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De Novo Pyrimidine Synthesis Mnemonic For USMLE

De Novo Pyrimidine Synthesis outlines the biochemical pathway for synthesizing pyrimidine nucleotides from glutamine and carbon dioxide. Key steps include the formation of carbamoyl phosphate and orotic acid, with potential inhibition by drugs like leflunomide and hydroxyurea. The pathway ultimately leads to the production of UMP, which can be further converted to CTP or dUMP.

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28 views1 page

De Novo Pyrimidine Synthesis Mnemonic For USMLE

De Novo Pyrimidine Synthesis outlines the biochemical pathway for synthesizing pyrimidine nucleotides from glutamine and carbon dioxide. Key steps include the formation of carbamoyl phosphate and orotic acid, with potential inhibition by drugs like leflunomide and hydroxyurea. The pathway ultimately leads to the production of UMP, which can be further converted to CTP or dUMP.

Uploaded by

lynds.edelman
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Medicine & USMLE

Dashboard List Extras

De Novo Pyrimidine Synthesis Biochemical Pathways


62,813 views

Electron Transport Chain (ETC)

Cori Cycle

De Novo Purine Synthesis

De Novo Pyrimidine Synthesis

Purine Salvage

Purine Excretion

Ethanol Metabolism

Pyruvate Metabolism

HMP Shunt (Pentose Phosphate


Pathway)

Galactose Metabolism

De Novo Pyrimidine Synthesis describes the biochemical pathway used to make pyrimidine nucleotides from building
blocks in the cell.

Pyrimidine Synthesis begins with glutamine and carbon dioxide, which combine to form carbamoyl phosphate, in a
reaction catalyzed by CPS2. Carbamoyl phosphate then combines with aspartate to form orotic acid, through steps
that can be inhibited by leflunomide. Afterwards, orotic acid reacts with PRPP to form UMP, in a reaction that is
impaired in orotic aciduria.

UMP is then phosphorylated to UDP, which has two possible fates: it can be converted into the pyrimidine nucleotide, 21:01

CTP, or undergo reduction by ribonucleotide reductase (RNR) to dUDP. Notably, RNR can be inhibited by the drug,
hydroxyurea. dUDP is then dephosphorylated to dUMP, which in turn undergoes methylation by thymidylate

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