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The document discusses the causes and therapeutic approaches for managing gastric ulcers, including the role of Helicobacter pylori and factors that aggravate conditions like GERD. It outlines various drug classes such as proton pump inhibitors, antacids, and mucosal protective agents that either decrease acid secretion or enhance mucosal defense. Additionally, it highlights contraindications for certain treatments, particularly during pregnancy.

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Little Learner
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11 views

7

The document discusses the causes and therapeutic approaches for managing gastric ulcers, including the role of Helicobacter pylori and factors that aggravate conditions like GERD. It outlines various drug classes such as proton pump inhibitors, antacids, and mucosal protective agents that either decrease acid secretion or enhance mucosal defense. Additionally, it highlights contraindications for certain treatments, particularly during pregnancy.

Uploaded by

Little Learner
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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/causes

Septic
Ulcer
Drugs
t
&

cenic rece & GERD aggravating factors


&
Helicobacter pylori
***
Increased secretion of HCl **
Excessive use of NSAIDS

&
Inadequate defence against acid secretion

Main
-
aim of therapy Mucostandin
tradicate H -

pylai Bicarbonate
Decrease acid secretion
Increase mucosal defence mechanism
good therapeutic
factors

Parietal cell Gastric

-
Histami
Act
recopter
Gastin Death
u
receptor -Lumen -

Drugs that inhibit gastric acid that enhance mucosal


↑ Drugs
5-
-

Secretion -
Absolutely contra
defence
-

I
- indicated during
pregnancy- > causes
abortion.
↑
>&
- Proton Purp Inhibitors
-
Prostaglandin analogues Smisoprostal

I
homeprazole
-

a Ulcer protective esucralate colloidal


Esomeprazole
,
Trade ? bismuth subcitrate (CBS)
>
-
name

Rabepulaa rugs that neutralize gastic acid


-
Lansaprazole E * Systemic antacids > NatCOz Na-citrate

I
* blockers
#2-receptor a
,

Non-systemic antacids MgOt , magnesium >


-
&

Limetidine
Ranitidine
Tricilliciate , AlOHgel , CaCOs

Fami See
tidine E
Anti-H
-
.

Amoxicilin
pylori drugs
tetracycline clarithromycin
,
, ,
metronidazole subsalicylate
&

- Ach bismuth
inhibitor
,
* Antimucarinic agents recep for

In
- H2 antagonist & PPISLH + pump
Pivenzipine
Telezipine
increasing production
&

mucous

#
a Prostaglanding
-
S Sucralfate ,
CBS or bismuth compounds
Misoprostol mucoprotective agents
Exprostil
Gastrin inhibitors
-
>
- Nasostril

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