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Isopyropanol

The document is a Safety Data Sheet (SDS) for 2-Propanol (CAS-No. 67-63-0), detailing its identification, hazards, handling, storage, and first aid measures. It classifies the substance as highly flammable, causing serious eye irritation, and may cause drowsiness or dizziness. The SDS includes emergency contact information and guidelines for safe use and exposure controls.

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0% found this document useful (0 votes)
4 views13 pages

Isopyropanol

The document is a Safety Data Sheet (SDS) for 2-Propanol (CAS-No. 67-63-0), detailing its identification, hazards, handling, storage, and first aid measures. It classifies the substance as highly flammable, causing serious eye irritation, and may cause drowsiness or dizziness. The SDS includes emergency contact information and guidelines for safe use and exposure controls.

Uploaded by

humeyrakaradoruk
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 13

SAFETY DATA SHEET Version 6.

12
Revision Date 05.02.2024
according to Regulation (EC) No. 1907/2006 Print Date 09.05.2025
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking


1.1 Product identifiers
Product name : 2-Propanol
Product Number : 34863
Brand : SIGALD
Index-No. : 603-117-00-0
REACH No. : 01-2119457558-25-XXXX
CAS-No. : 67-63-0

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemie GmbH
Eschenstrasse 5
D-82024 TAUFKIRCHEN
Telephone : +49 (0)89 6513-1130
Fax : +49 (0)89 6513-1161
E-mail address : [email protected]
1.4 Emergency telephone

Emergency Phone # : 0800 181 7059 (CHEMTREC Deutschland)


+49 (0)696 43508409 (CHEMTREC
weltweit)

SECTION 2: Hazards identification


2.1 Classification of the substance or mixture
Flammable liquids, (Category 2) H225: Highly flammable liquid and vapor.

Eye irritation, (Category 2) H319: Causes serious eye irritation.

Specific target organ toxicity - H336: May cause drowsiness or dizziness.


single exposure, (Category 3),
Central nervous system

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2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal Word Danger


Hazard Statements
H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use non-sparking tools.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
Supplemental Hazard none
Statements

Reduced Labeling (<= 125 ml)


Pictogram

Signal Word Danger


Hazard Statements none
Precautionary Statements none
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

Ecological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Toxicological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

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SECTION 3: Composition/information on ingredients
3.1 Substances
Synonyms : sec-Propyl alcohol
Isopropyl alcohol
Isopropanol

Formula : C3H8O
Molecular weight : 60,10 g/mol
CAS-No. : 67-63-0
EC-No. : 200-661-7
Index-No. : 603-117-00-0
Component Classification Concentration
2-Propanol
CAS-No. 67-63-0 Flam. Liq. 2; Eye Irrit. 2; <= 100 %
EC-No. 200-661-7 STOT SE 3; H225, H319,
Index-No. 603-003-00-0 H336
Concentration limits:
>= 20 %: STOT SE 3,
H336;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures


4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact
lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

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SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Carbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
5.4 Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water
from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures


6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage


7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary
measures against static discharge.

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Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and
sources of ignition.

Handle and store under inert gas. hygroscopic


Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection


8.1 Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Workers Inhalation Long-term systemic effects 500 mg/m3
Workers Skin contact Long-term systemic effects 888mg/kg BW/d
Consumers Inhalation Long-term systemic effects 89 mg/m3
Consumers Skin contact Long-term systemic effects 319mg/kg BW/d
Consumers Ingestion Long-term systemic effects 26mg/kg BW/d
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 28 mg/kg
Sea water 140,9 mg/l
Fresh water 140,9 mg/l
Sea sediment 552 mg/kg
Fresh water sediment 552 mg/kg
8.2 Exposure controls
Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other

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substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Chloroprene
Minimum layer thickness: 0,65 mm
Break through time: 120 min
Material tested:KCL 720 Camapren®
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic
compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties


9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color colorless
c) Odor alcohol-like
d) Melting Melting point/range: -89,5 °C
point/freezing point
e) Initial boiling point 82 °C
and boiling range
f) Flammability (solid, No data available
gas)
g) Upper/lower Upper explosion limit: 13,4 %(V)
flammability or Lower explosion limit: 2 %(V)
explosive limits

