DEPARTMENT OF RASASHASTRA & BHAISAJYA KALPANA

GOVERNMENT AYURVEDIC COLLEGE & HOSPITAL, BALANGIR

A COMPILATION

ON

CHAYAVANPRASH TO LEPA GUTI

Submitted by:-
50- Ipsita priyadarshini Pati

51- Rajesh Kumar Bhuyan

52- Soumyasmita Sahoo

53- Iram Iqbal

54- Swarupa Padhan

55- Dhalaram Murmu

Guided By:
Prof. Dr. Shibabrata Behera

Dr. Sushant Kumar Meher

Dr. Lily Meher

Dr. Subrat Kumar Bhutia

 ACKNOWLEDGEMENT
We want to thank everyone who helped with this project. Huge thanks to our teachers for
guiding us every step of the way. A big shoutout to our groupmates for coordinating with
each other so well. This project is a team effort, showing what we can achieve together. It's
been a great learning experience, getting us ready for whatever comes next.
CERTIFICATE

This is to certify that Ms. Ipsita priyadarsini pati, Mr. Rajesh Kumar Bhuyan, Ms.
Soumyasmita Sahoo, Ms. Iram Iqbal, Ms. Swarupa Padhan, Mr. Dhalaram Murmu.Roll
no.50,51,52,53,54,55, Has satisfactorily completed the course of compilation in
(RASASHASTRA & BHAISAJYA KALPANA) prescribed by SAMBALPUR
UNIVERSITY as a part of Second Professional B.A.M.S. Course.

Signature of Teacher Signature of H.O.D

Signature of External
 CONTENTS
1. CHAYAVANPRASH

2. DADIMAVALEHA

3. PANCHAGAVYA GHRITA

4. BRAHMI GHRITA

5. NARAYANA TAILA

6. NEELIBHRINGADI TAILA

7. PANCHAGUNA TAILA

8. ARAVINDASAVA

9. ASHOKARISHTA

10. KUMARYASAVA

11. KUTAJARISHTA

12. GANDHAKADYA MALAHARA

13. LEPA GUTI

 CYAVANAPRAŠA
(Carakasamhita, Cikitsästhāna, Adhyāya 1(1): 62-74)

बिल्वोऽग्निमन्थः श्योनाकः काश्मर्यः पाटलिर्बला । पर्ण्यश्चतस्रः

पिप्पल्यः श्वदंष्ट्रा बृहतीद्वयम् ।।६२ ।। शृङ्गी तामलकी द्राक्षा जीवन्ती
पुष्करागुरु । अभया चामृता ऋद्धिर्जीवकर्षभकौ शटी । । ६३ ।। मुस्तं पुनर्नवा
मेदा सैला चन्दनमुत्पलम् । विदारी वृषमूलानि काकोली काकनासिका ।। ६४ ।। एषां
पलोन्मितान् भागाञ्छतान्यामलकस्य च । पञ्च दद्यात्तदैकध्यं जलद्रोणे
विपाचयेत् । । ६५ ।। ज्ञात्वा गतरसान्येतान्यौषधान्यथ तं रसम् ।
तच्चामलकमुद्धृत्य निष्कुलं तैलसर्पिषोः । । ६६ ।। पलद्वादशके भृष्ट्वा
दत्त्वा चार्घतुलां भिषक् । मत्स्यण्डिकायाः पूताया लेहवत्साधु साधयेत् ।। ६७ ।।
षट्पलं मधुनश्चात्र सिद्धशीते प्रदापयेत् । चतुष्पलं तुगाक्षीर्याः
पिप्पलीद्विपलं तथा ।। ६८ ।। पलमेकं निदध्याच्च त्वगेलापत्रकेशरात् । इत्ययं च्यवनप्राशः
परमुक्तो रसायनः ।। ६९ ।।कासश्वासहरश्चैव विशेषेणोपदिश्यते । क्षीणक्षतानां
‌ ‌बालानां
‌ चा‌ङ्गवर्धनः ।।७० || स्वरक्षयमुरोरोगं हृद्रोगं वातशोणितम् ।
पिपासां मूत्रशुक्रस्थान् दोषांश्चाप्यपकर्षति । । ७१ ।। अस्य मात्रां
प्रयुञ्जीत योपरुन्ध्यान्न भोजनम्। अस्य प्रयोगाच्च्यवनः सुवृद्धोऽभूत्
पुनर्युवा ।। ७२ ।। मेधां स्मृतिं कान्तिमनामयत्वमायुः प्रकर्ष
बलमिन्द्रियाणाम्। स्रीषु प्रहर्ष परमग्निवृद्धिं वर्णप्रसादं
पवनानुलोम्यम् ।। ७३ ।। रसायनस्यास्य नरः प्रयोगाल्लभेत जीर्णोऽपि
कुटीप्रवेशात् । जराकृतं रूपमपास्य सर्वं बिभर्ति रूपं नवयौवनस्य ।। ७४ ।।
(चरकसंहिता, चिकित्सास्थान, अध्याय १ (१); ६२-७४)

1.Bilva(Rt./St. Bk.)48g

2.Agnimantha(Rt./St. Bk.)48g

3.Śyonāka(Rt./St. Bk.)48 g

4.Käśmari (Gambhari)(Rt./St. Bk.)48g

5.Patali (Patală)(Rt./St. Bk.)48g

6.Bala(Pl.)48g

7.Śālaparņi(Pl.)48g

8.Prśniparni(Pl.)48g

9. Mudgaparni(Pl.)48g

10.Māşaparni(PL.)48g

11. Pippali(Fr.)48g

12. Śvadamstră (Gokşura)(P1.)48g

13. Brhati(PL)48g

14. Kanțakārī(Pl.)48g

15. Śrigi (Karkataśrigi)(GL)48g

16. TAmalaki(Pl.)48g

17. Drāksā(Dr.Fr.)48g

18. Jivanti(Rt.)48g

19. Puşkara(Rt.)48g

20. Aguru(Ht.Wd.)48g

21. Abhaya (Haritaki)(P.)48g

22. Amṛtā (Guduci)(St.)48g

23. Rddhi(Sub.Rt. Tr.)48g

24. Jivaka(Rt. Tr.)48g

25. Rsabhaka(Rt. Tr.)48g

26. Śați(Rz.)48g

27. Musta(Rz.)48g

28. Punarnava (Raktapunarnava) (Pl.)48g

29. Medi(Rt. Tr.)48 g

30. Elā (Sükşmailā)(Sd.)48g

31. Candana (Śveta candana)(Ht. Wd.)48g

32. Utpala(FL)48g

33.Vidäri(Rt. Tr.)48g

34.Vrşamüla (Väsä)(Rt.)48g

35. Kāköli(Sub. Rt.)48g

36. Käkanäsikä(Fr.)48 g

37. Amlaka (Amalaki)(Fr.)500in number

38.Water for decoction12.288 1.reduced to3.072 1.

39.Ghrta288g

40. Taila (Tila)(OL)288g

41.Matsyändikä 2.400 kg
42. Madhu 288g

43.Tugākşiri (Vamsa)(S.C.)192g

44.Pippali(Fr.)96g

45. Tvak(St. Bk.)48g

46. Elā (Sükşmailā)(Sd.)48g

47. Patra (Tejapatra)(Lf.)48g

48. Kesara (Nagakēśara)(Stmn.)48g

Method of preparation:

All the kwatha dravya are coarsely powdered and added to a big decoction vessel containing
prescribed quantity of water. At the same time all the 'amalaki fruits' are tied in a cloth and suspended
into the decoction vessel fully immersed. The vessel is placed over mild fire, boiled and reduced to
one eighth.Soon the 'amalaki bundle' is taken out, it is allowed to cool on its own,later the seeds are
separated and the pulp is rubbed over a clean cloth or 40 numbered sieves to obtain fiber less fine
pulp. Meanwhile the reduced decoction liquid is filtered and placed separately for further use.

