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Fluorouracil-

Fluorouracil, commercially known as Drucil, is a pyrimidine analog used primarily in the treatment of various carcinomas, including those of the colon, liver, and breast. It is administered intravenously and has a narrow safety margin with potential severe side effects, including cardiac issues and hematological effects. The drug is contraindicated in patients with cardiac disease and severe liver or kidney dysfunction, and it is essential to store it properly to maintain its efficacy.

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7 views9 pages

Fluorouracil-

Fluorouracil, commercially known as Drucil, is a pyrimidine analog used primarily in the treatment of various carcinomas, including those of the colon, liver, and breast. It is administered intravenously and has a narrow safety margin with potential severe side effects, including cardiac issues and hematological effects. The drug is contraindicated in patients with cardiac disease and severe liver or kidney dysfunction, and it is essential to store it properly to maintain its efficacy.

Uploaded by

sanisaniul777
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Drucil

Fluorouracil USP
GROUP MEMBERS

Md Saniul Alam Tahsin Waseqa Md. Arif Rayhan Md. Samir


20203103 21103007 Rahat Rahman Sajin
21103023 21103042
Fluorouracil, known commercially as Drucil, is a pyrimidine analog and a
fluorinated derivative of uracil.

Uracil Fluorouracil(5-FU)
5-fluoro-2,4(1H,3H)-pyrimidinedione

Composition: Brand Names:


250 mg of Fluorouracil in 5 ml
of solution Drucil, Adrucil,
500 mg of Fluorouracil in 10 Efudex, Carax, Tolak
ml of solution
Injectable solution
Mechanism of action
Pharmacokinetics:
5-fluorouracil is rapidly metabolized in the liver to produce biologically inactive metabolite which are eventually converted to
carbon dioxide, eliminated by the lungs. 80 % of can be accounted for by conversion to respiratory CO2 within 12 hr of
administration. 15 % of the drug is excreted through urine.

Therapeutic indications
Fluorouracil is indicated alone or in combination for Carcinoma of the -

Colon Liver Breast Lung Bladder Cervical


or Carcinoma
rectum
Dosage & Administration
Usual Dose:
• Initial Course: 12 mg/kg once daily for 4 days

• Maintenance Therapy: 5–10 mg/kg weekly

• Cervical Cancer (with Cisplatin): 1 g/m² IV on day 1, repeated every 21 days

• Pediatric Use: Safety and efficacy not established


Combinations in Treatment:
Administration • With radiation and other anticancer drugs
Administered intravenously

Delivered by rapid IV bolus • Used in adjuvant treatment of


injection or by slow infusion breast and gastrointestinal cancers

Adult Dose (Combination with Radiation):


• 5–10 mg/kg based on systemic administration
Side Effects:
Precautions & Warnings:

• Highly toxic with narrow safety margin


Cardiac: Hematologic:
• Reports of angina, myocardial infarction,
Ischemic heart Bone marrow
and arrhythmias
disease suppression
• Severe hematological effects:
thrombocytopenia, leukopenia

Gastrointestinal:
Severe diarrhea, stomatitis
Contraindications Storage Condition:

Cardiac disease Severe liver or kidney


Keep in the original package
(rare but may cause cardiotoxicity, dysfunction
including angina or MI) ( May impair drug
metabolism/excretion. )
Store below 25°C
Keep away from direct sunlight

Packaging:
Pregnancy & Breast feeding Drucil IV Injection is
(Cytotoxic drugs are absolutely contraindicated during
pregnancy because they are reported to cause multiple
available in
congenital abnormalities) 5ml and 10ml vial.

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