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CRISPR-Cas9 is a groundbreaking genetic editing tool that allows precise DNA modifications, derived from bacterial immune systems. It has significant implications for biomedical research and the treatment of genetic disorders, but raises ethical concerns regarding off-target effects and gene editing in embryos. Ongoing research aims to enhance the accuracy and delivery of CRISPR technology, potentially making it a standard in gene therapy and personalized medicine.

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Technology

CRISPR-Cas9 is a groundbreaking genetic editing tool that allows precise DNA modifications, derived from bacterial immune systems. It has significant implications for biomedical research and the treatment of genetic disorders, but raises ethical concerns regarding off-target effects and gene editing in embryos. Ongoing research aims to enhance the accuracy and delivery of CRISPR technology, potentially making it a standard in gene therapy and personalized medicine.

Uploaded by

mitosis-mules3x
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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CRISPR-Cas9 and Genetic Editing

CRISPR-Cas9 is a revolutionary tool in genetic engineering, enabling scientists to edit


DNA with unprecedented precision. Derived from a natural immune system in bacteria,
CRISPR uses a guide RNA to target specific genetic sequences, while the Cas9 enzyme
cuts the DNA at that location.

This breakthrough has transformed biomedical research. Scientists can now study the
function of specific genes by disabling or altering them in living organisms. In medicine,
CRISPR holds promise for treating genetic disorders such as sickle cell anemia, cystic
fibrosis, and muscular dystrophy by directly correcting mutations at the DNA level.

Despite its potential, CRISPR technology raises ethical and safety concerns. Off-target
effects — unintended changes to other parts of the genome — remain a major
challenge. There is also debate around the use of gene editing in human embryos,
particularly for non-therapeutic enhancements.

Current research focuses on improving accuracy and delivery methods, such as using
lipid nanoparticles or viral vectors. As techniques become safer and more precise,
CRISPR may become a standard tool in gene therapy and personalized medicine,
offering hope for treating previously incurable diseases.

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