The pulp is taken in a clean wide mouthed vessel and fried properly in ghrta until it turns golden
brown. Meanwhile the sugar is added to the decoction and boiled over moderate fire to attain
appropriate pāka. Just before attaining paka, the fried pulp of amalaki is added and boiled further until
all the 'avaleha pāka lakşaņas' are attained.

Soon, the fire is put off and the fine powder of praksepa dravya is added little by little and stirred well
to a homogenous mixture. When cool on its own, the prescribed quantity of honey is added and
preserved in airtight containers as 'Cyavanaprāśāvaleha'. The end product will be blackish confection
with madhura-amla-kaşāya rasa and pāka gandha.

Dose

12 to 24 g

Anupana

Water, Milk

Therapeutic Uses

Kāsa (Cough), śvāsa (Dyspnoea/Asthma), Kşata Kşiņa (Debility due to chest injury), Svarabheda
(Hoarseness of voice), Kşaya (Pthisis), Hrdroga (Heart disease), Agnimändya (Digestive impairment),
Uroroga (Disease of thorax), Vatarakta (Gout), Pipāsā (Thirst), M ūtraroga (Urinary diseases), Šukra
Doşa (Vitiation of semen), Jarā (Senility/Progeriasis), used as Rasayana, Medhya, Smrtiprada
(Nutrient to body and mind with adapto-immuno- neuro-endocrino-modulator properties, Brain
Tonic/Nootropic, Improves memory)
RESEARCH ARTICLE

Chyawanprash: A Traditional Indian Binactive Health Supplement by Rohit Sharma, Natalia Martins,
Kanil Buce, Ashum Chaudhary Atul Kabra, Meda M. Ran, and Pradeep Kumar Prajapati

2. Evaluation of Cyavanaprata on Health and Immunity related Parameters in Healthy Children.A.Tw

Arm, Randomized, Open Labelest. Prospective, Multicenter, Clinical Study-Arun Gupta, Sunil Kumar
Sanjeeva Dole Shallesh Deshpande Vaishal Deshpande Sudha Singh, and Sesibhushan

3. Chyawanprash: A review of therapeutic benefits as in authoritative texts and documented clínical

terature by Da Ananthatiarayanaa Sharanbasappa Durgs, Ram Manohar, Anita Mahapatra

4. Chyewangrash, An Ancient Indian Aurvedic Melicinal Food, Regulates immune Reagent in

Zebrafish Model of inflammation by Moderating inflammatory Biomackers by Achurrys Balkrishna,
Meenu Tomer Moumita Manik Jyotish Srivastava, Rishabh DencSwati Haltar Anurag Varshney-
Dadimavaleha
Reference: Y.R. Jvaratisaradhyaya

दाडिमादिफलप्रस्थं चतुष्प्रस्थजले पचेत् । चतुर्भागकषायेऽस्मिशर्कराप्रस्थमेव च ।। नाग

पिप्पलीमूलं कणाधान्यकदीप्यकम्। जातीफलं जातिपत्र मरिचं जीरक तुगा ।। विजया निम्बपत्र च
‌कूटशाल्मली। अरल्वतिविषा पाठा लवड्ङ्ग च पृथक्पलम् ।। घृतस्य मधुनः प्रस्थ
सर्वलेह विपाचयेत् । दाडिम्बलेहकं नाम ज्वरातीसारनाशनम् ।। आमरक्तं
चाऽऽमशूलं मान्यशोफक्षयापहम् । धातुलीनं धातुगतमश्विभ्यां निर्मितं पुरा
।। इति दाडिमावलेहः ।

1.Dadima 768g

2.Jala 3.072 l Reduced to 1/4th

3.Sharkara 768g

4.Shunthi 48g

5.Pippalimula 48g

6.Maricha 48g

7.Dhaniyaka 48g

8.Jatiphala 48g

9.Jatipatra 48g

10.Maricha 48g

11.Jiraka 48g

12.Tuga 48g

13.Vijaya 48g

14.Nimba Patra 48g

15.Samanga 48g

16.Shalmali 48g

17.Aralu 48g

18.Ativisha 48g

19.Patha 48g

20.Lavanga 48g

21.Honey 768g
22.Ghee 768g

PROCEDURE

1. Take 768 grams of dadima fruit and add 4 parts of water.

2. Boil the mixture until the water is reduced to one fourth of its original volume.

3. After boiling, filter the mixture to collect the filtrate, which is the prepared dadima decoction.

4. Add 768 grams of sugar to this decoction and heat it until it reaches a consistency of 2-3 threads
(pakalakshana).

5. Then, add 48 grams of the ingredients from Sunthi to Lavanga. Also, add 768 grams 173/305
mixture. Tr

6. Allow the mixture to cool down and then add honey.

7. Store in air tight container.

Dose: 5-10 gms.

Anupana: Warm Water, Milk.

Indications: Sopha, Kshaya. Jvaraatisara, Aamavata, Shula,

PHARMACODYNAMICS

1. Antipyretic Dadimavaleha exhibits antipyretic properties, helping to reduce fever by lowering body
temperature. This action is beneficial in managing conditions characterized by fever, such as
infections and inflammatory disorders.

2. Anti-diarrheal: The combination of ingredients in Dadimavaleha possesses anti-diarrheal

properties, which help alleviate symptoms of diarrhea by reducing bowel motility and fluld loss from
the body

3. Anti-inflammatory. Several components of Dadimavaleha, such as Shunthi, Maricha, and Jiraka,

possess anti-inflammatory properties. These ingredients help reduce inflammation in the
gastrointestinal tract and other tissues, providing relief from conditions like colitis and inflammatory
bowel diseases

4. Digestive Stimulant: Dadimavaleha acts as a digestive stimulant, enhancing the digestive fire
(Agni) and promoting proper digestion and assimilation of nutrients. This property aids in the
management of digestive disorders like indigestion, b abdominal discomfort.

5. Immunomodulatory: The formulation may navelmmunomodulatory effects, helping to regulate the

immune response and strengthen the body's defense mechanisms against infections and diseases.
PHARMACOKINETICS

1. Absorption: The active constituents of Dadimavaleha are absorbed from the gastrointestinal tract,
where they exert their therapeutic effects.

2. Distribution: Once absorbed, the active compounds are distributed throughout the body via the
bloodstream, reaching target organs and tissues.

3. Metabolism: The ingredients undergo metabolism in the liver, where they may be biotransformed
into active metabolites or conjugated with glucuronic acid for elimination.

4. Excretion: Metabolites and unmetabolized compounds are primarily excreted through urine and to a
lesser extent through bile and feces.

REASERCH UPDATES

Article Name

1. Pharmaceutico-Analytical Study of Dadimavaleha

Author Name

Vd Manish S, Assistant Professor, Department of Rasashastra and Bhaishajyakalpana, Government

Ayurved College, Nagpur, MHA

Result

The study aims to establish a standardized manufacturing procedure for Dadimavaleha by analyzing
its pharmaceutico-analytical characteristics It examines parameters such as pH, total ash, acid
insoluble ash, wate soluble extractive, acid-soluble extractive, specific gravity, and sugar content.
This research fills a gap in existing protocols and serves as milestone in setting a standard
manufacturing process for Dadimavaleha.

