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VMED 5173 Cho's Gen Path Syllabus 09

The document outlines key topics in general pathology, including pigments, disturbances of cell growth, and neoplasia. It covers definitions, tumor characteristics, mechanisms of tumor spread, and the role of genetics in cancer. Additionally, it discusses cancer etiology, molecular determinants, and the relevance of animal models in clinical oncology.

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2 views

VMED 5173 Cho's Gen Path Syllabus 09

The document outlines key topics in general pathology, including pigments, disturbances of cell growth, and neoplasia. It covers definitions, tumor characteristics, mechanisms of tumor spread, and the role of genetics in cancer. Additionally, it discusses cancer etiology, molecular determinants, and the relevance of animal models in clinical oncology.

Uploaded by

wcvet3579
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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VMED 5173 GENERAL PATHOLOGY

April 1-15, 2009


Dr. Cho

1. PIGMENTS
Exogenous pigments - Carbon, soot, coal dust, silica, other environmental dusts, carotenoid,
tetracycline, etc
Endogenous pigments - Melanin, lipofuscin, hemoglobin, hemosiderin, bilirubin, etc

2. DISTURBANCES OF CELL GROWTH - NONNEOPLASTIC DISORDERS


Developmental (Congenital) Defects
Aplasia/Agenesis
Hypoplasia
Miscellaneous
Acquired Defects
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
Dysplasia

3. NEOPLASIA AND TUMOR BIOLOGY


DEFINITIONS
VETERINARY NOMENCLATURE
TUMOR CHARACTERISTICS
BENIGN VERSUS MALIGNANT TUMORS
DIFFERENTIATION
HALLMARKS OF DIFFERENTIATION
Morphology
Function
Behavior
STEM CELLS AND DIFFERENTIATION
PROLIFERATION
THE CELL CYCLE
CONTROL OF NORMAL CELL PROLIFERATION AND TISSSUE GROWTH
Proliferation
Differentiation
Apoptosis
TISSUE PROLIFERATIVE ACTIVITY
Continuously Dividing Tissues (Labile Tissues)
Quiescent Tissues (Stable Tissues)
Nondividing Tissues (Permanent Tissues)
TUMOR GROWTH
Proliferative Potential
Telomerase
Cell Cycle
Growth Modulation
Apoptosis
GENOMIC INSTABILITY
TUMOR EVOLUTION
STEPWISE TUMOR DEVELOPMENT
INITIATION
PROMOTION
PROGRESSION
TUMOR HETEROGENEITY AND CLONAL SELECTION

MOLECULAR CHANGES UNDERLYING TUMOR PROGRESSION

TUMOR SPREAD
FEATURES OF TUMOR SPREAD
PATHWAYS OF TUMOR METASTASIS
MECHANISMS OF INVASION AND METASTASIS
METASTASIS SUPPRESSION

TUMOR STROMA
COMPOSITION OF THE STROMA
TUMOR-STROMAL INTERACTIONS
ANGIOGENESIS
INFLAMMATION

TUMOR IMMUNITY will be dealt with in IMMUNOLOGY

SYSTEMIC EFFECTS ON THE HOST

GENETICS AND CANCER


STEPWISE ACCUMULATION OF CHANGES
GENETIC CHANGES IN CANCER

CANCER ETIOLOGY
GERMLINE MUTATIONS AND CANCER SYNDROMES
ACQUIRED SOMATIC MUTATIONS
INTRINSIC FACTORS
EXTRINSIC FACTORS
MECHANISMS OF CARCINOGENESIS

MOLECULAR DETERMINANTS OF CANCER


TUMOR SUPPRESOR GENES
ONCOGENES
EFECTS IN DNA REPAIR

ANIMALS AND CANCER


ANIMAL MODELS OF CANCER
CLINICAL ONCOLOGY
HISTOPATHOLOGICAL DIAGNOSIS
CLONALITY ASSAYS
OTHER MOLECULAR DIAGNOSTIC TECHNIQUES
GRADING
STAGING
SURGICAL MARGINS

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