Aksh Book
Aksh Book
SURGERY
Dr Akshpreet Kaur
Dr S P S Sodhi
Dr Ramandeep Singh Brar
Dr Gursimrat Kaur Brar
DENT
UBLICATION
Facial Aesthetic Surgery
Authors
Published by
DENT
UBLICATION
DENT
UBLICATION
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1. Introduction 09
2. Anatomy 11
3. Ageing 24
4. Facelift Procedures 30
5. Rhinoplasty 45
8. Complications 76
9. Bibliography 89
''The face is the most innate, most individual characteristic of your body. It is who you are''
O
ur face is a self portrait that we show to the world. Every person's face is unique. Even
identical twins possess certain distinguishing facial characteristics from each other. Our
face defines who we are as an individual. In fact, through the face it is possible to
recognize the expressions of happiness, suffering, wondering, and sadness among several other
reactions of the inner well-being of a person. Face being the mirror of what we are from inside, reflects
the signs and symptoms of aging, illness, deficiencies and personality traits.
Since time immemorial aesthetics is an individual's perception. People are treated differently
based on how physically attractive they are perceived to be. Even the minute defect on face engraves
an exaggerated long-lasting impression on person's mind.
Human beings undergo inexorable aging process which takes away youthfulness. No one is spared
from the rages of ageing. This natural alteration is noticeable more on the face although the entire body
presents significant metabolic disturbances during the life. This usual, unkind, complex process takes
place over 40 years of age. Fat compartments change their volume, thickness of subcutaneous fat
decreases, muscles exhibit mass reduction and bone undergo negative mineral balance and loose
volume & projection. The effects of aging, as well as other circumstances of life such as sun, pollution,
and general stress, are shown on individual's face and neckline. All these circumstances lead to laxity
of overlying skin, wrinkle formation, fold accentuation, drooping of upper eyelid, hollowness in the
under-eye area, deepening of nasolabial fold, sagginess of skin at the border of mandible etc.
Society's attitude toward ageing seems to have changed significantly over the past several
generations and although we have reluctantly accepted that but we do not necessarily need to show full
effects of ageing.
Aesthetic surgery is the pursuit of what is described by the Greek word 'aisthetikos' meaning
passion for that which is beautiful. Aesthetic surgery or cosmetic surgery represents a universal human
desire to maintain or restore normal appearance or to enhance it toward an aesthetic ideal. The goal
may be to return an abnormal or unsightly feature to normal or to produce a younger, more beautiful
appearance.
T o create a more youthful, natural-looking form, the surgeon endeavours to reverse some of
the changes that occur due to ageing. A sound knowledge of facial anatomy will increase
the likelihood of success and reduce the incidence of undesirable results and
complications.(Shiffman and Giuseppe, 2013)
Subcutaneous Layer
The subcutaneous layer has 2 components, subcutaneous fat which provides volume and the
fibrous retinacular cutis that connects the dermis with the underlying SMAS.
Superficial fat – It has varying degrees of thickness and adherence. The pretarsal part of the
eyelids and lips are compacted, and the subcutaneous fat is not present. The mid cheek can be divided
into 3 areas: lid cheek, malar, and nasolabial, and respectively, each area has thicker subcutaneous fat
The retinacular cutis fibres vary in their orientation throughout the face; they can have a more
horizontal configuration in less adherent areas, and are vertically arranged in more adherent areas of
the face.
Overlying the retaining ligaments, the fibres are more densely arranged and vertically oriented. As
a result, to surgically develop a subcutaneous flap here usually requires sharp release.
In contrast, in the subcutaneous compartments overlying the sub-SMAS spaces the retinacular
fibres are less dense and more horizontally oriented so that a relatively easy blunt dissection is usually
sufficient to elevate the subcutaneous facelift flap here.
Sub-SMAS Plane
This surgical plane contains the facial nerve motor branches
and the parotid duct and is best avoided by surgeons. The
parotidomasseteric fascia is the facial layer that overlies the
parotid gland and masseter muscle; when operating superior to
this layer, the facial nerve branches are generally protected. Just
as the SMAS is an extension of the superficial cervical fascia,
the parotidomasseteric fascia is an extension of the superficial
layer of the deep cervical fascia into the face and the deep
temporal fascia above the zygomatic arch. The facial nerve
branches are deeper in the parotid gland until they emerge at the
anterior border of the gland and cross the masseter muscle Figure 2.10 - Superficial fat and SMAS
have been removed, exposing the peripheral
branches of the facial nerve
Retaining Ligaments
The facial ligaments are
condensations of connective Osteocutaneous retaining ligaments Fasciocutaneous retaining ligaments
tissue that subdivide the face
into compartments and Zygomatic ligament (Mc Gregor Masseteric ligament
connect the facial layers from ligament
the skin superficially to the
bone deeply. The ligaments Mandibular ligament Parotid cutaneous ligament
can be termed true, which
extend from the skin to the
Table 2.1 Retaining ligaments of face
facial skeleton, or false,
which connect only the
muscles to the bone and do
not extend superficially to the
skin. Figure 2.11 - Left facial dissection
T h e y a r e s u rg i c a l l y Elevation of the superficial fascia
released during face-lifting showing the ligamentous connections
procedures to facilitate to the deep fascia, including the
temporal ligamentous adhesion,
mobilization and lateral orbital thickening, zygomatic
repositioning of soft tissue ligament, and mandibular ligament
layers.
Osteocutaneous ligament – They run from periosteum to the dermis.
Stout zygomatic retaining ligaments originate from the inferior border of the zygomatic arch
towards the junction between the arch and the body and insert into the dermis of the skin as fibrous
septa. It is posterior to the zygomaticus major muscle, approximately 3 mm in width, 0.5 mm in
thickness and 4.5 cm anterior to the tragus. Loss of support results in malar fat descent.(Furnas, 1989)
Fasciocutaneous retaining ligaments – They are formed from a coalescence of superficial and
deep facial fascia.
