p1
p1
G - 4 29, Shiv
Om Apartment Vishnupuri Colony
Bhawrkua Indore, M.P.
[email protected]
Costomer Care : 8770216832
LB090525002
LABORATORY TEST REPORTS
THYROID FUNCTION
THYROID STIMULATING HORMONE #(TSH 2.81 µlU/ml µlU/ml 0.35 - 5.5 µlU/ml
)
# - High Ultra Sensitive TSH Assay
Interpretation:
The following potential sources of variation should be considered while interpreting thyroid hormone results:
1. Circadian variation in TSH secretion: peak levels are seen between 2-4 am. Minimum levels seen between 6-10 am. This variation may
be as much as 50% thus, influence of sampling time needs to be considered for clinical interpretation.
2. Total T3 and T4 levels are seen to have physiological rise during pregnancy and in patients on steroid treatment
3. Circulating forms of T3 and T4 are mostly reversibly bound with Thyroxine binding globulins (TBG), and to a lesser extent with albumin
and Thyroid binding Pre-Albumin. Thus the conditions in which TBG and protein levels alter such as chronic liver disorders, pregnancy,
excess of estrogens, androgens, anabolic steroids and glucocorticoids may cause misleading total T3, total T4 and TSH interpretations.
4. T4 may be normal in the presence of hyperthyroidism under the following conditions : T3 thyrotoxicosis, Hypoproteinemia related
reduced binding, in presence of drugs (eg Phenytoin, Salicylates etc)
5. Neonates and infants have higher levels of T4 due to increased concentration of TBG
6. TSH levels may be normal in central hypothyroidism, recent rapid correction of hypothyroidism or hyperthyroidism, pregnancy,
phenytoin therapy etc.
7. TSH values of <0.03 uIU/mL must be clinically correlated to evaluate the presence of a rare TSH variant in certain individuals which is
undetected by conventional methods.
8. Presence of Autoimmune disorders may lead to spurious results of thyroid hormones
9. Various drugs can lead to interference in test results
It is recommended to evaluate unbound fractions, that is free T3 (fT3) and free T4 (fT4) for clinic-pathologic correlation, as these are the
metabolically active forms.
TSH results between 4.5 to 15 show considerable physiologic & seasonal variation, suggest clinical correlation or repeat testing with
fresh sample .
TSH results between 0.1 to 0.45 require correlation with patient age & clinical symptoms. As with increasing age, there are marked
changes in thyroid hormone production, metabolism & its actions resulting in an increased prevalence of subclinical thyroid disease .
TSH values may be transiently altered because of non thyroidal illness like severe infections,liver disease, renal and heart failure,severe
burns, trauma and surgery etc .
Drugs that decrease TSH values e.g:L-dopa,Glucocorticoid Drugs that increase TSH values e.g Iodine,Lithium,Amiodarone.
Patients on Biotin supplement may have interference in some immunoassays. With individuals taking high dose Biotin (more
than 5 mg per day) supplements, at least 8-hour wait time before blood draw is recommended.
strong>Arch Pathol Lab Med—Vol 141, November 2017
--------------------------------------------------------------------------End of Reports---------------------------------------------------------------------------------
Dr. R. THAKUR
Scan QR Code to Checy Lab Location MD (Pathologist)
Lab Address: Shop No.G - 4 29, Shiv
Om Apartment Vishnupuri Colony
Bhawrkua Indore, M.P.
[email protected]
Costomer Care : 8770216832
LB090525002
LABORATORY TEST REPORTS