Article Name

2. Efficacy of Dadima Avaleha in the Management of Garbhini Pandu with Special Reference to
Anaemia in Pregnancy.

Author Name

Vd Pushkaraj S. Valvi, P.G. Scholar, streerog- prasutitantra, Dept., R.A. Podar Medical College
(Ayu.), Worli, Mumbai, MHA, India.

Result

The efficacy of Dadimavaleha in treating anaemia during pregnancy underscores the confidence that
can be placed in Ayurvedic treatment. principles. This case demonstrates the successful application of
diagnosis and treatment, showcasing Dadimavaleha's efficacy as an appetizer, antiemetic, and
diuretic, as well as its ability to improve hemoglobin levels and alleviate hyperacidity.
PANCHAGAVYA GHRITA

गोमयस्वरसक्षीरदधिमूत्रैः मृतं हविः ।।

अपस्मारज्वरोन्मादकामलान्तकरं पिवेत् । (A.H.U., 7/18)

INGREDIENTS USED

1.Gomaya Svarasa -3.072 L

2.Go Dugdha-3.072 L

3.Go Dadhi-3.072 Kg

4.Go Mutra-3.072 L

5.Go Ghrita-768 gms

PROCEDURE

1. Preparation of Drava Dravya: Collect the Gomaya Svarasa, Go-Dugdha, Dadhi, andGo- Mutra as
mentioned quantity.

2. Mixing:In a clean vessel, add Go Ghrita as mention quantity along with Drava Dravya.

3. Heating: Place the mixture over a low flame. Stir conti nuously to prevent the burning a 174/305
cooking. Maintain a consistent low flame to avoid burning the ingredients. Heat the mixture until the
water content evaporates and sneha siddhi lakshanas.

4. Filtering: Once the Sneha siddhi lakshana attains, remove it from the heat. Filter the ghrita through
a clean, dry cloth to remove the solid residues of the herbal paste.

5. Cooling and Storage: Allow the filtered Ghrita to cool down to room temperature.. Store it in a
clean, dry, airtight container. Keep the container in a cool, dark place to preserve the potency of the
medicated oil or ghee.

Dose: 12 gms.

Anupana: Warm Milk, Warm Water.

Indications: Apasmara, Jvara, Unamada, Kamala

PHARMACODYNAMICS

1. Antiepileptic (Apasmara): Panchagavya Ghrita's antiepileptic properties help manage conditions

like epilepsy by stabilizing neuronal activity and reducing the frequency and severity of seizures.

2. Antipyretic (Jvara): It acts as an antipyretic agent, reducing fever by modulating the body's
temperature-regulating mechanisms and alleviating symptoms associated with pyrexia
3. Sedative (Unmada): Panchagavya Ghrita exhibits sedative effects, calming the mind and central
nervous system, which can be beneficial in conditions like hysteria and psychosis

4. Hepatoprotective (Kamala): The formulation may have hepatoprotective properties, protecting the
liver from damage and promoting its healthy function. This action is beneficial in managing
conditions like jaundice and other liver disorders

PHARMACOKINETICS

1. Absorption: The constituents of Panchagavya Ghrita are absorbed from the gastrointestinal tract,
facilitated by the lipid-rich nature of ghee.it

2. Distribution: Once absorbed, the active componentsare distributed throughout the body via the
bloodstream, reaching target organs such as the brain, liver, and nervous system.

3. Metabolism: The ingredients undergo metabolism primarily in the liver, where they may be
metabolized into active compounds or undergo conjugation for elimination.

4. Excretion Metabolites and unmetabolized compounde are excnned primarily through bile and Inves
with a minor portion excited via urine

RESEARCH UPDATES

Article Name

1.Panchagavya and Panchagavya Ghrita: A Conceptual study.

Author Name

Ashutosh Pandey, PhD Scholar, Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of
Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India.

Result

The study compiles literature on Panchagavya ghrita (PGG) formulations, prepared from five cow
products, traditionally used in Ayurveda for treating mental illness. Ayurvedic texts detail its
preparation method and recent government publications outline the standard process. Testing
parameters for PGG analysis are defined in the Ayurvedic Pharmacopeia of India. Previous research
has demonstrated its efficacy in treating CNS disorders, suggesting its potential as a standalone or
adjunct therapy with modern medications.

Article Name

2.Pharmacodynamic and Pharmacokinetic Interaction of Panchagavya Ghrita with Phenytoin and

Carbamazepine in Maximal Electroshock Induced Seizures in Rats.

Author Name

Rupa Joshi Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India

Result
The study found that Panchagavya ghrita (PG) effectively treated seizures in rats induced by maximal
electroshock (MES). When combined with sub-therapeutic doses of phenytoin (PHT) and
carbamazepine (CBZ), PG enhanced their antiepileptic effects, improved cognitive function, and
reduced oxidative stress. This suggests PG's potential as an adjunct therapy in epilepsy, with enhanced
efficacy and tolerability.

Article Name

3.Physico-Chemical Analysis of Panchagavya Ghrita Prepared as per Ashtanga Hridaya Reference

and Comparison with Market Samples.

Author Name

Lakshmi, P.N., PG Scholar, Department of Rasa shastra and Bhaishajya Kalpana, Government
Ayurveda College, Thiruvananthapuram, Kerala, India

Result

The study found significant differences in organoleptic characteristics and several physico-chemical
parameters between prepared and market samples. While all samples had an acidic PH, differences
were observed in iodine value, saponification value, peroxide value, pH, refractive index, and acid
value. Specific gravity showed minimal variance between the two groups.

Article Name

4.Panchgavya: A Precious Gift to Human kind

Author Name

Komal K. Bajaj Department of Pharmaceutical Sciences, RTM Nagpur University, Nagpur,

Maharashtra, India.

Result

Panchagavya, comprising cow-derived products, holds medicinal importance in Ayurveda as

'Cowpathy.' Revered as 'Gaumata,' the cow symbolizes nurturing qualities. Panchagavya treatment
offers diverse health benefits with minimal side effects, spanning healthcare, energy, nutrition,
poverty alleviation, pollution control, and organic farming. It also enhances soil fertility and crop
protection. Scientific validation is crucial for its clinical efficacy.
BRAHMI GHRITA

द्र्वौ प्रस्थौ स्वरसाद् ब्राह्मया घृतप्रस्थं च साधितम् ।।

व्योषश्यामात्रिवृदन्तीशङ्खपुष्पीनृपदुमैः । ससप्तलाकृमिहरैः
कल्कितैरक्षसम्मितैः ।। पलवृद्ध्या प्रयुञ्जीत पर माँत्रा चतुष्पलम् ।
उन्मादकॅष्ठापस्मारहर बन्ध्यासुतप्रदम् ।। वाक् स्वरस्मृतिमेधाकृट् धन्यं
ब्राह्मीघृतं स्मृतम् । (A.H.U., 6/23-252)

INGREDIENTS USED

1.BRAHMI SWARASA -PL-1.536 lt

2.GHRITA-768 gm

3.SUNTHI-Rz-12 gm

4.PIPALI-Fr-12gm

5.MARICHA-Fr-12gm

6.TRIVRIT-Rt-12gm

7.DANTI-Rt-12gm

PROCEDURE

1. Preparation of Kalka Dravya: Take all the ingredients for Kalka Dravya (Shunthi to Vidanga) and
grind them into a fine powder (Churna). Add a sufficient quantity of water herbs to make a thick paste
(bolus form).

2. Preparation of Drava Dravya: Prepare the Brahmi Svarasa as per classical references.

3. Mixing: In a clean vessel, add Go-Ghrita as mention quantity along with Kalka Dravya and Drava
Dravya.

4. Heating: Place the mixture over a low flame. Stir continuously to prevent the Kalka from sticking
to the bottom and ensure even cooking. Maintain a consistent low flame to avoid burning the
ingredients. Heat the mixture until the water content evaporates and sneha siddhi lakshanas

5. Filtering: Once the Sneha siddhi lakshana attains, remove it from the heat. Filter the ghrita through
a clean, dry cloth to remove the solid residues of the herbal paste

6. Cooling and Storage: Allow the filtered Ghrita to coo temperature.store it in a clean, dry, airtight
container. Keep the container in a cool, dark place to preserve the potency of the medicated oil or
ghee.

Dose: 12 gms

Anupana: Warm Milk, Warm water.

Indications: Apasmara, Unmada, Vandhyatva, Kushtha, Vakshvara Bhanga, Smriti Kshaya, Buddhi
Daurbalya

PHARMACODYNAMICS

1. Nootropic (Buddhi Daurbalya, Smriti Kshaya): Brahmi Ghrita's primary action involves enhancing
cognitive functions such as learning, memory, and concentration. It may achieve this by modulating
neurotransmitter levels, promoting neurogenesis, and protecting neurons from oxidative damage.

2. Antiepileptic (Apasmara): The formulation may exert antiepileptic effects by stabilizing

neuronalmembranes, reducing neuronal excitability, and regulating neurotransmitter release, thereby
reducing the frequency and severity of seizures

3. Antipsychotic (Unmada): Brahmi Ghrita's antipsychotic properties help manage condition like
hysteria and psychosis by balancing neurotransmitter levels in the brain and calming excessive
neuronal activity.

4. Galactagogue (Vandhyatva): It may stimulate prolactin release and promote lactation in nursing
mothers, thereby addressing conditions of infertility or low milk supply.

5. Anti-inflammatory (Kuccha): The formulation may possess anti-inflammatory properties, which

can help alleviate symptoms associated with skin disorders like eczema and dermatitis.6. Speech
Improvement (Vakshvara Bhanga): Brahmi Ghrita's use in speech disorders may be attributed to its
ability to improve neuronal coordination and enhance speech-related brain function.

PHARMACOKINETICS

1. Absorption: The lipid-based formulation facilitates the absorption of active constituents, especially
fat soluble compounds, from the gastrointestinal tract

2. Distribution: Once absorbed, the active ingredients are distributed throughout the body, including
the brain, where they exert their effects on cognitive and neurological functions.

3. Metabolism: Metabolism of the components may occur primarily in the liver, where they are
broken down into metabolites that may contribute to the observed therapeutic effects.

4. Excretion: Metabolites and unutilized constituents are excreted mainly through bile and feces, with
a minor portion eliminated via urine.

RESEARCH UPDATES

Article Name

1. Standardization of Brahmi Ghrita with Special Reference to its Pharmaceutical Study

Author Name
Yadav, Kapil Deo, Junior Resident, Department of Rasa Shastra, Faculty of Ayurveda IMS, BHU,
Varanasi, U.P.

Result

Three batches of Brahmi Ghrita were made, each using Brahmi Svarasa Kalka, comprising powdered
Vacha, Kushtha Shankhapushpi, and Brahmi, was mixed with Brahmi Svarasa Murchchhana was
performed before use as Sneha dravya The Ghrita was prepared over three days at mild heat, with
temperature and Siddhi lakshana recorded.

Article Name

2.Critical Review on Effect of Brahmi Ghrita in Psychiatric Disorders.

Author Name

Prabhakar Manu, PG Scholar, Department of Mano Vijyan evam Manasa Roga, Shri Dharmasthala
Manjunatheshwara College of Ayurveda & Hospital, Hassan, Karnataka, India.

Result

Brahmi Ghrita is extensively used for psychiatric disorden internally and externally. Its lipophilic
nature suggests it may have a significant impact on the blood-brain barrier. Howeves research on its
potential neuroplasticity, nootropic, and neuroprotective effects is lacking. Further exploration could
revolutionize psychiatry, given its minimal side effects and palatability.

NARAYANA TAILA

बिल्वाग्निमन्थश्योनाकपाट्र लापारिभद्रकम । प्रसारण्यश्वगन्धा च वहती कण्टकारिका ।।

बला चातिबला चैव श्वदेष्ट्रा सपनर्नवा । एषां दर्शपलान ।।
पादशेष परिस्त्रीव्य तैलपात्र प्रद्वापयेत्। शतपुष्पा देवदारु मासी शैलेयक वचा रास्ना तगगन्धा च
सैन्धव सपनर्नवम ।। भागाश्चदाणेऽम्भसः पचेत वचा ।।
चन्दन तगर कष्ठमेला पर्णीचतुष्टयम्व्रा एषां दविपलिकान् भागान पेर्षीयत्वा विनिक्षिपेत् ।
शतावरीरसञ्चैव तैलल्यं प्रदापयेत् ।।
आज वा यदि वा गव्य क्षीर दयाच्चतुर्गुणम। तथाऽभ्यङगे भोज्ये चैव प्रशस्यते ।।
अश्वो वा वाप्तम्भग्नो वा गजों वा यदि पीठसर्पी च तैलेनानेन सिद्धयति अधोभागे ये च वाताः
शिरोमध्यगतीश्च ये। मन्यास्तम्भ हुनस्तम्भ दन्तरोगे गलग्रहे ।।
यस्य शुष्यति चौकाइडग गतियेस्य च विह्वला। क्षीणेन्द्रियाः क्षीणशुक्रा ज्वरे क्षीणाश्च नरा; ।।
लल्लजिह्वाश्च मन्दमेघस अल्पप्रआ च नारी च गर्भन विन्दति ।।
वातात्तेत वषर्णो येषामन्त्रवदधिश्च दारुणा। एतत्तैलवर तेषानाम्नानारायणमतम्।
(B.R.Vatavyadhi.,26/140-150
INGREDIENTS

• Bilwa, agnimantha, shyonaka, patala, paribhadra, prasarini,ashvagandha,brihati,kantakari,

Bala,atibala,svadamstra,punanarba,tila
taila,satapuspa,devadaru,jatamamsi,shaileya,bacha,chandana,tagara,kustha,Ela,salaparni,prushni
pa rni,mudgaparni,masaparni,rasna,saindhaba lavana, satavari ,godugdha