Masseteric ligaments originate from the parotidomasseteric cutaneous ligaments, and. loss of
support results in facial jowling. Parotid cutaneous ligaments are formed by the posterior border of the
platysma, which had receded into fascial condensation. It is fused with the parotid fascia, is attached
to the overlying skin and provides firm anchorage between the platysma and the dermis in the inferior
auricular region.(Bonanthaya et al.,2021)
Deep Fascia
The deep fascia, the deepest soft-tissue layer of the face, is
formed by the periosteum where it overlies bone. Over the lateral
face, where the muscle of mastication (temporalis and masseter)
overlies the bone, the deep fascia is instead the fascial covering of the
muscles- deep temporal fascia and masseteric fascia above and
below the zygomatic arch, respectively. The parotid fascia is also
part of the deep fascia.(Jonathan et al.,2020)
The deep fascia, although thin, is tough and unyielding and gives
attachment to the retaining ligaments of the face. In the mobile Figure 2.12 - Left temporal fossa
with TPF (layer III) reflected inferiorly
shutters over the bony cavities, the deep fascia is absent, being The DTF (lay er V) is held by
replaced by a mobile lining derived from the cavities, that of the the forceps. The frontal and parietal
conjunctiva or oral mucosa. branches of the superficial temporal
ar ter y ar e seen cour sing al ong
the surface of the DTF
Muscles of Facial Expressions
The muscles of facial expression are the 'cosmetic muscles' as they are responsible for
hyperdynamic facial lines associated with ageing. The muscles of facial expression are manipulated
by cosmetic facial surgeons to camouflage the
ageing process. Interventions to these muscles
have profound effects on the upper, middle, and
lower thirds of the face. Muscular facial activity
and its relationship to the formation of wrinkles
is one of the major forces responsible for facial
ageing. Dividing the face into muscular thirds
will define the muscular groups responsible for
the formation of the lines, creases, furrows, and
folds that are so indicative of the aging Figure 2.13 - Muscles of facial expression
process.(Vigiliante,2005)
Of clinical note, there is a loose connective tissue surgical plane between the galea and the
pericranium that permits ease of dissection during brow- lift surgery.
The frontalis muscle is the main antagonist of the eyebrow depressors. Horizontal forehead
creases are treated effectively with botulinum toxin Type A treatment and are minimized by result of
brow lift.
The procerus muscle is one of the common sites for Botox injections. This treatment can produce a
medial brow chemo lift and eliminate the glabellar lines associated with aging.
Corrugator supercilliis the muscle of 'frowning'(Clemente, 1985). It can be easily softened with
injection of Botox into the muscle.
Forceful contraction of the orbital component of orbicularis oculiinduces concentric folds
emanating from the lateral canthus resulting in lateral canthal lines or crow's feet. In childhood, crow's
feet occur only in dynamic situations (e.g., laughter and squinting in bright light). In adulthood, these
lines are frequently seen even in facial repose. Botox and laser skin resurfacing are techniques often
used to soften and erase the line.(Carruthers and carruthers, 2001)
The upper nasalis lines or 'bunny lines' can be softened successfully with application of Botox on
each side. Care should be taken to not inject too low in the nasofacial groove which can weaken the
levator labii superioris alaque nasi and levator labii superioris, producing aesthetically significant
ipsilateral lip ptosis and creating an unpleasant aesthetic effect.(Carruthers and carruthers, 2001)
Injection intolevatorlabiisuperiorisalaequenasimuscle can result in temporary lip ptosis and an
unpleasant outcome. However, very small amount of Botox has been injected into this muscle to drop
the upper lip in the treatment of maxillary gingival excess on smiling.
Vertical lines in the midface (also known as Melo labial lines) give an impression of hostility,
fatigue and age. Weakening of the levatorlabiisuperioris with 1 to 2 U of Botox can soften the upper
half of the fold but at the cost of ptosis. Therefore, this treatment has not been popular.
The dynamic wrinkle produced by the action oflevatorangulioris muscle has a profound effect on
facial aging. Various wrinkle fillers and autologous fat have been used to camouflage a pronounced
nasolabial fold.
Vascular Anatomy
The anatomy of the arterial
supply to the face and venous
drainage in the area of dissection
is significant, not only to avoid
injury to the vessels, but also for
consideration of flap viability
postoperatively. The main
arteries of the face include facial
artery, superficial temporal
artery and transverse facial
artery from superficial temporal
artery, infraorbital artery from
maxillary artery.(Von Arxand Figure 2.15 - The arterial blood Figure 2.16 - Lateral view of the arterial
supply to the face The external facial blood supply The external carotid
Lozan off 2017) carotid artery (ECA, red area) artery provides all extracranial branches
According to Soikkonen et and the internal carotid artery
al. (1991), the blood supply to (ICA, pink area)
the face is mainly provided by the facial, transverse facial and infraorbital arteries that are in
hemodynamic balance. The blood supply to the skin follows the connective tissue framework. The
main arterial skin perforators pierce the deep fascia originating from their source arteries, then
radiating to the skin areas of the face. In general, the vessels are intimately related to the superficial
musculo-aponeurotic system (“facial musculature”). Midline anastomoses of arterial vessels are
especially rich in the forehead and lips. (Houseman, Taylor and Pan 2000)
Many veins in the face accompany the homonymous arteries, but there are some exceptions to the
rule (inferior ophthalmic vein, retromandibular vein). Furthermore, the facial vein and artery run a
different course in the face at a certain distance from each other. From a surgical standpoint, the most
frequently encountered vessels in face-lift surgery are the external jugular vein and the transverse
facial artery.
McKinney's point
Prior to surgery, McKinney's point is
marked on the skin surface at 6.5 cm inferior
to the bony external auditory meatus at the
Figure 2.17 - Venous drainage of Figure 2.18 - McKinney's midpoint of the sternocleidomastoid
the cranial region Note the super- point
ficial position of the facial nerve muscle. McKinney's point marks the site of
and its relationship with the super- the greater auricular nerve as it crosses over
ficial temporal vein the belly of the sternocleidomastoid muscle.
A 1-cm radius from this point is demarcated in all directions. The anterior portion of the resultant
circle will identify the site of the jugular vein as it passes the anterior border of the
sternocleidomastoid muscle.(Fonseca,2017)
Figure 2.20 - Illustration of the sensory territories of the skin of the face:
green = territory of ophthalmic division of trigeminal nerve;
blue = territory of maxillary division of trigeminal nerve;
beige = territory of mandibular division of trigeminal nerve;
red = territory of anterior branches of cervical plexus
Pitanguy line
The superior division of the facial nerve courses
superiorly within the substance of the parotid gland and
proceeds along the Pitanguy line toward the temporal
region.This line is marked by an inferior point at 0.5 cm
below the tragus and superior point 1.5 cm above the
lateral brow.(Niamtu, 2010)
The internal nose is constituted of the septum and the turbinates, all of which are covered by
mucosa.
§ Septum: The nasal septum is a rigid, quadrangular-shaped structure covered by mucosa that
separates the two nostrils, and it constitutes the principal support for the nose. In the junction
between the dorsal and caudal septum lies the anterior septal angle, which helps to determine nasal
projection. Through the internal nasal valve, it has a very important role in maintaining a patent
airway.
Ageing of Skin
The normal turnover rate for skin is 40-50 days. The natural process of desquamation sheds off the
dry, old, hardened skin cells and gives way to the new cells to come to the surface. This process also
eliminates damaged and contaminated cells that carry pollutants and microorganisms from the
environment.
The specialised fibroblasts in the dermal layer produce two key proteins-collagen and elastin.
Collagen constitutes 80% of the dermis and provides strength and firmness to the skin. While elastin,
as the name implies, provides elasticity to the skin and enables the skin to bounce back to its original
shape after it is stretched, thus preventing wrinkles. (Bonanthaya et al., 2021)
Extrinsic Ageing
Extrinsic ageing is because of the aggregated damage caused by environmental factors such as
sun's UV radiation, gravity, sleeping posture, pollution, smoking, exposure to chemicals, etc. These
exogenous factors along with the innate factors cause premature ageing of our facial skin.
Recurrent and continual UV exposure disintegrates collagen and impedes the synthesis ofnew
collagen. Alongside, there is a breakdown of elastin causing the facial skin to become slack, wrinkled
and leathery much earlier than a sun-protected skin.
Gravity constantly works on different parts of our facial skin. As the skin elasticity reduces with
age, the effects become evident. It precipitates jowls, nasolabial fold, drooping of eyelids, elongation
of ears, etc.
Sleeping posture - Sleep lines are wrinkles that are etched on the facial skin of the people who sleep
with the face pressed on the cushion or sleep on the sides.
Cigarette smoking over a period of time causes many biochemical alterations in our body. The
nicotine causes vasoconstriction thereby impairing the supply of oxygen and important nutrients,
such as vitamin A to the skin. Many of the over 7000 chemicals released from the burning cigarettes
cause increased production of matrix metalloproteinases (MMP) that causes degradation of collagen
and causes abnormal creation of elastosis materials. These cause premature facial skin wrinkling.
Ageing Epidermis
Having no blood supply, the epidermis gains its nutrition through contact with the dermis. A major
cutaneous change in intrinsic skin ageing is a reduction in the surface contact between the epidermis
and dermis. There is a loss of rete ridges, which negatively affects the capillary rich dermal papillae,
resulting in a reduced supply of nutrients, metabolites and oxygen to the epidermis (Tobin, 2017). The
reduced contact between dermis and epidermis also results in less resistance to shearing forces. In
addition, with age, the epidermis atrophies because cell production decreases up to 50% between 20s
and 70s (Cerimele Celleno and Serri, 1990)
Ageing Dermis
With the increasing age, there is a loss of dermal volume and dermal thickness by about 20%
(Farage et al., 2013) The collagen content of the dermis decreases by 1% per year throughout adult
life. In addition, collagen itself changes from well-organized bundles of fibers in young skin to
fragmented and disorganized fibers in older skin; it also loses its interwoven extensions with elastin
fibers, which in youth enable the skin to regain its shape after deformation.
Fibroblast activity decreases with age; these cells shrivel and fewer epidermal growth factor
receptors. There is associated drop in collagen synthesis, atrophy of collagen bundles and increase in
the levels of MMPs .(Khavkin and Ellis, 2011)
As collagen fibers decrease in number, rupture,
cross-link and stiffen, their capacity to bind water
diminishes and skin loses elasticity and becomes
wrinkled. Wrinkles appear not due to degeneration
of elastin fibers, as previously thought, but to a
decreased water-holding power of collagen and
mucopolysaccharides .
Skin ageing is also associated with a decrease in
cutaneous perfusion and reduced vascularity,
mainly in the papillary dermis.
Figure 3.2 – Age related changes in Dermis & Epidermis
Figure 3.3 – Superficial Fat compartments Figure 3.4 - Deep fat compartments
With the attenuation of the osteocutaneous ligaments, Corresponding volume loss or gain in the adjoining
there is vertical descent of facial soft tissue which areas of the face is what creates the deep creases of
contributes to the deep creases of the ageing face. age (Donofrio, 2000)
The diminished strength of the ligaments is because Ageing process was due to the relative deflation of
of the age-related elastosis and also because of the certain fat pads, especially the deep fat pads
repeated animation of the muscles of facial expression. (Lambros, 2007)
Midface
The rate of bony resorption in the
midface, however, is not uniform. The
maxilla is more susceptible to age-related
loss than the zygoma.
The maxilla retrudes with aging and
quantitated the changes. The maxillary
angle is decreased by about 10 between
young (age \30 years) and old (age [60
years) individuals (Mendelson and Figure 3.7 - The pyriform (pyriform angle) and the maxilla
(maxillary angle) significantly recede with aging from youth
Wong, 2020) (left) to old age (right)
Perinasal changes
The nose lengthens and the tip droops, with the columella and the lateral cruraedisplacing
posteriorly. Changes in the bony foundation i.e. the
paired nasal bone, and the ascending processes of the
maxillae are responsible for many of the soft tissues
changes seen in the nose with aging. Piriform Figure 3.8 - The loss
apertureenlarges with aging as the edges of the “nasal” of bone in the pyriform
bones recede with age. Similarly, bone loss is not area weakens the support
uniform, with the greatest resorption occurring in the of lateral crura. Deepening
of the maxilla results in
ascending process of the maxilla. The posterior posterior positioning of
displacement of the bone rim is greatest at the lower the nasolabial crease and
pyriform aperture, which is the critical area for support adjacent upper lip
of the lateral crura and the external nasal valves.
P reservation of one's youthful looks has been a goal of humans regardless of cultures and
ethnicities. The search for this elixir of youth was found unexpectedly in the hands of
cosmetic surgeons. Even with the recent advent of skin peels, botulinum toxin injections,
lasers and injectable filler injections, the century-old facelift still possesses the most dramatic
improvement to the moderate to severe ageing lower face when done well.(Bonanthaya et al., 2021)
Facelift or rhytidectomy as its name suggests is a procedure to partially eliminate folds, creases
and wrinkles (rhytids) caused by gravity and degeneration. In effect, the creation of two large cervico
facial faps, which, after suspension and trimming, produces an overall tightening of the skin and the
fascial envelope of the face and neck, resulting in restored anatomical structure.
