Semester-II Paper-1

Course Title: Bioorganic and Materials Chemistry

Programme: Certificate in Semester: II
Bioorganic and Medicinal Year: 1
Chemistry
Paper-1 Elective Subject: Chemistry
Course Code: B020201T Course Title: Bioorganic and Medicinal Chemistry
Course outcomes: Biomolecules are important for the functioning of living organisms. These molecules perform
or trigger important biochemical reactions in living organisms. When studying biomolecules, one can understand
the physiological function that regulates the proper growth and development of a human body. This course aims
to introduce the students with basic experimental understanding of carbohydrates, amino acids, proteins, nucleic acids
and medicinal chemistry. Upon completion of this course students may get job opportunities in food, beverage and
pharmaceutical industries.
Credits: 4 Elective

Max. Marks: 25+75 Min. Passing Marks:.

Total No. of Lectures = 60
No. of
Unit Topics Lectures
Chemistry of Carbohydrates: Classification of carbohydrates, reducing and non-reducing
sugars, General Properties of Glucose and Fructose, their open chain structure. Epimers
mutarotation and anomers. Mechanism of mutarotation Determination of configuration of
Glucose (Fischer's proof). Cyclic structure of glucose. Haworth projections. Cyclic structure
of fructose. Inter conversions of sugars (ascending and descending of sugar series, conversion 10
of aldoses to ketoses). Lobry de Bruyn-van Ekenstein rearrangement; stepping-up (Kiliani
Fischer method) and stepping-down (Ruff's &Wohl's methods) of aldoses; end-group
interchange of aldoses Linkage between monosachharides, structure of disacharrides (sucrose.
maltose, lactose.)
Chemistry of Proteins: Classification of amino acids, zwitter ion structure and Isoelectrid
point. Overview of primary, secondary. tertiary and quaternary structure of proteins
Determination of primary structure of peptides, determination of N-terminal amino acid (by
DNFB and Edman method) and C-terminal amino acid (by thiohydantoin and with
10
carboxypeptidase enzyme). Synthesis of simple peptides (upto dipeptides) by N-protection &
C-activating groups and Merrifield solid phase synthesis. Protein denaturation/ renaturation
Mechanism of enzyme action, factors affecting enzyme action, Coenzymes and cofactors and
their role in biological reactions).
Chemistry of Nucleic Acids: Constituents of Nucleic acids: Adenine, guanine, thymine and
II 05
Cytosine (Structure only). Nucleosides and nucleotides (nomenclature), Synthesis of nucleic
16

acids, Structure of polynucleotides: Structure of DNA (Watson-Crick model) and RNA (types
of RNA), Genetic Code, Biological roles of DNA and RNA: Replication, Transcription and
Translation
Introductory Medicinal Chemistry : Drug discovery, design and development; Basic
Retrosynthetic approach. Drug action-receptor theory. Structure -activity relationships of drug
molecules, binding role of -OH group,-NH, group, double bond and aromatic ring.
Mechanism of action of the representative drugs of the following classes: analgesics agents.
IV 10
antipyretic agents, anti-inflammatory agents (Aspirin, paracetamol): antibiotics
(Chloramphenico); antibacterial and antifungal agents (Sulphonamides; Sulphanethoxazol.
Sulphacetamide); antiviral agents (Acyclovir), Central Nervous System agents (Phenobarbital.
Diazepam), Cardiovascular (Glyceryl trinitrate), HIV-AIDS related drugs (AZT- Zidovudine
Solid State
Definition of space lattice, unit cell. Laws of crystallography - (0) Law of constancy of
linterfacial angles, (i) Law of rationality of indices and ii) Symmetry elements in crystals and 05
law of symmetry .X-ray diffraction by crystals. Derivation of Bragg equation. Determination
of crystal structure of NaCl, KCland CsCl (powder method).
Introduction to Polymer
Monomers, Oligomers, Polymers and their characteristics, Classification of polymers
Natural synthetic, linear, cross linked and network: plastics, elastomers, fibres
Homopolymers and Co-polymers, Bonding in polymers : Primary and secondary bond forces
lin polymers ;cohesive energy. and decomposition of polymers. Determination of Molecular
V 10
mass of polymers: Number Average molecular mass (Mn) and Weight average molecular mass
(Mw) of polymers and determination by (i) Viscosity (ii) Light scattering method (ii) Gel
permeation chromatography (iv) Osmometry and Ultracentrifuging.
Silicones and Phosphazenes -Silicones and phosphazenes as examples of inorganid
polymers, nature of bonding in triphosphazenes.
 P
Kinetics and Mechanism of Polymerization
Polymerization techniques, Mechanism and kinetics of copolymerization, Addition or chain
growth polymerization, Free radical vinyl polymerization, ionic vinyl polymerization, Ziegler
VII 05
Natta polymerization and vinyl polymers, Condensation or step growth-polymerization
Polyesters, polyamides, phenol formaldehyde resins, urea formaldehyde resins, epoxy resins
and polyurethanes.
Synthetic Dyes: Colour and constitution (electronic Concept), Classification of dyes.
VIII Chemistry and synthesis of Methyl orange, Congo red, Malachite green, crystal violet, 05
phenolphthalein, fluorescein, Alizarin and Indigo.