• PROCEDURE :
• 1. Preparation of Kalka Dravya: Take all the ingredients for Kalka Dravya (Shatapushpa grind
them into a fing powder (Churna). Add a sufficient quantity of water to the powdered herbs
• 2. Preparation of Drava Dravya: Prepare the kvatha, by adding kvatha dravya from Bliva to
P per classical references. Prepare the Shatavari Kvatha as per classical reference Take
Punarnava as also Go Dugdha asdravadravya.
• 3. Mixing: In a clean vessel, add Tlatalla as mention quantity along with Kalka Dravya and Drava
Dravya.
• 4. Heating Place the mixture over a low flame. Stor continuously to prevent ensure even the
Kalkaing to the bottom and 1. co Maintain a consistent low flame to avotu vurning t the
ingredients. Heat the mixture untit water content evaporates and sneha siddhi lakshanas.5. Filter
to Once the Socha dhilakshana attain, nove from the heat. Filter the taila through a dry remove
the solid residues he herbal past clean,
• 5. Cooling and Storage: Allow the fittered taila to cool down to airtight container, Keep the
container in a cool, dark place to preserve the potency of the medicated ghee.
PHARMACODYNAMICS
• Anti-inflammatory: Narayana Taila contains herbs like Bilva, Agnimantha, Shyonaka, Patala, and
Paribhadra, which possess potent an inflammatory properties. These ingredients help alleviate
inflammation associated with vario conditions such as joint pain, arthritis, and inflammatory
disorders,
• 2. Analgesic: The combination of Prasann Ashvagandha, Beihati, Kanthakarn, Bala, and Atibu provides
analgesic effects, helping to relieve pan and discomfort. This is beneficial for conditions C arthritis,
muscular pain, and neuralgia.
• 3. Muscle Relaxant: Certain herbs like Ashvagandha and Bala act as muscle relaxants,
reducing muscle stiffhess and spasms. This property is useful in conditions characterized by
muscular tension and rigidity.
• 4. Nervine Tonic: Jatamamsi, Tagara, and Vaca presen in Narayana Tatla act as nervine tonics, supporting
the nervous system's health and function. The help caim the nerves, reduce stress, and improve overall
mental well-being
• 5. Anti-arthntic: Punarnava possesses anti-arthrine properties, which help alleviate symptoms associated
with arthritis, such as joint pain, swelling and stiffness. It also aids in improving joint mobilit and
flexibility.
• Dose: 6 gms, externally used for Nasya, Abhayanga and Anuvasana also.
• Anupana: Warma Water, Milk.
 PHARMACOKINETICS

• . Topical Absorption: When applied externally Narayana Taila is absorbed through the skin
allowing its active constituents to exert their pharmacological effects locally on the affected area
• 2. Local Action: The herbal components of Narayana Taila act locally on the muscles, joints, and
nerves providing relief from pain, inflammation, and stiffness.
• 3. Metabolism: Metabolism of the absorbed compounds may occur locally in the skin or
systemically in the liver, depending on the nature of the ingredients.
• 4. Elimination: Any metabolites or unutilized constituents are eliminated primarily through the
skin or may undergo hepatic metabolism and subsequent excretion via urine or
RESEARCH UPDATES :
It’s nasya used for treatment of manyastambha.
 NILIBHRINGADI TAILA

नीलीभृङ्गलताशतक्रतुलताधात्रीफलानां रसे। क्षीरै राजकनालिके र महिषीधेनूद्धवैस्साधितम् ।

तैलं तत्पयसैव पिष्टलुलितैर्यष्ट्याह्ह्वगुञ्जाञ्जनैः के शान् सञ्जनयेत्तलेऽपि करयोरास्तामके शं शिरः ।। (Sahasrayoga, Tail.
38)

PROCEDURE:
• 1. Preparation of Kalka Dravya:• Take all the ingredients for Kalka Dravya (Yashti to
Daruharidra) and grind them into a fine powder (Churna).• Add a sufficient quantity of water
to the powdered herbs to make a thick paste (bolus form).
• 2. Preparation of Drava Dravya:Prepare the Nili Svarasa, Bhringaraja Svarasa,
Shatakratulata and Amalaki Svarasa as per classical refernces.
• 3. MixingIn a clean vessel, add Tilataila as mention quantity along with Kalka Dravya and Drava
Dravya
• 4. HeatingPlace the mixture over a low flame. Stir continuously to prevent the Kalka from
sticking to the bottom and ensure even cooking.Maintain a consistent low flame to avoid
burning the ingredients. Heat the mixture until the water content evaporates and sneha
siddhi lakshanas.
• 5. Filtering:Once the Sneha siddhi lakshana attains, remove it from the heat.• Filter the taila through a
clean, dry cloth to
remove the solid residues of the herbal paste.
• 6. Cooling and Storage:Allow the filtered taila to cool down to room temperature.Store it in a clean,
dry, airtight container.
Keep the container in a cool, dark place to preserve the potency of the medicated oil or ghee.
• Dose: Externally for Sirobhyanga
• Indications: - Keshapata, Palita.
PHARMACOKINETICS

• 1. Topical Absorption: Nilibhringadi Taila is applied externally to the scalp (Shirobhyanga). The
active constituents are absorbed through the skin and penetrate the hair follicles, exerting their
therapeutic effects locally.
• 2. Local Action: The herbal extracts present in the oil act locally on the scalp and hair follicles,
providing nourishment, promoting hair growth, and improving hair health.
• 3. Metabolism: Any absorbed compounds may undergo local metabolism within the scalp tissues.
Some constituents may also be absorbed systemically and undergo hepatic metabolism.
• 4. Elimination: Metabolites or unutilized constituents are likely eliminated through the skin or may
undergo hepatic metabolism and subsequent excretion via urine or faeces.
• RESEARCH UPDATES :
• It’s used for enhancing hair quality,treating split ends .
 PANCHAGUNA TAILA

• Reference: AFI, Part II, Page 145, Siddhayogasangraha, Vatarogadhikara; Adhyaya 20/17)
• INGREDIENTS USED:
• Haritaki,amalaki, BibhitakiNimba PatraNirgundi Patra,Water for DecoctionReduced to,Tila
Taila,Madhuchchhishta,SaralaShila RasaRala,Shuddha Guggulu,Karpura,Tarapina
Taila,Nilagiri Taila,Kejoputi Taila
• PROCEDURE:
• 1. Preparation of Kvatha:Take Haritaki, Vibhitaki, Amalaki, Nimba, and Sambhalu,Add about
4.320 liters of water to these ingredientsBoil the mixture until it is reduced to 1.080 liters
• 2. Preparation of Kalka:Take 48 grams each of Madhucchhishta Gandhaphiroja, Shilarasa,
Rala, and Guggulu.Grind these ingredients into a fine paste.
• 3. Mixing and Boiling:Mix the prepared herbal kalka with the decoctionBoil the mixture until all
moisture is evaporated, leaving behind the medicated oil.
• 4. Filtering:Filter the taila to remove any solid residues from the kalka
• 5. Adding Essential Oils:• Add Eucalyptus oil and Turpentine oil to the filtered oil.
• 6. On self-cooling, also add Karpura.
• 7. Stir the mixture well to ensure all ingredients are thoroughly combined.
• Dose: External use only.
• Indications: Sandhivata, Karna shula, Vranaopachara.Since Panchaguna Taila is
intended for external use only. its pharmacodynamics and pharmacokinetics would
primarily involve the interactions of its components with the skin and underlying
tissues.
• PHARMACODYNAMICS:
• 1. Skin Penetration: The active constituents of Pancha guna Taila, such as
Haritaki, Amalaki, Bibhitaki, Nimba Patra, and Nirgundi Patra, may penetrate
the skin barrier and exert pharmacological effects locally.5.20 Aravi
• 2. Anti-inflammatory Activity: Components like Nirgundi Patra and Nimba
Patra may possess anti- inflammatory properties, which can help alleviate
inflammation associated with conditions like Sandhivata (osteoarthritis) and
Vrana (wound).
• 3. Analgesic Effects: The formulation may provide analgesic effects due to the
presence of ingredients with pain-relieving properties, potentially beneficial in
conditions like Karna shula (earache)
• PHARMACOKINETICS:
• 1. Absorption: The lipophilic nature of oils like Tila Taila and essential oils
(Tarapina Taila, Nilagiri Taila, Kejoputi Taila) facilitates the absorption of
active constituents through the skin.INGREDIENTS
• 2. Distribution: Once absorbed, the active compounds distribute locally within the
tissues near the site of application, exerting their effects.
• RESEARCH UPDATES:
• Development of alternative forms and address issues like sticking.
ARAVINDASAVA

अरविन्दमुशौरञ्च काश्मरी नीलमुत्पलम्। मंजिष्ठैला बलामांसीरम्बुर्द शारिवां शिवाम् ।।