Patient Evaluation
Evaluation of prospective patients for face-lift surgery considers three main areas:
(1) Medical history,
(2) Facial esthetic evaluation, and
(3) Psychosocial considerations
Medical history
Thorough medical history is required. Complications associated with previous surgical
procedures should be noted. Peri-operative excess bleeding, postoperative infection, wound healing
problems, and any complications that resulted in patient dissatisfaction with the procedure. If
possible, all anticoagulation medication should be suspended prior to surgery.
Well-definedcervicomental angle
I Normal Good muscle tone
No submental fat
Incision
The purpose of a facelift incision is two-fold. First, the incision
allows elevation of a skin flap that can be repositioned to remove excess Figure 4.2 - Important landmarks
drawn preoperatively include the
skin – the primary goal of a skin-only subcutaneous facelift. Second, the trajectory of the temporal branch
incision provides access for the surgical manipulation of the deep tissues of the facial nerve, the deep plane
of the face – the primary goal of most modern facelift techniques. entry point, incision lines, & inferior
extent of neck skin elevation
The incision lines are divided into four sections (Bonanthaya et al.,2021):
§ Temporal
§ Preauricular
§ Postauricular and
§ Scalp extension
Temporal Incision
The temporal component is either into the hairline or just at the hairline/ sideburn border. If the
estimated postoperative lateral orbital rim to anterior hairline distance is <5cm (i.e., minimal temporal
skin resection), then the temporal portion of the incision can be concealed behind the hairline. If the
anticipated distance is >5cm, then a pre hairline incision is chosen to prevent post surgical sideburn
distortion. The latter has the advantage of not moving the sideburn position; however, it would give a
tell-tale sign of a visible scar. In the former approach, the sideburn area may get lifted into the
temporal area and the scar will be hidden.
Cervicoplasty Incision
A 2.5 cm curvilinear submental incision parallel to the mandibular contour to the neck lift section
in order to expose the anterior border of the platysma and the platysmal dissection.
This chapter will provide detailed knowledge of standard SMAS and extended deep plane face lift
procedures.
Surgical Technique
The submental flap dissection is carried out at first to expose the platysma muscle as much as
possible.(Bonanthaya et al.,2021)
While applying counter traction on the cheek (assistant's hand on the cheek), a skin flap is elevated
leaving adequate amount of fat on its
underside (3–4 mm). This is initially
done with a blade and can be advanced
using face lift scissors.
Next, the scalp and postauricular
dissection is carried out. The anterior
border of the sternocleidomastoid
muscle and posterior border of the
platysma are exposed, and a cavity of Figure 4.1.2 - Dissection is in Figure 4.1.3 - The postauricular flap is
the neck is connected anteriorly and the supraplatysmal plane then connected to the cervical fap and
the submental region made previously
posteriorly.
In the temporal, the deep part of deep temporalfascia is exposed, which we use as an anchor point
to the SMAS suturing.
SMAS Plication
Plication, or folding, is performed by simply excising a
crescent-shaped section of supra-SMAS adipose tissue from the
preauricular and infra-auricular areas followed by suture
suspension of the intact SMAS fascia. The plane of the SMAS is not
violated when the plication technique is used. Patients with slender
Figure 4.1.6 - Elevation of the face
or narrow faces often benefit from plication without removal of and neck skin flaps, exposing the
supra-SMAS adipose tissue. underlying SMAS layer
SMAS Imbrication
Alternatively, imbrication involves excising supra-SMAS adipose tissue and a segment of
redundant SMAS fascia, which
therefore violates the plane of the
SMAS.
Mobility of the SMAS is easily
determined by grasping the fascia with
blunt forceps and pulling the SMAS in
the vector of desired advancement,
posterosuperiorly.
The degree of sub-SMAS dissection
required is dictated by the amount of
Figure 4.1.7 - Sharp excision of a Figure 4.1.8 - A face and neck sub-
SMAS mobility. Over the parotid gland, vertical strip of preauricular SMAS SMAS layer is raised and elevated,
the facial nerve is relatively well- tissue is performed. Care is taken before lift
protected by the parenchyma of the not to violate the underlying parotid
gland tissue
Postoperative Care
The first postoperative appointment is on the day after surgery. Any dressings and drains are
removed, and careful examination of the skin flap is performed to evaluate skin vascularity. All areas
are inspected for the presence of a hematoma or seroma. A cooling mask can be used continuously for
the next 72 hours, taking short breaks for showering and wound care. The patient is allowed to shower
48 hours postoperatively. The patient is seen for their second visit on the seventh postoperative day for
complete suture removal and removal of one-half of the hairline staples. On the ninth postoperative
day, the remaining hairline staples are removed. If all wounds are healing well, the patient returns 4
weeks after surgery for evaluation
D eep plane facelifting targets the mobile medial superficial muscular aponeurotic system,
bypassing the lateral fixed superficial muscular aponeurotic system dissected in these
techniques. Releasing facial and cervical retaining ligaments allows greater redraping of
the superficial muscular aponeurotic system and platysma during rhytidectomy.
Extending the deep plane flap inferiorly into the neck and incorporating a platysmal
myotomy creates a platysma hammock to define the inferior mandibular contour and support the
submandibular gland. Deep plane composite flaps of skin, the superficial muscular aponeurotic
system, and malar fat can be repositioned to volumize the midface and gonial angle.
Figure 4.2.1 - Planes of dissection of the deep plane Figure 4.2.2 - Ligamentous attachments released in the
facelift extended deep plane face lift
Surgical Technique
Incision & Skin Flap Elevation
Skin incision is initiated with a No. 10 scalpel cutting perpendicular to the skin hairline of the
temporal hair tuft. The temporal and occipital hairline portions of the incision can be extended during
the operation if further skin redraping is need. Coursing inferiorly from the temporal region, the
Subcutaneous elevation in the cheek ends approximately 2 to 4mm beyond the marked line of the
deep plane entry point. The deep plane facelift approach poses no risk to the frontal branch because
the dissection is superficial in the subcutaneous plane where the frontal branch exists, and the sub-
SMAS dissection is begun at the deep plane entry point, which is 2 cm anterior and parallel to the
course of the frontal branch of the facial nerve.
Figure 4.2.8 - (A) An Anderson 5-prong retractor is placed at the anterior extent of the skin
dissection parallel to the deep plane entry point line. (B) With vertical tension on the retractor,
a No. 10 scalpel is used to make the incision into the deep plane
Composite flap of skin and SMAS is elevatedoff the parotid–masseteric fascia.