Suggested Readings:
1. Davis, B. G., Fairbanks, A. J., Carbohydrate Chemistry, Oxford Chemistry Primer, Oxford University Pres.
2. Finar, L. L. Organic Chemistry (Volume 2), Dorling Kindersley (India) Pvi. Ltd.(Pearson Education).
3. Nelson, D. L. &Cox, M. M. Lehninger's Principles of Bioctemistry 7th Ed, W. H. Freeman.
4. Berg. J. M.. Tymoczko, J. L. &Stryer, L. Biochemistry 7h Ed, W.H. Freeman. 1
5. Morrison, R. T. &Boyd, R. N. Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Educatiot.
6. Patrick, G. L. Introduction to Medicinal Chemistry, Oxford University Press, UK, 2013.
7. Singh,
2012.
H. &Kapoor, V.K. Medicinal and Pharmaceutical Chemistry, Vallabh Prakashan, Pitampura, New Delhi,
8. Atkins, P. W. &Paula, J. de Atkin's Physical Chemistry Ed, Oxford University Press 13 (2006).
9. Ball, D. W. Physical Chemistry Thomson Press, India (2007).
|10. Castellan, G. W. Physical Chemistry 4th Ed. Narosa (2004).
11. R.B. Seymour &C.E. Carraher: Polymer Chemistry: An Introduction, Marcel Dekker, Inc. New York
1981.
12. G. Odian: Principles of Polymerization, 4" Ed. Wiley, 2004.
13. F.W. Billmeyer: Textbook of PolymerScience, 2- Ed. Wiley Interscience, 1971.
14. P. Ghosh: Polymer Science &Technology. Tata McGraw-Hill Education, 1991
Note: For the promotion of Hindi language, course books published in Hindi may be prescribed by the University
Suggested online links:
http://heecontent.upsdc.gov.in/Home.aspx
https://nptel.ac.in/courses/104/105/104105124/
https://nptel.ac.in/courses/103/106/105106204/
https://nptel.ac.in/courses/104/105/104105034/
https://nptel.ac.in/courses/104/103/104103121/
https://nptel.ac.in/courses/104/102/104102016/
https://nptel.ac.in/courses/104/106/104106106/
https://nptel.ac.in/courses/104/105/104105120/

This course can be opted as an elective by the students of following subjects: Chemistry in 12th Class
Suggested Continuous Evaluation Methods:
Assessment and presentation of Assignment (10 marks)
04 Unit tests (Objective): Max marks of each unit test = (10 marks)
10 (average of all 04 unit tests)

Overall performance throughout the semester (05 marks)

(Discipline, participation in different activities)
Course prerequisites: To study this course, a student must have Passed Sem-I, Theory paper-1
Suggested equivalent online courses:
Further Suggestions:
 Semester-lI, Paper-2 (Practical)
Course Title: Blochemical Analysis
Programme: Certificate in Semester: I
Bioorganic and Medicinal Year: 1
Chemistry
Subject: Chemistry
Course Title: Biochemical Analysis
Course Code: B020202P

Course outcomnes
This course will provide basic qualitative and quantitative experimental knowledge of biomolecules such as
carbohydrates, proteins, amino acids, nucleic acids drug molecules. Upon successful completion of this course
students may get job opportunities in food, beverage and pharmaceutical industries.
Credits: 2 Elective

Max. Marks: 25+75 = 100 Min. Passing Marks:

Practical 60-h
No of
Unit Topics Lectures
Qualitative and quantitative analysis of Carbohydrates:
1. Separation of a mixture of two sugars by ascending paper chromatography
2. Differentiate between a reducing/ nonreducingssugar 15
3. Synthesis of Osazones.

Qualitative and quantitative analysis of Proteins, amino acids and Fats

1. Isolation of protein.
2. Determination of protein by the Biuret reaction.
3. TLC separation of a mixture containing 2/3 amino acids
4. Paper chromatographic separation of a mixture containing 2/3 amino acids 20
5. Action of salivary amylase on starch
6. To determine the concentration of glycine solution by formylation method.
7. To determine the saponification value of an oil/fat.
8. To determine the iodine value of an oil/fat

Determination and identification of Nucleic Acids

1. Determination of nucleic acids 12
2. Extraction of DNA from onion/cauliflower

Synthesis of Simple drug molecules

1. To synthesize aspirin by acetylation of salicylic acid and compare it with the
ingredient tof an aspirin tablet by TLC. 13
2. Synthesis of barbituric acid
3. Synthesis of propranolol

19

Suggested Readings:
1. Furniss, B.S.; Hannaford, A.J.: Smith, P.W.G.: Tatchell, A.R. Practlcal Organtc Chemistry, 5th Ed., Pearson
(2012).
2. Mann, F.G. & Saunders, B.C. Practical Organic Chemistry, Pearson Education.
3. Vogel's Qualitative Inorganic Analysis, Revised by G. Svehla.
4. Vogel, A.I. A
Textbook of QuantitativeAnalysis, ELBS. 1986
5. Furniss, B.S.; Hannaford, AJ.: Rogers, V.: Smith, P.W.G.; Tatchell, A.R. Vogel's Textbook of Practical
Organtc Chemistry, E
ELBS.
6. Ahluwalia, V.K. & Aggarwal, R. Comprehenstve Practical Organtc Chemlstry, Universities Pres
7. Cooper, T.G. Tool of Biochemistry. Wiley-Blackwell (1977).
8. Wilson, K. &Walker, J. Practical Biochemistry. Cambridge University Press (2009).
9. Varley, H., Gowenlock, A.H &Bell, M.: Practical Clinical Biochemistry, Heinemann,
Note: For the promotion of Hindi language, course books published in Hindi may be prescribed by the University
Suggestive digital platforms web links
1. https:llwww.labster.com/chemistry-virtual-labs/
2. https://www.vlab.co.in/broad-area-chemical-sciences
3. http://chemcollective,org/vlabs
This course can be opted as an elective by the students of following subjects: Chemistry in 12" Class
Suggested Continuous Evaluation Methods:
VIva voce (10 marks)
Mock test (10 marks)
Overall performance (05marks)
Course prerequisites: To study this course, a student must have Opted Sem-I, Theory Ppaer-1.
Suggested equivalent online courses:

Further Suggestions: