilent SS420X A/D Converter A.01.01 (build 65) x
Agilent Data Player 2.2.6 x
Agilent CTC PAL 3 A.01.04.1
Agilent CTC PAL-xt B.01.08

Non-Agilent Instrument Control Drivers

For the most current list of supported non-Agilent instruments visit the
OpenLab CDS product page at: www.agilent.com/chem/openlabcds

LC/MSD Driver Update

Method Editing with Gain
• Method editing now supports Gain instead of EMV. EMV from previous
methods will be reset to Gain=1. Using constant gain in methods
relieves the user from controlling delta EMV change in a regulated
environment.
Two Scan Types with Method Manual Resolution
• The driver now designates two scan types: Single Ion Monitoring (SIM)
and Scan. The “Scan” scan type will persist throughout the run. If there
are Scan method discrepancies, the Manual Resolution window with
hover-over tips will appear for users to adjust their method. Additionally,

OpenLab CDS Release Notes 33

 Version 2.4

users can check the “Target points per second” box to specify the
number of points across the peak. The driver software will automatically
calculate the scan time and dwell time to meet the “Target points per
second” setting.
Time Segments in Audit Trail but Not in UI
• Since the scan will be run throughout the time segments, the audit trail
reflects time segment changes although the UI no longer shows time
segments as an option.
Distinguishing Scan Traces with Overlapping Masses
• When there are overlapping masses in multiple “Scan” scan segments
and if all the parameters (fragmentor, gain, polarity) are the same, users
will not be able to distinguish the scan trace that the overlapped mass
came from in Data Analysis. If any of the above parameters is different,
users will be able to distinguish the spectrum data based on the
parameters shown in DA.

OpenLab CDS Release Notes 34

 Version 2.3

Version 2.3

OpenLab CDS version 2.3 is supported in the following configurations:

Workstation Plus, Workstation with file-based storage, and Client/Server.

Workstations, Clients and Agilent Instrument Controllers are supported on:

• Windows 10, Enterprise or Professional, 64-bit, version 1607 or later
• Windows 7 SP1, Enterprise or Professional, 64-bit
Licensing updates
• OpenLab CDS version 2.3 requires an update to the license file from
SubscribeNet when upgrading.
Functional verification following upgrade installation

Acquisition

LC shutdown options in run queue allows users to set shutdown actions

Shifting of runs/sequences in the run queue
• Users can edit the order of pending items in the run queue.
Ability to display all users currently using the same instrument
Automated sequence summary report
• Ability to specify the sequence summary report(s) at the time of
sequence submission.
Graphical display of sample location
• Optionally display the location of your samples in a sequence table when
using most Agilent LC injectors.

OpenLab CDS Release Notes 35

 Version 2.3

Data Analysis and Reporting

Extract 2D (UV) signal from 3D matrix
• Ability to define specific chromatogram extraction parameters and
identify and quantify compounds from extracted chromatograms.
Isoplot UI for interactive spectra and signal extraction
• Ability to display a 3D UV matrix as an isoplot and to provide tools for
method optimization.
MS peak purity
• MS Peak Purity for SCAN and SIM/SCAN data. Users can setup in the
processing method to calculate MS peak purity for identified peaks or all
peaks.
Mass annotation
• Ability to label the UV and MS chromatogram peaks with base peak m/z.
Chromatogram smoothing
• Ability to setup the smoothing parameters in the processing method.
Loading methods from another project
• Allows authorized users to browse to another project, open a method
and save a copy of that method to their current project or link it to a
result set.
Overlay chromatograms from different projects
• Allows users to load data from other projects to compare results.
MS tune report
• Ability to display the MS tune report for selected injection from the
injection tree.
Enhanced conditional formatting and Reporting
• Improved conditional formatting for tables, fields, and matrix including
multiple color choice.
Automated export of ChemStation and AIA Files
• Ability to define automatic export of raw data (ANDI/AIA, CH) during a
running sequence as part an automatic processing method.

OpenLab CDS Release Notes 36

 Version 2.3

Load ChemStation/EZChrom Method

• Users can open a result set from ChemStation or EZChrom (option to
have multiple methods imported and linked automatically).
OpenLab CDS data analysis updated to true native 64-bit support for
handling of large files/data.

Driver Updates
Driver packages (revision) installed with OpenLab CDS version 2.3:
Agilent LC A.02.19
Agilent LC/MSD A.01.02.35
Agilent GC B.01.03
Agilent GC/MSD A.01.02
Agilent 35900E A/D 2.3.0
Agilent SS420x Interface A.01.01
Agilent Data Player A.02.01

Other RC.NET drivers included on USB media:

CTC PAL3 A.01.04
PAL XT B.01.08
ELSD A.01.07
Agilent 490 Micro GC 1.12.3
Agilent Headspace B.01.07.2

Non-Agilent Instrument Control Drivers

For the most current list of supported Non-Agilent instruments visit the
OpenLab CDS product page at: www.agilent.com/chem/openlabcds

OpenLab CDS Release Notes 37

 Version 2.2

Version 2.2

Infrastructure Support
OpenLab CDS version 2.2 is supported in the following configurations are
Workstation Plus, Workstation with file-based storage, and Client/Server.
Workstations, Clients and Agilent Instrument Controllers can run under the
following:
• Windows 10, Enterprise or Professional, 64 bit
• Windows 7 SP1, Enterprise or Professional, 64 bit
• Windows 8.1, Enterprise or Professional, 64 bit

Acquisition
Automated creation of sequence result folder and name
Project enhancements supporting template file sharing
• Ability to share sequence and templates within multiple projects.
Failover state for operational continuity
• Allow submission of samples through the AIC in case of network connectivity
failure occurs.
Method translation from 68xx to 78xx and Intuvo
• Ability to open acquisition method created on a 68xx and use on 78xx or Intuvo.

Data Analysis
Snapshot via Data Analysis
• Ability to view, process and print from a sample that is being acquired.
Translation and import of MSD ChemStation data format to OpenLab CDS
Enhancement to user permissions and version access in Data Analysis
• Auto-lock result set when e-signing
• Version label will not change when a result set is signed or locked

OpenLab CDS Release Notes 38

 Version 2.2

• User can sign a locked result set

• Load older version of a processing method & single run result sets where
available
• Enhancements to user privilege control for MS functionality
Enhancements to reporting
• Zoom in/out of report preview with mouse wheel
• Ability to add any data field in header or footer
• Use of complex custom fields in filter, grouping and sorting expressions
• More formatting settings for custom tables
• New option to remove duplicate peaks when using named groups
• Ability to define sorting of a repeated table
Integrated template documentation tool
• Allows the template author to document the design of the report template.
Enhancements for MS data include:
• Report single values of method override parameters in table and single fields
• Print graphical qualifier results (limit lines) and missing qualifiers

Add-ons
The following add-ons are supported with OpenLab CDS (*additional licenses may
be required):
• Support for Sample Scheduler for OpenLab
• Support for Gel Permeation Chromatography (GPC)* add-on
• Manual export of data files in legacy formats:
• ChemStation Edition *.D (including ch)
• AIA
• Support for Match Compare for OpenLab*

OpenLab CDS Release Notes 39

 Version 2.2

Driver Updates
Driver packages (revision) installed with OpenLab CDS version 2.2:
Agilent LC A.02.16.6
Agilent LC/MSD A.01.02
Agilent GC B.01.02
Agilent GC/MSD A.01.01
Agilent 35900E A/D 2.3.0
Agilent SS420x Interface A.01.01
Agilent Data Player A.01.02
Other RC.NET drivers included on USB media:
CTC PAL3 A.01.03
PAL XT B.01.08
ELSD A.01.07
Agilent 490 Micro GC B.01.12
Agilent Headspace B.01.07.2

Non-Agilent Instrument Control Drivers

• Includes driver support for Waters e-Alliance, Alliance, Acquity and Acquity H-
Class LC instruments
• Includes support for Bruker/Varian CP-3800/3900 and Scion 430/450/456 GC
instruments
• Includes support for Valco Instruments Valves: EMHCA-CE, EMHA-C, EMTCA-C
• Includes support for Shimadzu GC and LC instruments
• Includes support for Thermo Accela / Surveyor LC instruments

OpenLab CDS Release Notes 40

 Version 2.2

Important Support Information

For known issues and workarounds in the OpenLab software at the time of release
see the Software Status Bulletins (SSB), which can be found online at:
http://www.agilent.com/en-us/support/software-informatics/openlab-software-
suite/openlab-chromatography-data-system-(cds)/m84xx

Software Support Lifecycle Policy

Check the Agilent Software Support Lifecycle Policy at
https://www.agilent.com/en/support/agilent-openlab-software-support-lifecycle-
policy so you can schedule the updates to keep your version up to date.

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informatics/analytical-software-suite for up-to-date issue information on
Agilent’s Analytical Software suite.

OpenLab CDS Release Notes 41

In This Book
This document provides a listing of the major
feature modifications made in each release of
OpenLab CDS Software.

www.agilent.com
© Agilent Technologies, Inc. 2022

Edition 04/2022
D0013814