The masseteric cutaneous ligaments are released, allowing for
more complete repositioning of the jowl. Elevation of this flap
continues superiorly until resistance is reached at the zygomatic
osteocutaneous ligament. Blunt dissection through the inferior
part of the deep plane flap is continued under the platysma below
the mandibular border and onto the neck to facilitate later release
of the platysma from the sternocleidomastoid muscle.
Once the lateral border of the orbicularis is identified, the
prezygomatic space can be easily dissected with blunt finger Figure 4.2.9 - The sub- SMAS dissection
continues anteriorly with vertical spreading
dissection. This dissection is carried medially into the motion with a facelift scissor until the
premaxillary space, ending at the nasal facial crease. This masseteric cutaneous ligaments are released
technique was originally described as the FAME or finger- to the anterior border of the masseter
assisted malar elevation by Aston. (Aston,1998)
Figure 4.2.11 - Release of the deep Figure 4.2.12 - (A) Deep plane flap is released through the zygomatic ligaments
plane flap with sharp dissection of and (B) elevated to the nasolabial fold
the zygomatic ligaments superior to
inferior and staying superficial to the
zygomaticus musculature
Release of the Cervical Retaining Ligaments
The deep plane flap in the neck is marked from the gonial angle to the anterior border of the
sternoclei-domastoid
muscle extending 5 cm
inferiorly into the neck.
The dissection plane
immediately below the
platysma ensures that the Figure 4.2.13 - Release of the cervical retaining ligaments (A) Surgical marking of the
marginal mandibular and lateral platysmal border at its connection to the sternocleidomastoid muscle extending
5 cm below the angle of the mandible. (B) A No. 15 scalpel is used to make a broad and
cervical branches of the gentle incision until a lip of tissue is obtained, the edge grasped and sharp dissection
facial nerve down remain within the sternocleidomastoid muscle fascia is continued for approximately 1 cm,
deep, on the superficial (C) Subplatysmal flap freed after bluntly dissecting through the ligaments 3 cm anterior
to the sharply elevated flap
cervical fascia.
Figure 4.2.15 - (A) The flap is suspended vertically at an angle that maximizes elevation of the cheek fat pads and
revolumizes the midface. (B) Suture suspension along vertically oblique vector of 60 degree
Figure 4.2.17 - Lateral Playtsmal suspension in neck (C) The inferior platysmal tab is anchored to the mastoid fascia
with a 3-0 nylon suture and positioned just below the margin of the mandible creating a platysma hammock that elevates
the ptotic submandibular gland. Mandibular contour. (D) Note contour improvement of jawline and upper neck with
tension placed on platysmal hammock
After resuspension of the face and neck, attention is turned to redraping of the skin. The facial skin
is suspended in the same plane as the composite flap. The majority of the skin is removed vertically in
the temporal region. Deep, everting 4-0 Vicryl sutures are placed along the temporal incision prevent
depression and spreading of the scar over time. Skin closure is completed with everting 5-0 nylon
vertical mattress sutures. The remainder of the incision is closed with 5-0 nylon sutures anteriorly, 5- 0
nylon sutures behind the ear, and 4-0 nylon sutures in the occipital hairline.
Adjunctive submental procedures and platysmaplasty is indicated only if submental platysmal and
skin laxity is not corrected when surgeon places 3 fingers at deep entry point, a line from angle of
mandible to lateral canthus, on both sides of face and moves skin vertically.(Jacono and Bryant,
2018)
R hinoplasty remains presently one of the most complex surgical procedures in aesthetic
Surgery. As a central landmark of the face, nasal proportions and symmetry are directly
linked to facial beauty. Technical difficulties, the wide range of different techniques
described, and the struggle to achieve consistent results can be challenging even for very
experienced surgeons.
Surface Landmarks
Radix : The deepest depression of the nasal dorsum, located at the junction between
the frontal bone and the nasal bones.
Glabella : The most forward projecting portion of the forehead, located at the midline
between the supraorbital ridges.
Rhinion : The osseocartilaginous junction formed by the nasal bones and upper lateral
cartilages.
Dorsum : The anterior surface of the nose formed by the nasal bones and upper lateral
cartilages.
Supratip break : The slight depression seen in profile at the point where the nasal dorsum joins
the lobule of the nasal tip.
Infratip lobule : The portion of the tip lobule located between the columella and the most
projected portion of the nasal tip.
Tip defining points : For proper nasal tip definition four points should be visualized. These four
points are composed of the supratip break, the infratip lobule, and the most
projected portion or domes of the lower lateral cartilages.
Alar sidewall : The rounded eminence forming the lateral nostril wall.
Alar-facial junction : The depressed groove formed at the junction where the ala joins the face.
Columella : The skin that separates the nostrils at the base of the nose.
Nasofrontal angle : The angle formed between the forehead and nasal dorsum as seen in profile
view.
Nasolabial angle : The angle formed by the columella and the upper lip as seen in profile view.
Pronasale : The most projected portion of the nasal tip.
Local
General/ systemic
Facial Nose
Indications
§ Marked asymmetry
§ Secondary rhinoplasty
§ Need for structural grafting
§ Post traumatic nasal deformity
§ Nasal valve correction
Incisions
§ Marginal
§ Columellar
Marginal
Figure 5.4 - Marginal and rim
(infracartilaginous) incisions
The incision is
The marginal incision (dotted placed along the
line) parallels the caudal edge caudal margins of the
of the lower lateral cartilages LLC, starting at the
and is commonly used in rhin- caudal margin of the
oplasty. The rim incision (red
line) follows the contour of medial crus, running
the nostril along the mucosa along the entire
just inside the nostril dome and extended
laterally along the
caudal margin of the
lateral crus.
Figure 5.5 - The transcolu-
mellar incision Various con- Columellar incision
figurations of the transcolu-
mellar incision are used to This is a transverse
prevent linear scar contrac- mid-columellar
ture and aid in re-approxima- incision extending
ting the skin at closure. across to connect the
The common configurations
include a V, inverted V, or
marginal incisions
stairstep configuration on either side.
After dissecting the soft tissues of the lower and upper lateral cartilages, the soft tissues of the
columella and the domes are elevated and joined with the previously made pockets. Converse scissors
are used to begin dissection along the vestibular mucosa and a tunnel is created just caudal to the
medial crura. Next, a single skin hook is placed at the apex of the inverted V incision and the Converse
scissors are used to elevate the columellar skin.