विभीतकवचाधात्रीः शर्टी श्यामां सनीलिनीम्। पटोलं पर्पट पार्थ मधुके मधुकं मुराम् ।।
पलमानेन संगृह्य दाक्षायाः पलविशतिम्। धातकी षोडशपला जलदोणद्वये क्षिपेत् ।।
शर्क रायास्तुला तत्र तुलार्दध माक्षिकस्य च। मास संस्थापयेद् भाण्डे मृत्तिकापरिनिर्मिते ।।
बालाना सर्वरोगघ्नों बलपुष्ट्यग्निवर्दधनः । अरविन्दासवः प्रोक्त आयुष्यो ग्रहदोषहत् ।।
(B.R., Balaroga., 17/185-189)

INGREDIENTS USED
Kamala
Ushira
Utpala
Gambhari
Manjistha
Ela
Bala
Jatamansi
Musta
Shvet Sariva
Haritaki
Bibhitaki
Vacha
Amalaki
Sati
Trivrit
Patola
Parpata
Arjuna
Madhu
Each 1 pal
PROCEDURE

1. Prepare a coarse powder of all the dravyas.

2. Take a Sandhana Patra (fermentation vessel) and smear it with Sarshapa (mustard) oil. Pour the
water into the Sandhana Patra.

3. Add Melted Guda (Jaggery), Madhu, along with all the remaining dravyas in the form of
Yavakuta Churna (coarse powder).

4. Close the Sandhana Patra with Sandhi-bandhana (sealing the lid) and allow the mixture to
ferment properly.

5. Once it attain sandhana lakshana, then filter the final product.

6. Store it in a clean, dry, airtight container. Keep the container in a cool, dark place to
preserve the potency.

Dose: 3 to 12 ml

Indications: Agnimandya, Karshya, Balakshaya, Sarva Balaroga, Graha Dosha.

PHARMACODYNAMICS

1. Nutritive and Rejuvenating: Aravindasava is rich in various herbal ingredients like Kamala,
Ushira, Gambhari, Bala, and others, which are known for their nutritive and rejuvenating
properties. These components help in nourishing the body tissues, promoting growth, and enhancing
vitality.

2. Digestive Stimulant: Ingredients such as Haritaki, Bibhitaki, Amalaki, and Musta possess
digestive stimulant properties, which aid in improving appetite, digestion, and assimilation of nutrients.
This action is particularly beneficial in conditions like Agnimandya (digestive impairment).

3. Immunomodulatory: Some herbs present in Aravindasava, like Manjishtha, Jatamansi, and

Shveta Sariva, exhibit immunomodulatory effects. They help in enhancing the body's defense
mechanisms, thereby providing protection against various infections and diseases.

4. Anti-inflammatory and Antioxidant: Certain constituents like Arjuna and Patola have anti-
inflammatory and antioxidant properties, which can help in reducing inflammation, oxidative stress,
and associated tissue damage.

5. Tonic and Restorative: The formulation acts as a tonic and restorative, promoting overall well-
being, strength, and vitality. It is particularly beneficial in conditions of Karshya
(emaciation) and Balakshaya (loss of strength).

PHARMACOKINETICS

1. Absorption: The aqueous extract of Aravindasava allows for the emcient absorption of active
constituents through the gastrointestinal tract

RESEARCH UPDATES

Aticle Name

1. Experimental Studies on the Fermen- tation of Aravindasava

Author Name

Muzaffer Alam, Captain Srinivasa Murti Drug Research Institute For Ayurveda, Arumbakkam, Madras
600106, Τ.Ν., India

Result

Aravindasava was pre- pared using traditional and modified methods. The modified approach, using a
glass vessel and ino Aulation with yeasts from Dashamularishta and Pippaliasava, re- sulted in higher
alcohol production compared to the classical earthen pot method.
Dashamularish ta yeast II showed the highest alcohol produc- tion among the inoculat ed
organisms. Variations in the utilization of sugars were observed across different preparation methode
ASHOKARISHTA

अशोकस्य तुलामैकाञ्चतुदोणे जले पचेत्। पादशेषे रसे पूते शीते

पलशतद्वयम् ।। दद्याद गुडस्य घातक्याः पलषोडशिक मतम् । अजाजी
मुस्तकं शुण्ठी दार्यत्पलफलत्रिकम् ।। आग्रास्थि जीरक वासा चन्दनज्य
विनिक्षिपेत्। चूर्णयित्वा पलाशेन ततो भाण्डे निधापयेत् ।। मासादू र्ध्वञ्च
पीत्यैनमस्म्दररुजां जयेत्। ज्वरञ्च रक्तपित्ताशों मन्दाग्नित्वमरोचकम् ।।
मेहशोधा रुचिहरस्त्वशोकारिष्टसजितः II. (B.R. strirogadhikar)

INGREDIENTS USED
Ashoka

Water

Guda

Dhataki

Sveta

jiraka

Musta

Sunthi
PROCEDURE

1. Prepare a coarse powder of all the dravyas

2. Add water to the Ashoka coarse powders and soak the mixture overnight.

3. The next morning, add 50 liters of water to the soaked mixture.

4. Boil the mixture and reduce it to one-fourth of its original volume and filter the kvatha
(decoction).

5. Take a Sandhana Patra (fermentation vessel) and smear it with Sarshapa (mustard) oil. Pour the
filtered kvatha into the Sandhana Patra.

6. Add melted Guda (Jaggery) to the kwatha, along with all the remaining dravyas in the form of
Yavakuta Churna (coarse powder).

7.Close the Sandhana Patra with Sandhi bandhana (sealing the lid) and allow the mixture to
ferment properly.

8. Once it attain sandhana lakshana, then filter the final product.9. Store it in a clean, dry.
airtight container. Keep the container in a cool, dark place to preserve the potency.

PHARMACODYNAMICS

1. Hemostatic: Ashokarishta contains Ashoka flowers, which are renowned for their
hemostatic properties. This action helps in managing conditions like Asrigdara Ruja (painful
menstruation) and Yoniruja (uterine disorders).

2. Anti-inflammatory: Ingredients such as Daruharidra possess potent anti-inflammatory

properties, which aid In reducing inflammation associated with w various conditions tions like
Shveta Pradara (leucorrhea), Arsha (piles), and Shotha (Inflammation).

3. Digestive Stimulant: Compounds like Shunthi and Shveta Jiraka act as digestive stimulants,
enhancing digestive fire (Agni) and thereby improving digestion (Mandagni).soak

4. Antipyretic: The formulation exhibits antipyretic properties, which help in reducing fever (Jvara)
by lowering body temperature.

5. Astringent and Uterine Tonic: Ashoka flowers have astringent properties, beneficial in
conditions like Shveta Pradara. Additionally, Ashokarishta acts as a uterine tonic, promoting uterine
health and regulating menstrual flow.

PHARMACOKINETICS

1. Absorption: The water-based decoction of Ashoka flowers allows for emcient absorption of active
constituents in the gastrointestinal tract

2. Metabolism: Once absorbed, the herbal components undergo metabolism in the liver and other
tissues, where they are metabolized into active compounds.

3. Distribution: The active compounds are then distributed throughout the body, reaching target
organs such as the uterus, digestive system, and blood vessels.

4. Elimination: Metabolites and any unutilized constituents are primarily eliminated via urine and
feces.

Dose: 12 to 24 ml.
Indications: Asrigdara Ruja, Yoniruja, Shveta Pradara, Ivara, Raktapitta, Arsha, Mandagni, Arochaka,
Meha, Shotha.