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h) Flash point 12,0 °C - closed cup
i) Autoignition 425,0 °C
temperature
j) Decomposition Distillable in an undecomposed state at normal pressure.
temperature
k) pH at 20 °C
neutral
l) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: 2,2 mPa.s at 20 °C
m) Water solubility at 20 °C soluble
n) Partition coefficient: log Pow: 0,05 - Bioaccumulation is not expected.
n-octanol/water
o) Vapor pressure 43 hPa at 20 °C
p) Density 0,785 g/mL at 25 °C
Relative density No data available
q) Relative vapor No data available
density
r) Particle No data available
characteristics

s) Explosive properties No data available


t) Oxidizing properties none
9.2 Other safety information
Minimum ignition 0,65 mJ
energy
Conductivity < 0,1 µS/cm
Surface tension 20,8 mN/m at 25,0 °C

Relative vapor 2,07


density

SECTION 10: Stability and reactivity


10.1 Reactivity
Formation of peroxides possible.
Vapors may form explosive mixture with air.
10.2 Chemical stability
Reacts with air to form peroxides.
The product is chemically stable under standard ambient conditions (room temperature) .
Stable under recommended storage conditions.

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10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information


11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 5.840 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - 37,5 mg/l - vapor

(OECD Test Guideline 403)


LD50 Dermal - Rabbit - 12.800 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation
(OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative
(OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative

Test Type: In vivo micronucleus test


Species: Mouse
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Cell type: Bone marrow
Application Route: Intraperitoneal injection
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
This product is or contains a component that is not classifiable as to its carcinogenicity
based on its IARC, ACGIH, NTP, or EPA classification.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Inhalation, Oral - May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
RTECS: NT8050000
Central nervous system depression, prolonged or repeated exposure can cause:, Nausea,
Headache, Vomiting, narcosis, Drowsiness, Overexposure may cause mild, reversible liver
effects., Aspiration may lead to:, Lung edema, Pneumonia
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
After absorption:

Headache
Dizziness
inebriation
Unconsciousness
narcosis

After uptake of large quantities:

Coma

Handle in accordance with good industrial hygiene and safety practice.

Kidney - Irregularities - Based on Human Evidence

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SECTION 12: Ecological information
12.1 Toxicity
Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) -
9.640 mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to daphnia EC50 - Daphnia magna (Water flea) - 13.299 mg/l - 48 h
and other aquatic Remarks: (IUCLID)
invertebrates
Toxicity to algae IC50 - Desmodesmus subspicatus (green algae) - > 1.000 mg/l - 72
h
Remarks: (IUCLID)

Toxicity to bacteria EC5 - Pseudomonas putida - 1.050 mg/l - 16 h


Remarks: (Lit.)

12.2 Persistence and degradability


Biodegradability aerobic - Exposure time 5 d
Result: 53 % - Readily biodegradable.
(Directive 67/548/EEC, Annex V, C.6)
Theoretical oxygen 2.400 mg/g
demand Remarks: (Lit.)
Ratio BOD/ThBOD 49 %
Remarks: (IUCLID)
12.3 Bioaccumulative potential
No bioaccumulation is to be expected (log Pow <= 4).
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects


No data available

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SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

SECTION 14: Transport information


14.1 UN number
ADR/RID: 1219 IMDG: 1219 IATA: 1219
14.2 UN proper shipping name
ADR/RID: ISOPROPANOL
IMDG: ISOPROPANOL
IATA: Isopropanol
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
Tunnel restriction code : (D/E)
Further information : No data available

SECTION 15: Regulatory information


15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
National legislation
Seveso III: Directive 2012/18/EU of the P5c FLAMMABLE LIQUIDS
European Parliament and of the Council
on the control of major-accident hazards
involving dangerous substances.
P5c FLAMMABLE LIQUIDS

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Other regulations
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information


Full text of H-Statements
H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM -
American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen,
Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for
Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration
associated with x% response; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; GHS - Globally Harmonized
System; GLP - Good Laboratory Practice; IARC - International Agency for Research on
Cancer; IATA - International Air Transport Association; IBC - International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization;
IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial
Safety and Health Law (Japan); ISO - International Organisation for Standardization;
KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a
test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. -
Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration;
NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading
Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic
Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID - Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS -
Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand
Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

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Further information
The information is believed to be correct but is not exhaustive and will be used solely as
a guideline, which is based on current knowledge of the chemical substance or mixture
and is applicable to appropriate safety precautions for the product. It does not represent
any guarantee of the properties of the product. Sigma-Aldrich Corporation and its
Affiliates shall not be held liable for any damage resulting from handling or from contact
with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The branding on the header and/or footer of this document may temporarily not visually match
the product purchased as we transition our branding. However, all of the information in the
document regarding the product remains unchanged and matches the product ordered. For
further information please contact [email protected].

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