Then tissues of the nasal dorsum are elevated. An Aufricht retractor is placed and the soft tissues
should be freed to the junction of the upper lateral cartilages with the nasal bones. The periosteum of
the nasal bones should be elevated sharply with a periosteal elevator.
Indications
§ Minimal tip correction
§ Access to dorsum and middle vault
§ Volume reduction of LLC
§ Septal surgery
§ Bony and cartilaginous hump removal
Incisions
§ Trans cartilaginous (Cartilage splitting)
§ Intercartilaginous (Retrograde eversion)
In Delivery approaches the first inter-cartilaginous incision and the subsequent marginal incision
to mark the chondrocutaneous unit of the LLC. The nonvestibular side is then dissected off the
overlying SSTE permitting the delivery of the LLC chondrocutaneous unit as a bipedicled flap.
A retractor is placed holding the alar rim superiorly, and slight pressure is applied in order to evert
the mucosa and visualize the intercartilaginous groove. Depending on the surgical planning, an
approach to the tip area could be done via delivery or non-delivery of the lower lateral cartilages
The trans-cartilaginous incision is usually performed in the context of a patient with a bulbous or boxy
tip, and the cephalic trim of the lower lateral cartilages is planned. After the incision, with the use of a
hook, eversion of the nasal mucosa is performed, and excess cartilage is detached using scissors. At
least a 5 mm rim strip should be maintained in order to avoid a pinched tip or an external valve
collapse.(Fichman, 2020)
The delivery technique is used when more complex tip modifications are planned. It allows for
better visualization as an open approach would provide. It is performed by making a marginal incision
from lateral crus to medial crus and an intercartilaginous incision bilaterally, which connect in the
midline and can continue to a hemi transfixion incision. The soft tissue between the marginal and the
intercartilaginous incision is dissected so that the lower lateral cartilages can be “delivered out” of the
incisions in order to modify them. These modifications can include trimming of the cephalic portion
of upper lateral cartilages, inter or intradomal sutures, tip grafts, and controlled weakening of the
cartilages. After this step, using a periosteal elevator, soft tissues are separated from the cartilaginous
and bony dorsum in a subperichondrial and subperiosteal plane.
Septoplasty
Deformities of the nasal septum may either be congenital or acquired.
Killian incision
Figure 5.8 - Septoplasty intra-operative steps (a) The part of the septum anterior to the line dropped from the tip
of nasal bone (NB) to the anterior nasal spine (ANS) has tobe preserved (b) Dysjunction of the cartilaginous septum
from the bony septum (c) Septal repositioning with sutures to the midline crest of the maxilla
Nasal Osteotomies
Indication
§ Close an open roof after dorsal hump removal
§ Correction of a deviated bony nasal vault (crooked nose/ bent nose)
§ Correction of concave or convex nasal bones
§ Reduce or narrow bony base width
§ Mobilise malunited fractured nasal bones prior to reduction
Lateral osteotomy is performed with a 2mm/ 4mm A 7mm osteotome placed on the edge of the nasal
osteotome from inferior, swept laterally to the bony bone where it meets the dorsal septum angling 15
nasofacial groove and then superiorly at the level degrees laterally. Tapped with a mallet till the level
of medial canthus of the medial canthus.
Implants:
§Autografts: Nasal septum, pinna & rib
cartilage, Iliac crest, Mastoid cortex or
tibia.
§ Homograft (allografts): Preserved,
irradiated or lyophilized cartilage and
bone.
§ Heterograft (xenograft): porcine or
bovine collagen.
§ Synthetic Alloplasts: Silastic, acrylic,
ivory, silicon, teflon, gore-tex, supramid Figure 5.12 – Augmentation of Post traumatic Saddle
mesh, proplast. nose deformity (a, b) with subtotal loss of the cartilaginous
septum using multi-layered quilted septal and conchal
cartilage graft (c)
Correction of the Deviated Nose
Deviated noses can be of two types
1. “Bent” nose where the nasal bones and the upper lateral cartilages point to the same side
2. “Crooked” nose where the nasal bones and the upper lateral cartilages face in opposite directions
Tip Plasty
The nasal tip is the centre of focus for both nasal anatomy and aesthetics. It is a very important
anatomical subunit and can be most challenging to refine surgically. The nasal tip is the centre of focus
for both nasal anatomy and aesthetics. It is a very important anatomical subunit and can be most
challenging to refine surgically. (Tasman,2007)
Figure 5.15 - Narrowing of boxy Figure 5.16 - Lateral crural steal A horizontal mattress suture
tip The dome can be (A) Dissected placed in the lateral crura which is advanced to the midline can
(B) Transected (C, D) and recons- increase nasal tip projection
tructed after resection of segment
intermediate crus
52 Facial Aesthetic Surgery
Figure 5.17 - Rotation of tip (A)Transfixion (B)Excision of skin and cartilage wedge of caudal septum
(C) Columella anchored to caudal cartilaginous septum in desired position with anchoring suture
Wide Ala
The normal width of the ala falls within or just beyond an imaginary vertical line dropped from the
medial canthus to the upper lip.(Bonanathaya et al., 2021)
T he ageing process typically leads to forehead and brow ptosis for almost every patient.
Of all the forehead and brow lift procedures, the endoscopic forehead and brow lift has proved to
be the most common and predictable of the facial cosmetic techniques.
Indications Contraindications
Table 6.1 – Indications and Contraindications of Endoscopic Brow and forehead lift
Several key assessments necessary for any patient undergoing an endoscopic brow lift include:
§Position of the eye brows
§Presence of dermatochalasis of the upper lids
§Forehead rhytids
§Position of the frontal hairline
§Slope and length of the forehead
§Status of the corrugator muscles
An endoscopic brow lift is intended to elevate the ptotic brows more normal position. Forehead
rhytids, especially deep rhytids, are improved with an endoscopic brow lift.Superficial and shallow
rhytids usually require a laser resurfacing.
Surgical Procedure
After administration of a local anesthetic with a vasoconstrictor, the central and paramedian
incisions are made with a No. 15 blade through all five layers of the scalp onto the bone.
The two temporal incisions are then made with a No. 15 blade through skin, subcutaneous layer
and temporoparietal fascia. The incision stops at the superficial layer of the deep temporal fascia. All
incisions should be beveled along the length of hair follicles to reduce alopecia.