RESEARCH UPDATES

Article Name

1. Review on Quality Evaluation of Ashokarishta: An Ayurvedic Formulation

Author Name

Soumya S. Fadnis, ind Yearn P.G. Scholar, Dept. of Rasashastra & Bhaishajya Kalpana, KLE Shri
BMK Ayurveda Mahavidyalaya & PAGE Research Centre, a constituent unit of KAHER,
Belagavi, Karnataka, India

Result

Ashokarishta, a traditional alcoholic preparation, is renowned for its emcacy in treating

gynecological disorders. This review article highlights the importance of quality control
parameters in ensuring its safety and effectiveness. By examining various analytical methods,
it underscores the formulation's reliability and versatility, Quality control measures authenticate raw
materials, validate preparation methods, and amrm therapeutic emcacy, bolstering confidence in
Ashokarishta's utilities.
 KUMARYASAVA

कु मार्याश्च रसद्रोणे गुड पलशत तथा। तुलाइघ सङ् ख्या विजया क्वाधयेतज्जलार्मणे ।। चतुर्थांशावशेषे तु पूर्त तस्मिन्निधापयेत् ।
मधुनश्चाऽऽढक दत्त्वा घातक्या विद्वपलाष्टकम् ।। स्निग्धभाण्डे विनिक्षिप्य कल्क चैव प्रदापयेत्। जातीफल लवङ्ग च कड्‌कोल च
कवाबकम् ।। जटिलाचव्यचित्र च जातिपत्री सकर्क टम्। अदक्ष पुष्करमूल च प्रत्येक च पल पलम् ।। मृत शुल्व तथा लोह
शुक्तिमात्र प्रदापयेत् । 6. (Y.R. Gulma, p. 527)

INGREDIENTS USE
Kumari
Guda
Haritaki
Water for Decoction
Madhu
Dhataki
Jatiphala
Lavang
Jatamansi
Chavya
Eranda
Jatiphala
Karkatashringi
Bibbhitaki
Pushkara
Tamra Bhasma
Lauha Dhatu

PROCEDURE

1. Prepare a coarse powder of all the dravyas except draksha.

2. Add water to the Kutaja coarse powders and soak the mixture overnight.

3. Take a vessel add draksha along with quantity sumcient water. Soak for 3-4 hrs. Grind it
properly and to form paste of draksha

4. The next morning, add 50 liters of water to the soaked mixture

PROCEDURE

5. Prepare a coarse powder of all the dravyas except draksha.

6. Add water to the Kutaja coarse powders and soak the mixture overnight.

7. Take a vessel add draksha along with quantity sumcient water. Soak for 3-4 hrs. Grind it
properly and to form paste of draksha

8. The next morning, add 50 liters of water to the soaked mixture.

9. Boil the mixture and reduce it to one-fourth of its original volume and filter the kvatha
(decoction).)

10. Take a Sandhana Patra (fermentation vessel) and smear it with Sarshapa (mustard) oil. Pour
the

filtered kwathaalong with pulp of draksha into the Sandhana Patra.

11. Add melted Guda (jaggery) to the kvatha, along with all the remaining dravyas in the form of
Yavakuta Churna (coarse powder).

12. Close the Sandhana Patra with Sandhi-bandhana (sealing the lid) and allow the mixture to
ferment properly.

13. Once it attain sandhana lakshana, then filter the final product.

14. Store it in a clean, dry, airtight container. Keep the container in a cool, dark place to
preserve the potency.

PHARMACODYNAMICS

1. Digestive Stimulant: Kumaryasavacontains ingredients like Haritaki, which acts as a

digestive stimulant, enhancing appetite and improving digestion. This action helps in
managing conditionslike Agnimandya (digestive weakness) and Koshtha Shula (abdominal
colic).

2. Antitussive and Expectorant: Components like Jatiphala, Lavanga, and Kankola possess
antitussive properties, relieving cough symptoms, while also acting as expectorants,
facilitating the expulsion of mucus from from the t n respiratory tract. Thi makes Kumaryasava
beneficial in conditions like Kasa (cough) and Shvasa (breathing dimculty).

3. Anti-inflammatory: The presence of herbs like Eranda and Bibhitaki confers anti-
inflammatory properties to which can help alleviate inflammation associated with conditions like Arsha
(piles) (abdominal distension). and Udara

4. Antispasmodic: Ingredients like Jatamansi and Cavy like Jatamansi and Cavya exhibit
antispasmodic actions, which can help relieve spasms and cramps associated with conditions like
Manyaroga (abdominal disorders) and Koshtha Shula.

5. Hepatoprotective: Kumaryasava contains Kumari (Aloevera), which is known for its

hepatoprotective properties. This can be beneficial in managing liver disorders and
promoting liver health.
PHARMACOKINETICS

1. Absorption: The water-based decoction of Kumari and other herbs allows for emcient
absorption of active constituents in the gastrointestinal tract.

2. Metabolism: Once absorbed, the herbal components undergo metabolism in the liver and other
tissues, where they are metabolized into active compounds.

3. Distribution: The active compounds are then distributed throughout the body, reaching
target organs such as the digestive system, respiratory system, liver, and abdominal organs.

4. Elimination: Metabolites and any unutilized constituents are primarily eliminated via urine and
feces.

Dose: 12 to 24 ml.

Indications: Gulma, Kasa, Shvasa, Arsha, Vata Vyadhi. Apasmara, Kshaya, Udara, Manyaroga,
Agnimandya, Koshtha Shula, Nasta Pushpa.

RESEARCH UPDATES

Article Name

1. Effect of Preparation Method on Antioxidant Activity of Ayurvedic Formulation

Kumaryasava

2. Hepatoprotective Potential of Kumaryasava and Its Concentrate Against CCI, Induced

Hepatic Toxicity in Wistar Rats

Author Name

Rahul Manmode, Depart of Chemistry, University of Massachusetts, Lowell-01854, USA

Mohammad Ahmed Khan, Department of Pharmacognosy and Phytochemistry, Bioactive Natural

Product Laboratory, Faculty of Pharmacy, Hamdard University, New Delhi, India

Formulations were evaluated for antioxidant activity against DPPH and hydrogen peroxide, with
WFKA showing the highest emcacy. Its IC50 values were 481.78 (DPPH) and 50.13
(hydrogen peroxide), indicating superior antioxidant potential relative to others.
 Despite slower fermentation with W. fruticosa flowers, they notably enhance Kumaryasava's
antioxidant activity. Phenolic compounds in the flowers likely contribute to this effect. Thus, the
traditional formulation, per Ayurvedic Pharmacopoeia, demonstrates superior antioxidant activity.

Animals were divided into groups: control (saline), toxicant (CCI), and treatment (KS, KS concentrate,
standard). After 10 days of oral administration, blood and liver tissue were collected. Results showed
KS and its concentrate protected against CCI, induced hepatic toxicity, evidenced by reduced SGOT,
SGPT, ALP levels, and increased albumin levels.
Histopathological analysis supported these findings. KS concentrate demonstrated potential as a
hepatoprotective formulation, possibly allowing a dosage reduction to one-third of the
recommended dose

KUTAJARISHTA

तुला कु टजमूलस्य मृद्धीकाऽधतुलां तथा। मधूकपुष्पकाश्मर्योर्भागान् दशपलोन्मितान् ।।

चतुदर्दोणेऽम्भसः पक्त्वा द्रोणञ्चैवाँवशेषितम् । घातक्या विंशतिपलं गुडस्य च तुलां क्षिपेत् ।।
मासमात्रं स्थितो भाण्डे कु टजारिष्टसंजितः । ज्वरान् प्रशमयेत् सर्वान् कु र्यातीक्ष्णं धनञ्जयम् ।।
दुर्वारां ग्रहणीं हन्ति रक्तातीसारमुल्वणम् II (B.R., Atisara., 7/97-99)

INGREDIENTS USED:
Drug Name:Kutaja,Draksha,Madhuka ,Kusuma,GambhariWater for decoctionReduced
to,Guda,Dhataki.

