Scribd
Upload
4 views11 pages

Case Presentation PDF

The case presentation details a 40-year-old patient with numerous moles showing changes in size and color, with one mole exhibiting irregular borders and color variation. Diagnostic procedures including dermoscopy and skin biopsy indicate the presence of atypical cells but no evidence of melanoma, leading to a diagnosis of sporadic dysplastic nevus. The document discusses the pathogenesis involving mutations in NRAS, BRAF, and CDKN2A, highlighting the cellular changes associated with dysplastic nevi.

Uploaded by

miguelalbertoramos
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
4 views11 pages

Case Presentation PDF

The case presentation details a 40-year-old patient with numerous moles showing changes in size and color, with one mole exhibiting irregular borders and color variation. Diagnostic procedures including dermoscopy and skin biopsy indicate the presence of atypical cells but no evidence of melanoma, leading to a diagnosis of sporadic dysplastic nevus. The document discusses the pathogenesis involving mutations in NRAS, BRAF, and CDKN2A, highlighting the cellular changes associated with dysplastic nevi.

Uploaded by

miguelalbertoramos
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 11

CASE

PRESENTATION

Miguel Ramos
LBBBI23 N03B
PATIENT
INFORMATION
Name SD

Age 40 years old

History Numerous moles (which exhibited change


in size and color)

No family history of melanoma

Frequent sun exposure


PHYSICAL EXAMINATION
Moles on the torso, limbs, and back
One mole on the upper back exhibit:
Irregular borders
Color variation
Diameter larger than 6mm
No signs of inflammation and ulceration
DIAGNOSTIC PROCEDURES

DERMOSCOPY SKIN BIOPSY

TOTAL BODY
PHOTOGRAPHY
DERMOSCOPY SKIN BIOPSY

Irregular pigment patterns Presence of atypical cell


Asymmetric structure No evidence of melanoma

TOTAL BODY PHOTOGRAPHY


SPORADIC
DYSPLASTIC NEVUS
CLINICAL FEATURES MICROSCOPIC FEATURES
>5mm Architectural changes
Irregular borders Shouldering
Target-like lesions Bridging
Variegated pigmentation Lentiginous hyperplasia
Irregular Nesting

Cytologic changes
Pleomorphism
UNCLEAR ETIOLOGY Increased nuclear size
Hyperchromatic nuclei
Prominent nucleoli
Irregular nuclear membrane

(Asadbeigi & Nguyen, n.d.)


PATHOGENESIS

MUTATIONS IN NRAS
present in melanocytic nevi
AND BRAF GENE

LOSS OF FUNCTION CDKN2A encodes for p16/INK4a


OF CDKN2A which is a negative regulator

provides resistance to CDK4 to


MUTATIONS IN CDK4
p16/INK4a
SHOULDERING BRIDGING

(Asadbeigi & Nguyen, n.d.)


MELANOMA!!!

REGRESSION
ECCRINE GLANDS

(Gardner, 2020)
THANK YOU
REFERENCES
Asadbeigi, S., & Nguyen, C. (n.d.). Dysplastic nevus. Pathology Outlines. Retrieved January 21, 2024, from
https://www.pathologyoutlines.com/topic/skintumormelanocyticdysplasticnevus.html

Gardner, J. (2020). Survival guide to dermatopathology.

You might also like