A s individuals enter their 30s and 40s, fine lines, creases, rhytids, and sagging skin become
apparent, and deep furrows and frown/scowl lines often develop. A wrinkle, or rhytid, is
categorized into dynamic and static conditions.
Dynamic wrinkles appear when expressing Static wrinkles, however, remain on the face
emotions, such as fear, worry, joy, sadness, even after our facial muscles relax and tend
or surprise. Dynamic wrinkles fade as to deepen with age. With aging, collagen
quickly as they appear. Once the emotion production declines and causes the skin to
passes and face goes blank, they will no lose elasticity. As a result, dynamic wrinkles,
longer be appreciated. Common dynamic such as smile lines around the nose & mouth
wrinkles include: will eventually become static wrinkles.
Frown Lines (between the eyebrows) Lines at the corners of the mouth, across
the cheeks, and along the neck.
Forehead wrinkles
Crow's Feet
Smile lines
M ethod of restoring facial aesthetics in a minimally invasive way is now well established.
Soft tissue augmentation may be accomplished by surgery or intradermal injection of
synthetic or biological fillers.
Classification
The majority of injectable fillers are temporary, lasting from several weeks to several months,
although some reportedly last 9–12 months. (Langdon et al., 2017)
These are mainly used to Calcium hydroxy apatite is These are mostly synthetic
replace collagen in the skin, one of the commonest semi- implants, Which are made
which weakens with age permanent fillers. It creates of polymethylmethacrylate
and loses its elasticity. a stable scaffold for soft (PMMA) microspheres.
Collagen has three main tissues to grow. PMMA microspheres may
sources—bovine, porcine, be mixed with denatured
human. It can be injected into the Bovine collagen & lidocaine,
deep dermis, where the and suspended in a phosphate-
Bovine collagen is very similar microspheres are held in
to the human molecule and is buffered saline solution.
place until they are resorbed Since PMMA is inert, it is
widely used. and collagen deposition well tolerated by the body
Hyaluronic acid is the most occurs. and does not induce allergic
commonly used temporary reactions
filler.
Depot: In this technique, a small amount of the filler is deposited in the correct plane.
Serial Puncture: In a single wrinkle or fold, multiple closely spaced depot injections are placed.
Temporal Fossa
Depression of the temporal area tends to become much more visible with aging. This is due in part
to fat atrophy and in part to temporal muscle atrophy.
Superficial temporal artery and frontal branch of facial nerve should be taken care of while
working in this area.
Figure 7.1.19 - Injection Technique for marionette lines. The cannula slides in a natural plane so no
hard resistance should be perceived by the practitioner. Multiple threads are disposed beneath of the
skin of the cheek area using a fanning technique in a retrograde manner from the same port of entry
Chin Augmentation
Chin augmentation can lead to substantial improvement in the appearance of the face, giving a
better look to the patient
The injection of local anaesthesia takes place in 3 different points. The first safe point of injection
is located at the centre of the
mandibular symphysis and
lateral point is located on the
left, 1 cm medially to the
mental foramen and around 1
cm laterally to the centre of
the symphysis. The mental
foramen is placed 1 cm
superiorly to the inferior
mandibular border between Figure 7.1.20 – Markings for chin Figure 7.1.21–Injection technique for
the first and second premolar augmentation. Three safe points where chin augmentation. Filler is injected in
and can be identified through to inject; there is 1 cm distance between every of the three points in the supra-
palpation. (Goisis, 2014) the central and the lateral point periosteal layer
B otulinum Toxin type A was first used on the face by Carruthers and Carruthers in the late
1980s. Following studies in the 1990s about its cosmetic use, botulinum toxin was
approved by the USA Food and Drug Administration (FDA). This led to a revolution in
treating ageing skin in recent years.
Basic - Areas of hyperdynamic muscles in the upper third of the face (frown lines, crow's feet and
horizontal forehead lines) yield the most predictable results with the greatest efficacy, and fewest
reported side- effects when treated with botulinum toxin.
Patient Selection
Patients with dynamic wrinkles that have minimal to no static component demonstrate the most
dramatic improvements with botulinum toxin treatment. Patients with static wrinkles are slower and
cumulative, and may require two to three consecutive treatments for significant improvements. Deep
static lines may not fully respond to botulinum toxin treatment alone and may require combination
treatment with dermal fillers or resurfacing procedures to achieve optimal results. Severe static
wrinkles and laxity, commonly seen in patients aged 65 years or older, may require surgical
intervention. Discussion regarding realistic expectations and results during the evaluation and
consultation process is essential.
Frown Lines
Muscles targeted -Botulinum toxin frown line treatment targets the glabellar complex depressor
muscles, which include the corrugator supercilii, procerus, and depressor supercilii.
Figure 7.2.3 - Recom- Figure 7.2.4 - Lateral and medial corrugator muscle botulinum Figure 7.2.5 - Procerus
mended injection points, toxin injection technique muscle botulinum toxin
the mid-pupillary lines injection technique
and the upper orbital
rim line are illustrated
Horizontal Forehead Lines
The frontal region should always be treated in association with the glabellar area to avoid
increased compensatory use of glabellar muscle, which are mainly depressors.
Muscles targeted - Botulinum toxin horizontal forehead line treatment targets the broad frontalis
muscle, which spans the forehead attaching laterally at the temporal fusion lines.
Eyebrow Lift
Muscles targeted - Lateral eyebrow lift with botulinum toxin targets the superior lateral orbital
portion of the orbicularis oculi muscle.
Marionette Lines
Muscles targeted - Botulinum toxin treatment of marionette lines targets the depressor angulioris
muscle.
Haematoma
Haematoma formation is by far the most
common complication (Bloom, Immerman and
Rosenberg, 2012). Hematomas may present as
small collections or may occur as large rapidly
expanding bleeds. The most dangerous hematomas
occur from arterial bleeding and should be
considered acute emergencies. These present with
sudden onset of unilateral or even bilateral facial
pain, swelling, firmness, and tightness of the
overlying skin, followed by ecchymosis and
trismus. Late signs of hematoma include swelling
and discoloration of the lips and buccal mucosa. If
large enough, an expanding hematoma can lead to
dyspnoea with ensuing loss of the airway and death.
Most major hematomas occur within 10 to 12 hours Figure 8.1 - Haematoma. A and B, Appearance
of hematoma prior to evacuation. Note boggy dark
after surgery and almost all within the first 24 hours appearance of the preauricular and infra-auricular
after of surgery. (Moyer and Baker,2005) regions in the immediate postoperative period.