PROCEDURE:
1. Prepare a coarse powder of all the dravyas except draksha.

2. Add water to the Kutajacoarse powders and soak the mixture overnight.

3. Take a vessel add draksha along with quantity sufficient water. Soak for 3-4 hrs. Grind it properly and
to form paste of draksha

4. The next morning, add 50 liters of water to the soaked mixture.

5. Boil the mixture and reduce it to one-fourth of its original volume and filter the kvatha (decoction).

6. Take a Sandhana Patra (fermentation vessel) and smear it with Sarshapa (mustard) oil. Pour the
filtered kvatha along with pulp of drakshainto the Sandhana Patra.

7. Add melted Guda (jaggery) to the kwatha, along with all the remaining dravyas in the form of
YavakutaChurna (coarse powder).
8. Close the Sandhana Patra with Sandhi-bandhana (sealing the lid) and allow the mixture to ferment
properly.

9. Once it attain sandhana lakshana, then filter the final product.

10. Store it in a clean, dry, airtight container. Keep the container in a cool, dark place to preserve the
potency.

Dose: 12 to 24 ml.
Indications: Jvara, Grahani, Raktatisara, Agnimandya.

PHARMACODYNAMICS:
1. Antipyretic:Kutajarishta contains Kutaja (Holarrhena antidysenterica) and Draksha (Vitis vinifera),
which possess antipyretic
properties. Thisaction helps in reducing fever (Jvara) by lowering body temperature.
2. Anti-diarrheal: Kutaja is well-known for its anti-diarrheal properties. It helps in managing conditions
like Grahani (irritable bowel syndrome). Raktatisara (bloody diarrhea), and Atisara (acute diarrhea) by
regulating bowel movements and reducing the frequency of loose stools.
3. Digestive Stimulant: The presence of Dhataki (Woodfordia fruticosa) in Kutajarishta acts as a
digestive stimulant, improving
appetite and digestion. It helps in addressing Agnimandya (digestive weakness) and promoting overall
gastrointestinal healths ).
4. Hematinic: Madhuka Kusuma (Madhuca longifolia flowers) in the formulation provides hematinic
properties, contributing to the restoration of hemoglobin levels in conditions associated with blood loss,
such as Raktatisara.

PHARMACOKINETICS:
1. Absorption: The water-based decoction of Kutaja and other herbs allows for efficient absorption of
active constituents in the
gastrointestinal tract.
2. Metabolism: Once absorbed, the herbal components undergo metabolism in the liver and other
tissues, where they are
metabolized into active compounds.
3. Distribution: The active compounds are then distributed throughout the body, reaching target organs
such as the gastrointestinal
tract and the bloodstream.
4. Elimination: Metabolites and any unutilized constituents are primarily eliminated via urine and feces.

RESEARCH UPDATES:
It’s research found that it slows intestinal motility, which can be used to cure diarrhoea and dysentery.

GANDHAKADYA MALAHARA

सिक्थतैलं सुविमलं रसतोलकसम्मितम् । गन्धकं गिरिसिन्दू रं तोलकार्दमितं पृथक् ।।

टङ्कणं धनसारं च पृथक् माषद्वयोन्मितम् । दत्त्वा सम्मेल्य यत्नेन काचकु प्या निधापयेत् ।।
मतो मलहरोऽयं तु गन्धकाव्यसमाह्ह्वयः । विनाशयत्याशु भृशं पामामत्यर्थदाँरुणाम् ।। (R.T. 8/63-65)

INGREDIENTS:

Shikta taila,gandhaka,girisindura,tankana,karpura.

PROCEDURE:

Collect all the ingredients of Gandhakadya Malahara. All the ingredients except Sikta Taila should be
taken in a mortar and ground well. Then, Siktha Taila should be
mixed in thoroughly and ground continuously for some hours. This mixture is known as Gandhakadya
Malahara and should be preserved in a glass container.
Dose: External use only.
Indications: Pama.

PHARMACODYNAMICS:
1. Antibacterial: Gandhakadya Malahara containsShuddha Gandhaka (purified sulfur) and Girisindura,
which possess potent antibacterial properties. These
components help in inhibiting the growth of bacteria responsible for skin infections, promoting wound
healing, and preventing further infection.

PHARMACOKINETICS:
1. Topical Absorption: When applied topically, the herbal oils and other active constituents in
Gandhakadya Malahara are absorbed through the skin barrier.
2. Local Action: Upon absorption, the active ingredientsexert their pharmacological effects locally on the
affected area, providing relief from symptoms associated with
Pama.
Metabolism:Metabolism of the absorbed compounds may occur locally in the skin tissues or
systemically in the liver, depending on the nature of theingredients.
4. Elimination: Any metabolitesor unutilized constituents are eliminated primarily through the skin or
may undergo hepatic metabolism and subsequent excretion via
urine or Faeces .

RESEARCH UPDATES :
It’s reduced the symptoms of padari .

LEPA GUTI
Reference: AFI, Part III, page 232CGHS Formulary, Anubhuta Yoga
INGREDIENTS USED:
Punarnava,lodhara,chitrakar,shunthi,Guggulu haldi,triphala kwatha,gomutra.

PROCEDURE:
1. Collect all the ingredients of Lepa Guti and grind them into a fine powder.
2. Place all the ingredients in a vessel, add the dravadravyas, and heat the mixture until it reaches a
semi-solid consistency.
3. Shape the mixture into guti or any feasible form, and store it in an airtight container.
4. Before applying it to the body, grind it with water as the medium for application.
Dose: External Application after grinding with water.
Indications: Amavata, Shotha, Vridharoga, Gandamala, Arbuda, Yoniroga.

PHARMACODYNAMICS:
1. Anti-inflammatory: Lepa Guti contains ingredients like Punarnava, Lodhara, Citraka, and Haldi, which
possess potent anti-inflammatory properties These components help reduce inflammation associated
with various conditions such as Amavata (rheumatoid arthritis), Shotha (swelling), and Vriddharoga
(hydrocele). They alleviate pain, swelling, and discomfort.

Antimicrobial: Shunthi (ginger) present in the formulation exhibits antimicrobial effects, helping to inhibit
the growth of microorganisms. This property is beneficial in treating skin infections like Gandamala
(goitre) and Yoniroga (genitourinary disorders), where microbial overgrowth may contribute to the
pathology.
3. Analgesic: The anti-inflammatory and analgesic properties of the herbs in Lepa Guti contribute to
pain relieflt can help alleviate the pain associated with conditions like Amavata and hydrocele,
enhancing the overall therapeutic effect.
4. Detoxifying: Punarnava is known for its detoxifying properties, aiding in the elimination of toxins from
the body. This action is beneficial in conditions like Amavata, where the accumulation of ama (toxins)
aggravates joint inflammation and pain.

PHARMACOKINETICS:
1. Topical Absorption: When applied externally as a paste (lepa) after grinding with water, the active
constituents of Lepa Guti are absorbed through the skin.
2. Local Action: Upon absorption, the herbal compounds exert their pharmacological effects locally on
the affected area, providing relief from inflammation, pain, and swelling.

RESEARCH UPDATES:
For its better usability Lepa guti was modified into gel and cream form.