C and D, Intraoperative photo of evacuation of
hematoma
Obvious Scarring
Scarring can occur when the wounds are Figure 8.3 – Post
closed under excessive tension or if the operative scarring
(A) View of a patient
incisions are placed at an inappropriate pre se nting fo r a
position due to poor design. Skin slough and re visio n fa ce-li ft
necrosis of the flap can lead to severe scarring. aft er a p rev io u s
short-scar face-lift.
Patients who are more prone to hypertrophic The patient's tragal
scarring or keloids should be warned. Wound incisions have mig-
tension can develop and cause scarring if there rated to a visible
preauricular position.
is excessive removal of skin or if undermining (B) Close-up of the
of the flap is inadequate. visible tragal incisions
Alopecia
The incidence of alopecia after rhytidectomy is as high as 8.4% with rates of permanent hair loss
requiring surgical revision ranging from 1 to 3% (Bloom,Immerman and Rosenberg, 2012).
Patients with thinning hair and those having a tendency for alopecia are prone to greater hair loss after
face-lift surgery. Usually hair loss is transient, and patients with healthy scalps can expect their hair to
grow back promptly. Most permanent hair loss occurs in the temporal areas adjacent to the skin
incisions rather than in the postauricular area. This can be secondary to several factors: direct trauma
to the hair follicles during dissection, either due to transection of follicles or electrocautery; necrosis
of hair-bearing skin, infection with destruction of hair follicles; or a hypertrophic scar in which hair
cannot grow. To avoid incisional alopecia, hairline incisions are bevelled at a 45-degree angle toward
the anterior or inferior edge, allowing hair to grow up through the incision site. (Kabaker,1979)
Sensory Disturbances
Sensory disturbances occur invariably due to the dissection and separation of the facial planes
during the facelift procedures but this usually occurs temporarily and resolves in 1 year. The most
common sensory disturbance occurs to the great auricular nerve. The greater auricular nerve crosses
the sternocleidomastoid muscle at approximately 6.5 cm inferior to the external auditory meatus and
travels superiorly to supply the postauricular region. Injury to this nerve can be temporary or
permanent due to dissection over the postauricular, mastoid region and to a lesser extent in the cervical
region. This results in numbness of the ear lobe and postauricular area. Other forms of numbness can
be found in preauricular region
The most common postoperative complication is nasal bleeding, and it is estimated that
troublesome bleeding will occur less than 2% to 4% of the time. If nasal bleeding does occur, it
usually occurs in a bimodal distribution either in 48 hours from raw mucosal edges or in 10 to 14 days
after escharsbegin to separate. The patient is instructed to use 0.05% oxymetazoline nasal spray and
apply ice compresses. If the patient cannot control the bleeding, the surgeon may need to cauterize the
bleeding points or perform nasal packing. Obviously, the patient should also be avoiding medications
that interfere with bleeding.
The key to minimise or preventing unfavourable outcomes depends on proper case selection after a
thorough evaluation of the patient both physically and psychologically. It is important to understand
our limitations and accept them while not refraining from seeking professional help/support when
needed.
The skin and soft tissue envelope may also show scarring, ischemia/discolouration.
Management of complications may be necessary when the deformity is visible to both the surgeon
and the patient. This necessitates revision or secondary surgery which may be indicated in about 5–8%
of the patients. Even when indicated, it is better to wait for a year prior to attempting revisions or
secondary interventions. This is to facilitate a careful assessment of long-term changes following the
procedure and the final outcome prior to intervention.
Bleeding
Excessive bleeding can occur that could be arterial, venous or from skin edges. Preoperative
evaluation to note blood dyscrasias and patient education on avoidance of agents that cause bleeding
will prevent most issues. Injection with haemostatic agent, ensuring intraoperative haemostasis, and
avoidance of injury to superficial temporal or zygomaticotemporal arteries, supraorbital or
supratrochlear vascular bundles, and sentinel vein will decrease postoperative haematomas.
Alopecia
Alopecia can also result from improper incision design and closure, including inappropriate
wound tension, rough handling of wound margins, and excessive use of electrocautery. Peri-
incisional alopecia can appear as a widened scar; when the scar is visible by the endoscopic approach,
the scar can be excised at a later date. Alopecia around endoscopic scars can make them more obvious
and scar revision can be performed to improve the scars by excision of the widened scars and close
reapproximation of the hair-bearing scalp.
Recommendations
§Apply pressure at the site before and after treatment. Cold packs may also be used.
§The use of small syringes and fine-gauge (30 g) needles can reduce pain and bruising at the injected
site.
§Using topical anaesthesia (EMLA—Eutectic Mixture of Local Anaesthesia) reduces pain while
injecting.
Undesired Effects
The complications related to botulinum toxin occur less frequently than injection reactions. These
are primarily caused by temporary denervation of adjacent muscles outside of intended treatment
area. These complications are technique dependent; incidence declines as injector skill improves.
Temporary blepharoptosis is uncommon (1% to 5%) but is distressing for patient (Carruthers et
al.,2002). It is caused by deep migration of
botulinum toxin through orbital septum fascia to
levator palpebrae superioris. It can be avoided by
placing injection 1cm above the supraorbital ridge
at mid-pupillary line (Ascher et al.,
2010).Blepharoptosis may be treated using
ophthalmic solutions that have alpha-adrenergic
effects, such as over-the-counter naphazoline
0.025%/ pheniramine 0.3% or prescription
apraclonidine 0.5% (Iopidine). Both medications
cause contraction of Müller muscle, an adrenergic
levator muscle of the upper eyelid, resulting in Figure 8.7 - Right eye blepharoptosis three weeks after
botulinum toxin treatment of glabellar complex
elevation of the upper eyelid.
Facial asymmetry can result from uneven dosing of botulinum toxin. Consistent technique and
careful attention to injection volumes at the time of treatment can reduce the incidence of
asymmetries. Other rare complications associated with botulinum toxin injections include formation
of antibodies (less than 1%), which can render treatments ineffective (Naumann et al., 2010).
Although extremely rare, immediate hypersensitivity and allergic reactions may occur, with signs of
urticaria, oedema, and possibly anaphylaxis. Distant spread has not been reported with cosmetic use
of botulinum toxin for frown lines or other facial indications
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Clinical Applications. Aesthetic surgery journal, 33(6), pp.769-782.
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and Viel, M., 2010. International consensus recommendations on the aesthetic usage of
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